| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emmanuel Chorianopoulos, Mark Rosenberg, Christian Zugck, Johanna Wolf, Hugo A Katus, Norbert Fre. Decreased soluble TWEAK levels predict an adverse prognosis in patients with chronic stable heart failure. European journal of heart failure. vol 11. issue 11. 2010-03-25. PMID:19875405. |
tumour necrosis factor (tnf)-like weak inducer of apoptosis (stweak) is a multifunctional cytokine that has recently been implicated in cardiovascular disease. |
2010-03-25 |
2023-08-12 |
Not clear |
| Jennifer S Michaelson, Stephen J Demarest, Brian Miller, Aldo Amatucci, William B Snyder, Xiufeng Wu, Flora Huang, Samantha Phan, Sharon Gao, Adam Doern, Graham K Farrington, Alexey Lugovskoy, Ingrid Joseph, Veronique Bailly, Xin Wang, Ellen Garber, Jeff Browning, Scott M Glase. Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR. mAbs. vol 1. issue 2. 2010-03-25. PMID:20061822. |
the stability-engineered igg-like bsab was envisioned to target and crosslink two tnf family member receptors, trail-r2 (tnf-related apoptosis inducing ligand receptor-2) and ltbetar (lymphotoxin-beta receptor), expressed on the surface of epithelial tumor cells with the goal of triggering an enhanced anti-tumor effect. |
2010-03-25 |
2023-08-12 |
mouse |
| F Lamoureux, G Moriceau, G Picarda, J Rousseau, V Trichet, F Rédin. Regulation of osteoprotegerin pro- or anti-tumoral activity by bone tumor microenvironment. Biochimica et biophysica acta. vol 1805. issue 1. 2010-03-23. PMID:19733222. |
however, its therapeutic use in bone tumors remains controversial due to its ability to bind and inhibit another member of the tnf superfamily, tnf related apoptosis inducing ligand (trail), which is a potent inducer of tumor cell apoptosis. |
2010-03-23 |
2023-08-12 |
Not clear |
| R S Al-Lamki, A P Brookes, J Wang, M J Reid, J Parameshwar, M J Goddard, G Tellides, T Wan, W Min, J S Pober, J R Bradle. TNF receptors differentially signal and are differentially expressed and regulated in the human heart. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 9. issue 12. 2010-03-15. PMID:19788501. |
rejecting cardiac allografts showed increased tnf in microvessels, diminished tnfr1, activation of ask1, upregulated tnfr2 co-expressed with activated endothelial/epithelial tyrosine kinase (etk), increased apoptosis and cell cycle entry in cm. |
2010-03-15 |
2023-08-12 |
mouse |
| R S Al-Lamki, A P Brookes, J Wang, M J Reid, J Parameshwar, M J Goddard, G Tellides, T Wan, W Min, J S Pober, J R Bradle. TNF receptors differentially signal and are differentially expressed and regulated in the human heart. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 9. issue 12. 2010-03-15. PMID:19788501. |
in (wt)c57bl/6 myocardium, tnf activated both ask1 and etk, and increased both apoptosis and cell cycle entry. |
2010-03-15 |
2023-08-12 |
mouse |
| Pei-Lin Chen, Alexander S Easto. Evidence that tumor necrosis factor-related apoptosis inducing ligand (TRAIL) inhibits angiogenesis by inducing vascular endothelial cell apoptosis. Biochemical and biophysical research communications. vol 391. issue 1. 2010-03-15. PMID:19962958. |
tumor necrosis factor (tnf) and its related ligands tnf-related apoptosis inducing ligand (trail) and fas ligand (fasl) play roles in the regulation of vascular responses, but their effect on the formation of new blood vessels (angiogenesis) is unclear. |
2010-03-15 |
2023-08-12 |
human |
| Laiqun Zhang, Ken Blackwell, Zhaohui Shi, Hasem Habelha. The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB. Journal of molecular biology. vol 396. issue 3. 2010-03-12. PMID:20064526. |
tumor necrosis factor (tnf) receptor-associated factor 2 (traf2) and receptor-interacting protein 1 (rip1) play critical roles in activating c-jun n-terminal kinase (jnk) and inhibitor of kappab kinase (ikk), as well as in inhibiting apoptosis induced by tnfalpha. |
2010-03-12 |
2023-08-12 |
Not clear |
| Stefan Schütze, Wulf Schneider-Bracher. Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling. Results and problems in cell differentiation. vol 49. 2010-03-09. PMID:19132322. |
finally, the lessons learnt from the strategy of adenovirus to escape apoptosis by targeting death receptor internalization demonstrate the biological significance of tnf receptor compartmentalization for immunosurveillance. |
2010-03-09 |
2023-08-12 |
Not clear |
| Jennifer S Michaelson, Linda C Burkl. Therapeutic targeting of TWEAK/Fnl4 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway. Results and problems in cell differentiation. vol 49. 2010-03-09. PMID:19513634. |
tnf-like weak inducer of apoptosis (tweak) and fgf-inducible molecule 14 (fn14) are a tnf superfamily ligand-receptor pair. |
2010-03-09 |
2023-08-12 |
Not clear |
| Derick Han, Maria D Ybanez, Sara Ahmadi, Kelvin Yeh, Neil Kaplowit. Redox regulation of tumor necrosis factor signaling. Antioxidants & redox signaling. vol 11. issue 9. 2010-03-01. PMID:19361274. |
the cellular response (e.g., proliferation versus apoptosis) to tnf is determined by the balance between the apoptotic signaling pathway and the nf-kappab survival pathway stimulated by tnf. |
