| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenzhen Deng, Yang Li, Yanjun Jia, Liang Tang, Qirui He, Dongfang Li. [Over-expression of thioredoxin-interacting protein promotes apoptosis of MIN6 cells via activating p38MAPK pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 10. 2018-05-15. PMID:29169415. |
objective to investigate the effect of thioredoxin interacting protein (txnip) over-expression on the apoptosis of min6 β-cells and the mechanism involved. |
2018-05-15 |
2023-08-13 |
Not clear |
| Wenzhen Deng, Yang Li, Yanjun Jia, Liang Tang, Qirui He, Dongfang Li. [Over-expression of thioredoxin-interacting protein promotes apoptosis of MIN6 cells via activating p38MAPK pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 10. 2018-05-15. PMID:29169415. |
conclusion txnip over-expression might promote the apoptosis of min6 cells via activating the p38 mapk pathway. |
2018-05-15 |
2023-08-13 |
Not clear |
| Naif Mohammad Alhawiti, Saeed Al Mahri, Mohammad Azhar Aziz, Shuja Shafi Malik, Sameer Mohamma. TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook. Current drug targets. vol 18. issue 9. 2018-04-02. PMID:28137209. |
overexpression of txnip in animal models has been shown to induce apoptosis of pancreatic β-cells, reduce insulin sensitivity in peripheral tissues like skeletal muscle and adipose, and decrease energy expenditure. |
2018-04-02 |
2023-08-13 |
Not clear |
| Qing Zhao, Xudong Che, Hongxia Zhang, Pianpian Fan, Guanping Tan, Liu Liu, Dengzhi Jiang, Jun Zhao, Xiang Xiang, Yidan Liang, Xiaochuan Sun, Zhaohui H. Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage. Journal of neuroinflammation. vol 14. issue 1. 2018-03-26. PMID:28490373. |
recently, it was confirmed that thioredoxin-interacting protein (txnip) not only participates in inflammatory amplification but also stimulates the apoptosis signalling cascade pathway. |
2018-03-26 |
2023-08-13 |
Not clear |
| Jian Li, Zhongyi Yue, Wancheng Xiong, Peisheng Sun, Kun You, Jianguo Wan. TXNIP overexpression suppresses proliferation and induces apoptosis in SMMC7221 cells through ROS generation and MAPK pathway activation. Oncology reports. vol 37. issue 6. 2018-03-01. PMID:28440491. |
txnip overexpression suppresses proliferation and induces apoptosis in smmc7221 cells through ros generation and mapk pathway activation. |
2018-03-01 |
2023-08-13 |
Not clear |
| Jian Li, Zhongyi Yue, Wancheng Xiong, Peisheng Sun, Kun You, Jianguo Wan. TXNIP overexpression suppresses proliferation and induces apoptosis in SMMC7221 cells through ROS generation and MAPK pathway activation. Oncology reports. vol 37. issue 6. 2018-03-01. PMID:28440491. |
however, the role of txnip in hepatocellular carcinoma cell proliferation and apoptosis remains unknown. |
2018-03-01 |
2023-08-13 |
Not clear |
| Jian Li, Zhongyi Yue, Wancheng Xiong, Peisheng Sun, Kun You, Jianguo Wan. TXNIP overexpression suppresses proliferation and induces apoptosis in SMMC7221 cells through ROS generation and MAPK pathway activation. Oncology reports. vol 37. issue 6. 2018-03-01. PMID:28440491. |
moreover, txnip over-expression inhibited hepatocellular carcinoma cell proliferation and induced apoptosis by triggering mitochondrial-mediated ros generation and activating mapk pathways. |
2018-03-01 |
2023-08-13 |
Not clear |
