| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fei Chen, Xiaoping Sheng, Haobo Sun, Qunfeng Guo, Haibin Wang, Lecheng Wu, Bin Ni, Jun Yan. Advanced glycation end products induce nucleus pulposus cell apoptosis by upregulating TXNIP via inhibiting glycolysis pathway in intervertebral disc degeneration. Journal of biochemical and molecular toxicology. 2023-08-26. PMID:37632267. |
in npcs, ages reduced cell viability, induced apoptosis, inhibited glycolysis, and increased txnip expression. |
2023-08-26 |
2023-09-07 |
human |
| Fei Chen, Xiaoping Sheng, Haobo Sun, Qunfeng Guo, Haibin Wang, Lecheng Wu, Bin Ni, Jun Yan. Advanced glycation end products induce nucleus pulposus cell apoptosis by upregulating TXNIP via inhibiting glycolysis pathway in intervertebral disc degeneration. Journal of biochemical and molecular toxicology. 2023-08-26. PMID:37632267. |
silencing txnip compromised the effects of ages on cell viability, apoptosis, and glycolysis in npcs. |
2023-08-26 |
2023-09-07 |
human |
| Songchang Shi, Xiaobin Pan, Minyong Chen, Lihui Zhang, Shujuan Zhang, Xincai Wang, Songjing Shi, Zhixin Chen, Wei Lin, Yi Jian. USP5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein. Hepatology communications. vol 7. issue 8. 2023-08-03. PMID:37534934. |
usp5 promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the txnip protein. |
2023-08-03 |
2023-08-14 |
mouse |
| Eui-Hwan Choi, Sun-Ji Par. TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target. Experimental & molecular medicine. 2023-07-02. PMID:37394581. |
txnip activates endoplasmic reticulum (er) stress-mediated nucleotide-binding oligomerization domain (nod)-like receptor protein-3 (nlrp3) inflammasome complex formation, triggers mitochondrial stress-induced apoptosis, and stimulates inflammatory cell death (pyroptosis). |
2023-07-02 |
2023-08-14 |
Not clear |
| Junhyung Kim, Jaejoon Lim, Ik Dong Yoo, Samel Park, Jong-Seok Moo. TXNIP contributes to induction of pro-inflammatory phenotype and caspase-3 activation in astrocytes during Alzheimer's diseases. Redox biology. vol 63. 2023-05-12. PMID:37172394. |
txnip induced mitochondria-dependent apoptosis via caspase-9 and caspase-3 activation in human astrocytes. |
2023-05-12 |
2023-08-14 |
mouse |
| Jingxue Ma, Ruiying Ma, Xiaoyue Zhao, Yingxiu Wang, Shengxue Liao, Cong Nong, Fengling Lu, Zhao Liang, Junhui Huang, Yan Huang, Zhengxi Zhu, Junjie Wan. Cyr61 Mediates Angiotensin II-Induced Podocyte Apoptosis via the Upregulation of TXNIP. Journal of immunology research. vol 2023. 2023-04-10. PMID:37032654. |
cyr61 mediates angiotensin ii-induced podocyte apoptosis via the upregulation of txnip. |
2023-04-10 |
2023-08-14 |
Not clear |
| Stella Amarachi Ihim, Yukiko K Kaneko, Moe Yamamoto, Momoka Yamaguchi, Toshihide Kimura, Tomohisa Ishikaw. Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells. Biological & pharmaceutical bulletin. vol 46. issue 4. 2023-04-02. PMID:37005308. |
these results suggest that apigenin is an attractive candidate with remarkable and potent anti-diabetic effects on β-cells, which are mediated by facilitating glucose-stimulated insulin secretion and preventing er stress-mediated β-cell apoptosis, the latter of which may be possibly mediated by reduced expression of chop and txnip, thereby promoting β-cell survival and function. |
2023-04-02 |
2023-08-14 |
Not clear |
