| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Liu, Shaik Althaf Hussain, Xiaoyan H. Fisetin reduces the resistance of MOLT-4 and K562 cells to TRAIL-induced apoptosis through upregulation of TRAIL receptors. Naunyn-Schmiedeberg's archives of pharmacology. 2024-06-25. PMID:38918236. |
tnf-related apoptosis-inducing ligand (trail) is a member of the tnf superfamily that is capable of apoptosis induction selectively in tumor cells. |
2024-06-25 |
2024-06-29 |
Not clear |
| Biao Song, Xin Ning, Lan Guo, Weida Liu, Hongzhong Ji. Comparative Proteomics Analysis Reveals Distinct Molecular Phenotype and Biomarkers in Patients with Erythrodermic Atopic Dermatitis and Erythrodermic Psoriasis. Inflammation. 2024-06-14. PMID:38877357. |
ead demonstrated a more pronounced inflammation tone, characterized by th1/th2/th22/il-1-dominant patterns, as well as increased tnf superfamily, th17, and apoptosis markers. |
2024-06-14 |
2024-06-17 |
Not clear |
| Diego Rojas-Rivera, Sebastián Beltrán, Francisco Muñoz-Carvajal, Pablo Ahumada-Montalva, Lorena Abarzúa, Laura Gomez, Fernanda Hernandez, Cristian A Bergmann, Luis Labrador, Melissa Calegaro-Nassif, Mathieu J M Bertrand, Patricio A Manque, Ute Woehlbie. The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis. Autophagy. 2024-06-14. PMID:38873940. |
tnf promotes inflammation by inducing ripk1 kinase-dependent apoptosis or necroptosis. |
2024-06-14 |
2024-06-16 |
Not clear |
| Diego Rojas-Rivera, Sebastián Beltrán, Francisco Muñoz-Carvajal, Pablo Ahumada-Montalva, Lorena Abarzúa, Laura Gomez, Fernanda Hernandez, Cristian A Bergmann, Luis Labrador, Melissa Calegaro-Nassif, Mathieu J M Bertrand, Patricio A Manque, Ute Woehlbie. The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis. Autophagy. 2024-06-14. PMID:38873940. |
we determine that mscs succumb to ripk1 kinase-dependent apoptosis upon tnf sensing and necroptosis when caspases are inactivated. |
2024-06-14 |
2024-06-16 |
Not clear |
| Reiri Takeuchi, Takatoshi Nomura, Manabu Yaguchi, Chieko Taguchi, Itaru Suzuki, Haruka Suzuki, Hiroko Matsumoto, Yuichiro Okada, Kazumune Arikawa, Takato Nomoto, Koichi Hiratsuk. 18‑α‑glycyrrhetinic acid induces apoptosis in gingival fibroblasts exposed to phenytoin. Experimental and therapeutic medicine. vol 28. issue 1. 2024-06-13. PMID:38868612. |
these results demonstrated that 18α-ga induced apoptosis through the activation of the fas and tnf pathways in the death receptor signaling pathway in gingival fibroblasts treated with pht. |
2024-06-13 |
2024-06-15 |
human |
| Jing Sun, Wen-Juan Xu, Lin-Ying Zhong, Jian-Bo Chen, Ling Don. [UPLC-QE-Orbitrap-MS combined with network pharmacology to explore differential components and mechanisms of raw and scorched rhubarb for treatment of ulcerative colitis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 7. 2024-05-30. PMID:38812196. |
network pharmacology and molecular docking suggested that free anthraquinones, gallic acid, and 5-hmf may act on core targets such as b-cell lymphoma-2(bcl2), epidermal growth factor receptor(egfr), tumor necrosis factor(tnf), and caspase-3(casp3) and influence the signaling pathways such as phosphoinositide-3-kinase/protein kinase b(pi3k/akt), hypoxia inducible factor-1(hif-1), tnf, and mitogen-activated protein kinase(mapk), so as to regulate the inflammation response, oxidative stress, and cell apoptosis to relieve uc symptoms. |
2024-05-30 |
2024-06-17 |
mouse |
| Carlos Matellan, Ciarán Kennedy, Miren Itxaso Santiago-Vela, Johanna Hochegger, Méabh B Ní Chathail, Amanda Wu, Christopher Shannon, Helen M Roche, Seema S Aceves, Catherine Godson, Mario C Manres. The TNFSF12/TWEAK Modulates Colonic Inflammatory Fibroblast Differentiation and Promotes Fibroblast-Monocyte Interactions. Journal of immunology (Baltimore, Md. : 1950). 2024-05-03. PMID:38700420. |
