| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Zhang, Runzhou Pan, Zhang Shou, Yongcai Zha. Xanthohumol attenuates TXNIP-mediated renal tubular injury in vitro and in vivo diabetic models. Journal of natural medicines. 2025-01-03. PMID:39752106. |
cell viability and apoptosis of renal tubular epithelial cells (rtecs) were evaluated using cck-8, annexin v/7-aad, and tunel staining after exposure to normal glucose (ng; 5 mm), high glucose (hg; 30 mm), or treatment with txnip inhibitors (xanthohumol, xan). |
2025-01-03 |
2025-01-05 |
mouse |
| Yan Zhang, Runzhou Pan, Zhang Shou, Yongcai Zha. Xanthohumol attenuates TXNIP-mediated renal tubular injury in vitro and in vivo diabetic models. Journal of natural medicines. 2025-01-03. PMID:39752106. |
both genetic inhibition of txnip using sh-rna and pharmacological inhibition with xan were found to reverse hg-induced rtec apoptosis and inflammatory response. |
2025-01-03 |
2025-01-05 |
mouse |
| Qin Zhang, Hai-Jin Huang, Jing-Ling Zhang, Ying Tian, Ying H. E3 ubiquitination ligase XIAP lightens diabetes-induced cognitive impairment by inactivating TXNIP-ERS-mediated neuronal injury. The Kaohsiung journal of medical sciences. 2024-12-04. PMID:39629879. |
this study aims to elucidate the role and mechanisms of the x-linked inhibitor of apoptosis protein (xiap)/thioredoxin-interacting protein (txnip) in hippocampal neuron cell death and cognitive function within dcd models. |
2024-12-04 |
2024-12-06 |
rat |
| Zhang Yaoting, Li Bing, Fu Yu, Cai He, Zheng Yan. Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation. Cellular signalling. 2024-10-13. PMID:39396562. |
txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating foxo1 and its acetylation. |
2024-10-13 |
2024-10-16 |
mouse |
| Zhang Yaoting, Li Bing, Fu Yu, Cai He, Zheng Yan. Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation. Cellular signalling. 2024-10-13. PMID:39396562. |
additionally, we observed an increase in txnip expression in the myocardium of diabetic mice and in high glucose-treated h9c2 cells, which regulates autophagic apoptosis in high glucose-treated h9c2 cells. |
2024-10-13 |
2024-10-16 |
mouse |
| Zhang Yaoting, Li Bing, Fu Yu, Cai He, Zheng Yan. Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation. Cellular signalling. 2024-10-13. PMID:39396562. |
furthermore, txnip regulates autophagic apoptosis through the modulation of forkhead box-1 (foxo1) expression and acetylation. |
2024-10-13 |
2024-10-16 |
mouse |
| Zhang Yaoting, Li Bing, Fu Yu, Cai He, Zheng Yan. Txnip promotes autophagic apoptosis in diabetic cardiomyopathy by upregulating FoxO1 and its acetylation. Cellular signalling. 2024-10-13. PMID:39396562. |
these findings revealed that txnip mediates autophagic apoptosis in dcm by upregulating foxo1 via ros and enhancing foxo1 acetylation through the suppression of sirt1 activity. |
2024-10-13 |
2024-10-16 |
mouse |
| Zhen-Ye Zhang, Lu Pan, Shipeng Dang, Ning Wang, Shan-Ying Zhao, Feng Li, Li-Da Wu, Lei Zhang, Huan-Huan Liu, Ning Zhao, Ya-Juan Yang, Ling-Ling Qian, Tong Liu, Ru-Xing Wan. Glucose fluctuations aggravate cardiomyocyte apoptosis by enhancing the interaction between Txnip and Akt. BMC cardiovascular disorders. vol 24. issue 1. 2024-09-03. PMID:39223509. |
