| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A A van de Loosdrecht, G J Ossenkoppele, R H Beelen, M G Broekhoven, A M Dräger, M M Langenhuijse. Apoptosis in tumor necrosis factor-alpha-dependent, monocyte-mediated leukemic cell death: a functional, morphologic, and flow-cytometric analysis. Experimental hematology. vol 21. issue 13. 1993-12-23. PMID:8243565. |
light and electron microscopic examination showed the characteristic features of apoptosis of u937 cells after incubation with either monocytes or tumor necrosis factor (tnf)-alpha. |
1993-12-23 |
2023-08-12 |
human |
| T Hernández-Caselles, O Stutma. Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation. Journal of immunology (Baltimore, Md. : 1950). vol 151. issue 8. 1993-11-09. PMID:8409382. |
3) tnf induces direct thymocyte apoptosis (a property not shared by il-1 beta, il-2, il-4, il-6 and il-7). |
1993-11-09 |
2023-08-12 |
mouse |
| T Hernández-Caselles, O Stutma. Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation. Journal of immunology (Baltimore, Md. : 1950). vol 151. issue 8. 1993-11-09. PMID:8409382. |
of the cytokines studied, only il-7 reduced tnf apoptosis. |
1993-11-09 |
2023-08-12 |
mouse |
| T Hernández-Caselles, O Stutma. Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation. Journal of immunology (Baltimore, Md. : 1950). vol 151. issue 8. 1993-11-09. PMID:8409382. |
thymocyte apoptosis by tnf showed the same species specificity as costimulation (i.e., human tnf had no effect) and was not inhibited by cy. |
1993-11-09 |
2023-08-12 |
mouse |
| T Hernández-Caselles, O Stutma. Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation. Journal of immunology (Baltimore, Md. : 1950). vol 151. issue 8. 1993-11-09. PMID:8409382. |
however, only the two antibodies that also neutralize tnf lytic activity (2e2, xt22) could inhibit tnf-mediated apoptosis, implying two different but neighboring functional domains in the tnf molecule mediating apoptosis/lysis and costimulation. |
1993-11-09 |
2023-08-12 |
mouse |
| S C Wright, J Zhong, H Zheng, J W Larric. Nicotine inhibition of apoptosis suggests a role in tumor promotion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 7. issue 11. 1993-10-12. PMID:8370474. |
the results demonstrate that nicotine inhibits apoptosis induced by diverse stimuli including tumor necrosis factor (tnf), uv light, chemotherapeutic drugs, and calcium ionophore. |
1993-10-12 |
2023-08-12 |
Not clear |
| N Itoh, Y Tsujimoto, S Nagat. Effect of bcl-2 on Fas antigen-mediated cell death. Journal of immunology (Baltimore, Md. : 1950). vol 151. issue 2. 1993-08-25. PMID:7687619. |
fas ag is a cell surface protein that can mediate apoptosis and belongs to the tnf receptor family. |
1993-08-25 |
2023-08-12 |
human |
| W Malorni, R Rivabene, M T Santini, G Donell. N-acetylcysteine inhibits apoptosis and decreases viral particles in HIV-chronically infected U937 cells. FEBS letters. vol 327. issue 1. 1993-08-24. PMID:7687566. |
tumor necrosis factor (tnf), a cytokine capable of inducing oxygen free radicals and apoptosis, appears also to be involved in hiv activation. |
1993-08-24 |
2023-08-12 |
Not clear |
| T Koike, K Fehsel, J Zielasek, H Kolb, V Burkar. Gangliosides protect from TNF alpha-induced apoptosis. Immunology letters. vol 35. issue 3. 1993-07-22. PMID:8514331. |
gangliosides protect from tnf alpha-induced apoptosis. |
1993-07-22 |
2023-08-12 |
cattle |
| T Koike, K Fehsel, J Zielasek, H Kolb, V Burkar. Gangliosides protect from TNF alpha-induced apoptosis. Immunology letters. vol 35. issue 3. 1993-07-22. PMID:8514331. |
in situ nick translation revealed that bbg (2 mg/ml) significantly reduces the number of cells with tnf alpha-induced dna-strand breaks from 71.2% to 6.6% (p < 0.0001), indicating a protection against tnf alpha-mediated apoptosis. |
1993-07-22 |
2023-08-12 |
cattle |
