| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Zhao, Yang Xiao, Ye Fu, Xin Guan, Ming Fu, Chenming Wang, Yuhan Zhou, Shiru Hong, Yingqian You, Yuxi Wang, Shengli Chen, Yichi Zhang, Yansen Bai, Huan Gu. Benzo[a]pyrene exposure and incident risks of digestive system cancers: Insights from nested case-control studies and adverse outcome pathway network analysis. Journal of hazardous materials. vol 487. 2025-01-18. PMID:39826461. |
furthermore, the adverse outcome pathway (aop) network indicated five molecular initiation events and 18 subsequent key events, particularly, the alterations in receptors of ahr, egfr accompanied by regulations of cell proliferation and apoptosis pathways (e.g., pi3k-akt, tnf signaling) may facilitate common carcinogenic processes. |
2025-01-18 |
2025-01-23 |
human |
| Xinyu Yan, Yiyi Zhang, Jingwen Mo, Lindong Xu, Keyu Shi, Yi Zho. Molecular docking and network pharmacology research on the Danggui Sini Decoction's mechanism of action for treating erectile dysfunction. Medicine. vol 103. issue 47. 2025-01-14. PMID:39809170. |
this study demonstrates that dgsnd's compounds stimulate no synthesis and reduce inflammation and cell apoptosis to improve ed by acting on akti, alb, il6, tnf, tp53, and bcl2. |
2025-01-14 |
2025-01-17 |
Not clear |
| Ling-Kun Yang, Wan-Jing Ma, Xiao Wang, Huan-Ran Chen, Ya-Nan Jiang, Hui Su. Apoptosis in polycystic ovary syndrome: Mechanisms and therapeutic implications. Life sciences. 2025-01-14. PMID:39809382. |
this review aims to summarize the relationship between pcos and apoptosis, discuss how apoptosis affects normal ovarian function and how it becomes dysfunctional in the ovaries of pcos patients, and investigate the signaling pathways associated with apoptosis in pcos, including pi3k-akt, tnf, nf-κb, and p53. |
2025-01-14 |
2025-01-17 |
Not clear |
| Dirk Wohlleber, Percy A Knoll. Tissue Determinants of Antiviral Immunity in the Liver. Zeitschrift fur Gastroenterologie. vol 63. issue 1. 2025-01-10. PMID:39793603. |
second, virus-infected hepatocytes support clearance of infection by responding to tnf, which is released from virus-specific cd8 t cells, with the selective induction of apoptosis. |
2025-01-10 |
2025-01-14 |
human |
| Lijuan Huang, Bing Du, Xiaohu Cui, Hanqing Zhao, Yanlin Feng, Ziying Xu, Jianhai Long, Jing Yuan, Fuping Yo. Nerelimomab Alleviates Capsaicin-Induced Acute Lung Injury by Inhibiting TNF Signaling and Apoptosis. Pharmaceuticals (Basel, Switzerland). vol 17. issue 12. 2025-01-08. PMID:39770536. |
nerelimomab alleviates capsaicin-induced acute lung injury by inhibiting tnf signaling and apoptosis. |
2025-01-08 |
2025-01-13 |
Not clear |
| Xiaorong Yang, Lan We. Analysis of long Non-Coding RNA and mRNA expression in Clostridium butyricum-Induced apoptosis in SW480 colon cancer cells. Gene. vol 940. 2025-01-05. PMID:39755264. |
apoptosis analysis revealed that cb treatment induced apoptosis in sw480 cells, as evidenced by the upregulation of pro-apoptotic genes such as casp1, tnf, and bnip3l, and the downregulation of anti-apoptotic bcl family members. |
2025-01-05 |
2025-01-08 |
Not clear |
| Yun-Li Tang, Hui-Qiong Zhang, Chen Sun, Dai-Bo Wang, Qiao-Ling Ma, Su-Juan Wang, Jian-Hao Gu, Xiao-Fang Xie, Cheng Pen. [Prediction of anti-gastric cancer effect of Panacis Quinquefolii Radix by network pharmacology and in vivo validation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 20. 2024-12-19. PMID:39701737. |
apoptosis induced by tumor necrosis factor(tnf)-α activation and caspase-1 may be key molecular mechanisms of its anti-cancer effects. |
