| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Zhao, Yuanyuan Chen, Ziru Liu, Lei Zhou, Jiao Huang, Xi Luo, Yunpeng Luo, Jia Li, Yunan Lin, Jian Lai, Jingchen Li. TXNIP Knockdown Protects Rats against Bupivacaine-Induced Spinal Neurotoxicity via the Inhibition of Oxidative Stress and Apoptosis. Free radical biology & medicine. 2024-04-13. PMID:38614227. |
the role of txnip in bup-induced oxidative stress and apoptosis remains to be elucidated. |
2024-04-13 |
2024-04-16 |
rat |
| Yang Zhao, Yuanyuan Chen, Ziru Liu, Lei Zhou, Jiao Huang, Xi Luo, Yunpeng Luo, Jia Li, Yunan Lin, Jian Lai, Jingchen Li. TXNIP Knockdown Protects Rats against Bupivacaine-Induced Spinal Neurotoxicity via the Inhibition of Oxidative Stress and Apoptosis. Free radical biology & medicine. 2024-04-13. PMID:38614227. |
in this context, the present study aimed to explore the effects of txnip knockdown on bup-induced oxidative stress and apoptosis in the spinal cord of rats and in pc12 cells through the transfection of adeno-associated virus-txnip short hairpin rna (aav-txnip shrna) and sirna-txnip, respectively. |
2024-04-13 |
2024-04-16 |
rat |
| Yang Zhao, Yuanyuan Chen, Ziru Liu, Lei Zhou, Jiao Huang, Xi Luo, Yunpeng Luo, Jia Li, Yunan Lin, Jian Lai, Jingchen Li. TXNIP Knockdown Protects Rats against Bupivacaine-Induced Spinal Neurotoxicity via the Inhibition of Oxidative Stress and Apoptosis. Free radical biology & medicine. 2024-04-13. PMID:38614227. |
in addition, treated with bup both in vitro and in vivo exhibited upregulated txnip expression and increased oxidative stress and apoptosis. |
2024-04-13 |
2024-04-16 |
rat |
| Yang Zhao, Yuanyuan Chen, Ziru Liu, Lei Zhou, Jiao Huang, Xi Luo, Yunpeng Luo, Jia Li, Yunan Lin, Jian Lai, Jingchen Li. TXNIP Knockdown Protects Rats against Bupivacaine-Induced Spinal Neurotoxicity via the Inhibition of Oxidative Stress and Apoptosis. Free radical biology & medicine. 2024-04-13. PMID:38614227. |
these findings suggested that txnip knockdown protected against bup-induced spinal neurotoxicity by suppressing oxidative stress and apoptosis. |
2024-04-13 |
2024-04-16 |
rat |
| Yang Zhao, Yuanyuan Chen, Ziru Liu, Lei Zhou, Jiao Huang, Xi Luo, Yunpeng Luo, Jia Li, Yunan Lin, Jian Lai, Jingchen Li. TXNIP Knockdown Protects Rats against Bupivacaine-Induced Spinal Neurotoxicity via the Inhibition of Oxidative Stress and Apoptosis. Free radical biology & medicine. 2024-04-13. PMID:38614227. |
in summary, txnip could be a central signaling hub that positively regulates oxidative stress and apoptosis during neuronal damage, which renders txnip a promising target for treatment strategies against bup-induced spinal neurotoxicity. |
2024-04-13 |
2024-04-16 |
rat |
| Xi Gu, Tian Xi. LncRNA AC005165.1 Alleviates IL-1β-Induced Osteoarthritis via miR-199a-3p/TXNIP Axis. Biochemical genetics. 2024-04-08. PMID:38587691. |
in rescue assay, mir-199a-3p knockdown and txnip overexpression significantly reduced apoptosis and mitigated inflammatory response in il-1β-treated chondrocytes with ac005165.1 knockdown. |
2024-04-08 |
2024-04-10 |
human |
| Sojung Kwak, Cho Lok Song, Yee Sook Cho, Inpyo Choi, Jae-Eun Byun, Haiyoung Jung, Jungwoon Le. Txnip regulates the Oct4-mediated pluripotency circuitry via metabolic changes upon differentiation. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-03-15. PMID:38485770. |