| Xuan-Zhang Huang, Min-Jiao Pang, Jia-Yi Li, Han-Yu Chen, Jing-Xu Sun, Yong-Xi Song, Hong-Jie Ni, Shi-Yu Ye, Shi Bai, Teng-Hui Li, Xin-Yu Wang, Jing-Yuan Lu, Jin-Jia Yang, Xun Sun, Jason C Mills, Zhi-Feng Miao, Zhen-Ning Wan. Single-cell sequencing of ascites fluid illustrates heterogeneity and therapy-induced evolution during gastric cancer peritoneal metastasis. Nature communications. vol 14. issue 1. 2023-02-14. PMID:36788228. |
two autophagy-related genes (marcks and txnip) mark high-plasticity gc with poorer prognosis, and autophagy inhibitors induce apoptosis in patient-derived organoids. |
2023-02-14 |
2023-08-14 |
Not clear |
| Marlon R Schneider, Silja Zettler, Birgit Rathkolb, Maik Dahlhof. TXNIP overexpression in mice enhances streptozotocin-induced diabetes severity. Molecular and cellular endocrinology. 2023-02-11. PMID:36773839. |
thioredoxin-interacting protein (txnip) is a key player in the endocrine pancreas; it induces beta cell apoptosis, such that txnip deficiency promotes beta cell survival. |
2023-02-11 |
2023-08-14 |
mouse |
| Aiyun Li, Li Guan, Wanzhen Su, Ning Zhao, Xuwen Song, Jin Wang, Xiaoxiao Tang, Weize Li, Xiangying Jia. TXNIP inhibition in the treatment of type 2 diabetes mellitus: design, synthesis, and biological evaluation of quinazoline derivatives. Journal of enzyme inhibition and medicinal chemistry. vol 38. issue 1. 2023-01-18. PMID:36651294. |
in vitro cell viability assay showed that compounds d-2 and c-1 could effectively protect β cell from pa-induced apoptosis, and subsequent results showed that these two compounds decreased txnip expression by accelerating its protein degradation. |
2023-01-18 |
2023-08-14 |
Not clear |
| Yuhao Yuan, Qing Liu, Ziyi Wu, Wei Zhong, Zili Lin, Wei Lu. TXNIP inhibits the progression of osteosarcoma through DDIT4-mediated mTORC1 suppression. American journal of cancer research. vol 12. issue 8. 2022-09-19. PMID:36119812. |
various cell phenotype experiments have shown that txnip inhibits the proliferation, migration, and invasion of os cells, and promotes their apoptosis. |
2022-09-19 |
2023-08-14 |
Not clear |
| Miaoyu Zhang, Haiyang Zhou, Rongni He, Juan Yang, Yang Zou, Yiting Deng, Huifang Xie, Zhenxing Ya. Up-regulating microRNA-214-3p relieves hypoxic-ischemic brain damage through inhibiting TXNIP expression. Molecular and cellular biochemistry. 2022-08-18. PMID:35980563. |
up-regulating mir-214-3p or depleting txnip improved neurological function, reduced neuronal inflammation and neuronal apoptosis, attenuated morphological damage of neurons, and increased the number of nissl bodies in mice with hibd. |
2022-08-18 |
2023-08-14 |
mouse |
| Jin Wang, Xue-Jiao Wang, Yan Zhang, Wen-Juan Shi, Zhan-Dong Lei, Xiang-Ying Jia. TXNIP knockout improves cardiac function after myocardial infarction by promoting angiogenesis and reducing cardiomyocyte apoptosis. Cardiovascular diagnosis and therapy. vol 12. issue 3. 2022-07-08. PMID:35800356. |
txnip knockout improves cardiac function after myocardial infarction by promoting angiogenesis and reducing cardiomyocyte apoptosis. |
2022-07-08 |
2023-08-14 |
Not clear |
| Jin Wang, Xue-Jiao Wang, Yan Zhang, Wen-Juan Shi, Zhan-Dong Lei, Xiang-Ying Jia. TXNIP knockout improves cardiac function after myocardial infarction by promoting angiogenesis and reducing cardiomyocyte apoptosis. Cardiovascular diagnosis and therapy. vol 12. issue 3. 2022-07-08. PMID:35800356. |
our study aimed to investigate the specific regulatory mechanism of txnip on angiogenesis and cardiomyocyte apoptosis after mi. |
