| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Zhong, Qing Liu, Yan Sie Ting, Vun Yien Thien, Nurwafa Syafiqah Binti Kalong, Dehua Yang, Ming-Wei Wan. Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression. Chemical biology & drug design. vol 92. issue 6. 2019-08-01. PMID:30043441. |
overexpression of thioredoxin-interacting protein (txnip) is associated with reduced insulin sensitivity and β-cell apoptosis. |
2019-08-01 |
2023-08-13 |
Not clear |
| Li Zhong, Qing Liu, Yan Sie Ting, Vun Yien Thien, Nurwafa Syafiqah Binti Kalong, Dehua Yang, Ming-Wei Wan. Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression. Chemical biology & drug design. vol 92. issue 6. 2019-08-01. PMID:30043441. |
in this study, we describe structural modification and optimization of w2476 leading to three more active derivatives, 8d, 8g, and 9h, capable of suppressing txnip expression in bg73 and ins-1e cells, increasing insulin production, and reducing high glucose-induced apoptosis in ins-1e cells. |
2019-08-01 |
2023-08-13 |
Not clear |
| Xu Lixin, Yan Lijun, Huang Songpin. Ganoderic acid A against cyclophosphamide-induced hepatic toxicity in mice. Journal of biochemical and molecular toxicology. vol 33. issue 4. 2019-06-04. PMID:30506662. |
with the increase of the thioredoxin interaction protein (txnip)/trx/nf-кb pathway, the histological structure of the liver has significantly changed as well as apoptosis events. |
2019-06-04 |
2023-08-13 |
mouse |
| Ming Wu, Ruoyu Li, Yanjuan Hou, Shan Song, Weixia Han, Nan Chen, Yunxia Du, Yunzhuo Ren, Yonghong Sh. Thioredoxin-interacting protein deficiency ameliorates kidney inflammation and fibrosis in mice with unilateral ureteral obstruction. Laboratory investigation; a journal of technical methods and pathology. vol 98. issue 9. 2019-05-28. PMID:29884908. |
txnip deletion reduced renal fibrosis, apoptosis, α-sma, tgf-β1 and ctgf expression, and activation of smad3, p38 mapk, and erk1/2 in uuo kidneys. |
2019-05-28 |
2023-08-13 |
mouse |
| Xiao Fei Lan, Xiu Juan Zhang, Ying Ni Lin, Qiong Wang, Hua Jun Xu, Li Na Zhou, Pei Li Chen, Qing Yun L. Estradiol Regulates Txnip and Prevents Intermittent Hypoxia-Induced Vascular Injury. Scientific reports. vol 7. issue 1. 2019-05-09. PMID:28871193. |
knock-down of txnip by specific sirna rescued oxidative stress and apoptosis. |
2019-05-09 |
2023-08-13 |
mouse |
| Yidan Liang, Xudong Che, Qing Zhao, Rami Darwazeh, Hongxia Zhang, Dengzhi Jiang, Jun Zhao, Xiang Xiang, Wang Qin, Liu Liu, Zhaohui H. Thioredoxin-interacting protein mediates mitochondrion-dependent apoptosis in early brain injury after subarachnoid hemorrhage. Molecular and cellular biochemistry. vol 450. issue 1-2. 2019-03-06. PMID:29905889. |
recently, our team found that thioredoxin-interacting protein (txnip) links endoplasmic reticulum stress (er stress) to neuronal apoptosis and aggravates ebi. |
2019-03-06 |
2023-08-13 |
rat |
| Yidan Liang, Xudong Che, Qing Zhao, Rami Darwazeh, Hongxia Zhang, Dengzhi Jiang, Jun Zhao, Xiang Xiang, Wang Qin, Liu Liu, Zhaohui H. Thioredoxin-interacting protein mediates mitochondrion-dependent apoptosis in early brain injury after subarachnoid hemorrhage. Molecular and cellular biochemistry. vol 450. issue 1-2. 2019-03-06. PMID:29905889. |
therefore, our study further confirms that txnip may participate in neuronal apoptosis through the mitochondrial signaling pathway and that txnip may be a target for sah treatment. |
2019-03-06 |
2023-08-13 |
rat |
| Lingling Xu, Xiaopu Lin, Meiping Guan, Yanmei Zeng, Yingshan Li. Verapamil Attenuated Prediabetic Neuropathy in High-Fat Diet-Fed Mice through Inhibiting TXNIP-Mediated Apoptosis and Inflammation. Oxidative medicine and cellular longevity. vol 2019. 2019-03-04. PMID:30733849. |
in mitochondria, txnip binding to trx2 induced mitochondria dysfunction and apoptosis. |
2019-03-04 |
2023-08-13 |
mouse |
| Marcin Gamdzyk, Desislava Met Doycheva, Jay Malaguit, Budbazar Enkhjargal, Jiping Tang, John H Zhan. Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats. Neuropharmacology. vol 140. 2019-02-20. PMID:30086290. |
in the present study, we hypothesized that ppar-β/δ agonist gw0742 can activate mir-17-5p, consequently inhibiting txnip and ask1/p38 pathway leading to attenuation of apoptosis. |
2019-02-20 |
2023-08-13 |
rat |
| Marcin Gamdzyk, Desislava Met Doycheva, Jay Malaguit, Budbazar Enkhjargal, Jiping Tang, John H Zhan. Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats. Neuropharmacology. vol 140. 2019-02-20. PMID:30086290. |
furthermore, gw0742 treatment increased ppar-β/δ nuclear expression and mir-17-5p level and reduced txnip in ipsilateral hemisphere after hi, resulting in inhibition of ask1/p38 pathway and attenuation of apoptosis. |
2019-02-20 |
2023-08-13 |
rat |
