| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Baotran Ho, Grace Huang, Vita M Golubovskay. Focal adhesion kinase regulates expression of thioredoxin-interacting protein (TXNIP) in cancer cells. Anti-cancer agents in medicinal chemistry. vol 14. issue 1. 2014-08-18. PMID:23387972. |
in addition, treatment of dbtrg glioblastoma cells with fak inhibitor y15 increased txnip mrna, decreased cancer cell viability and increased apoptosis. |
2014-08-18 |
2023-08-12 |
Not clear |
| Gu Jing, Clara Westwell-Roper, Junqin Chen, Guanlan Xu, C Bruce Verchere, Anath Shale. Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2. The Journal of biological chemistry. vol 289. issue 17. 2014-06-25. PMID:24627476. |
thioredoxin-interacting protein (txnip) is up-regulated by glucose and diabetes and plays a critical role in glucotoxicity, inflammation, and beta-cell apoptosis, whereas we have found that txnip deficiency protects against diabetes. |
2014-06-25 |
2023-08-12 |
mouse |
| Gil Leibowitz, Nurit Kaiser, Erol Ceras. β-Cell failure in type 2 diabetes. Journal of diabetes investigation. vol 2. issue 2. 2014-06-24. PMID:24843466. |
its inhibitor, thioredoxin-interacting protein (txnip), might be important in leading to β-cell apoptosis and type 2 diabetes. |
2014-06-24 |
2023-08-13 |
human |
| Young-Jun Park, Sung-Jin Yoon, Hyun-Woo Suh, Dong Oh Kim, Jeong-Ran Park, Haiyoung Jung, Tae-Don Kim, Suk Ran Yoon, Jeong-Ki Min, Hee-Jun Na, Seon-Jin Lee, Hee Gu Lee, Young Ho Lee, Hee-Bong Lee, Inpyo Cho. TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis. PLoS pathogens. vol 9. issue 10. 2014-05-26. PMID:24098117. |
thioredoxin-interacting protein (txnip) has multiple functions, including tumor suppression and involvement in cell proliferation and apoptosis. |
2014-05-26 |
2023-08-12 |
mouse |
| Ayaka Ikeda, Kiyomitsu Nemoto, Chiaki Yoshida, Shingo Miyata, Junki Mori, Saori Soejima, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Masakuni Degaw. Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells. Neuroscience letters. vol 549. 2014-03-06. PMID:23774476. |
increased expression of thioredoxin-interacting protein (txnip) has recently been proved to be a crucial event for irremediable endoplasmic reticulum (er) stress resulting in the programmed cell death (apoptosis) of pancreatic β-cells. |
2014-03-06 |
2023-08-12 |
human |
| Ayaka Ikeda, Kiyomitsu Nemoto, Chiaki Yoshida, Shingo Miyata, Junki Mori, Saori Soejima, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Masakuni Degaw. Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells. Neuroscience letters. vol 549. 2014-03-06. PMID:23774476. |
the present study demonstrated that treatment with 1-10 μg/ml tunicamycin, a potent revulsant of er stress, drastically induced txnip expression accompanied by the generation of cleaved caspase-3 as an indicator of apoptosis in sk-n-sh human neuroblastoma cells. |
2014-03-06 |
2023-08-12 |
human |
| Ayaka Ikeda, Kiyomitsu Nemoto, Chiaki Yoshida, Shingo Miyata, Junki Mori, Saori Soejima, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Masakuni Degaw. Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells. Neuroscience letters. vol 549. 2014-03-06. PMID:23774476. |
moreover, we evaluated the effects of nobiletin, a citrus polymethoxyflavonoid, on tunicamycin-induced apoptosis and txnip expression in sk-n-sh cells, because we reported previously that this flavonoid might be able to reduce txnip expression. |
2014-03-06 |
2023-08-12 |
human |
| Ayaka Ikeda, Kiyomitsu Nemoto, Chiaki Yoshida, Shingo Miyata, Junki Mori, Saori Soejima, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Masakuni Degaw. Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells. Neuroscience letters. vol 549. 2014-03-06. PMID:23774476. |
co-treatment of sk-n-sh cells with 100 μm nobiletin and 1 μg/ml tunicamycin for 24h strongly suppressed apoptosis and increased txnip expression induced by 1 μg/ml tunicamycin treatment alone. |
2014-03-06 |
2023-08-12 |
human |
| Guanlan Xu, Junqin Chen, Gu Jing, Anath Shale. Thioredoxin-interacting protein regulates insulin transcription through microRNA-204. Nature medicine. vol 19. issue 9. 2013-11-25. PMID:23975026. |
we identified thioredoxin-interacting protein (txnip), a cellular redox regulator, as a crucial factor in beta-cell biology and show that beta-cell txnip is upregulated in diabetes, whereas txnip deficiency protects against diabetes by preventing beta-cell apoptosis. |
2013-11-25 |
2023-08-12 |
mouse |
| Hui Su, Lele Ji, Wenjuan Xing, Wei Zhang, Heping Zhou, Xinhong Qian, Xiaoming Wang, Feng Gao, Xin Sun, Haifeng Zhan. Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia/reperfusion injury: role of thioredoxin-interacting protein. Journal of cellular and molecular medicine. vol 17. issue 1. 2013-11-13. PMID:23305039. |