tnf superfamily member 12 (tnfsf12, or tnf-like weak inducer of apoptosis [tweak]) has gained interest as a mediator of chronic inflammation. |
2024-05-03 |
2024-05-05 |
human |
| Ana Catarina Cristovão-Silva, Maria Carolina Accioly Brelaz-de-Castro, Elis Dionisio da Silva, Ana Cristina Lima Leite, Lizandra Beatriz Amorim Alves Santiago, Juliana Maria da Conceição, Robert da Silva Tiburcio, Davi Pereira de Santana, Danilo Cesar Galindo Bedor, Breno Ítalo Valença de Carvalho, Luiz Felipe Gomes Rebello Ferreira, Rafael de Freitas E Silva, Valéria Rêgo Alves Pereira, Marcelo Zaldini Hernande. Trypanosoma cruzi Killing and Immune Response Boosting by Novel Phenoxyhydrazine-Thiazole against Chagas Disease. Experimental parasitology. 2024-04-09. PMID:38593864. |
liz311 induced the secretion of tnf, ifnγ, il-2, il-4, il-10, and il-17, cell death by apoptosis, decreased acidic compartment formation, and induced changes in the mitochondrial membrane potential. |
2024-04-09 |
2024-04-12 |
human |
| Zigang Shen, Zhuojun Ke, Qiong Yang, Samson Teweldeberhan Ghebremichael, Tangxin Li, Tian Li, Jie Chen, Xianzhi Meng, Heng Xiang, Chunfeng Li, Zeyang Zhou, Guoqing Pan, Ping Che. Transcriptomic changes in the microsporidia proliferation and host responses in congenitally infected embryos and larvae. BMC genomics. vol 25. issue 1. 2024-04-01. PMID:38556880. |
for the transcriptome of b. mori infected with n. bombycis, beyond numerous degs related to dna replication and repair, mrna surveillance pathway, rna transport, protein biosynthesis, and proteolysis, with the progression of infection, a large number of degs related to immune and infection pathways, including phagocytosis, apoptosis, tnf, toll-like receptor, nf-kappa b, fc epsilon ri, and some diseases, were successively identified. |
2024-04-01 |
2024-04-03 |
Not clear |
| Lei Xu, Yang Zhang, Qian Tao, Tong Xu, Feng-Qin Lee, Li-Shuang Deng, Zhijie Jian, Jun Zhao, Yanting Yang, Siyuan Lai, Yuan-Cheng Zhou, Zhi-Wen Xu, Ling Zh. Transcriptome and metabolome analysis reveals PRV XJ delgE/gI/TK protects intracranially infected mice from death by regulating the inflammation. Frontiers in microbiology. vol 15. 2024-03-29. PMID:38550870. |
go and kegg enrichment analysis indicated that the differentially expressed genes were primarily enriched in pathways such as tnf, nod-like receptor, jak-stat, mapk, il-17 and apoptosis signaling. |
2024-03-29 |
2024-03-31 |
mouse |
| Zhen Shang, Weipeng Shi, Haitao Fu, Yingze Zhang, Tengbo Y. Identification of key autophagy-related genes and pathways in spinal cord injury. Scientific reports. vol 14. issue 1. 2024-03-20. PMID:38504116. |
go and kegg pathway enrichment analysis showed that these 129 genes were mainly involved in the process of cell apoptosis, angiogenesis, il-1 production, and inflammatory reactions, the tnf signaling pathway and the p53 signaling pathway. |
2024-03-20 |
2024-03-23 |
Not clear |
| Lijuan Xiong, Kexin Lin, Tianmu He, Xingyan Liu, Rui Yuan, Xiaofei Li, Jianyong Zhan. A novel approach combining network pharmacology and experimental validation to study the protective effect of ginsenoside Rb1 against cantharidin-induced hepatotoxicity in mice. Basic & clinical pharmacology & toxicology. 2024-03-13. PMID:38477401. |
kegg enrichment analysis revealed that 75 hub genes were mainly enriched in tnf, il-17 and apoptosis signalling pathways. |
2024-03-13 |
2024-03-15 |
mouse |
| Marcus K Preedy, Michael R H White, Vinay Tergaonka. Cellular heterogeneity in TNF/TNFR1 signalling: live cell imaging of cell fate decisions in single cells. Cell death & disease. vol 15. issue 3. 2024-03-12. PMID:38467621. |
tnf promotes cell survival by activating pro-inflammatory nf-κb and mapk signalling pathways but may also trigger apoptosis and necroptosis. |
2024-03-12 |
2024-03-14 |
Not clear |
