| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia Xiao, Yinghui Zhu, Yingxia Liu, George L Tipoe, Feiyue Xing, Kwok-Fai S. Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway. International journal of biological macromolecules. vol 69. 2015-03-12. PMID:24858535. |
in conclusion, inhibition of hepatic txnip by lbp contributes to the reduction of cellular apoptosis, oxidative stress and nlrp3 inflammasome-mediated inflammation. |
2015-03-12 |
2023-08-13 |
rat |
| Junqin Chen, Gu Jing, Guanlan Xu, Anath Shale. Thioredoxin-interacting protein stimulates its own expression via a positive feedback loop. Molecular endocrinology (Baltimore, Md.). vol 28. issue 5. 2014-12-17. PMID:24628418. |
thioredoxin-interacting protein (txnip) has emerged as a key regulator of important cellular processes including redox state, inflammation, and apoptosis and plays a particularly critical role in pancreatic β-cell biology and diabetes development. |
2014-12-17 |
2023-08-12 |
Not clear |
| Junqin Chen, Gu Jing, Guanlan Xu, Anath Shale. Thioredoxin-interacting protein stimulates its own expression via a positive feedback loop. Molecular endocrinology (Baltimore, Md.). vol 28. issue 5. 2014-12-17. PMID:24628418. |
high glucose and diabetes induce txnip expression, whereas inhibition of txnip expression or txnip deficiency protects against pancreatic β-cell apoptosis and diabetes. |
2014-12-17 |
2023-08-12 |
Not clear |
| Junqin Chen, Gu Jing, Guanlan Xu, Anath Shale. Thioredoxin-interacting protein stimulates its own expression via a positive feedback loop. Molecular endocrinology (Baltimore, Md.). vol 28. issue 5. 2014-12-17. PMID:24628418. |
considering the detrimental effects of elevated txnip in β-cell biology, this novel pathway sheds new light onto the vicious cycle of increased txnip, leading to even more txnip expression, oxidative stress, inflammation, β-cell apoptosis, and diabetes progression. |
2014-12-17 |
2023-08-12 |
Not clear |
| Baotran Ho, Grace Huang, Vita M Golubovskay. Focal adhesion kinase regulates expression of thioredoxin-interacting protein (TXNIP) in cancer cells. Anti-cancer agents in medicinal chemistry. vol 14. issue 1. 2014-08-18. PMID:23387972. |
in addition, treatment of dbtrg glioblastoma cells with fak inhibitor y15 increased txnip mrna, decreased cancer cell viability and increased apoptosis. |
2014-08-18 |
2023-08-12 |
Not clear |
| Gu Jing, Clara Westwell-Roper, Junqin Chen, Guanlan Xu, C Bruce Verchere, Anath Shale. Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2. The Journal of biological chemistry. vol 289. issue 17. 2014-06-25. PMID:24627476. |
thioredoxin-interacting protein (txnip) is up-regulated by glucose and diabetes and plays a critical role in glucotoxicity, inflammation, and beta-cell apoptosis, whereas we have found that txnip deficiency protects against diabetes. |
2014-06-25 |
2023-08-12 |
mouse |
| Gil Leibowitz, Nurit Kaiser, Erol Ceras. β-Cell failure in type 2 diabetes. Journal of diabetes investigation. vol 2. issue 2. 2014-06-24. PMID:24843466. |
its inhibitor, thioredoxin-interacting protein (txnip), might be important in leading to β-cell apoptosis and type 2 diabetes. |
2014-06-24 |
2023-08-13 |
human |
| Young-Jun Park, Sung-Jin Yoon, Hyun-Woo Suh, Dong Oh Kim, Jeong-Ran Park, Haiyoung Jung, Tae-Don Kim, Suk Ran Yoon, Jeong-Ki Min, Hee-Jun Na, Seon-Jin Lee, Hee Gu Lee, Young Ho Lee, Hee-Bong Lee, Inpyo Cho. TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis. PLoS pathogens. vol 9. issue 10. 2014-05-26. PMID:24098117. |
thioredoxin-interacting protein (txnip) has multiple functions, including tumor suppression and involvement in cell proliferation and apoptosis. |
2014-05-26 |
2023-08-12 |
mouse |
| Ayaka Ikeda, Kiyomitsu Nemoto, Chiaki Yoshida, Shingo Miyata, Junki Mori, Saori Soejima, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Masakuni Degaw. Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells. Neuroscience letters. vol 549. 2014-03-06. PMID:23774476. |
increased expression of thioredoxin-interacting protein (txnip) has recently been proved to be a crucial event for irremediable endoplasmic reticulum (er) stress resulting in the programmed cell death (apoptosis) of pancreatic β-cells. |
2014-03-06 |
2023-08-12 |
human |
| Ayaka Ikeda, Kiyomitsu Nemoto, Chiaki Yoshida, Shingo Miyata, Junki Mori, Saori Soejima, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Masakuni Degaw. Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells. Neuroscience letters. vol 549. 2014-03-06. PMID:23774476. |
