| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun-Shiang Chung, Fabienne Venet, Yaping Chen, Leslie N Jones, Douglas C Wilson, Carol A Ayala, Alfred Ayal. Deficiency of Bid protein reduces sepsis-induced apoptosis and inflammation, while improving septic survival. Shock (Augusta, Ga.). vol 34. issue 2. 2010-11-10. PMID:20023601. |
these data support not only the contribution of bid to sepsis-induced apoptosis and the onset of septic morbidity/mortality, but also the existence of a bridge between extrinsic apoptotic signals, e.g., fasl:fas, tnf:tnfr, and so on, and the intrinsic mitochondrial pathway via bid-tbid activation during sepsis. |
2010-11-10 |
2023-08-12 |
mouse |
| Gillian L Drury, Sergio Di Marco, Virginie Dormoy-Raclet, Julie Desbarats, Imed-Eddine Gallouz. FasL expression in activated T lymphocytes involves HuR-mediated stabilization. The Journal of biological chemistry. vol 285. issue 41. 2010-11-04. PMID:20675370. |
fas ligand (fasl), a member of the tnf superfamily, plays a crucial role in controlling this excessive lymphoproliferation by inducing apoptosis in t cells leading to their rapid elimination. |
2010-11-04 |
2023-08-12 |
Not clear |
| Rie Kajino-Sakamoto, Emily Omori, Prashant K Nighot, Anthony T Blikslager, Kunihiro Matsumoto, Jun Ninomiya-Tsuj. TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 8. 2010-11-04. PMID:20855879. |
disruption of tnf signaling, which is a major intestinal damage inducer, rescued the inflammatory conditions but not apoptosis or disruption of tight junctions in the tak1-deficient intestinal epithelium, suggesting that tnf is not a primary inducer of the damage noted in tak1-deficient intestinal epithelium. |
2010-11-04 |
2023-08-12 |
mouse |
| Patrick G Flynn, David M Helfma. Non-muscle myosin IIB helps mediate TNF cell death signaling independent of actomyosin contractility (AMC). Journal of cellular biochemistry. vol 110. issue 6. 2010-10-29. PMID:20564232. |
non-muscle myosin ii (nm ii) helps mediate survival and apoptosis in response to tnf-alpha (tnf), however, nm ii's mechanism of action in these processes is not fully understood. |
2010-10-29 |
2023-08-12 |
Not clear |
| Patrick G Flynn, David M Helfma. Non-muscle myosin IIB helps mediate TNF cell death signaling independent of actomyosin contractility (AMC). Journal of cellular biochemistry. vol 110. issue 6. 2010-10-29. PMID:20564232. |
the present study focused on isoform specific functions of nm iia and iib in mediating tnf induced apoptosis. |
2010-10-29 |
2023-08-12 |
Not clear |
| In-Ja Park, Min-Jung Kim, Ock Jin Park, Myoung Gyu Park, Wonchae Choe, Insug Kang, Sung-Soo Kim, Joohun H. Cryptotanshinone sensitizes DU145 prostate cancer cells to Fas(APO1/CD95)-mediated apoptosis through Bcl-2 and MAPK regulation. Cancer letters. vol 298. issue 1. 2010-10-28. PMID:20638780. |
fas/apo-1/cd95, a member of the tumor necrosis factor (tnf) receptor superfamily, is a potential anti-cancer factor as it can induce apoptosis in tumor cells. |
2010-10-28 |
2023-08-12 |
human |
| F Gonzalvez, A Ashkenaz. New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene. vol 29. issue 34. 2010-10-07. PMID:20531300. |
apoptosis ligand 2 tumor necrosis factor (tnf)-related apoptosis-inducing ligand (apo2l/trail) belongs to a small subset of proapoptotic protein ligands in the tnf superfamily. |
2010-10-07 |
2023-08-12 |
Not clear |
