| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Terri D McBride, U Andrew, Nicko Ly, Julio G Sot. RNA sequence analyses of r-Moj-DM treated cells: TXNIP is required to induce apoptosis of SK-Mel-28. Toxicon : official journal of the International Society on Toxinology. vol 121. 2017-05-09. PMID:27567705. |
rna sequence analyses of r-moj-dm treated cells: txnip is required to induce apoptosis of sk-mel-28. |
2017-05-09 |
2023-08-13 |
Not clear |
| Marco Antonio Zaragoza-Campillo, Julio Morá. Reactive Oxygen Species Evoked by Potassium Deprivation and Staurosporine Inactivate Akt and Induce the Expression of TXNIP in Cerebellar Granule Neurons. Oxidative medicine and cellular longevity. vol 2017. 2017-04-20. PMID:28367274. |
it has been shown that thioredoxin-interacting protein (txnip) overexpression renders cells more susceptible to oxidative stress and promotes apoptosis and that the activation of pi3k/akt pathway leads to a downregulation of txnip. |
2017-04-20 |
2023-08-13 |
Not clear |
| Benjamin J Forred, Skyla Neuharth, Dae In Kim, Michael W Amolins, Khatereh Motamedchaboki, Kyle J Roux, Peter F Vitiell. Identification of Redox and Glucose-Dependent Txnip Protein Interactions. Oxidative medicine and cellular longevity. vol 2016. 2017-03-13. PMID:27437069. |
although txnip has been implicated with numerous cellular processes such as proliferation, fatty acid and glucose metabolism, inflammation, and apoptosis, the molecular mechanisms underlying these processes are largely unknown. |
2017-03-13 |
2023-08-13 |
Not clear |
| Fatih Erdi, Fatih Keskin, Hasan Esen, Bulent Kaya, Bahadir Feyzioglu, Ibrahim Kilinc, Yasar Karatas, Gokhan Cuce, Erdal Kalka. Telmisartan ameliorates oxidative stress and subarachnoid haemorrhage-induced cerebral vasospasm. Neurological research. vol 38. issue 3. 2017-01-13. PMID:27078703. |
in this study, we have explored the effects of telmisartan on the vascular morphological changes, endothelial apoptosis, tissue oxidative stress status and the level of trx cycle enzymes/ txnip in a rabbit sah model. |
2017-01-13 |
2023-08-13 |
rabbit |
| Daoyin Dong, Noah Fu, Peixin Yan. MiR-17 Downregulation by High Glucose Stabilizes Thioredoxin-Interacting Protein and Removes Thioredoxin Inhibition on ASK1 Leading to Apoptosis. Toxicological sciences : an official journal of the Society of Toxicology. vol 150. issue 1. 2016-12-13. PMID:26660634. |
high glucose-induced ask1 activation and consequent apoptosis were abrogated by either the mir-17 mimic or txnip sirna knockdown. |
2016-12-13 |
2023-08-13 |
Not clear |
| Daoyin Dong, Noah Fu, Peixin Yan. MiR-17 Downregulation by High Glucose Stabilizes Thioredoxin-Interacting Protein and Removes Thioredoxin Inhibition on ASK1 Leading to Apoptosis. Toxicological sciences : an official journal of the Society of Toxicology. vol 150. issue 1. 2016-12-13. PMID:26660634. |
in contrast, the mir-17 inhibitor or txnip ectopic overexpression mimicked the stimulative effect of high glucose on ask1 and apoptosis. |
2016-12-13 |
2023-08-13 |
Not clear |
| Kyunghee Hong, Guanlan Xu, Truman B Grayson, Anath Shale. Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways. The Journal of biological chemistry. vol 291. issue 16. 2016-10-07. PMID:26858253. |
thioredoxin-interacting protein (txnip) is a key regulator of diabetic β-cell apoptosis and dysfunction, and txnip inhibition prevents diabetes in mouse models of type 1 and type 2 diabetes. |
2016-10-07 |
2023-08-13 |
mouse |