2024-12-19 |
2024-12-22 |
mouse |
| Mohamed N Alibrahim, Annunziata Gloghini, Antonino Carbon. Pathobiological Features and Therapeutic Opportunities Linked to TNF Family Member Expression in Classic Hodgkin Lymphoma. Cancers. vol 16. issue 23. 2024-12-17. PMID:39682256. |
the tumor necrosis factor (tnf) family, which includes 19 ligands and 29 receptors, influences cellular proliferation, differentiation, and apoptosis. |
2024-12-17 |
2024-12-21 |
Not clear |
| Xin Gong, Zhijian Tan, Henghui Xu, Xu Jiang, Lei Che. Paeoniflorin Attenuates Oxidative Stress and Inflammation in Parkinson's Disease by Activating the HSF1-NRF1 Axis. The American journal of Chinese medicine. vol 52. issue 7. 2024-12-11. PMID:39663263. |
apoptosis; cleaved-caspase 3, cleaved-caspase 8, repulsive guidance molecule a (rgma), gap-43, and brain-derived neurotrophic factor (bdnf) expression; and superoxide dismutase (sod), malondialdehyde (mda), glutathione peroxidase (gsh-px), catalase (cat), tumor necrosis factor (tnf)-α, interleukin (il)-2, il-6, and il-10 levels were determined in mice and cells. |
2024-12-11 |
2024-12-14 |
mouse |
| Jihye Hwang, Tejeshwar C Rao, Jiahui Tao, Bingdong Sha, Yoshiki Narimatsu, Henrik Clausen, Alexa L Mattheyses, Susan L Belli. Apoptotic signaling by TNFR1 is inhibited by the α2-6 sialylation, but not α2-3 sialylation, of the TNFR1 N-glycans. The Journal of biological chemistry. 2024-11-30. PMID:39615678. |
upon binding to tnf, plasma membrane-localized tnfr1 initiates survival signaling, whereas tnfr1 internalization promotes caspase-mediated apoptosis. |
2024-11-30 |
2024-12-06 |
Not clear |
| Boyun Jang, Youngsoo Kim, Jungbin Song, Young-Woo Kim, Won-Yung Le. Identifying Herbal Candidates and Active Ingredients Against Postmenopausal Osteoporosis Using Biased Random Walk on a Multiscale Network. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596387. |
notably, compounds such as falcarindiol from glehniae radix and tetrahydrocoptisine from corydalis tuber-previously unstudied for osteoporosis-were predicted to interact with inflammation-related proteins, including il6, il1b, and tnf, affecting key biological processes like apoptosis and cell proliferation. |
2024-11-27 |
2024-11-29 |
Not clear |
| Xiangjin Wang, Lijiao Wu, Dan Luo, Langyu He, Hao Wang, Bo Pen. Mechanism of action of Salvia miltiorrhiza on avascular necrosis of the femoral head determined by integrated network pharmacology and molecular dynamics simulation. Scientific reports. vol 14. issue 1. 2024-11-19. PMID:39558045. |
subsequent enrichment analysis revealed that these targets were mainly enriched in the age-rage, il-17, and tnf pathways, which were mainly associated with inflammatory responses, apoptosis, and oxidative stress. |
2024-11-19 |
2024-11-22 |
Not clear |
| Liang Cao, Min Du, Mengmeng Cai, Yan Feng, Juanjuan Miao, Jiafeng Sun, Jie Song, Boxiang D. Neutrophil membrane-coated nanoparticles for targeted delivery of toll-like receptor 4 siRNA ameliorate LPS-induced acute lung injury. International journal of pharmaceutics. 2024-11-17. PMID:39551221. |
meanwhile, they also reduced the expression of tlr4, and its downstream genes including tnf receptor-associated factor 6 (traf6), x-linked inhibitor of apoptosis protein (xiap), and nuclear factor kappa-b (nf-κb), but elevated the levels of aquaporin 1 (aqp1) and aquaporin 5 (aqp5). |
2024-11-17 |
2024-11-22 |
mouse |