2010-03-01 |
2023-08-12 |
Not clear |
| Derick Han, Maria D Ybanez, Sara Ahmadi, Kelvin Yeh, Neil Kaplowit. Redox regulation of tumor necrosis factor signaling. Antioxidants & redox signaling. vol 11. issue 9. 2010-03-01. PMID:19361274. |
ros are important in mediating the sustained activation of jnk, to help mediate apoptosis after tnf treatment. |
2010-03-01 |
2023-08-12 |
Not clear |
| Derick Han, Maria D Ybanez, Sara Ahmadi, Kelvin Yeh, Neil Kaplowit. Redox regulation of tumor necrosis factor signaling. Antioxidants & redox signaling. vol 11. issue 9. 2010-03-01. PMID:19361274. |
in some cells, ros are second messengers that mediate apoptosis after tnf stimulation. |
2010-03-01 |
2023-08-12 |
Not clear |
| Celina García-García, Claudia Fumarola, Naveenan Navaratnam, David Carling, Abelardo López-Riva. AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators. Biochemical pharmacology. vol 79. issue 6. 2010-03-01. PMID:19896469. |
the tumor necrosis factor-related apoptosis-inducing ligand (trail) is a tnf superfamily member that is being considered as a new strategy in anticancer therapy because of its ability to induce apoptosis, alone or in combination with other stimuli, in many cancer cells. |
2010-03-01 |
2023-08-12 |
Not clear |
| Chao Zhao, Wei Zhang, Xiaochen Tian, Caiyun Fang, Haojie Lu, Zhenghong Yuan, Pengyuan Yang, Yumei We. Proteomic analysis of cell lines expressing small hepatitis B surface antigen revealed decreased glucose-regulated protein 78 kDa expression in association with higher susceptibility to apoptosis. Journal of medical virology. vol 82. issue 1. 2010-02-26. PMID:19950238. |
some have been implicated in apoptosis, including glucose-regulated protein 78 kda (grp78), heterogeneous nuclear ribonucleoprotein h3 (hnrnp h), rho gdp dissociation inhibitor (gdi), cystatin b, far upstream element-binding protein (fusebp), and tnf receptor-associated protein 1 (trap1). |
2010-02-26 |
2023-08-12 |
Not clear |
| Qiyan Zeng, Yu Huang, Linjie Zeng, Xiuwan Lan, Yongqi Huang, Shujia He, Hong Zhan. Effect of IPP5, a novel inhibitor of PP1, on apoptosis and the underlying mechanisms involved. Biotechnology and applied biochemistry. vol 54. issue 4. 2010-02-25. PMID:19874272. |
we also showed that the expression of active mutant ipp5 in hela cells was further enhanced on tnf (tumour necrosis factor) treatment and overexpression of active mutant ipp5 sensitized hela cells to tnf-induced jnk (c-jun n-terminal kinase) and p38 activation as well as tnf-mediated apoptosis. |
2010-02-25 |
2023-08-12 |
human |
| J Silke, R Brin. Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs. Cell death and differentiation. vol 17. issue 1. 2010-02-24. PMID:19680262. |
there have been a number of recent discoveries relating to the functions of inhibitors of apoptosis (iaps) and tnf receptor-associated factors (trafs) in regulating signalling from tnf receptor superfamily (tnfrsf) members and some tantalizing glimpses into a wider area of influence, that of innate immune signalling. |
2010-02-24 |
2023-08-12 |
Not clear |
| Sreelatha Gopinath, Sravan K Vanamala, Meena Gujrati, Jeffrey D Klopfenstein, Dzung H Dinh, Jasti S Ra. Doxorubicin-mediated apoptosis in glioma cells requires NFAT3. Cellular and molecular life sciences : CMLS. vol 66. issue 24. 2010-02-24. PMID:19784808. |
inhibition of nfat3 activation by shnfat3 (shnf3) significantly downregulated tumor necrosis factor (tnf)-alpha induction, its receptor tnfr1, caspase 10, caspase 3, and poly (adp-ribose) polymerase, abrogating dox-mediated apoptosis in glioma cells. |
2010-02-24 |
2023-08-12 |
Not clear |
| A M Sheikh, X Li, G Wen, Z Tauqeer, W T Brown, M Mali. Cathepsin D and apoptosis related proteins are elevated in the brain of autistic subjects. Neuroscience. vol 165. issue 2. 2010-02-24. PMID:19854241. |
it plays an important role in regulation of cellular apoptosis and has been shown to mediate apoptosis induced by cytokines tumor necrosis factor (tnf)-alpha and interferon (ifn)-gamma. |
2010-02-24 |
2023-08-12 |
human |
| D E Choi, J Y Jeong, B J Lim, K R Na, Y T Shin, K W Le. Pretreatment with the tumor nerosis factor-alpha blocker etanercept attenuated ischemia-reperfusion renal injury. Transplantation proceedings. vol 41. issue 9. 2010-02-24. PMID:19917350. |
tumor necrosis factor (tnf)-alpha mediates inflammation and apoptosis in ischemia-reperfusion (ir) injury of the kidneys. |
2010-02-24 |
2023-08-12 |
Not clear |
| Seung-Hyun Lee, Dong-Woon Park, Eun-Sil Sung, Hye-Ran Park, Jin-Kyoo Kim, Yong-Sung Ki. Humanization of an agonistic anti-death receptor 4 single chain variable fragment antibody and avidity-mediated enhancement of its cell death-inducing activity. Molecular immunology. vol 47. issue 4. 2010-02-19. PMID:19864027. |
development of agonistic monoclonal antibodies (mabs) against the pro-apoptotic molecule death receptor 4 (dr4) [or tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail) receptor 1] is an attractive anti-cancer strategy because of their potential for inducing tumor-specific cell death. |
2010-02-19 |
2023-08-12 |
mouse |