| Yan-Jin Feng, Jin Wang, Zhu-Jie Cao, Dan Li, Hai-Yan Huo, Xu-Mei Zhang, Xiang-Ying Jia. [Angiotensin II promotes the expression of TXNIP through angiotensin II type 1 receptor in islet β cells]. Sheng li xue bao : [Acta physiologica Sinica]. vol 70. issue 2. 2019-01-04. PMID:29691579. |
this study investigated the effect of angiotensin ii (ang ii) on apoptosis and thioredoxin-interacting protein (txnip) expression in ins-1 islet cells and the underlying mechanism. |
2019-01-04 |
2023-08-13 |
Not clear |
| Yong Zhang, Liang-Sheng Miao, Ying-Min Cai, Jia-Xuan He, Zhen-Ni Zhang, Gang Wu, Juan Zhen. TXNIP knockdown alleviates hepatocyte ischemia reperfusion injury through preventing p38/JNK pathway activation. Biochemical and biophysical research communications. vol 502. issue 3. 2018-11-05. PMID:29852169. |
txnip overexpression remarkably promoted ogd/r-induced cell apoptosis and lactate dehydrogenase (ldh) release, both of which were significantly decreased by txnip knockdown. |
2018-11-05 |
2023-08-13 |
human |
| Jing Wang, Jin Wang, Juan-Juan Wang, Wei-Fang Zhang, Xiang-Ying Jia. [Role of autophagy in TXNIP overexpression-induced apoptosis of INS-1 islet cells]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 4. 2018-10-30. PMID:28825103. |
[role of autophagy in txnip overexpression-induced apoptosis of ins-1 islet cells]. |
2018-10-30 |
2023-08-13 |
Not clear |
| Jing Wang, Jin Wang, Juan-Juan Wang, Wei-Fang Zhang, Xiang-Ying Jia. [Role of autophagy in TXNIP overexpression-induced apoptosis of INS-1 islet cells]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 4. 2018-10-30. PMID:28825103. |
this study was to explore whether txnip overexpression could cause ins-1 cell autophagy under normal glucose and lipid concentrations, and to analyze the role of autophagy in the apoptosis of ins-1 cells. |
2018-10-30 |
2023-08-13 |
Not clear |
| Jing Wang, Jin Wang, Juan-Juan Wang, Wei-Fang Zhang, Xiang-Ying Jia. [Role of autophagy in TXNIP overexpression-induced apoptosis of INS-1 islet cells]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 4. 2018-10-30. PMID:28825103. |
the inhibitor of autophagy, 3-ma, reduced txnip overexpression-induced apoptosis in ins-1 cells. |
2018-10-30 |
2023-08-13 |
Not clear |
| Jing Wang, Jin Wang, Juan-Juan Wang, Wei-Fang Zhang, Xiang-Ying Jia. [Role of autophagy in TXNIP overexpression-induced apoptosis of INS-1 islet cells]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 4. 2018-10-30. PMID:28825103. |
taken together, our data demonstrate that autophagy appears to be an important pathway in txnip overexpression-induced apoptosis in ins-1 cells. |
2018-10-30 |
2023-08-13 |
Not clear |
| Irina Belaya, Masataka Suwa, Tao Chen, Rashid Giniatullin, Katja M Kanninen, Mustafa Atalay, Shuzo Kumaga. Long-Term Exercise Protects against Cellular Stresses in Aged Mice. Oxidative medicine and cellular longevity. vol 2018. 2018-10-05. PMID:29765493. |
aging was associated with a higher thioredoxin-interacting protein (txnip) level, lower thioredoxin-1 (trx-1) to txnip ratio-a determinant of redox regulation and increased chop, an indicator of er stress-related apoptosis signaling in both muscles. |
2018-10-05 |
2023-08-13 |
mouse |
| Mohamed A Abu El Maaty, Fadi Almouhanna, Stefan Wölf. Expression of TXNIP in Cancer Cells and Regulation by 1,25(OH)₂D₃: Is It Really the Vitamin D₃ Upregulated Protein? International journal of molecular sciences. vol 19. issue 3. 2018-08-27. PMID:29534438. |
thioredoxin-interacting protein (txnip) was originally identified in hl-60 cells as the vitamin d₃ upregulated protein 1, and is now known to be involved in diverse cellular processes, such as maintenance of glucose homeostasis, redox balance, and apoptosis. |
2018-08-27 |
2023-08-13 |
Not clear |
| Xiang Ren, Heyuan Lu, Nina Wang, Chenghong Zhang, Yunpeng Ji, Shiqi Cui, Yichen Dong, Kaiyuan Yang, Mengyi Du, Fengsheng Diao, Li Kon. Thioredoxin is implicated in the anti‑apoptotic effects of grape seed proanthocyanidin extract during hyperglycemia. Molecular medicine reports. vol 16. issue 5. 2018-06-06. PMID:28944891. |
furthermore, the protein expression of apoptosis signal‑regulating kinase (ask) 1 and trx‑interacting protein (txnip) was also upregulated by hyperglycemia, whereas gspe was revealed to counteract this upregulation. |
2018-06-06 |
2023-08-13 |
mouse |
| Wenzhen Deng, Yang Li, Yanjun Jia, Liang Tang, Qirui He, Dongfang Li. [Over-expression of thioredoxin-interacting protein promotes apoptosis of MIN6 cells via activating p38MAPK pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 10. 2018-05-15. PMID:29169415. |
objective to investigate the effect of thioredoxin interacting protein (txnip) over-expression on the apoptosis of min6 β-cells and the mechanism involved. |
2018-05-15 |
2023-08-13 |
Not clear |