the present study demonstrated that treatment with 1-10 μg/ml tunicamycin, a potent revulsant of er stress, drastically induced txnip expression accompanied by the generation of cleaved caspase-3 as an indicator of apoptosis in sk-n-sh human neuroblastoma cells. |
2014-03-06 |
2023-08-12 |
human |
| Ayaka Ikeda, Kiyomitsu Nemoto, Chiaki Yoshida, Shingo Miyata, Junki Mori, Saori Soejima, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Masakuni Degaw. Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells. Neuroscience letters. vol 549. 2014-03-06. PMID:23774476. |
moreover, we evaluated the effects of nobiletin, a citrus polymethoxyflavonoid, on tunicamycin-induced apoptosis and txnip expression in sk-n-sh cells, because we reported previously that this flavonoid might be able to reduce txnip expression. |
2014-03-06 |
2023-08-12 |
human |
| Ayaka Ikeda, Kiyomitsu Nemoto, Chiaki Yoshida, Shingo Miyata, Junki Mori, Saori Soejima, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Masakuni Degaw. Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells. Neuroscience letters. vol 549. 2014-03-06. PMID:23774476. |
co-treatment of sk-n-sh cells with 100 μm nobiletin and 1 μg/ml tunicamycin for 24h strongly suppressed apoptosis and increased txnip expression induced by 1 μg/ml tunicamycin treatment alone. |
2014-03-06 |
2023-08-12 |
human |
| Guanlan Xu, Junqin Chen, Gu Jing, Anath Shale. Thioredoxin-interacting protein regulates insulin transcription through microRNA-204. Nature medicine. vol 19. issue 9. 2013-11-25. PMID:23975026. |
we identified thioredoxin-interacting protein (txnip), a cellular redox regulator, as a crucial factor in beta-cell biology and show that beta-cell txnip is upregulated in diabetes, whereas txnip deficiency protects against diabetes by preventing beta-cell apoptosis. |
2013-11-25 |
2023-08-12 |
mouse |
| Hui Su, Lele Ji, Wenjuan Xing, Wei Zhang, Heping Zhou, Xinhong Qian, Xiaoming Wang, Feng Gao, Xin Sun, Haifeng Zhan. Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia/reperfusion injury: role of thioredoxin-interacting protein. Journal of cellular and molecular medicine. vol 17. issue 1. 2013-11-13. PMID:23305039. |
thioredoxin-interacting protein (txnip) is a modulator of cellular redox state and contributes to cell apoptosis. |
2013-11-13 |
2023-08-12 |
rat |
| Hui Su, Lele Ji, Wenjuan Xing, Wei Zhang, Heping Zhou, Xinhong Qian, Xiaoming Wang, Feng Gao, Xin Sun, Haifeng Zhan. Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia/reperfusion injury: role of thioredoxin-interacting protein. Journal of cellular and molecular medicine. vol 17. issue 1. 2013-11-13. PMID:23305039. |
overexpression of txnip enhanced hg-induced superoxide generation and aggravated cardiomyocyte apoptosis, whereas txnip rnai significantly blunted the deleterious effects of hg. |
2013-11-13 |
2023-08-12 |
rat |
| Jianbiao Zhou, Wee-Joo Chn. Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer. Mitochondrion. vol 13. issue 3. 2013-09-10. PMID:22750447. |
roles of thioredoxin binding protein (txnip) in oxidative stress, apoptosis and cancer. |
2013-09-10 |
2023-08-12 |
mouse |
| Jianbiao Zhou, Wee-Joo Chn. Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer. Mitochondrion. vol 13. issue 3. 2013-09-10. PMID:22750447. |
txnip increases the production of reactive oxygen species (ros), and oxidative stress, resulting in cellular apoptosis. |
2013-09-10 |
2023-08-12 |
mouse |
| Takhellambam S Devi, Ken-Ichi Hosoya, Tetsuya Terasaki, Lalit P Sing. Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy. Experimental cell research. vol 319. issue 7. 2013-05-14. PMID:23353834. |
critical role of txnip in oxidative stress, dna damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy. |
2013-05-14 |
2023-08-12 |
rat |
| Takhellambam S Devi, Ken-Ichi Hosoya, Tetsuya Terasaki, Lalit P Sing. Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy. Experimental cell research. vol 319. issue 7. 2013-05-14. PMID:23353834. |
we recently showed that pro-oxidative stress and pro-apoptotic thioredoxin interacting protein (txnip) is significantly up-regulated in rat retinas in experimental diabetes and mediates inflammation and apoptosis. |
2013-05-14 |
2023-08-12 |
rat |
| Takhellambam S Devi, Ken-Ichi Hosoya, Tetsuya Terasaki, Lalit P Sing. Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy. Experimental cell research. vol 319. issue 7. 2013-05-14. PMID:23353834. |
therefore, we hypothesize here that txnip up-regulation in pericyte plays a causative role in oxidative stress and apoptosis under sustained high glucose exposure in culture. |
2013-05-14 |
2023-08-12 |
rat |