thioredoxin interacting protein (txnip) is a stress-responsive factor regulating trx1 for redox balance and involved in diverse cellular processes including proliferation, differentiation, apoptosis, inflammation, and metabolism. |
2024-03-15 |
2024-03-17 |
mouse |
| Masaru Takashima, Masaya Nagaya, Yoshihiro Takamura, Masaru Inatani, Masaya Ok. HIF-1 inhibition reverses opacity in a rat model of galactose-induced cataract. PloS one. vol 19. issue 2. 2024-02-28. PMID:38416732. |
acta2, a known marker for emt, and txnip, a suppressor of cell proliferation and activator of apoptosis, were present in each cluster. |
2024-02-28 |
2024-03-02 |
rat |
| Shenggui Xu, Weimin Lin, Wang Lin, Chengshou Lin, Weizhong Gu. Blocking TXNIP reduced IL-1β Induced chondrocyte cell inflammation. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 15. 2024-01-27. PMID:38279454. |
after inhibiting the expression of txnip by transfecting shtxnip into normal mouse chondrocytes, the cck-8 kit was used for detecting its effect on cell proliferation after transfection, and the effect on chondrocyte apoptosis was detected by flow cytometry. |
2024-01-27 |
2024-01-29 |
mouse |
| Shenggui Xu, Weimin Lin, Wang Lin, Chengshou Lin, Weizhong Gu. Blocking TXNIP reduced IL-1β Induced chondrocyte cell inflammation. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 15. 2024-01-27. PMID:38279454. |
after silencing txnip by shrna, cell proliferation increased, chondrocyte apoptosis was weakened, and chondrocyte aging was weakened. |
2024-01-27 |
2024-01-29 |
mouse |
| Shenggui Xu, Weimin Lin, Wang Lin, Chengshou Lin, Weizhong Gu. Blocking TXNIP reduced IL-1β Induced chondrocyte cell inflammation. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 15. 2024-01-27. PMID:38279454. |
in conclusion, silencing txnip can inhibit il-1β-induced chondrocyte apoptosis and aging, and has a positive effect on cell proliferation. |
2024-01-27 |
2024-01-29 |
mouse |
| Yao Chen, Hanzhou Li, Yan Yang, Lei Feng, Ling Yang, Jie Zhao, Xiaochi Xin, Shuquan Lv, Xixing Fang, Weibo Wen, Youxiang Cui, Huantian Cu. Polygalasaponin F ameliorates middle cerebral artery occlusion-induced focal ischemia / reperfusion injury in rats through inhibiting TXNIP/NLRP3 signaling pathway. Journal of neuroimmunology. vol 387. 2024-01-10. PMID:38198981. |
meanwhile, pgsf treatment inhibited apoptosis, and reduced the levels of ros, inflammatory cytokine and txnip/nlrp3 pathway-related proteins (txnip, nlrp3, asc, cleaved caspase-1, il-1β, and il-18) in ogd/r-induced neuronal injury cells. |
2024-01-10 |
2024-01-13 |
rat |
| Asraa Faris Aldoghachi, Daijiro Yanagisawa, Aslina Pahrudin Arrozi, Zulzikry Hafiz Abu Bakar, Hiroyasu Taguchi, Shinsuke Ishigaki, Katsutaro Morino, Ikuo Tooyam. Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes. Biochemical and biophysical research communications. vol 694. 2023-12-24. PMID:38142581. |
on day 29, the mice were euthanized, following which the serum levels of glucose, insulin, and glucagon were measured using elisa, the expression of txnip in pancreatic tissue lysates was determined using western blotting, and the level of β-cell apoptosis was assessed using the tunel assay. |
2023-12-24 |
2023-12-27 |
mouse |
| Asraa Faris Aldoghachi, Daijiro Yanagisawa, Aslina Pahrudin Arrozi, Zulzikry Hafiz Abu Bakar, Hiroyasu Taguchi, Shinsuke Ishigaki, Katsutaro Morino, Ikuo Tooyam. Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes. Biochemical and biophysical research communications. vol 694. 2023-12-24. PMID:38142581. |