| Belal M Ali, Sawsan A Zaitone, Samia A Shouman, Yasser M Moustaf. Dorzolamide synergizes the antitumor activity of mitomycin C against Ehrlich's carcinoma grown in mice: role of thioredoxin-interacting protein. Naunyn-Schmiedeberg's archives of pharmacology. vol 388. issue 12. 2016-09-12. PMID:26264806. |
the present study aimed to investigate the antitumor activity of the ca inhibitor, dorzolamide, in combination with mitomycin c and to study the effect of these drugs on tumoral thioredoxin-interacting protein (txnip) as well as tumor cell proliferation and apoptosis. |
2016-09-12 |
2023-08-13 |
mouse |
| Belal M Ali, Sawsan A Zaitone, Samia A Shouman, Yasser M Moustaf. Dorzolamide synergizes the antitumor activity of mitomycin C against Ehrlich's carcinoma grown in mice: role of thioredoxin-interacting protein. Naunyn-Schmiedeberg's archives of pharmacology. vol 388. issue 12. 2016-09-12. PMID:26264806. |
the current data demonstrated that the antitumor activity of mitomycin c and dorzolamide was, at least in part, mediated through stimulating tumoral expression of txnip and enhancing tumor apoptosis. |
2016-09-12 |
2023-08-13 |
mouse |
| Shasha Liu, Xue Wu, Minru Zong, Wolfram Tempel, Peter Loppnau, Yanli Li. Structural basis for a novel interaction between TXNIP and Vav2. FEBS letters. vol 590. issue 6. 2016-08-08. PMID:26919541. |
thioredoxin-interacting protein (txnip) is a multifunctional protein involved in diverse cellular processes such as cell proliferation and apoptosis. |
2016-08-08 |
2023-08-13 |
Not clear |
| Jia Li, Yilei Wang, Yapu Wang, Xiaodong Wen, Xiao-Nan Ma, Weijie Chen, Fang Huang, Junping Kou, Lian-Wen Qi, Baolin Liu, Kang Li. Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction. Journal of molecular and cellular cardiology. vol 86. 2016-05-27. PMID:26196303. |
the effects of ampk activators salicylate and aica riboside (aicar) on mitochondrial ros production, drp1 phosphorylation, mitochondrial fission, er stress, thioredoxin-interacting protein (txnip)/nlrp3 inflammasome activation, inflammation, cell apoptosis and endothelium-dependent vasodilation were observed. |
2016-05-27 |
2023-08-13 |
rat |
| Ping Wu, Guan-hua D. [Thioredoxin-interacting protein: a new potential target for diabetes and related vascular complications therapy]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 50. issue 12. 2016-05-26. PMID:27169277. |
txnip regulates cellular survival, apoptosis and inflammation induced by glucotoxicity, heat shock and mechanical pressure. |
2016-05-26 |
2023-08-13 |
Not clear |
| Xiaoyu Li, Karen L Kover, Daniel P Heruth, Dara J Watkins, Wayne V Moore, Kathyrin Jackson, Mengwei Zang, Mark A Clements, Yun Ya. New Insight Into Metformin Action: Regulation of ChREBP and FOXO1 Activities in Endothelial Cells. Molecular endocrinology (Baltimore, Md.). vol 29. issue 8. 2016-05-10. PMID:26147751. |
thioredoxin-interacting protein (txnip), a key regulator of cellular redox state induced by high-glucose concentration, decreases thioredoxin reductase activity and mediates apoptosis induced by oxidative stress. |
2016-05-10 |
2023-08-13 |
human |
| Anu Shah, Ling Xia, Elodie A Y Masson, Chloe Gui, Abdul Momen, Eric A Shikatani, Mansoor Husain, Susan Quaggin, Rohan John, I G Fantu. Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy. Journal of the American Society of Nephrology : JASN. vol 26. issue 12. 2016-03-28. PMID:25855771. |
furthermore, in cultured human podocytes exposed to hg, txnip knockdown with sirna abolished the increased mitochondrial o2 (-) generation and apoptosis. |
2016-03-28 |
2023-08-13 |
mouse |
