| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lan Dai, Liying Gu, Chuanwei Ding, Lihua Qiu, Wen D. TWEAK promotes ovarian cancer cell metastasis via NF-kappaB pathway activation and VEGF expression. Cancer letters. vol 283. issue 2. 2009-09-04. PMID:19398263. |
it has been demonstrated that tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak)-fibroblast growth factor inducible-14 (fn14) signaling system may be a potential regulator of human tumorigenesis. |
2009-09-04 |
2023-08-12 |
human |
| Xiaoyan Wu, Rongqing Guo, Peili Chen, Quan Wang, Patrick N Cunningha. TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism. American journal of physiology. Renal physiology. vol 297. issue 2. 2009-08-27. PMID:19420112. |
in cultured renal ecs, tnf induced apoptosis through a caspase-8-dependent pathway. |
2009-08-27 |
2023-08-12 |
mouse |
| Liang Qiao, Benjamin C Y Won. Targeting apoptosis as an approach for gastrointestinal cancer therapy. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 12. issue 3. 2009-08-25. PMID:19278896. |
apoptosis can be induced by many different approaches including activating cell surface death receptors (for example, fas, trail and tnf receptors), inhibiting cell survival signaling (such as egfr, mapk and pi3k), altering apoptosis threshold by modulating pro-apoptotic and anti-apoptotic members of the bcl-2 family, down-regulating anti-apoptosis proteins (such as xiap, survivin and c-iap2), and using other pro-apoptotic agents. |
2009-08-25 |
2023-08-12 |
Not clear |
| Sylvia K E Messerschmidt, Anna Musyanovych, Martin Altvater, Peter Scheurich, Klaus Pfizenmaier, Katharina Landfester, Roland E Konterman. Targeted lipid-coated nanoparticles: delivery of tumor necrosis factor-functionalized particles to tumor cells. Journal of controlled release : official journal of the Controlled Release Society. vol 137. issue 1. 2009-08-19. PMID:19306900. |
thus, tnf nanocytes are potent activators of tnf receptor 1 and 2 leading to a striking enhancement of apoptosis. |
2009-08-19 |
2023-08-12 |
human |
| Naimish R Patel, Katharine Swan, Xin Li, Souvenir D Tachado, Henry Kozie. Impaired M. tuberculosis-mediated apoptosis in alveolar macrophages from HIV+ persons: potential role of IL-10 and BCL-3. Journal of leukocyte biology. vol 86. issue 1. 2009-08-19. PMID:19383626. |
further study showed that il-10 reduced tnf release in response to mtb in am through a reduction in tnf mrna levels, and exogenous tnf could partially reverse il-10-associated effects on am apoptosis. |
2009-08-19 |
2023-08-12 |
human |
| L Kheirandish-Gozal, L D Serpero, E Dayyat, J Kim, J L Goldman, A Snow, R Bhattacharjee, D Goza. Corticosteroids suppress in vitro tonsillar proliferation in children with obstructive sleep apnoea. The European respiratory journal. vol 33. issue 5. 2009-08-18. PMID:19047310. |
proliferation and apoptosis were assessed, and supernatants were assayed for the cytokines tumour necrosis factor (tnf)-alpha, interleukin (il)-6 and il-8. |
2009-08-18 |
2023-08-12 |
Not clear |
| Claudine Tardy, Frédérique Sabourdy, Virginie Garcia, Anu Jalanko, Nicole Therville, Thierry Levade, Nathalie Andrieu-Abadi. Palmitoyl protein thioesterase 1 modulates tumor necrosis factor alpha-induced apoptosis. Biochimica et biophysica acta. vol 1793. issue 7. 2009-08-18. PMID:19345705. |
induction of apoptosis by tnf has recently been shown to implicate proteases from lysosomal origin, the cathepsins. |
2009-08-18 |
2023-08-12 |
mouse |
| Fahu He, Weirong Dang, Kohei Saito, Satoru Watanabe, Naohiro Kobayashi, Peter Güntert, Takanori Kigawa, Akiko Tanaka, Yutaka Muto, Shigeyuki Yokoyam. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily. Protein science : a publication of the Protein Society. vol 18. issue 3. 2009-08-14. PMID:19241374. |
fn14 is the smallest member of the tumor necrosis factor (tnf) receptor superfamily, and specifically binds to its ligand, tweak (tnf-like weak inducer of apoptosis), which is a member of the tnf superfamily. |
2009-08-14 |
2023-08-12 |
human |
| Peter O Simon, Jonathan E McDunn, Hiroyuki Kashiwagi, Katherine Chang, Peter S Goedegebuure, Richard S Hotchkiss, William G Hawkin. Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma. International journal of cancer. vol 125. issue 4. 2009-08-04. PMID:19405118. |
tat-ctmp induced similar levels of active caspase-3 as several other known inducers of apoptosis: gemcitabine, radiation therapy, wortmannin and recombinant tumor necrosis factor (tnf)-alpha. |
2009-08-04 |
2023-08-12 |
mouse |
| Duan-Wu Zhang, Jing Shao, Juan Lin, Na Zhang, Bao-Ju Lu, Sheng-Cai Lin, Meng-Qiu Dong, Jiahuai Ha. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science (New York, N.Y.). vol 325. issue 5938. 2009-07-29. PMID:19498109. |
necrosis can be induced by stimulating death receptors with tumor necrosis factor (tnf) or other agonists; however, the underlying mechanism differentiating necrosis from apoptosis is largely unknown. |
2009-07-29 |
2023-08-12 |
Not clear |