glucose fluctuations aggravate cardiomyocyte apoptosis by enhancing the interaction between txnip and akt. |
2024-09-03 |
2024-09-05 |
Not clear |
| Xiangchen Zeng, Wenkai Chen, Naichun Yu, Zongguang Li, Hongyu Li, Yongjie Chen, Fengqing Gong, Xing Jiang, Guangrong J. Trifluoperazine exerts anti-osteosarcoma effect by inducing mitochondria-dependent apoptosis via AKT/TXNIP signaling pathway. Toxicology and applied pharmacology. 2024-08-31. PMID:39216834. |
combined with rna-seq data and further research, we confirmed that tfp promoted reactive oxygen species (ros) production by elevating thioredoxin binding protein (txnip) expression to induce mitochondria-dependent apoptosis. |
2024-08-31 |
2024-09-04 |
Not clear |
| Lili Shi, Yingying Xu, Chao Zhao, Guangjin Qu, Ming Ha. Liraglutide ameliorates high glucose-induced vascular endothelial injury through TRIB3/NF-κB signaling pathway. In vitro cellular & developmental biology. Animal. 2024-07-22. PMID:39039329. |
furthermore, silencing of tribbles homolog 3 (trib3) could markedly reduce hg-induced huvec apoptosis, ros level, the expressions of txnip, cleaved caspase3, nlrp3, and caspase1, indicating trib3 inhibition protected huvecs against hg-induced vascular endothelial injury. |
2024-07-22 |
2024-07-25 |
human |
| Xiang Cao, Zhixin Jiang, Xiaofei Bu, Qingyu Li, Ye Tian, Zijiao Xu, Boyang Zhang, Xiaoyong Yua. MicroRNA-204-5p Attenuates Oxidative Stress, Apoptosis and Inflammation by Targeting TXNIP in Diabetic Cataract. Biochemical genetics. 2024-06-19. PMID:38896379. |
microrna-204-5p attenuates oxidative stress, apoptosis and inflammation by targeting txnip in diabetic cataract. |
2024-06-19 |
2024-06-21 |
human |
| Xiang Cao, Zhixin Jiang, Xiaofei Bu, Qingyu Li, Ye Tian, Zijiao Xu, Boyang Zhang, Xiaoyong Yua. MicroRNA-204-5p Attenuates Oxidative Stress, Apoptosis and Inflammation by Targeting TXNIP in Diabetic Cataract. Biochemical genetics. 2024-06-19. PMID:38896379. |
therefore, this study demonstrated that mir-204-5p effectively reduced oxidative damage, apoptosis, and inflammation in hlecs under hg conditions by targeting txnip. |
2024-06-19 |
2024-06-21 |
human |
| Yong Zhang, Jianrui Lv, Jian Bai, Xue Zhang, Gang Wu, Xiaoming Lei, Wei Li, Zhenni Zhan. TXNIP knockdown ameliorates hepatic ischemia/reperfusion injury by inhibiting apoptosis and improving mitochondrial dysfunction via HIF-1α. Molecular and cellular biochemistry. 2024-06-13. PMID:38872070. |
txnip knockdown ameliorates hepatic ischemia/reperfusion injury by inhibiting apoptosis and improving mitochondrial dysfunction via hif-1α. |
2024-06-13 |
2024-06-16 |
Not clear |
| Yong Zhang, Jianrui Lv, Jian Bai, Xue Zhang, Gang Wu, Xiaoming Lei, Wei Li, Zhenni Zhan. TXNIP knockdown ameliorates hepatic ischemia/reperfusion injury by inhibiting apoptosis and improving mitochondrial dysfunction via HIF-1α. Molecular and cellular biochemistry. 2024-06-13. PMID:38872070. |
this study aims to investigate whether thioredoxin-interacting protein (txnip) regulates cell viability, cell apoptosis and mitochondrial damage in ogd/r-induced hepatocytes and to explore its underlying mechanism. |