2022-07-08 |
2023-08-14 |
Not clear |
| Fengyu Cheng, Nan Wan. N-Lobe of TXNIP Is Critical in the Allosteric Regulation of NLRP3 Frontiers in aging neuroscience. vol 14. 2022-06-20. PMID:35721021. |
the activation of inflammasome and apoptosis caused by txnip are widespread in brain diseases. |
2022-06-20 |
2023-08-14 |
Not clear |
| Karina Rodrigues-Dos-Santos, Gitanjali Roy, Derk D Binns, Magdalena G Grzemska, Luiz F Barella, Fiona Armoo, Melissa K McCoy, Andrew V Huynh, Jonathan Z Yang, Bruce A Posner, Melanie H Cobb, Michael A Kalwa. Small molecule-mediated insulin hypersecretion induces transient ER stress response and loss of beta cell function. Endocrinology. 2022-05-31. PMID:35641126. |
distinct from the effects of thapsigargin, sw016789 did not affect beta cell viability or apoptosis, potentially due to a rapid induction of adaptive genes, weak signaling through the eif2α kinase perk, and lack of oxidative stress gene txnip induction. |
2022-05-31 |
2023-08-13 |
human |
| Yu Zhang, Cheng-Jun Xing, Xiao Liu, Ya-Hong Li, Jing Jia, Jian-Guo Feng, Cheng-Jie Yang, Ye Chen, Jun Zho. Thioredoxin-Interacting Protein (TXNIP) Knockdown Protects against Sepsis-Induced Brain Injury and Cognitive Decline in Mice by Suppressing Oxidative Stress and Neuroinflammation. Oxidative medicine and cellular longevity. vol 2022. 2022-05-16. PMID:35571246. |
furthermore, the alterations in microglial activity, oxidative response, proinflammatory factors, apoptosis, protein levels (txnip and nlrp3 inflammasome), and apoptosis were examined in the hippocampal tissues. |
2022-05-16 |
2023-08-13 |
mouse |
| Yu Zhang, Cheng-Jun Xing, Xiao Liu, Ya-Hong Li, Jing Jia, Jian-Guo Feng, Cheng-Jie Yang, Ye Chen, Jun Zho. Thioredoxin-Interacting Protein (TXNIP) Knockdown Protects against Sepsis-Induced Brain Injury and Cognitive Decline in Mice by Suppressing Oxidative Stress and Neuroinflammation. Oxidative medicine and cellular longevity. vol 2022. 2022-05-16. PMID:35571246. |
txnip knockdown dramatically ameliorated the 7-day survival rate, cognitive decline, brain damage, neuronal apoptosis, and the brain water content, inhibited the activation of microglia, downregulated the nlrp3/caspase-1 signaling pathway, and reduced the oxidative stress and the neuroinflammatory cytokine levels at 24 h post-lps injection. |
2022-05-16 |
2023-08-13 |
mouse |
| Shanting Gao, Xiaomin Bu, Yongyue Gao, Zengtao Bao, Wenchao Shi, Lipeng Luan, Huiyu Chen, Baoming Zhang, Qingshui Tian, Wenxian Guan, Liuqing Yan. The miR-532-E2F1 feedback loop contributes to gastric cancer progression. Cell death & disease. vol 13. issue 4. 2022-04-20. PMID:35440106. |
mir-532 directly targeted and inhibited e2f1 expression, leading to the decrease of ask1 and elevation of txnip, and affected proliferation, cell cycle, apoptosis and dna damage in vitro and tumor growth in vivo. |
2022-04-20 |
2023-08-13 |
Not clear |
| Yiting Chen, Xueping Feng, Yuhao Yuan, Jiahui Jiang, Peihe Zhang, Bin Zhan. Identification of a novel mechanism for reversal of doxorubicin-induced chemotherapy resistance by TXNIP in triple-negative breast cancer via promoting reactive oxygen-mediated DNA damage. Cell death & disease. vol 13. issue 4. 2022-04-13. PMID:35414060. |
the results showed that txnip inhibited the proliferation of tnbc drug-resistant cells and promoted apoptosis in vitro and in vivo. |
2022-04-13 |
2023-08-13 |
human |