| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tanmoy Mondal, Himanshu Gaur, Brice E N Wamba, Abby Grace Michalak, Camryn Stout, Matthew R Watson, Sophia L Aleixo, Arjun Singh, Salvatore Condello, Roland Faller, Gary Scott Leiserowitz, Sanchita Bhatnagar, Jogender Tushir-Sing. Characterizing the regulatory Fas (CD95) epitope critical for agonist antibody targeting and CAR-T bystander function in ovarian cancer. Cell death and differentiation. 2023-10-14. PMID:37838774. |
receptor clustering is the most critical step to activate extrinsic apoptosis by death receptors belonging to the tnf superfamily. |
2023-10-14 |
2023-11-08 |
Not clear |
| Pramisha Kharel, Chen Jia, Kamal Raj Dhital, Pukar Chapagain, Sabita Arya. TWEAK Progress in Dermatology: A Review. Indian journal of dermatology. vol 68. issue 4. 2023-10-12. PMID:37822396. |
tumour necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is a member of the tnf superfamily (tnfsf). |
2023-10-12 |
2023-10-15 |
Not clear |
| Fabian Schorn, J Paul Werthenbach, Mattes Hoffmann, Mila Daoud, Johanna Stachelscheid, Lars M Schiffmann, Ximena Hildebrandt, Su Ir Lyu, Nieves Peltzer, Alexander Quaas, Domagoj Vucic, John Silke, Manolis Pasparakis, Hamid Kashka. cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. The EMBO journal. 2023-10-04. PMID:37789765. |
cellular inhibitor of apoptosis proteins (ciaps) are ring-containing e3 ubiquitin ligases that ubiquitylate receptor-interacting protein kinase 1 (ripk1) to regulate tnf signalling. |
2023-10-04 |
2023-10-07 |
mouse |
| Xiaoyu Liu, Jie Chen, Nan Gao, Zhonghao Li, Guoqiang Zhan. EXPRESS: cIAP1/2 can regulate the inflammatory response and lung injury induced by apoptosis in septic rats. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2023-10-03. PMID:37784217. |
ciap1/2, an essential e3 ubiquitin ligase in the tnf pathway, plays a pivotal role in positively regulating the activation of nuclear factor κb (nf-κb) and mitogen-activated protein kinase (mapk) signaling pathways to promote inflammation while inhibiting apoptosis. |
2023-10-03 |
2023-10-07 |
rat |
| Andrea Fracchia, Drirh Khare, Samar Da'na, Reuven Or, Amnon Buxboim, Boaz Nachmias, Claudine Barkatz, Regina Golan-Gerstl, Swasti Tiwari, Polina Stepensky, Yuval Nevo, Hadar Benyamini, Sharona Elgavish, Osnat Almogi-Hazan, Batia Avn. Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Modulate Apoptosis, TNF Alpha and Interferon Gamma Response Gene mRNA Expression in T Lymphocytes. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37761990. |
mesenchymal stromal cell-derived small extracellular vesicles modulate apoptosis, tnf alpha and interferon gamma response gene mrna expression in t lymphocytes. |
2023-09-28 |
2023-10-07 |
human |
| Éva S Vanamee, Denise L Faustma. The benefits of clustering in TNF receptor superfamily signaling. Frontiers in immunology. vol 14. 2023-09-04. PMID:37662920. |
the tumor necrosis factor (tnf) receptor superfamily is a structurally and functionally related group of cell surface receptors that play crucial roles in various cellular processes, including apoptosis, cell survival, and immune regulation. |
2023-09-04 |
2023-09-07 |
Not clear |
| Rinkesh K Gupta, Jacqueline Miller, Michael Crof. TNF-like weak inducer of apoptosis inhibition is comparable to IL-13 blockade in ameliorating atopic dermatitis inflammation. Allergy. 2023-08-31. PMID:37650473. |
we investigated the importance of the tnf family cytokine tnf-like weak inducer of apoptosis (tweak; tnfsf12) to keratinocyte dysregulation and the pathogenesis of ad in mice and also tested if blocking tweak has a similar therapeutic effect as targeting il-13. |
