| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eiji Yoshihara, Zhe Chen, Yoshiyuki Matsuo, Hiroshi Masutani, Junji Yodo. Thiol redox transitions by thioredoxin and thioredoxin-binding protein-2 in cell signaling. Methods in enzymology. vol 474. 2010-10-29. PMID:20609905. |
the interaction of thioredoxin and thioredoxin-binding proteins such as thioredoxin-binding protein-2 (tbp-2, also called as txnip or vdup1), apoptosis signal kinase (ask-1), redox factor 1 (ref-1), forkhead box class o 4 (foxo4), and nod-like receptor proteins (nlrps) suggested unconventional functions of thioredoxin and a novel mechanism of redox regulation. |
2010-10-29 |
2023-08-12 |
Not clear |
| Sweta Rani, Jai Prakash Mehta, Niall Barron, Padraig Doolan, Per Bendix Jeppesen, Martin Clynes, Lorraine O'Driscol. Decreasing Txnip mRNA and protein levels in pancreatic MIN6 cells reduces reactive oxygen species and restores glucose regulated insulin secretion. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 25. issue 6. 2010-09-22. PMID:20511712. |
recently, thioredoxin-interacting protein (txnip) expression has been implicated in a number of cellular events associated with diabetes, with increased txnip levels associated with reduced glucose uptake into peripheral tissues, increased reactive oxygen species (ros) in endothelial cells, beta cell glucotoxicity and apoptosis. |
2010-09-22 |
2023-08-12 |
Not clear |
| Geetu Saxena, Junqin Chen, Anath Shale. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. The Journal of biological chemistry. vol 285. issue 6. 2010-04-09. PMID:19959470. |
the thioredoxin-interacting protein txnip is a ubiquitously expressed redox protein that promotes apoptosis. |
2010-04-09 |
2023-08-12 |
Not clear |
| Geetu Saxena, Junqin Chen, Anath Shale. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. The Journal of biological chemistry. vol 285. issue 6. 2010-04-09. PMID:19959470. |
recently, we found that txnip deficiency protects against type 1 and 2 diabetes by inhibiting beta cell apoptosis and maintaining pancreatic beta cell mass, indicating that txnip plays a key role in beta cell biology. |
2010-04-09 |
2023-08-12 |
Not clear |
| Geetu Saxena, Junqin Chen, Anath Shale. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. The Journal of biological chemistry. vol 285. issue 6. 2010-04-09. PMID:19959470. |
in mitochondria, txnip binds to and oxidizes trx2, thereby reducing trx2 binding to ask1 and allowing for ask1 phosphorylation/activation, resulting in induction of the mitochondrial pathway of apoptosis with cytochrome c release and caspase-3 cleavage. |
2010-04-09 |
2023-08-12 |
Not clear |
| Junqin Chen, Ghislaine Fontes, Geetu Saxena, Vincent Poitout, Anath Shale. Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes. vol 59. issue 2. 2010-02-24. PMID:19875615. |
lack of txnip protects against mitochondria-mediated apoptosis but not against fatty acid-induced er stress-mediated beta-cell death. |
2010-02-24 |
2023-08-12 |
rat |
| Junqin Chen, Ghislaine Fontes, Geetu Saxena, Vincent Poitout, Anath Shale. Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes. vol 59. issue 2. 2010-02-24. PMID:19875615. |
we have previously shown that lack of thioredoxin-interacting protein (txnip) protects against diabetes and glucotoxicity-induced beta-cell apoptosis. |
2010-02-24 |
2023-08-12 |
rat |
| Hyunjoo Cha-Molstad, Geetu Saxena, Junqin Chen, Anath Shale. Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells. The Journal of biological chemistry. vol 284. issue 25. 2009-10-20. PMID:19411249. |
recently, we identified txnip (thioredoxin-interacting protein) as a mediator of glucotoxic beta cell death and discovered that lack of txnip protects against streptozotocin- and obesity-induced diabetes by preventing beta cell apoptosis and preserving endogenous beta cell mass. |
2009-10-20 |
2023-08-12 |
human |
| Junqin Chen, Hyunjoo Cha-Molstad, Anna Szabo, Anath Shale. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. American journal of physiology. Endocrinology and metabolism. vol 296. issue 5. 2009-07-14. PMID:19258488. |
thioredoxin-interacting protein (txnip) has recently been shown to have deleterious effects in the cardiovascular system and we therefore investigated whether it may also play a role in diabetes-associated cardiomyocyte apoptosis. |
2009-07-14 |
2023-08-12 |
mouse |
| Junqin Chen, Hyunjoo Cha-Molstad, Anna Szabo, Anath Shale. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. American journal of physiology. Endocrinology and metabolism. vol 296. issue 5. 2009-07-14. PMID:19258488. |