| Priyanka Sharma, Anju Bansal, Prakash Chand Sharm. RNA-seq-based transcriptome profiling reveals differential gene expression in the lungs of Sprague-Dawley rats during early-phase acute hypobaric hypoxia. Molecular genetics and genomics : MGG. vol 290. issue 6. 2016-03-01. PMID:26050109. |
upregulation of early-phase response genes including dusp1 (dual specificity phosphatase), cdkn1a (cyclin-dependent kinase inhibitor 1a), txnip (thioredoxin-interacting protein), rgs1 (regulator of g-protein signaling 1) and rgs2 (regulator of g-protein signaling 2) in susceptible rats indicated a progression toward growth arrest and apoptosis. |
2016-03-01 |
2023-08-13 |
rat |
| Federica Baldan, Catia Mio, Elisa Lavarone, Carla Di Loreto, Fabio Puglisi, Giuseppe Damante, Cinzia Puppi. Epigenetic bivalent marking is permissive to the synergy of HDAC and PARP inhibitors on TXNIP expression in breast cancer cells. Oncology reports. vol 33. issue 5. 2016-01-06. PMID:25812606. |
the synergy between saha and pj34 on txnip expression was associated with variation in cell viability and apoptosis. |
2016-01-06 |
2023-08-13 |
Not clear |
| Weiwei Nie, Weisun Huang, Wenwen Zhang, Jing Xu, Wei Song, Yanru Wang, Aiyu Zhu, Jiayan Luo, Guichun Huang, Yucai Wang, Xiaoxiang Gua. TXNIP interaction with the Her-1/2 pathway contributes to overall survival in breast cancer. Oncotarget. vol 6. issue 5. 2015-11-25. PMID:25605021. |
furthermore, txnip transfection induced p27 expression and g1 cell cycle arrest and apoptosis. |
2015-11-25 |
2023-08-13 |
human |
| Min Li-Webe. Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines). International journal of cancer. vol 137. issue 8. 2015-11-24. PMID:24895251. |
rocaglamides (= flavaglines) are potent natural anti-cancer phytochemicals that inhibit cancer growth at nanomolar concentrations by the following mechanisms: (1) inhibition of translation initiation via inhibition of phosphorylation of the mrna cap-binding eukaryotic translation initiation factor eif4e and stabilization of rna-binding of the translation initiation factor eif4a in the eif4f complex; (2) blocking cell cycle progression by activation of the atm/atr-chk1/chk2 checkpoint pathway; (3) inactivation of the heat shock factor 1 (hsf1) leading to up-regulation of thioredoxin-interacting protein (txnip) and consequent reduction of glucose uptake and (4) induction of apoptosis through activation of the mapk p38 and jnk and inhibition of the ras-craf-mek-erk signaling pathway. |
2015-11-24 |
2023-08-13 |
Not clear |
| Hai-Ying Sun, Yu-Juan Hu, Xue-Yan Zhao, Yi Zhong, Ling-Ling Zeng, Xu-Bo Chen, Jie Yuan, Jing Wu, Yu Sun, Wen Kong, Wei-Jia Kon. Age-related changes in mitochondrial antioxidant enzyme Trx2 and TXNIP-Trx2-ASK1 signal pathways in the auditory cortex of a mimetic aging rat model: changes to Trx2 in the auditory cortex. The FEBS journal. vol 282. issue 14. 2015-10-26. PMID:25996168. |
we also explored changes in thioredoxin-interacting protein (txnip), apoptosis signal regulating kinase 1 (ask1) and phosphorylated ask1 (p-ask1) expression, as well as the trx2-txnip/trx2-ask1 binding complex in the auditory cortex of mimetic aging rats. |
2015-10-26 |
2023-08-13 |
rat |
| Jianjun Wu, Xiaoshan Xu, Yi Li, Junping Kou, Fang Huang, Baolin Liu, Kang Li. Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells. European journal of pharmacology. vol 745. 2015-08-24. PMID:25446924. |
quercetin, luteolin and epigallocatechin gallate alleviate txnip and nlrp3-mediated inflammation and apoptosis with regulation of ampk in endothelial cells. |
2015-08-24 |
2023-08-13 |
Not clear |