2023-08-31 |
2023-09-07 |
mouse |
| Xin Cao, Sisi Peng, Ying Yan, Jun Li, Jianping Zhou, Hongwei Dai, Jie X. Alleviation of temporomandibular joint osteoarthritis by targeting RIPK1-mediated inflammatory signalling. Journal of cellular and molecular medicine. 2023-08-29. PMID:37643315. |
herein, inhibition of ripk1 suppressed the elevated levels of inflammatory factors, nuclear factor kappa b (nf-κb), along with markers of apoptosis and necroptosis after tumour necrosis factor (tnf)-α/cycloheximide (chx) treatment in synoviocytes. |
2023-08-29 |
2023-09-07 |
Not clear |
| Laurel A Grisant. TRAIL and its receptors in cardiac diseases. Frontiers in physiology. vol 14. 2023-08-25. PMID:37621762. |
extrinsic apoptosis occurs through a subset of tumor necrosis receptor (tnf) family receptors termed "death receptors." |
2023-08-25 |
2023-09-07 |
Not clear |
| Laurel A Grisant. TRAIL and its receptors in cardiac diseases. Frontiers in physiology. vol 14. 2023-08-25. PMID:37621762. |
one poorly characterized cardiac tnf related ligand is tnf-related apoptosis inducing ligand (trail). |
2023-08-25 |
2023-09-07 |
Not clear |
| Nicholas S Jones, Smita Kshirsagar, Vishnu Mohanan, Vidya Ramakrishnan, Flavia Di Nucci, Ling Ma, Jialin Mao, Hao Ding, Sha Klabunde, Domagoj Vucic, Lin Pan, Annemarie N Lekkerkerker, Yuan Chen, Michael E Rothenber. A phase I, randomized, ascending-dose study to assess safety, pharmacokinetics, and activity of GDC-8264, a RIP1 inhibitor, in healthy volunteers. Clinical and translational science. 2023-08-24. PMID:37596814. |
rip1 kinase activity mediates apoptosis and necroptosis induced by tumor necrosis factor (tnf)-α, toll-like receptors, and ischemic tissue damage. |
2023-08-24 |
2023-09-07 |
human |
| Xupu Wang, Lizheng Wang, Wenmo Liu, Xinyao Liu, Xinyuan Jia, Xinyao Feng, Fangshen Li, Rui Zhu, Jiahao Yu, Haihong Zhang, Hui Wu, Jiaxin Wu, Chu Wang, Bin Yu, Xianghui Y. Dose-related immunomodulatory effects of recombinant TRAIL in the tumor immune microenvironment. Journal of experimental & clinical cancer research : CR. vol 42. issue 1. 2023-08-22. PMID:37605148. |
in addition to specifically inducing tumor cell apoptosis, recombinant tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) has also been reported to influence the cancer immune microenvironment; however, its underlying effects and mechanisms remain unclear. |
2023-08-22 |
2023-09-07 |
Not clear |
| Lien Verboom, Christopher J Anderson, Maude Jans, Ioanna Petta, Gillian Blancke, Arne Martens, Mozes Sze, Tino Hochepied, Kodi S Ravichandran, Lars Vereecke, Geert van Lo. OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection. Cell death & disease. vol 14. issue 8. 2023-08-19. PMID:37598207. |
we show that mice with intestinal epithelial cell (iec)-specific otulin deficiency exhibit increased susceptibility to experimental colitis and are highly sensitive to tnf toxicity, due to excessive apoptosis of otulin deficient iecs. |
2023-08-19 |
2023-09-07 |
mouse |
| Kaibo Zhang, Bin Zhang, Yeqiang Son. Molecular Mechanism of Bai-Bo Formula for Treatment of Vitiligo Based on Network Pharmacology and Molecular Docking. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 5. 2023-08-12. PMID:37571906. |
bai-bo formula regulates immune inflammation, apoptosis, and autophagy via various pathways, including age-rage, pi3k-akt, and tnf signaling. |
2023-08-12 |
2023-08-16 |
Not clear |
