| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Geetu Saxena, Junqin Chen, Anath Shale. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. The Journal of biological chemistry. vol 285. issue 6. 2010-04-09. PMID:19959470. |
in mitochondria, txnip binds to and oxidizes trx2, thereby reducing trx2 binding to ask1 and allowing for ask1 phosphorylation/activation, resulting in induction of the mitochondrial pathway of apoptosis with cytochrome c release and caspase-3 cleavage. |
2010-04-09 |
2023-08-12 |
Not clear |
| Junqin Chen, Ghislaine Fontes, Geetu Saxena, Vincent Poitout, Anath Shale. Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes. vol 59. issue 2. 2010-02-24. PMID:19875615. |
lack of txnip protects against mitochondria-mediated apoptosis but not against fatty acid-induced er stress-mediated beta-cell death. |
2010-02-24 |
2023-08-12 |
rat |
| Junqin Chen, Ghislaine Fontes, Geetu Saxena, Vincent Poitout, Anath Shale. Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes. vol 59. issue 2. 2010-02-24. PMID:19875615. |
we have previously shown that lack of thioredoxin-interacting protein (txnip) protects against diabetes and glucotoxicity-induced beta-cell apoptosis. |
2010-02-24 |
2023-08-12 |
rat |
| Hyunjoo Cha-Molstad, Geetu Saxena, Junqin Chen, Anath Shale. Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells. The Journal of biological chemistry. vol 284. issue 25. 2009-10-20. PMID:19411249. |
recently, we identified txnip (thioredoxin-interacting protein) as a mediator of glucotoxic beta cell death and discovered that lack of txnip protects against streptozotocin- and obesity-induced diabetes by preventing beta cell apoptosis and preserving endogenous beta cell mass. |
2009-10-20 |
2023-08-12 |
human |
| Junqin Chen, Hyunjoo Cha-Molstad, Anna Szabo, Anath Shale. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. American journal of physiology. Endocrinology and metabolism. vol 296. issue 5. 2009-07-14. PMID:19258488. |
thioredoxin-interacting protein (txnip) has recently been shown to have deleterious effects in the cardiovascular system and we therefore investigated whether it may also play a role in diabetes-associated cardiomyocyte apoptosis. |
2009-07-14 |
2023-08-12 |
mouse |
| Junqin Chen, Hyunjoo Cha-Molstad, Anna Szabo, Anath Shale. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. American journal of physiology. Endocrinology and metabolism. vol 296. issue 5. 2009-07-14. PMID:19258488. |
oral administration of verapamil for 3 wk also reduced cardiac txnip expression in mice even in the face of severe diabetes, and these reduced txnip levels were associated with decreased apoptosis. |
2009-07-14 |
2023-08-12 |
mouse |
| Junqin Chen, Hyunjoo Cha-Molstad, Anna Szabo, Anath Shale. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. American journal of physiology. Endocrinology and metabolism. vol 296. issue 5. 2009-07-14. PMID:19258488. |
to determine whether lack of txnip can mimic the verapamil-induced decrease in apoptosis, we used txnip-deficient hcb-19 mice, harboring a natural nonsense mutation in the txnip gene. |
2009-07-14 |
2023-08-12 |
mouse |
| Junqin Chen, Hyunjoo Cha-Molstad, Anna Szabo, Anath Shale. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. American journal of physiology. Endocrinology and metabolism. vol 296. issue 5. 2009-07-14. PMID:19258488. |
interestingly, we found significantly reduced cleaved caspase-3 levels in hcb-19 hearts, suggesting that txnip plays a critical role in cardiac apoptosis and that the verapamil effects were mediated by txnip reduction. |
2009-07-14 |
2023-08-12 |
mouse |
| M Shaked, M Ketzinel-Gilad, Y Ariav, E Cerasi, N Kaiser, G Leibowit. Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets. Diabetologia. vol 52. issue 4. 2009-06-19. PMID:19214472. |
thioredoxin-interacting protein (txnip) is a critical mediator of glucose-induced beta cell apoptosis. |
2009-06-19 |
2023-08-12 |
Not clear |
| Parameswaran G Sreekumar, Yi Ding, Stephen J Ryan, Ram Kannan, David R Hinto. Regulation of thioredoxin by ceramide in retinal pigment epithelial cells. Experimental eye research. vol 88. issue 3. 2009-05-26. PMID:18996115. |
we found no direct interaction between apoptosis signal regulating kinase (ask-1) and txnip under the same experimental conditions. |
2009-05-26 |
2023-08-12 |