| Zhiying Feng, Kangyu Wang, Jiawang Huang, Zhuolin Liu, Jingmin Fu, Jianing Shi, Xinyue Ma, Ling Li, Qiong W. Exploration of the Active Components and Mechanism of Jiegeng (Platycodonis Radix) in the Treatment of Influenza Virus Pneumonia Through Network Pharmacology Analysis and Experimental Verification. Chemical biology & drug design. vol 104. issue 5. 2024-11-11. PMID:39523498. |
go and kegg enrichment analyses showed that the pathways most related to the mechanisms of jiegeng (platycodonis radix) against influenza virus pneumonia included the tnf and il-17 signaling pathways and apoptosis. |
2024-11-11 |
2024-11-17 |
Not clear |
| Xin-Xin Hu, Ying-Chuan Yin, Peng Xu, Min Wei, Wang Zhan. Network toxicology and cell experiments reveal the mechanism of DEHP-induced diabetic nephropathy via Wnt signaling pathway. Toxicology and applied pharmacology. vol 493. 2024-11-09. PMID:39515621. |
mouse glomerular podocytes (mpc-5) exposed to graded concentrations of dehp, with or without the wnt pathway inhibitor xav-939, displayed significant dehp-induced disruptions: reduced cell adhesion, proliferation, and differentiation; increased autophagy, apoptosis, and migratory activity; elevated inflammatory mediator release; and pronounced activation of the wnt signaling pathway, evidenced by upregulation of β-catenin, egfr, tnf, ccnd1, bcl2 and downregulation of casp3. |
2024-11-09 |
2024-11-17 |
mouse |
| Miaomiao Ye, Tingxian Liu, Liqing Miao, Huihui Ji, Zhihui Xu, Huihui Wang, Jian'an Zhang, Xueqiong Zh. Cisplatin-encapsulated TRAIL-engineered exosomes from human chorion-derived MSCs for targeted cervical cancer therapy. Stem cell research & therapy. vol 15. issue 1. 2024-11-05. PMID:39497209. |
tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail) selectively triggers cancer cells apoptosis by binding to cognate death receptors (dr4 and dr5). |
2024-11-05 |
2024-11-07 |
human |
| Na Zhang, Jianping Liu, Rui Guo, Lingjie Yan, Yuanxin Yang, Chen Shi, Mengmeng Zhang, Bing Shan, Wanjin Li, Jinyang Gu, Daichao X. Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway. Molecular cell. 2024-10-29. PMID:39471814. |
tumor necrosis factor (tnf)-induced receptor-interacting serine/threonine protein kinase 1 (ripk1)-mediated cell death, including apoptosis and necroptosis, is increasingly recognized as a major driver of inflammatory diseases. |
2024-10-29 |
2024-11-02 |
mouse |
| Qiang You, Lan Li, Haiyan Ding, Youping Li. Proteomics-based network pharmacology and molecular docking reveal the potential mechanisms of 5,6,7,4'-tetramethoxyflavone against HeLa cancer cells. Heliyon. vol 10. issue 20. 2024-10-26. PMID:39449708. |
these targets are primarily involved in mapk, apoptosis, and tnf signaling pathways. |
2024-10-26 |
2024-10-28 |
Not clear |
| Marton Fogarasi, Simona Dim. Immunomodulatory Functions of TNF-Related Apoptosis-Inducing Ligand in Type 1 Diabetes. Cells. vol 13. issue 20. 2024-10-25. PMID:39451194. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a member of the tnf protein superfamily and was initially identified as a protein capable of inducing apoptosis in cancer cells. |
2024-10-25 |
2024-10-28 |
Not clear |
| Zahra Mozooni, Rezvaneh Ghadyani, Shahrzad Soleimani, Ehsan Rouhollahpour Ahangar, Mojgan Sheikhpour, Mehrdad Haghighi, Marzieh Motallebi, Abolfazl Movafagh, Seyed Mohsen Aghaei-Zarc. TNF-α, and TNFRs in gastrointestinal cancers. Pathology, research and practice. vol 263. 2024-10-23. PMID:39442225. |
in contrast, binding of cytokines to certain family members, such as tnf ri and fas ligand (fas l), leads to the secretion and initiation of apoptosis. |
2024-10-23 |
2024-10-26 |
Not clear |