| Yanhong Li, Guiying Shi, Wei Liang, Haiquan Shang, Huiwu Li, Yunlin Han, Wenjie Zhao, Lin Bai, Chuan Qi. Allogeneic Adipose-Derived Mesenchymal Stem Cell Transplantation Alleviates Atherosclerotic Plaque by Inhibiting Ox-LDL Uptake, Inflammatory Reaction and Endothelial Damage in Rabbits. Cells. vol 12. issue 15. 2023-08-11. PMID:37566014. |
compared with the model group, blood lipid levels declined, the plaque area, oxidized low-density lipoprotein (ox-ldl) uptake, scavenger receptor a1 and cluster of differentiation (cd) 36 levels were all significantly reduced, and the accumulation of inflammatory m1 macrophages, apoptosis, interleukin (il)-6 and tumor necrosis factor (tnf)-α expression were decreased. |
2023-08-11 |
2023-08-16 |
rabbit |
| Edward S Mocarsk. Programmed Necrosis in Host Defense. Current topics in microbiology and immunology. 2023-08-10. PMID:37563336. |
pro-apoptotic caspase-8 activity (along with caspase-10 in humans) executes extrinsic apoptosis, a nonlytic form of cell death triggered by tnf family death receptors (drs). |
2023-08-10 |
2023-08-16 |
Not clear |
| Olena Zaitseva, Annett Hoffmann, Margaretha Löst, Mohamed A Anany, Tengyu Zhang, Kirstin Kucka, Armin Wiegering, Christoph Otto, Harald Wajan. Antibody-based soluble and membrane-bound TWEAK mimicking agonists with FcγR-independent activity. Frontiers in immunology. vol 14. 2023-08-07. PMID:37545514. |
in contrast to conventional 18d1, the majority of 18d1 antibody variants with four or more fn14 binding sites displayed a strong ability to trigger the alternative nfκb pathway and to enhance tnf-induced cell death and therefore resemble in their activity soluble (tnf)-like weak inducer of apoptosis (tweak), one form of the natural occurring ligand of fn14. |
2023-08-07 |
2023-08-14 |
Not clear |
| Junqi Xiao, Yang Xie, Qing Duan, Tao Liu, Rong Ye, Xunhong Duan, Zhibiao Le, Nan Deng, Fengen Li. LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models. International heart journal. vol 64. issue 4. 2023-07-30. PMID:37518356. |
afterward, gain- and loss-of-function assays were performed in huvecs, followed by detection of cell viability, invasion, migration, and apoptosis and the expression of inflammatory factors [tumor necrosis factor (tnf) -α, interleukin (il) -1β, and il-6], endmt-related proteins [cd31, vascular epithelium (ve) -cadherin, vimentin, α-smooth muscle actin (sma), snai1, snai2, and twist1], and the apoptotic protein cleaved caspase-3. |
2023-07-30 |
2023-08-14 |
human |
| So-Young Lee, Geun-Hye Hong, Ji Hyung Chung, Kun-Young Par. Anticancer Effects of Washed-Dehydrated Solar Salt Doenjang on Colon Cancer-Induced C57BL/6 Mice. Journal of medicinal food. 2023-07-27. PMID:37498372. |
besides, wdsd regulated the protein expression of apoptosis (bcl-2-associated x protein [bax], b cell lymphoma-2 [bcl-2], b cell lymphoma-extra large [bcl-xl], and caspase 9, caspase 3), and p53, p21, and proinflammatory cytokines (interleukin [il]-6, tumor necrosis factor [tnf]- |
2023-07-27 |
2023-08-14 |
mouse |
| Vishal S Patil, Darasaguppe R Harish, Ganesh H Sampat, Subarna Roy, Sunil S Jalalpure, Pukar Khanal, Swarup S Gujarathi, Harsha V Hegd. System Biology Investigation Revealed Lipopolysaccharide and Alcohol-Induced Hepatocellular Carcinoma Resembled Hepatitis B Virus Immunobiology and Pathogenesis. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446321. |
in accordance with the enrichment analysis, hbv activates the signaling pathways for apoptosis, cell cycle, pi3k-akt, tnf, jak-stat, mapk, chemokines, nf-kappa b, and tgf-beta. |
2023-07-14 |
2023-08-14 |
Not clear |