oral administration of verapamil for 3 wk also reduced cardiac txnip expression in mice even in the face of severe diabetes, and these reduced txnip levels were associated with decreased apoptosis. |
2009-07-14 |
2023-08-12 |
mouse |
| Junqin Chen, Hyunjoo Cha-Molstad, Anna Szabo, Anath Shale. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. American journal of physiology. Endocrinology and metabolism. vol 296. issue 5. 2009-07-14. PMID:19258488. |
to determine whether lack of txnip can mimic the verapamil-induced decrease in apoptosis, we used txnip-deficient hcb-19 mice, harboring a natural nonsense mutation in the txnip gene. |
2009-07-14 |
2023-08-12 |
mouse |
| Junqin Chen, Hyunjoo Cha-Molstad, Anna Szabo, Anath Shale. Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein. American journal of physiology. Endocrinology and metabolism. vol 296. issue 5. 2009-07-14. PMID:19258488. |
interestingly, we found significantly reduced cleaved caspase-3 levels in hcb-19 hearts, suggesting that txnip plays a critical role in cardiac apoptosis and that the verapamil effects were mediated by txnip reduction. |
2009-07-14 |
2023-08-12 |
mouse |
| M Shaked, M Ketzinel-Gilad, Y Ariav, E Cerasi, N Kaiser, G Leibowit. Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets. Diabetologia. vol 52. issue 4. 2009-06-19. PMID:19214472. |
thioredoxin-interacting protein (txnip) is a critical mediator of glucose-induced beta cell apoptosis. |
2009-06-19 |
2023-08-12 |
Not clear |
| Parameswaran G Sreekumar, Yi Ding, Stephen J Ryan, Ram Kannan, David R Hinto. Regulation of thioredoxin by ceramide in retinal pigment epithelial cells. Experimental eye research. vol 88. issue 3. 2009-05-26. PMID:18996115. |
we found no direct interaction between apoptosis signal regulating kinase (ask-1) and txnip under the same experimental conditions. |
2009-05-26 |
2023-08-12 |
human |
| Anath Shale. Lack of TXNIP protects beta-cells against glucotoxicity. Biochemical Society transactions. vol 36. issue Pt 5. 2008-11-12. PMID:18793170. |
incubation of ins-1 beta-cells and isolated primary mouse and human islets at high glucose levels led to a significant increase in txnip as well as in apoptosis. |
2008-11-12 |
2023-08-12 |
mouse |
| Anath Shale. Lack of TXNIP protects beta-cells against glucotoxicity. Biochemical Society transactions. vol 36. issue Pt 5. 2008-11-12. PMID:18793170. |
we incubated islets of hcb-19 and c3h control mice at low and high glucose levels and assessed them for txnip expression and apoptosis. |
2008-11-12 |
2023-08-12 |
mouse |
| Anath Shale. Lack of TXNIP protects beta-cells against glucotoxicity. Biochemical Society transactions. vol 36. issue Pt 5. 2008-11-12. PMID:18793170. |
interestingly, whereas in c3h islets, high glucose levels led again to significant elevation of txnip and apoptosis levels as measured by tunel (terminal deoxynucleotidyl transferase-mediated dutp nick-end labelling) and cleaved caspase 3, no increase in apoptosis was observed in txnip-deficient hcb-19 islets, indicating that txnip is required for beta-cell death caused by glucotoxicity. |
2008-11-12 |
2023-08-12 |
mouse |
| Anath Shale. Lack of TXNIP protects beta-cells against glucotoxicity. Biochemical Society transactions. vol 36. issue Pt 5. 2008-11-12. PMID:18793170. |
thus inhibition of txnip protects against glucotoxic beta-cell apoptosis and therefore may represent a novel therapeutic approach to halt diabetes progression. |
2008-11-12 |
2023-08-12 |
mouse |
| Junqin Chen, Simon T Hui, Francesca M Couto, Imran N Mungrue, Dawn B Davis, Alan D Attie, Aldons J Lusis, Roger A Davis, Anath Shale. Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 10. 2008-10-21. PMID:18552236. |
when intercrossed with obese, insulin-resistant, and diabetic mice, double-mutant btbrlep(ob/ob)txnip(hcb/hcb) are even more obese, but are protected against diabetes and beta-cell apoptosis, resulting in a 3-fold increase in beta-cell mass. |
2008-10-21 |
2023-08-12 |
mouse |
| Junqin Chen, Simon T Hui, Francesca M Couto, Imran N Mungrue, Dawn B Davis, Alan D Attie, Aldons J Lusis, Roger A Davis, Anath Shale. Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 10. 2008-10-21. PMID:18552236. |
beta-cell-specific txnip deletion also enhanced beta-cell mass (p<0.005) and protected against diabetes, and terminal deoxynucleotidyl transferase-mediated nick end labeling (tunel) revealed a approximately 50-fold reduction in beta-cell apoptosis in streptozotocin-treated btko mice. |
2008-10-21 |
2023-08-12 |
mouse |