| Yang Xiao, Bingbing Xu, Xiaolan Li, Tianhao Ding, Wenxin Zhao, Xiaoxue Nie, Junxia Mu, Zhiyou Xiao, Qian Wang, Qunli Ren, Enkui Zhan. Potential targets of diosgenin for the treatment of oral squamous cell carcinoma and their bioinformatics and transcriptional profiling analyses. Steroids. 2024-03-08. PMID:38458369. |
the results revealed that there were 146 potential targets of diosgenin for oscc treatment, which involved signaling pathways such as ras, tnf, pi3k-akt, hif, nf-κb, and could regulate cellular activity through apoptosis, autophagy, proliferation and differentiation, inflammatory response, dna repair, etc. |
2024-03-08 |
2024-03-11 |
Not clear |
| Saiyare Xuekelati, Zhuoya Maimaitiwusiman, Xue Bai, Hong Xiang, Yangjing Li, Hongmei Wan. Sarcopenia is associated with hypomethylation of TWEAK and increased plasma levels of TWEAK and its downstream inflammatory factor TNF-α in older adults: A case-control study. Experimental gerontology. 2024-03-04. PMID:38437928. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) and its receptor fibroblast growth factor inducible 14 (fn14) are known to play important roles in the pathogenesis of sarcopenia. |
2024-03-04 |
2024-03-07 |
Not clear |
| Yu He, Fei Liu, Mingjuan He, Fayu Long, Ding Hu, Jingwen Chen, Miao Fang, Zhenlong Wan. Molecular mechanism of resveratrol promoting differentiation of preosteoblastic MC3T3-E1 cells based on network pharmacology and experimental validation. BMC complementary medicine and therapies. vol 24. issue 1. 2024-02-29. PMID:38424533. |
apoptosis, foxo signaling pathway, and tnf signaling pathway are the primary kegg signaling pathways. |
2024-02-29 |
2024-03-03 |
mouse |
| Jiacheng Wu, Xiaoqing Xu, Jiaqi Duan, Yangyang Chai, Jiaying Song, Dongsheng Gong, Bingjing Wang, Ye Hu, Taotao Han, Yuanyuan Ding, Yin Liu, Jingnan Li, Xuetao Ca. EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death. Nature communications. vol 15. issue 1. 2024-02-12. PMID:38346956. |
mechanistically, efhd2 interacts with cofilin and suppresses cofilin phosphorylation, thus blocking tnf receptor i (tnfr1) internalization to inhibit iec apoptosis and consequently protecting intestine from inflammation. |
2024-02-12 |
2024-02-15 |
mouse |
| Guangyu Cheng, Xuan Wang, Chaojie Wang, Qi Zhang, Yiwen Zhan. Understanding the molecular mechanisms of Acori Tatarinowii Rhizoma: Nardostahyos Radix et Rhizoma in epilepsy treatment using network pharmacology and molecular docking. Medicine. vol 103. issue 6. 2024-02-09. PMID:38335401. |
these 53 targets were found to influence ep by manipulating pi3k-akt, il-17, tnf, and apoptosis signaling pathways. |
2024-02-09 |
2024-02-12 |
Not clear |
| Man Zhao, Aixian Liu, Jiaojiao Wu, Linhong Mo, Fang Lu, Guiling Wa. Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis. Medicine. vol 103. issue 4. 2024-01-26. PMID:38277520. |
in kyoto encyclopedia of genes and genomes (kegg) analysis, they were mainly enriched in nf-κb signaling pathway, fluid shear stress and atherosclerosis, p53 signaling pathway, tnf signaling pathway, and apoptosis. |
2024-01-26 |
2024-01-29 |
Not clear |
| Saadet Busra Aksoyer Sezgin, Sermin Durak, Faruk Celik, Arezoo Gheybi, Murat Diramali, Ramazan Cakmak, Ali Osman Gurol, Ilhan Yaylim, Umit Zeybe. Genetic Investigation of the Trail Mechanism in Diabetic and Non-diabetic Obese Patients. Biochemical genetics. 2024-01-19. PMID:38243005. |
tumor necrosis factor-associated apoptosis-inducing ligand(trail), which is a member of the tumor necrosis factor(tnf)-family with an important role in adipose tissue biology, is included in many studies with its ability to induce apoptosis in cancer cells, but the number of human-studies conducted on the gene related to its protective-role against diabetes and obesity at this level is insufficient. |
2024-01-19 |
2024-01-22 |
human |