| Hongbo Shen, Chao Wang, Enzhuo Yang, Ying Xu, Wei Liu, Jingran Yan, Feifei Wang, Honghai Wan. Novel recombinant BCG coexpressing Ag85B, ESAT-6 and mouse TNF-alpha induces significantly enhanced cellular immune and antibody responses in C57BL/6 mice. Microbiology and immunology. vol 54. issue 8. 2010-10-04. PMID:20646207. |
release of tnf, which would induce mycobacteria-mediated macrophage apoptosis and thus reduce the spread of mycobacteria, is one of the most important and early responses of macrophages challenged with mtb. |
2010-10-04 |
2023-08-12 |
mouse |
| Hwei-Fang Tsai, Ping-Ning Hs. Interplay between Helicobacter pylori and immune cells in immune pathogenesis of gastric inflammation and mucosal pathology. Cellular & molecular immunology. vol 7. issue 4. 2010-09-29. PMID:20190789. |
in addition to directly triggering apoptosis, h. pylori induces sensitivity to tumor-necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-mediated apoptosis in gastric epithelial cells via modulation of trail apoptosis signaling. |
2010-09-29 |
2023-08-12 |
Not clear |
| b' Philippe Ratajczak, Anne Janin, Regis Peffault de Latour, Christophe Leboeuf, Allison Desveaux, Keyvan Keyvanfar, Marie Robin, Emmanuel Clave, Corine Douay, Anne Quinquenel, Claire Pichereau, Philippe Bertheau, Jean Yves Mary, G\\xc3\\xa9rard Soci\\xc3\\xa. Th17/Treg ratio in human graft-versus-host disease. Blood. vol 116. issue 7. 2010-09-28. PMID:20484086.' |
a th17/treg ratio less than 1 also correlated with the intensity of apoptosis of epithelial cells (p = .03), fas expression in the cellular infiltrate (p = .003), tnf, and tnf receptor expression (p < .001). |
2010-09-28 |
2023-08-12 |
human |
| Zhengyuan Xia, Tao Luo, Hui-min Liu, Fang Wang, Zhong-yuan Xia, Michael G Irwin, Paul M Vanhoutt. L-arginine enhances nitrative stress and exacerbates tumor necrosis factor-alpha toxicity to human endothelial cells in culture: prevention by propofol. Journal of cardiovascular pharmacology. vol 55. issue 4. 2010-09-27. PMID:20125033. |
tumor necrosis factor-alpha (tnf) production is increased during myocardial ischemia/reperfusion, which may exacerbate myocardial injury by inducing endothelial cell apoptosis. |
2010-09-27 |
2023-08-12 |
human |
| Sahdeo Prasad, Vivek R Yadav, Chitra Sundaram, Simone Reuter, Padmanabhan S Hema, Mangalam S Nair, Madan M Chaturvedi, Bharat B Aggarwa. Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway. The Journal of biological chemistry. vol 285. issue 35. 2010-09-17. PMID:20576605. |
we found that crotepoxide potentiated tumor necrosis factor (tnf), and chemotherapeutic agents induced apoptosis and inhibited the expression of nf-kappab-regulated gene products involved in anti-apoptosis (bcl-2, bcl-xl, iap1,(2) mcl-1, survivin, and traf1), apoptosis (bax, bid), inflammation (cox-2), proliferation (cyclin d1 and c-myc), invasion (icam-1 and mmp-9), and angiogenesis (vegf). |
2010-09-17 |
2023-08-12 |
human |
| Claudia Roos, Andreas Wicovsky, Nicole Müller, Steffen Salzmann, Tina Rosenthal, Holger Kalthoff, Anna Trauzold, Axel Seher, Frank Henkler, Christian Kneitz, Harald Wajan. Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 3. 2010-09-08. PMID:20610643. |
tnf-like weak inducer of apoptosis, tweak, is a typical member of the tnf ligand family. |
2010-09-08 |
2023-08-12 |
Not clear |
| Christian D Fingas, Boris R A Blechacz, Rory L Smoot, Maria E Guicciardi, Justin Mott, Steve F Bronk, Nathan W Werneburg, Alphonse E Sirica, Gregory J Gore. A smac mimetic reduces TNF related apoptosis inducing ligand (TRAIL)-induced invasion and metastasis of cholangiocarcinoma cells. Hepatology (Baltimore, Md.). vol 52. issue 2. 2010-09-07. PMID:20683954. |
