| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maayan Shaked, Mali Ketzinel-Gilad, Erol Cerasi, Nurit Kaiser, Gil Leibowit. AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells. PloS one. vol 6. issue 12. 2012-08-27. PMID:22194917. |
thioredoxin-interacting protein (txnip) regulates critical biological processes including inflammation, stress and apoptosis. |
2012-08-27 |
2023-08-12 |
rat |
| Maayan Shaked, Mali Ketzinel-Gilad, Erol Cerasi, Nurit Kaiser, Gil Leibowit. AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells. PloS one. vol 6. issue 12. 2012-08-27. PMID:22194917. |
txnip is upregulated by glucose and is a critical mediator of hyperglycemia-induced beta-cell apoptosis in diabetes. |
2012-08-27 |
2023-08-12 |
rat |
| Maayan Shaked, Mali Ketzinel-Gilad, Erol Cerasi, Nurit Kaiser, Gil Leibowit. AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells. PloS one. vol 6. issue 12. 2012-08-27. PMID:22194917. |
in light of the important role of txnip in beta-cell apoptosis, its inhibition by fatty acids can be regarded as an adaptive/protective response to glucolipotoxicity. |
2012-08-27 |
2023-08-12 |
rat |
| E Reich, A Tamary, R Vogt Sionov, D Mellou. Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death. Diabetologia. vol 55. issue 4. 2012-08-06. PMID:22246375. |
our objective was to elucidate the mechanisms by which gcs affect beta cell survival with a specific emphasis on the role of the thioredoxin-interacting protein (txnip) in beta cell apoptosis. |
2012-08-06 |
2023-08-12 |
Not clear |
| Takhellambam S Devi, Icksoo Lee, Maik Hüttemann, Ashok Kumar, Kwaku D Nantwi, Lalit P Sing. TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathy. Experimental diabetes research. vol 2012. 2012-07-26. PMID:22474421. |
thioredoxin interacting protein (txnip) mediates retinal inflammation, gliosis, and apoptosis in experimental diabetes. |
2012-07-26 |
2023-08-12 |
rat |
| Takhellambam S Devi, Icksoo Lee, Maik Hüttemann, Ashok Kumar, Kwaku D Nantwi, Lalit P Sing. TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathy. Experimental diabetes research. vol 2012. 2012-07-26. PMID:22474421. |
thus, our results show that hg sustains txnip up-regulation in muller glia and evokes a program of cellular defense/survival mechanisms that ultimately lead to oxidative stress, er stress/inflammation, autophagy and apoptosis. |
2012-07-26 |
2023-08-12 |
rat |
| Oded N Spindel, Chen Yan, Bradford C Ber. Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling. Arteriosclerosis, thrombosis, and vascular biology. vol 32. issue 5. 2012-07-10. PMID:22345166. |
because txnip is an α-arrestin that regulates vegfr2 signaling, we hypothesized that parp1 regulates txnip localization and function that might affect huvec stress-induced apoptosis. |
2012-07-10 |
2023-08-12 |
human |
| Guanlan Xu, Junqin Chen, Gu Jing, Anath Shale. Preventing β-cell loss and diabetes with calcium channel blockers. Diabetes. vol 61. issue 4. 2012-06-04. PMID:22442301. |
glucose and diabetes upregulate β-cell txnip expression, and txnip overexpression induces β-cell apoptosis. |
2012-06-04 |
2023-08-12 |
mouse |
| Guanlan Xu, Junqin Chen, Gu Jing, Anath Shale. Preventing β-cell loss and diabetes with calcium channel blockers. Diabetes. vol 61. issue 4. 2012-06-04. PMID:22442301. |
we were surprised to discover that calcium channel blockers inhibited txnip expression in ins-1 cells and human islets and that orally administered verapamil reduced txnip expression and β-cell apoptosis, enhanced endogenous insulin levels, and rescued mice from stz-induced diabetes. |
2012-06-04 |
2023-08-12 |
mouse |
| Mohammed M H Al-Gayyar, Mohammed A Abdelsaid, Suraporn Matragoon, Bindu A Pillai, Azza B El-Remess. Thioredoxin interacting protein is a novel mediator of retinal inflammation and neurotoxicity. British journal of pharmacology. vol 164. issue 1. 2012-02-02. PMID:21434880. |
up-regulation of thioredoxin interacting protein (txnip), an endogenous inhibitor of thioredoxin (trx), compromises cellular antioxidant and anti-apoptotic defences and stimulates pro-inflammatory cytokines expression, implying a role for txnip in apoptosis. |
2012-02-02 |
2023-08-12 |
Not clear |
| Jianbiao Zhou, Chonglei Bi, Lip-Lee Cheong, Sylvia Mahara, Shaw-Cheng Liu, Kian-Ghee Tay, Tze-Loong Koh, Qiang Yu, Wee-Joo Chn. The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML. Blood. vol 118. issue 10. 2011-11-02. PMID:21734239. |
using rna interference (rnai), gene expression profiling, and chip, we identified that txnip, a major redox control molecule, plays a crucial role in dznep-induced apoptosis. |