| Jian Li, Zhongyi Yue, Wancheng Xiong, Peisheng Sun, Kun You, Jianguo Wan. TXNIP overexpression suppresses proliferation and induces apoptosis in SMMC7221 cells through ROS generation and MAPK pathway activation. Oncology reports. vol 37. issue 6. 2018-03-01. PMID:28440491. |
this study provides insight into the molecular mechanisms of txnip overexpression in liver cancer cell survival and apoptosis and indicated that txnip may be a novel promising agent for liver cancer treatment. |
2018-03-01 |
2023-08-13 |
Not clear |
| Ting Li, Guang-Yao Lin, Li Zhong, Yan Zhou, Jia Wang, Yue Zhu, Yang Feng, Xiao-Qing Cai, Qing Liu, Olivier Nosjean, Jean A Boutin, Pierre Renard, De-Hua Yang, Ming-Wei Wan. W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway. Acta pharmacologica Sinica. vol 38. issue 7. 2018-02-26. PMID:28502980. |
overexpression of txnip not only induces β-cell apoptosis but also reduces insulin production. |
2018-02-26 |
2023-08-13 |
mouse |
| Ming Wei, Dian Jiao, Donghui Han, Jieheng Wu, Feilong Wei, Guoxu Zheng, Zhangyan Guo, Wenjin Xi, Fa Yang, Pin Xie, Lingling Zhang, An-Gang Yang, He Wang, Weijun Qin, Weihong We. Knockdown of RNF2 induces cell cycle arrest and apoptosis in prostate cancer cells through the upregulation of TXNIP. Oncotarget. vol 8. issue 3. 2018-02-23. PMID:28029659. |
knockdown of rnf2 induces cell cycle arrest and apoptosis in prostate cancer cells through the upregulation of txnip. |
2018-02-23 |
2023-08-13 |
mouse |
| Ming Wei, Dian Jiao, Donghui Han, Jieheng Wu, Feilong Wei, Guoxu Zheng, Zhangyan Guo, Wenjin Xi, Fa Yang, Pin Xie, Lingling Zhang, An-Gang Yang, He Wang, Weijun Qin, Weihong We. Knockdown of RNF2 induces cell cycle arrest and apoptosis in prostate cancer cells through the upregulation of TXNIP. Oncotarget. vol 8. issue 3. 2018-02-23. PMID:28029659. |
simultaneously knockdown of rnf2 and txnip can partially rescue the arrested cell cycle, increased apoptosis and inhibited cell proliferation in rnf2 single knockdown cells. |
2018-02-23 |
2023-08-13 |
mouse |
| Takhellambam Swornalata Devi, Mallika Somayajulu, Renu Anjan Kowluru, Lalit Pukhrambam Sing. TXNIP regulates mitophagy in retinal Müller cells under high-glucose conditions: implications for diabetic retinopathy. Cell death & disease. vol 8. issue 5. 2018-02-16. PMID:28492550. |
thioredoxin-interacting protein (txnip) is involved in oxidative stress and apoptosis in diabetic retinopathy. |
2018-02-16 |
2023-08-13 |
rat |
| Bing F Wang, Jun Yoshiok. The Emerging Role of Thioredoxin-Interacting Protein in Myocardial Ischemia/Reperfusion Injury. Journal of cardiovascular pharmacology and therapeutics. vol 22. issue 3. 2017-11-08. PMID:27807222. |
thioredoxin-interacting protein binds to and inhibits thioredoxin, a redox protein that neutralizes reactive oxygen species (ros), and through its interaction with thioredoxin, txnip sensitizes cardiomyocytes to ros-induced apoptosis. |
2017-11-08 |
2023-08-13 |
human |
| Pradeep Bompada, David Atac, Cheng Luan, Robin Andersson, Judit Domènech Omella, Emilia Ottosson Laakso, Jason Wright, Leif Groop, Yang De Marini. Histone acetylation of glucose-induced thioredoxin-interacting protein gene expression in pancreatic islets. The international journal of biochemistry & cell biology. vol 81. issue Pt A. 2017-11-02. PMID:27989964. |
in ins1 832/13 cells, ep300 knock-out by crispr/cas9 elevated glucose-induced insulin secretion and greatly reduced glucose-stimulated txnip expression and cell apoptosis. |
2017-11-02 |
2023-08-13 |
human |