thioredoxin-interacting protein (txnip) is a modulator of cellular redox state and contributes to cell apoptosis. |
2013-11-13 |
2023-08-12 |
rat |
| Hui Su, Lele Ji, Wenjuan Xing, Wei Zhang, Heping Zhou, Xinhong Qian, Xiaoming Wang, Feng Gao, Xin Sun, Haifeng Zhan. Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia/reperfusion injury: role of thioredoxin-interacting protein. Journal of cellular and molecular medicine. vol 17. issue 1. 2013-11-13. PMID:23305039. |
overexpression of txnip enhanced hg-induced superoxide generation and aggravated cardiomyocyte apoptosis, whereas txnip rnai significantly blunted the deleterious effects of hg. |
2013-11-13 |
2023-08-12 |
rat |
| Jianbiao Zhou, Wee-Joo Chn. Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer. Mitochondrion. vol 13. issue 3. 2013-09-10. PMID:22750447. |
roles of thioredoxin binding protein (txnip) in oxidative stress, apoptosis and cancer. |
2013-09-10 |
2023-08-12 |
mouse |
| Jianbiao Zhou, Wee-Joo Chn. Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer. Mitochondrion. vol 13. issue 3. 2013-09-10. PMID:22750447. |
txnip increases the production of reactive oxygen species (ros), and oxidative stress, resulting in cellular apoptosis. |
2013-09-10 |
2023-08-12 |
mouse |
| Takhellambam S Devi, Ken-Ichi Hosoya, Tetsuya Terasaki, Lalit P Sing. Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy. Experimental cell research. vol 319. issue 7. 2013-05-14. PMID:23353834. |
critical role of txnip in oxidative stress, dna damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy. |
2013-05-14 |
2023-08-12 |
rat |
| Takhellambam S Devi, Ken-Ichi Hosoya, Tetsuya Terasaki, Lalit P Sing. Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy. Experimental cell research. vol 319. issue 7. 2013-05-14. PMID:23353834. |
we recently showed that pro-oxidative stress and pro-apoptotic thioredoxin interacting protein (txnip) is significantly up-regulated in rat retinas in experimental diabetes and mediates inflammation and apoptosis. |
2013-05-14 |
2023-08-12 |
rat |
| Takhellambam S Devi, Ken-Ichi Hosoya, Tetsuya Terasaki, Lalit P Sing. Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy. Experimental cell research. vol 319. issue 7. 2013-05-14. PMID:23353834. |
therefore, we hypothesize here that txnip up-regulation in pericyte plays a causative role in oxidative stress and apoptosis under sustained high glucose exposure in culture. |
2013-05-14 |
2023-08-12 |
rat |
| Takhellambam S Devi, Ken-Ichi Hosoya, Tetsuya Terasaki, Lalit P Sing. Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: implications for diabetic retinopathy. Experimental cell research. vol 319. issue 7. 2013-05-14. PMID:23353834. |
treatment of tr-rpct1 with nac or an inhibition of txnip by azas or sitxnip3 each reduces hg-induced ros, caspase-3 activation and dna damage demonstrating that txnip up-regulation under chronic hyperglycemia is critically involved in cellular oxidative stress, dna damage and retinal pericyte apoptosis. |
2013-05-14 |
2023-08-12 |
rat |
| Xiaoqing He, Qiang M. Redox regulation by nuclear factor erythroid 2-related factor 2: gatekeeping for the basal and diabetes-induced expression of thioredoxin-interacting protein. Molecular pharmacology. vol 82. issue 5. 2013-02-12. PMID:22869588. |
txnip promoted reactive oxygen species production and apoptosis by inhibiting thioredoxin. |
2013-02-12 |
2023-08-12 |
mouse |
| Yanling Zhang, Darren A Yuen, Andrew Advani, Kerri Thai, Suzanne L Advani, David Kepecs, M Golam Kabir, Kim A Connelly, Richard E Gilber. Early-outgrowth bone marrow cells attenuate renal injury and dysfunction via an antioxidant effect in a mouse model of type 2 diabetes. Diabetes. vol 61. issue 8. 2012-10-08. PMID:22596053. |
untreated db/db mice developed mesangial matrix expansion and tubular epithelial cell apoptosis in association with increased reactive oxygen species (ros) and overexpression of thioredoxin interacting protein (txnip). |
2012-10-08 |
2023-08-12 |
mouse |
| Yanling Zhang, Darren A Yuen, Andrew Advani, Kerri Thai, Suzanne L Advani, David Kepecs, M Golam Kabir, Kim A Connelly, Richard E Gilber. Early-outgrowth bone marrow cells attenuate renal injury and dysfunction via an antioxidant effect in a mouse model of type 2 diabetes. Diabetes. vol 61. issue 8. 2012-10-08. PMID:22596053. |
without affecting blood glucose or blood pressure, eocs not only attenuated mesangial and peritubular matrix expansion, as well as tubular apoptosis, but also diminished ros and txnip overexpression in the kidney of db/db mice. |
2012-10-08 |
2023-08-12 |
mouse |