2011-11-02 |
2023-08-12 |
Not clear |
| Jianbiao Zhou, Chonglei Bi, Lip-Lee Cheong, Sylvia Mahara, Shaw-Cheng Liu, Kian-Ghee Tay, Tze-Loong Koh, Qiang Yu, Wee-Joo Chn. The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML. Blood. vol 118. issue 10. 2011-11-02. PMID:21734239. |
we show that disruption of prc2, either by dznep treatment or ezh2 knockdown, reactivates txnip, inhibits thioredoxin activity, and increases reactive oxygen species (ros), leading to apoptosis. |
2011-11-02 |
2023-08-12 |
Not clear |
| Yonghong Shi, Yunzhuo Ren, Lijuan Zhao, Chunyang Du, Yuehua Wang, Yanling Zhang, Ying Li, Song Zhao, Huijun Dua. Knockdown of thioredoxin interacting protein attenuates high glucose-induced apoptosis and activation of ASK1 in mouse mesangial cells. FEBS letters. vol 585. issue 12. 2011-09-05. PMID:21510938. |
here we show that thioredoxin interacting protein (txnip) is involved in high glucose (hg)-induced mouse mesangial cell (mmc) apoptosis. |
2011-09-05 |
2023-08-12 |
mouse |
| Yonghong Shi, Yunzhuo Ren, Lijuan Zhao, Chunyang Du, Yuehua Wang, Yanling Zhang, Ying Li, Song Zhao, Huijun Dua. Knockdown of thioredoxin interacting protein attenuates high glucose-induced apoptosis and activation of ASK1 in mouse mesangial cells. FEBS letters. vol 585. issue 12. 2011-09-05. PMID:21510938. |
treatment with antioxidant, tempol, or knockdown of txnip in mmcs reduced hg-mediated apoptosis, expression of cleaved caspase-3, bax/bcl-2 ratio and activation of ask1. |
2011-09-05 |
2023-08-12 |
mouse |
| Yonghong Shi, Yunzhuo Ren, Lijuan Zhao, Chunyang Du, Yuehua Wang, Yanling Zhang, Ying Li, Song Zhao, Huijun Dua. Knockdown of thioredoxin interacting protein attenuates high glucose-induced apoptosis and activation of ASK1 in mouse mesangial cells. FEBS letters. vol 585. issue 12. 2011-09-05. PMID:21510938. |
these data suggest that knockdown of txnip prevented hg-induced cell apoptosis and activation of ask1 may be via reduction of oxidative stress in mmcs. |
2011-09-05 |
2023-08-12 |
mouse |
| Mengchang Wang, Shaanxi Liu, Pengbo Li. Gene expression profile of multiple myeloma cell line treated by arsenic trioxide. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 27. issue 6. 2010-12-07. PMID:18231732. |
alk-1 and txnip genes may play an important role in the apoptosis and partial differentiation of rpmi8226 cells. |
2010-12-07 |
2023-08-12 |
human |
| Eiji Yoshihara, Zhe Chen, Yoshiyuki Matsuo, Hiroshi Masutani, Junji Yodo. Thiol redox transitions by thioredoxin and thioredoxin-binding protein-2 in cell signaling. Methods in enzymology. vol 474. 2010-10-29. PMID:20609905. |
the interaction of thioredoxin and thioredoxin-binding proteins such as thioredoxin-binding protein-2 (tbp-2, also called as txnip or vdup1), apoptosis signal kinase (ask-1), redox factor 1 (ref-1), forkhead box class o 4 (foxo4), and nod-like receptor proteins (nlrps) suggested unconventional functions of thioredoxin and a novel mechanism of redox regulation. |
2010-10-29 |
2023-08-12 |
Not clear |
| Sweta Rani, Jai Prakash Mehta, Niall Barron, Padraig Doolan, Per Bendix Jeppesen, Martin Clynes, Lorraine O'Driscol. Decreasing Txnip mRNA and protein levels in pancreatic MIN6 cells reduces reactive oxygen species and restores glucose regulated insulin secretion. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 25. issue 6. 2010-09-22. PMID:20511712. |
recently, thioredoxin-interacting protein (txnip) expression has been implicated in a number of cellular events associated with diabetes, with increased txnip levels associated with reduced glucose uptake into peripheral tissues, increased reactive oxygen species (ros) in endothelial cells, beta cell glucotoxicity and apoptosis. |
2010-09-22 |
2023-08-12 |
Not clear |
| Geetu Saxena, Junqin Chen, Anath Shale. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. The Journal of biological chemistry. vol 285. issue 6. 2010-04-09. PMID:19959470. |
the thioredoxin-interacting protein txnip is a ubiquitously expressed redox protein that promotes apoptosis. |
2010-04-09 |
2023-08-12 |
Not clear |
| Geetu Saxena, Junqin Chen, Anath Shale. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. The Journal of biological chemistry. vol 285. issue 6. 2010-04-09. PMID:19959470. |
recently, we found that txnip deficiency protects against type 1 and 2 diabetes by inhibiting beta cell apoptosis and maintaining pancreatic beta cell mass, indicating that txnip plays a key role in beta cell biology. |
2010-04-09 |
2023-08-12 |
Not clear |