| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Yoshioka, Kenichi Imahashi, Scott A Gabel, William A Chutkow, Aurora A Burds, Joseph Gannon, P Christian Schulze, Catherine MacGillivray, Robert E London, Elizabeth Murphy, Richard T Le. Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circulation research. vol 101. issue 12. 2008-01-04. PMID:17916779. |
thioredoxin-interacting protein (txnip) is encoded by a mechanically-regulated gene that controls cell growth and apoptosis in part through interaction with the endogenous dithiol antioxidant thioredoxin. |
2008-01-04 |
2023-08-12 |
mouse |
| Jun Yoshioka, Eric R Schreiter, Richard T Le. Role of thioredoxin in cell growth through interactions with signaling molecules. Antioxidants & redox signaling. vol 8. issue 11-12. 2007-01-30. PMID:17034356. |
mechanisms by which thioredoxin regulates cell growth include binding to signaling molecules such as apoptosis signal-regulating kinase-1 (ask-1) and thioredoxin-interacting protein (txnip). |
2007-01-30 |
2023-08-12 |
human |
| Alexandra H Minn, Francesca M Couto, Anath Shale. Metabolism-independent sugar effects on gene transcription: the role of 3-O-methylglucose. Biochemistry. vol 45. issue 37. 2006-10-18. PMID:16964965. |
however, the example of thioredoxin-interacting protein (txnip), a glucose-regulated gene involved in the cellular redox state and pancreatic beta cell apoptosis, demonstrates that this rule may not always apply. |
2006-10-18 |
2023-08-12 |
human |
| Junqin Chen, Francesca M Couto, Alexandra H Minn, Anath Shale. Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein. Biochemical and biophysical research communications. vol 346. issue 3. 2006-08-21. PMID:16782054. |
we found that ex-4 protects ins-1 beta-cells against oxidative stress-induced apoptosis (tunel) and also reduces expression (mrna and protein) of thioredoxin-interacting protein (txnip), a pro-apoptotic factor involved in beta-cell glucose toxicity and oxidative stress. |
2006-08-21 |
2023-08-12 |
mouse |
| Junqin Chen, Francesca M Couto, Alexandra H Minn, Anath Shale. Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein. Biochemical and biophysical research communications. vol 346. issue 3. 2006-08-21. PMID:16782054. |
to determine whether ex-4-mediated txnip reduction is critical for this inhibition of apoptosis, we stably overexpressed txnip in ins-1 cells, which completely blunted the anti-apoptotic ex-4 effects. |
2006-08-21 |
2023-08-12 |
mouse |
| Junqin Chen, Francesca M Couto, Alexandra H Minn, Anath Shale. Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein. Biochemical and biophysical research communications. vol 346. issue 3. 2006-08-21. PMID:16782054. |
thus, ex-4 inhibits apoptosis by reducing txnip expression and early initiation of ex-4 treatment may help preserve endogenous beta-cell mass, protect against oxidative stress, and delay type 2 diabetes progression. |
2006-08-21 |
2023-08-12 |
mouse |
| Z Wang, Y P Rong, M H Malone, M C Davis, F Zhong, C W Distelhors. Thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis. Oncogene. vol 25. issue 13. 2006-05-04. PMID:16301999. |
thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis. |
2006-05-04 |
2023-08-12 |
mouse |
| Z Wang, Y P Rong, M H Malone, M C Davis, F Zhong, C W Distelhors. Thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis. Oncogene. vol 25. issue 13. 2006-05-04. PMID:16301999. |
expression of a gfp-txnip fusion protein was sufficient to induce apoptosis in wehi7.2 cells, and repression of endogenous txnip by rna interference inhibited dexamethasone-induced apoptosis in wehi7.2 cells. |
2006-05-04 |
2023-08-12 |
mouse |
| Z Wang, Y P Rong, M H Malone, M C Davis, F Zhong, C W Distelhors. Thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis. Oncogene. vol 25. issue 13. 2006-05-04. PMID:16301999. |
together, these findings indicate that txnip is a novel glucocorticoid-induced primary target gene involved in mediating glucocorticoid-induced apoptosis. |
2006-05-04 |
2023-08-12 |
mouse |
| Alexandra H Minn, Christian Hafele, Anath Shale. Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis. Endocrinology. vol 146. issue 5. 2005-05-24. PMID:15705778. |
we therefore generated a stable transfected beta-cell line (ins-1) overexpressing human txnip and found that txnip overexpression induced apoptosis as assessed by bax, bcl2, caspase-3, and cleaved caspase-9 as well as hoechst staining. |
2005-05-24 |
2023-08-12 |
mouse |
| Alexandra H Minn, Christian Hafele, Anath Shale. Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis. Endocrinology. vol 146. issue 5. 2005-05-24. PMID:15705778. |
thus, txnip is a novel proapoptotic beta-cell gene elevated in insulin resistance/diabetes and up-regulated by glucose through a unique chore and may link glucotoxicity and beta-cell apoptosis. |
2005-05-24 |
2023-08-12 |
mouse |
| Shoichiro Ohta, Edwin W Lai, Alan L Y Pang, Frederieke M Brouwers, Wai-Yee Chan, Graeme Eisenhofer, Ronald de Krijger, Lucia Ksinantova, Jan Breza, Pavel Blazicek, Richard Kvetnansky, Robert A Wesley, Karel Paca. Downregulation of metastasis suppressor genes in malignant pheochromocytoma. International journal of cancer. vol 114. issue 1. 2005-02-25. PMID:15523699. |
these genes are known to be involved in the regulation of important cancer-related cellular events, such as cell growth regulation and apoptosis (nm23-h1, timp-1, timp-2, timp-3, timp-4, txnip and crsp-3), cell-cell communication (brms-1), invasion (crmp-1) and cell adhesion (e-cad and kiss1). |
2005-02-25 |
2023-08-12 |
Not clear |