2024-06-13 |
2024-06-16 |
Not clear |
| Yong Zhang, Jianrui Lv, Jian Bai, Xue Zhang, Gang Wu, Xiaoming Lei, Wei Li, Zhenni Zhan. TXNIP knockdown ameliorates hepatic ischemia/reperfusion injury by inhibiting apoptosis and improving mitochondrial dysfunction via HIF-1α. Molecular and cellular biochemistry. 2024-06-13. PMID:38872070. |
txnip knockdown increased cell viability and reduced cell apoptosis under ogd/r treatment. |
2024-06-13 |
2024-06-16 |
Not clear |
| Yong Zhang, Jianrui Lv, Jian Bai, Xue Zhang, Gang Wu, Xiaoming Lei, Wei Li, Zhenni Zhan. TXNIP knockdown ameliorates hepatic ischemia/reperfusion injury by inhibiting apoptosis and improving mitochondrial dysfunction via HIF-1α. Molecular and cellular biochemistry. 2024-06-13. PMID:38872070. |
in summary, txnip deletion ameliorated aml12 cell injury caused by ogd/r via promoting hif-1α expression and nuclear translocation, manifested by inhibiting cell apoptosis and alleviating mitochondrial dysfunction. |
2024-06-13 |
2024-06-16 |
Not clear |
| Wentong Wu, Jinjin Li, Yiming Yin, Yourong Zhou, Xiangliang Huang, Yashi Cao, Xueqin Chen, Yunfang Zhou, Jiangxia Du, Zhifei Xu, Bo Yang, Qiaojun He, Xiaochun Yang, Yuhuai Hu, Hao Yan, Peihua Lu. Rutin attenuates ensartinib-induced hepatotoxicity by non-transcriptional regulation of TXNIP. Cell biology and toxicology. vol 40. issue 1. 2024-05-25. PMID:38789868. |
a high txnip level and abnormal txnip translocation severely impaired hepatic function via mitochondrial dysfunction and hepatocyte apoptosis, and txnip deficiency attenuated hepatocyte apoptosis under ensartinib treatment. |
2024-05-25 |
2024-05-27 |
Not clear |
| Chia-Wen Lo, Chong-Kuei Lii, Kuan-Shuan Lin, Chien-Chun Li, Kai-Li Liu, Ya-Chen Yang, Haw-Wen Che. Luteolin, apigenin, and chrysin inhibit lipotoxicity-induced NLRP3 inflammasome activation and autophagy damage in macrophages by suppressing endoplasmic reticulum stress. Environmental toxicology. 2024-04-24. PMID:38654489. |
with luteolin, apigenin, and chrysin treatment, pa-induced ros production, er stress, txnip expression, autophagic flux damage, and apoptosis were ameliorated. |
2024-04-24 |
2024-04-28 |
Not clear |
| Yang Zhao, Yuanyuan Chen, Ziru Liu, Lei Zhou, Jiao Huang, Xi Luo, Yunpeng Luo, Jia Li, Yunan Lin, Jian Lai, Jingchen Li. TXNIP Knockdown Protects Rats against Bupivacaine-Induced Spinal Neurotoxicity via the Inhibition of Oxidative Stress and Apoptosis. Free radical biology & medicine. 2024-04-13. PMID:38614227. |
txnip knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis. |
2024-04-13 |
2024-04-16 |
rat |
| Yang Zhao, Yuanyuan Chen, Ziru Liu, Lei Zhou, Jiao Huang, Xi Luo, Yunpeng Luo, Jia Li, Yunan Lin, Jian Lai, Jingchen Li. TXNIP Knockdown Protects Rats against Bupivacaine-Induced Spinal Neurotoxicity via the Inhibition of Oxidative Stress and Apoptosis. Free radical biology & medicine. 2024-04-13. PMID:38614227. |
thioredoxin-interacting protein (txnip) is a member of the α-arrestin protein superfamily that binds covalently to thioredoxin (trx) to inhibit its function, leading to increased oxidative stress and activation of apoptosis. |
2024-04-13 |
2024-04-16 |
rat |