| Marine E Gasparian, Boris V Chernyak, Dmitry A Dolgikh, Anne V Yagolovich, Ekaterina N Popova, Anna M Sycheva, Sergey A Moshkovskii, Mikhail P Kirpichniko. Generation of new TRAIL mutants DR5-A and DR5-B with improved selectivity to death receptor 5. Apoptosis : an international journal on programmed cell death. vol 14. issue 6. 2009-07-23. PMID:19412666. |
trail (tumor necrosis factor (tnf) related apoptosis-inducing ligand) has been introduced as an extrinsic pathway inducer of apoptosis that does not have the toxicities of fas and tnf. |
2009-07-23 |
2023-08-12 |
Not clear |
| Chi-Chen Wei, Ming-Shi Chan. Mouse interleukin-20 receptor 1a targets renal epithelial cells and is associated with renal calcium deposition. Genes and immunity. vol 10. issue 3. 2009-07-17. PMID:19078987. |
the renal epithelial cell lines exposed to caox in the presence of mil-20r1a showed significantly increased lactate dehydrogenase release; loss of cell viability through apoptosis; increased caox internalization; higher tumor necrosis factor (tnf)-alpha, mcp-1 and rantes expression; and higher reactive oxygen species production. |
2009-07-17 |
2023-08-12 |
mouse |
| Indrajit Chowdhury, Binu Tharakan, Ganapathy K Bha. Current concepts in apoptosis: the physiological suicide program revisited. Cellular & molecular biology letters. vol 11. issue 4. 2009-07-15. PMID:16977376. |
among them, bcl-2 family proteins, tnf and p53 play pivotal roles in the regulation of caspase activation and in the regulation of apoptosis. |
2009-07-15 |
2023-08-12 |
Not clear |
| Thomas S Griffit. Induction of tumor cell apoptosis by TRAIL gene therapy. Methods in molecular biology (Clifton, N.J.). vol 542. 2009-07-15. PMID:19565910. |
whereas interest in the apoptosis-inducing molecules tnf and fas ligand has peaked because of their participation in events such as autoimmune disorders, activation-induced cell death, immune privilege, and tumor evasion from the immune system, another death-inducing family member, tnf-related apoptosis-inducing ligand (trail), or apo-2 ligand, has generated excitement because of its unique ability to induce apoptosis in a wide range of transformed cell lines but not in normal tissues. |
2009-07-15 |
2023-08-12 |
mouse |
| Sabrina L Spencer, Suzanne Gaudet, John G Albeck, John M Burke, Peter K Sorge. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature. vol 459. issue 7245. 2009-07-14. PMID:19363473. |
in the case of apoptosis mediated by trail (tumour necrosis factor (tnf)-related apoptosis-inducing ligand) it is common for some cells in a clonal population to die while others survive-a striking divergence in cell fate. |
2009-07-14 |
2023-08-12 |
human |
| Wei Wei, Yanxin Liu, Dexian Zhen. Current understanding on the immunological functions of tumor necrosis factor-related apoptosis-inducing ligand. Cellular & molecular immunology. vol 2. issue 4. 2009-06-30. PMID:16274624. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) selectively induces apoptosis in various tumor cells and virus-infected cells, but rarely in normal cells. |
2009-06-30 |
2023-08-12 |
Not clear |
| Prisco Mirandola, Giuliana Gobbi, Ivonne Sponzilli, Chiara Malinverno, Andrea Cavazzoni, Roberta Alfieri, Pier Giorgio Petronini, Marco Vital. TRAIL-induced apoptosis of FHIT-negative lung cancer cells is inhibited by FHIT re-expression. Journal of cellular physiology. vol 220. issue 2. 2009-06-29. PMID:19418484. |
tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail) can induce apoptosis in the fhit-negative non-small lung cancer cell line calu-1. |
2009-06-29 |
2023-08-12 |
human |
| Qinxi Li, Zhiyun Ye, Jun Wen, Lin Ma, Ying He, Guili Lian, Zhen Wang, Luyao Wei, Di Wu, Bin Jian. Gelsolin, but not its cleavage, is required for TNF-induced ROS generation and apoptosis in MCF-7 cells. Biochemical and biophysical research communications. vol 385. issue 2. 2009-06-26. PMID:19465002. |
the tumor necrosis factor (tnf) can induce apoptosis in many cells including mcf-7 cells. |
2009-06-26 |
2023-08-12 |
Not clear |
| Qinxi Li, Zhiyun Ye, Jun Wen, Lin Ma, Ying He, Guili Lian, Zhen Wang, Luyao Wei, Di Wu, Bin Jian. Gelsolin, but not its cleavage, is required for TNF-induced ROS generation and apoptosis in MCF-7 cells. Biochemical and biophysical research communications. vol 385. issue 2. 2009-06-26. PMID:19465002. |
exogenous expression of gelsolin in this mutant cell line (gel(mut)) restored the sensitivity to tnf-induced cell death and knock-down of gelsolin by sirna conferred mcf-7 cells with resistance to tnf, indicating that gelsolin is required for tnf-induced apoptosis. |
2009-06-26 |
2023-08-12 |
Not clear |
| Qinxi Li, Zhiyun Ye, Jun Wen, Lin Ma, Ying He, Guili Lian, Zhen Wang, Luyao Wei, Di Wu, Bin Jian. Gelsolin, but not its cleavage, is required for TNF-induced ROS generation and apoptosis in MCF-7 cells. Biochemical and biophysical research communications. vol 385. issue 2. 2009-06-26. PMID:19465002. |
interestingly, the resistance of gel(mut) cells to apoptosis induction is selective to tnf, since gel(mut) and wild-type cells showed similar sensitivity to other death stimuli that were tested. |
2009-06-26 |
2023-08-12 |
Not clear |