a smac mimetic reduces tnf related apoptosis inducing ligand (trail)-induced invasion and metastasis of cholangiocarcinoma cells. |
2010-09-07 |
2023-08-12 |
rat |
| Abhinbhen Saraya, Supaporn Wacharapluesadee, Pakamatz Khawplod, Saowaluck Tepsumethanon, Deborah Briggs, Thanin Asawavichienjinda, Thiravat Hemachudh. A preliminary study of chemo- and cytokine responses in rabies vaccine recipients of intradermal and intramuscular regimens. Vaccine. vol 28. issue 29. 2010-08-27. PMID:20470796. |
il-1 alpha, -2, and -6, hemofiltrate cysteine-cysteine chemokine (hcc-4), glucocorticoid induced tumor necrosis factor receptor (gitr), tumor necrosis factor (tnf) related apoptosis inducing ligand-receptor (trail-r3) had some degree of elevation in the id group. |
2010-08-27 |
2023-08-12 |
Not clear |
| Lang Bai, Wenjie Chen, Xia Wang, Wei Ju, Shanling Xu, Yong Li. Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cells. Journal of cellular biochemistry. vol 108. issue 5. 2010-08-09. PMID:19739098. |
smac mimetics are potential anticancer therapeutics selectively killing cancer cells through autocrine tumor necrosis factor (tnf)-mediated apoptosis pathway. |
2010-08-09 |
2023-08-12 |
human |
| Bruna Pucci, Manuela Indelicato, Valentina Paradisi, Valentina Reali, Laura Pellegrini, Michele Aventaggiato, Natalie O Karpinich, Massimo Fini, Matteo A Russo, John L Farber, Marco Tafan. ERK-1 MAP kinase prevents TNF-induced apoptosis through bad phosphorylation and inhibition of Bax translocation in HeLa Cells. Journal of cellular biochemistry. vol 108. issue 5. 2010-08-09. PMID:19777442. |
to explore this further and to demonstrate the central role of the mitochondria in the erk1/2 pathway we used the hela cellular model where apoptosis was induced by tumor necrosis factor (tnf) and cycloheximide (chx). |
2010-08-09 |
2023-08-12 |
Not clear |
| Bruna Pucci, Manuela Indelicato, Valentina Paradisi, Valentina Reali, Laura Pellegrini, Michele Aventaggiato, Natalie O Karpinich, Massimo Fini, Matteo A Russo, John L Farber, Marco Tafan. ERK-1 MAP kinase prevents TNF-induced apoptosis through bad phosphorylation and inhibition of Bax translocation in HeLa Cells. Journal of cellular biochemistry. vol 108. issue 5. 2010-08-09. PMID:19777442. |
our study demonstrates that in hela cells the erk-1 kinase prevents tnf + chx apoptosis by regulating the intrinsic mitochondrial pathway through different mechanisms. |
2010-08-09 |
2023-08-12 |
Not clear |
| Vanessa Nicolin, Paola Narducc. Soluble TRAIL could enhance bone destruction acting on Rank-ligand in estrogen-independent human breast cancer cell line MDA-MB-231. Acta histochemica. vol 112. issue 2. 2010-08-06. PMID:19058836. |
in addition to the well-described role of osteoprotegerin in the regulation of bone turnover, there is an emerging evidence that osteoprotegerin may have an additional function due to its ability to bind and inhibit the members of the tumor necrosis factor (tnf)-superfamily, such as tnf-alpha and tnf-related apoptosis inducing ligand (trail). |
2010-08-06 |
2023-08-12 |
human |
| Moo-Seung Lee, Rama P Cherla, Erin K Lentz, Dinorah Leyva-Illades, Vernon L Tes. Signaling through C/EBP homologous protein and death receptor 5 and calpain activation differentially regulate THP-1 cell maturation-dependent apoptosis induced by Shiga toxin type 1. Infection and immunity. vol 78. issue 8. 2010-08-06. PMID:20515924. |
ligation of dr5 by tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) activates the extrinsic pathway of apoptosis. |
2010-08-06 |
2023-08-12 |
Not clear |