| Pradeep Bompada, David Atac, Cheng Luan, Robin Andersson, Judit Domènech Omella, Emilia Ottosson Laakso, Jason Wright, Leif Groop, Yang De Marini. Histone acetylation of glucose-induced thioredoxin-interacting protein gene expression in pancreatic islets. The international journal of biochemistry & cell biology. vol 81. issue Pt A. 2017-11-02. PMID:27989964. |
our study provides evidence that histone acetylation serves as a key regulator of glucose-induced increase in txnip gene expression and thereby glucotoxicity-induced apoptosis. |
2017-11-02 |
2023-08-13 |
human |
| Yanlin Yin, Zhihui Zhou, Weiwei Liu, Qun Chang, Guanqun Sun, Yalei Da. Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway. The international journal of biochemistry & cell biology. vol 84. 2017-11-02. PMID:28064010. |
in addition, the expressions of nlrp3 inflammasome related genes, asc (apoptosis associated speck-like protein containing a card), txnip, cleaved caspase-1 and il-1β, were also increased in vitro and in vivo studies. |
2017-11-02 |
2023-08-13 |
Not clear |
| Xiaoyu Li, Karen L Kover, Daniel P Heruth, Dara J Watkins, Yanchun Guo, Wayne V Moore, Luke G He, Mengwei Zang, Mark A Clements, Yun Ya. Thioredoxin-interacting protein promotes high-glucose-induced macrovascular endothelial dysfunction. Biochemical and biophysical research communications. vol 493. issue 1. 2017-10-16. PMID:28890350. |
in addition, txnip overexpression in primary human aortic endothelial cells (haecs) induced by either high glucose or overexpression of carbohydrate response element binding protein (chrebp), a major transcriptional activator of txnip, promoted early apoptosis and impaired no bioactivity. |
2017-10-16 |
2023-08-13 |
human |
| Qing Zhao, Xudong Che, Hongxia Zhang, Guanping Tan, Liu Liu, Dengzhi Jiang, Jun Zhao, Xiang Xiang, Xiaochuan Sun, Zhaohui H. Thioredoxin-Interacting Protein Mediates Apoptosis in Early Brain Injury after Subarachnoid Haemorrhage. International journal of molecular sciences. vol 18. issue 4. 2017-06-29. PMID:28420192. |
here, we report that thioredoxin-interacting protein (txnip), which is induced by protein kinase rna-like endoplasmic reticulum (er) kinase (perk), participates in ebi by promoting apoptosis. |
2017-06-29 |
2023-08-13 |
rat |
| Qing Zhao, Xudong Che, Hongxia Zhang, Guanping Tan, Liu Liu, Dengzhi Jiang, Jun Zhao, Xiang Xiang, Xiaochuan Sun, Zhaohui H. Thioredoxin-Interacting Protein Mediates Apoptosis in Early Brain Injury after Subarachnoid Haemorrhage. International journal of molecular sciences. vol 18. issue 4. 2017-06-29. PMID:28420192. |
after administration of txnip inhibitor-resveratrol (60 mg/kg), txnip small interfering rna (sirna) and the perk inhibitor gsk2656157, txnip expression was significantly reduced, accompanied by an attenuation of apoptosis and prognostic indicators, including sah grade, neurological deficits, brain water content, and blood-brain barrier (bbb) permeability. |
2017-06-29 |
2023-08-13 |
rat |
| Qing Zhao, Xudong Che, Hongxia Zhang, Guanping Tan, Liu Liu, Dengzhi Jiang, Jun Zhao, Xiang Xiang, Xiaochuan Sun, Zhaohui H. Thioredoxin-Interacting Protein Mediates Apoptosis in Early Brain Injury after Subarachnoid Haemorrhage. International journal of molecular sciences. vol 18. issue 4. 2017-06-29. PMID:28420192. |
collectively, these results suggest that txnip may participate in ebi after sah by mediating apoptosis. |
2017-06-29 |
2023-08-13 |
rat |