| J E Belizario, J L Tilly, S W Sherwoo. Caffeine potentiates the lethality of tumour necrosis factor in cancer cells. British journal of cancer. vol 67. issue 6. 1993-07-21. PMID:8512808. |
l929 cells stimulated with tnf died via apoptosis, as judged by both morphological criteria and the occurrence of internucleosomal dna cleavage. |
1993-07-21 |
2023-08-12 |
mouse |
| B Vanhaesebroeck, J C Reed, D De Valck, J Grooten, T Miyashita, S Tanaka, R Beyaert, F Van Roy, W Fier. Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. Oncogene. vol 8. issue 4. 1993-04-20. PMID:8455935. |
we investigated the effect of bcl-2 expression on cellular sensitivity to lysis by tumor necrosis factor (tnf), a cytokine capable of inducing apoptosis in several tumor cell lines. |
1993-04-20 |
2023-08-12 |
mouse |
| B Vanhaesebroeck, J C Reed, D De Valck, J Grooten, T Miyashita, S Tanaka, R Beyaert, F Van Roy, W Fier. Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. Oncogene. vol 8. issue 4. 1993-04-20. PMID:8455935. |
bcl-2-overexpressing derivatives of these cell lines did not acquire reduced tnf sensitivity and still exhibited the characteristic pattern of internucleosomal dna fragmentation of tnf-induced apoptosis. |
1993-04-20 |
2023-08-12 |
mouse |
| B Vanhaesebroeck, J C Reed, D De Valck, J Grooten, T Miyashita, S Tanaka, R Beyaert, F Van Roy, W Fier. Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. Oncogene. vol 8. issue 4. 1993-04-20. PMID:8455935. |
moreover, bcl-2 expression in the interleukin 3 (il-3)-dependent myeloid cell line 32d protected these cells from apoptosis resulting from growth factor deprivation, but not from apoptosis induced by tnf. |
1993-04-20 |
2023-08-12 |
mouse |
| K M Manchester, W D Heston, D B Donne. Tumour necrosis factor-induced cytotoxicity is accompanied by intracellular mitogenic signals in ME-180 human cervical carcinoma cells. The Biochemical journal. vol 290 ( Pt 1). 1993-03-23. PMID:8439287. |
tnf induced dna fragmentation in sensitive cells, suggesting that cytotoxicity occurred via apoptosis. |
1993-03-23 |
2023-08-12 |
human |
| R Munker, L Greither, M Darsow, S Pander, W Wilmann. TNF induces cytoplasmic vesicles in actinomycin D-treated K 562 cells. Annals of hematology. vol 65. issue 1. 1992-09-10. PMID:1643161. |
the formation of these vesicles is characteristic for the combination of actinomycin d with tnf and precedes the changes of apoptosis and cellular disintegration. |
1992-09-10 |
2023-08-11 |
human |
| S C Wright, P Kumar, A W Tam, N Shen, M Varma, J W Larric. Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. Journal of cellular biochemistry. vol 48. issue 4. 1992-06-05. PMID:1577874. |
within 2-3 h of exposure to tnf, u937 underwent the morphological alterations characteristic of apoptosis. |
1992-06-05 |
2023-08-11 |
Not clear |
| S C Wright, P Kumar, A W Tam, N Shen, M Varma, J W Larric. Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. Journal of cellular biochemistry. vol 48. issue 4. 1992-06-05. PMID:1577874. |
a tnf-resistant variant derived from u937 did not undergo apoptosis in response to tnf, even in the presence of cycloheximide. |
1992-06-05 |
2023-08-11 |
Not clear |
| S C Wright, P Kumar, A W Tam, N Shen, M Varma, J W Larric. Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. Journal of cellular biochemistry. vol 48. issue 4. 1992-06-05. PMID:1577874. |
morphological, biochemical, and kinetic criteria established that tnf activates apoptosis as opposed to necrosis. |
1992-06-05 |
2023-08-11 |
Not clear |
| S C Wright, P Kumar, A W Tam, N Shen, M Varma, J W Larric. Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. Journal of cellular biochemistry. vol 48. issue 4. 1992-06-05. PMID:1577874. |
taken altogether, these data support the hypothesis that activation of apoptosis is at least one essential step in the tnf lytic pathway in the u937 model system. |
1992-06-05 |
2023-08-11 |
Not clear |