findings from the present study suggest a potential of shiga-y6 as an antidiabetic agent through lowering txnip protein levels and ameliorating pancreatic β-cells apoptosis. |
2023-12-24 |
2023-12-27 |
mouse |
| Ying Gu, Minkai Cao, Yu Chen, Jingyang Li, Lingli Hu, Xiao-Jun Yan. Knockdown of TXNIP alleviates gestational diabetes mellitus by activating autophagy to regulate cell proliferation and apoptosis in high glucose-treated trophoblasts. Reproductive biology. vol 24. issue 1. 2023-12-20. PMID:38118268. |
knockdown of txnip alleviates gestational diabetes mellitus by activating autophagy to regulate cell proliferation and apoptosis in high glucose-treated trophoblasts. |
2023-12-20 |
2023-12-23 |
human |
| Hossein Arefanian, Lubaina Koti, Sardar Sindhu, Rasheed Ahmad, Ashraf Al Madhoun, Fahd Al-Mull. Verapamil chronicles: advances from cardiovascular to pancreatic β-cell protection. Frontiers in pharmacology. vol 14. 2023-12-13. PMID:38089047. |
although, verapamil reduces the expression of thioredoxin-interacting protein (txnip), a molecule which is involved in β-cell apoptosis and glucotoxicity-induced β-cell death, other signaling pathways are also modulated by verapamil. |
2023-12-13 |
2023-12-17 |
Not clear |
| Jasvinder Singh, Bindeshwar Sah, Yao Shen, Liang Li. Histone methyltransferase inhibitor UNC0642 promotes breast cancer cell death by upregulating TXNIP-dependent oxidative stress. Chemico-biological interactions. 2023-09-25. PMID:37748637. |
we further showed that txnip upregulation was associated with dose-dependent elevation of reactive oxygen species, concurrent with loss of mitochondrial membrane potential and activation of caspase-3-dependent apoptosis. |
2023-09-25 |
2023-10-07 |
mouse |
| Jasvinder Singh, Bindeshwar Sah, Yao Shen, Liang Li. Histone methyltransferase inhibitor UNC0642 promotes breast cancer cell death by upregulating TXNIP-dependent oxidative stress. Chemico-biological interactions. 2023-09-25. PMID:37748637. |
finally, we demonstrated that unc0642 treatment induced bc cell apoptosis in vitro and suppression of tumor growth in xenograft mouse models that was coupled with txnip activation. |
2023-09-25 |
2023-10-07 |
mouse |
| Fei Chen, Xiaoping Sheng, Haobo Sun, Qunfeng Guo, Haibin Wang, Lecheng Wu, Bin Ni, Jun Yan. Advanced glycation end products induce nucleus pulposus cell apoptosis by upregulating TXNIP via inhibiting glycolysis pathway in intervertebral disc degeneration. Journal of biochemical and molecular toxicology. 2023-08-26. PMID:37632267. |
advanced glycation end products induce nucleus pulposus cell apoptosis by upregulating txnip via inhibiting glycolysis pathway in intervertebral disc degeneration. |
2023-08-26 |
2023-09-07 |
human |
| Fei Chen, Xiaoping Sheng, Haobo Sun, Qunfeng Guo, Haibin Wang, Lecheng Wu, Bin Ni, Jun Yan. Advanced glycation end products induce nucleus pulposus cell apoptosis by upregulating TXNIP via inhibiting glycolysis pathway in intervertebral disc degeneration. Journal of biochemical and molecular toxicology. 2023-08-26. PMID:37632267. |
the purpose of this study was to determine the roles of thioredoxin-interacting protein (txnip) in the mechanisms underlying age-induced apoptosis of npcs. |
2023-08-26 |
2023-09-07 |
human |