human |
| Anath Shale. Lack of TXNIP protects beta-cells against glucotoxicity. Biochemical Society transactions. vol 36. issue Pt 5. 2008-11-12. PMID:18793170. |
incubation of ins-1 beta-cells and isolated primary mouse and human islets at high glucose levels led to a significant increase in txnip as well as in apoptosis. |
2008-11-12 |
2023-08-12 |
mouse |
| Anath Shale. Lack of TXNIP protects beta-cells against glucotoxicity. Biochemical Society transactions. vol 36. issue Pt 5. 2008-11-12. PMID:18793170. |
we incubated islets of hcb-19 and c3h control mice at low and high glucose levels and assessed them for txnip expression and apoptosis. |
2008-11-12 |
2023-08-12 |
mouse |
| Anath Shale. Lack of TXNIP protects beta-cells against glucotoxicity. Biochemical Society transactions. vol 36. issue Pt 5. 2008-11-12. PMID:18793170. |
interestingly, whereas in c3h islets, high glucose levels led again to significant elevation of txnip and apoptosis levels as measured by tunel (terminal deoxynucleotidyl transferase-mediated dutp nick-end labelling) and cleaved caspase 3, no increase in apoptosis was observed in txnip-deficient hcb-19 islets, indicating that txnip is required for beta-cell death caused by glucotoxicity. |
2008-11-12 |
2023-08-12 |
mouse |
| Anath Shale. Lack of TXNIP protects beta-cells against glucotoxicity. Biochemical Society transactions. vol 36. issue Pt 5. 2008-11-12. PMID:18793170. |
thus inhibition of txnip protects against glucotoxic beta-cell apoptosis and therefore may represent a novel therapeutic approach to halt diabetes progression. |
2008-11-12 |
2023-08-12 |
mouse |
| Junqin Chen, Simon T Hui, Francesca M Couto, Imran N Mungrue, Dawn B Davis, Alan D Attie, Aldons J Lusis, Roger A Davis, Anath Shale. Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 10. 2008-10-21. PMID:18552236. |
when intercrossed with obese, insulin-resistant, and diabetic mice, double-mutant btbrlep(ob/ob)txnip(hcb/hcb) are even more obese, but are protected against diabetes and beta-cell apoptosis, resulting in a 3-fold increase in beta-cell mass. |
2008-10-21 |
2023-08-12 |
mouse |
| Junqin Chen, Simon T Hui, Francesca M Couto, Imran N Mungrue, Dawn B Davis, Alan D Attie, Aldons J Lusis, Roger A Davis, Anath Shale. Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 10. 2008-10-21. PMID:18552236. |
beta-cell-specific txnip deletion also enhanced beta-cell mass (p<0.005) and protected against diabetes, and terminal deoxynucleotidyl transferase-mediated nick end labeling (tunel) revealed a approximately 50-fold reduction in beta-cell apoptosis in streptozotocin-treated btko mice. |
2008-10-21 |
2023-08-12 |
mouse |
| Chia-Ling Chen, Chiou-Feng Lin, Wen-Tsan Chang, Wei-Ching Huang, Chiao-Fang Teng, Yee-Shin Li. Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. Blood. vol 111. issue 8. 2008-05-13. PMID:18270325. |
similarly, the chemotherapeutic agent etoposide induced txnip expression en route to apoptosis, which was blocked by inhibitors of ceramide production. |
2008-05-13 |
2023-08-12 |
Not clear |
| Chia-Ling Chen, Chiou-Feng Lin, Wen-Tsan Chang, Wei-Ching Huang, Chiao-Fang Teng, Yee-Shin Li. Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. Blood. vol 111. issue 8. 2008-05-13. PMID:18270325. |
txnip colocalized with thioredoxin and reduced its activity, which caused dissociation of thioredoxin from apoptosis signal-regulating kinase 1 (ask1). |
2008-05-13 |
2023-08-12 |
Not clear |
| Chia-Ling Chen, Chiou-Feng Lin, Wen-Tsan Chang, Wei-Ching Huang, Chiao-Fang Teng, Yee-Shin Li. Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. Blood. vol 111. issue 8. 2008-05-13. PMID:18270325. |
furthermore, ceramide-induced ask1, p38, and jnk phosphorylation and cell apoptosis were inhibited by txnip sirna transfection. |
2008-05-13 |
2023-08-12 |
Not clear |
| Chia-Ling Chen, Chiou-Feng Lin, Wen-Tsan Chang, Wei-Ching Huang, Chiao-Fang Teng, Yee-Shin Li. Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway. Blood. vol 111. issue 8. 2008-05-13. PMID:18270325. |
taken together, we show that ceramide exhibits a mechanism of transcriptional regulation involving up-regulation of txnip expression, also induced by etoposide, which results in ask1 activation, er stress, and p38 and jnk phosphorylation, all leading to apoptosis. |
2008-05-13 |
2023-08-12 |
Not clear |