| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S C Wright, P Kumar, A W Tam, N Shen, M Varma, J W Larric. Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. Journal of cellular biochemistry. vol 48. issue 4. 1992-06-05. PMID:1577874. |
the percentage of cells undergoing apoptosis depended on the concentration of tnf and was augmented by the addition of cycloheximide. |
1992-06-05 |
2023-08-11 |
Not clear |
| T W Salcedo, H B Flei. Detection of tumor necrosis factor induced nuclear damage with p-phenylenediamine. Journal of immunological methods. vol 148. issue 1-2. 1992-05-19. PMID:1373426. |
using the intercalating dye p-phenylenediamine to stain nuclei, we detected tnf alpha-induced nuclear alterations which characteristically occur during apoptosis in the tnf alpha sensitive u937 cell line. |
1992-05-19 |
2023-08-11 |
Not clear |
| L B Owen-Schaub, S Yonehara, W L Crump, E A Grim. DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. Cellular immunology. vol 140. issue 1. 1992-03-20. PMID:1371242. |
previous studies demonstrated that the anti-fas antibody mediated apoptosis in those cells sensitive to tumor necrosis factor (tnf) and, further, triggered the co-downregulation of tumor necrosis factor receptors (tnf-rs). |
1992-03-20 |
2023-08-11 |
mouse |
| J G Sinkovic. Viral oncolysates as human tumor vaccines. International reviews of immunology. vol 7. issue 4. 1992-03-09. PMID:1663989. |
in contrast, immune t cells (including some til) are mhc-restricted, act under the direction of memory cells and lyse target cells primarily but not exclusively by the release of lymphotoxin (tnf beta) causing programmed cell death (apoptosis) through endonuclease activation and target cell dna fragmentation. |
1992-03-09 |
2023-08-11 |
human |
| T Shinagawa, K Yoshioka, S Kakumu, T Wakita, T Ishikawa, Y Itoh, M Takayanag. Apoptosis in cultured rat hepatocytes: the effects of tumour necrosis factor alpha and interferon gamma. The Journal of pathology. vol 165. issue 3. 1992-02-07. PMID:1762032. |
tnf alpha killed cultured rat hepatocytes by increasing apoptosis, and this effect was potentiated by the addition of ifn gamma, which by itself was also weakly cytotoxic. |
1992-02-07 |
2023-08-11 |
rat |
| P Golstein, D M Ojcius, J D Youn. Cell death mechanisms and the immune system. Immunological reviews. vol 121. 1991-12-13. PMID:1937533. |
cell death is strikingly polymorphic: it can proceed via necrosis (as in complement-mediated cell death) or apoptosis, but the latter displays different patterns (in the receptor-mediated death of some thymocytes, in cell death mediated by tnf alpha or by cytotoxic t cells), perhaps reflecting different pathways of control of a common core mechanism. |
1991-12-13 |
2023-08-11 |
Not clear |
| D M Ojcius, A Zychlinsky, L M Zheng, J D Youn. Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes. Experimental cell research. vol 197. issue 1. 1991-11-21. PMID:1915662. |
two ionophores specific for k+, valinomycin and beauvericin, induce a type of cell death very similar to apoptosis due to tumor necrosis factor (tnf alpha). |
1991-11-21 |
2023-08-11 |
Not clear |
| K Fehsel, V Kolb-Bachofen, H Kol. Analysis of TNF alpha-induced DNA strand breaks at the single cell level. The American journal of pathology. vol 139. issue 2. 1991-09-06. PMID:1867316. |
treatment of l929 cells with tnf alpha initiates apoptosis and subsequent cell death. |
1991-09-06 |
2023-08-11 |
Not clear |
| S M Laster, J G Wood, L R Goodin. Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. Journal of immunology (Baltimore, Md. : 1950). vol 141. issue 8. 1988-11-09. PMID:3171180. |
for example, in f17 cells we found that tnf treatment induced a classical form of apoptosis. |
1988-11-09 |
2023-08-11 |
Not clear |
| S M Laster, J G Wood, L R Goodin. Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. Journal of immunology (Baltimore, Md. : 1950). vol 141. issue 8. 1988-11-09. PMID:3171180. |
the goal of this investigation was to determine whether tnf caused one of the classic forms of cell death, i.e., apoptosis, which is characterized by nuclear disintegration and cytoplasmic "boiling," or necrosis, which is characterized by the formation of a "balloon-like" plasma membrane and a lack of nuclear disintegration. |
1988-11-09 |
2023-08-11 |
Not clear |
| S M Laster, J G Wood, L R Goodin. Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. Journal of immunology (Baltimore, Md. : 1950). vol 141. issue 8. 1988-11-09. PMID:3171180. |
in contrast, tnf induced a necrotic form of cell death in l-m cells, similar to the lysis induced by antibody and c. finally, we found that sensitized c3ha cells displayed a novel cytolytic phenotype which resembled apoptosis but did not include dna fragmentation. |
1988-11-09 |
2023-08-11 |
Not clear |