| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julio M Pimentel, Jun-Ying Zhou, Gen Sheng W. The Role of TRAIL in Apoptosis and Immunosurveillance in Cancer. Cancers. vol 15. issue 10. 2023-06-22. PMID:37345089. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a member of the tnf superfamily that selectively induces apoptosis in tumor cells without harming normal cells, making it an attractive agent for cancer therapy. |
2023-06-22 |
2023-08-14 |
Not clear |
| Francesca Sibilia, Nasim Sheikh-Bahaei, Wendy J Mack, Jeiran Choupa. Perivascular spaces in Alzheimer's disease are associated with inflammatory, stress-related, and hypertension biomarkers. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333097. |
in the pvs basal ganglia, a significant positive association was found with trail (a tnf receptor inducing apoptosis). |
2023-06-19 |
2023-08-14 |
Not clear |
| O Avci, A S Taskiran, O Gundogd. Dexmedetomidine, an α Revista espanola de anestesiologia y reanimacion. 2023-06-07. PMID:37286034. |
dexmedetomidine, an α the aim of the present study is to examine the possible effect de dexmedetomidine on the development of morphine tolerance in rats including nociception, morphine analgesia, apoptosis, oxidative stress, and tumour necrosis factor (tnf)/ interleukin-1 (il-1) pathways. |
2023-06-07 |
2023-08-14 |
rat |
| Roberta Figueiroa Souza, Marcos Antônio Ferreira Caetano, Henrique Inhauser Riceti Magalhães, Patricia Castelucc. Study of tumor necrosis factor receptor in the inflammatory bowel disease. World journal of gastroenterology. vol 29. issue 18. 2023-06-05. PMID:37274062. |
the soluble tnf form binds to the tnfr1 receptor with, and its activation results in a signaling cascade effects such as apoptosis, cell proliferation and cytokine secretion. |
2023-06-05 |
2023-08-14 |
Not clear |
| Truong Quynh Nhu, Hang Bui Thi Bich, Huong Do Thi Thanh, Marie-Louise Scippo, Phuong Nguyen Thanh, Joëlle Quetin-Leclercq, Patrick Kestemon. Psidium guajava L.- dichloromethane and ethyl acetate fractions ameliorate striped catfish (Pangasianodon hypophthalmus) status via immune response, inflammatory, and apoptosis pathways. Fish & shellfish immunology. 2023-05-28. PMID:37245678. |
with regards to the in vivo experiment, the cc fraction of the guava extract could significantly enhance the tlrs-myd88-nf-κb signaling pathway by upregulating its cytokine genes (tlr1, tlr4, myd88, and traf6), following the upregulation of inflammatory (nfκb, tnf, il1β, and il6) and apoptosis (tp53 and casp8) genes 6 h after injection. |
2023-05-28 |
2023-08-14 |
Not clear |
| Xiaohan Huang, Wenxia Fan, Jing Sun, Jiaqing Yang, Yanjun Zhang, Qian Wang, Pingchao Li, Yudi Zhang, Shengnan Zhang, Heying Li, Jianhua Wang, Liqiang Feng, Jincun Zhao, Ling Chen, Qu Linbin. SARS-CoV-2 induces cardiomyocyte apoptosis and inflammation but can be ameliorated by ACE inhibitor Captopril. Antiviral research. 2023-05-19. PMID:37207821. |
furthermore, we found that captopril (hypotensive drugs targeting ace) treatment could alleviate sars-cov-2 induced inflammatory response and apoptosis in cardiomyocytes via inactivating tnf signaling pathways, suggesting captopril may be beneficial for reducing covid-19 associated cardiomyopathy. |
2023-05-19 |
2023-08-14 |
mouse |
| Jing-Nan Fu, Shu-Chang Liu, Yi Chen, Jie Zhao, Ning Lu, Tao M. Forsythiaside A alleviates Lipopolysacchrride-induced acute liver Injury through inhibiting endoplasmic reticulum stress and NLRP3 inflammasome activation. Biological & pharmaceutical bulletin. 2023-05-14. PMID:37183023. |
forsythiaside a (fta), an active constituent of forsythia suspensa, has been reported to have anti-inflammatory properties, antioxidant properties, and protective properties against neuroinflammation, sepsis, and edema.therefore, the purpose of the present study was to examine fta's potential effects on lipopolysaccharide (lps)-induced sali in mice.our results indicated that pretreatment with fta significantly attenuated aspartate aminotransferase (ast) and aminoleucine transferase (alt) levels in plasma, ameliorated histopathological damage, inhibited hepatocyte apoptosis, diminished the expression of tumor necrosis factor (tnf)-α, interleukin (il)-1β, and il-6 in the liver from mice exposed to lps. |
2023-05-14 |
2023-08-14 |
mouse |
| Elisabete Nascimento-Gonçalves, Fernanda Seixas, Carlos Palmeira, Gabriela Martins, Carolina Fonseca, José Alberto Duarte, Ana I Faustino-Rocha, Bruno Colaço, Maria João Pires, Maria João Neuparth, Daniel Moreira-Gonçalves, Margarida Fardilha, Magda C Henriques, Daniela Patrício, Steven Pelech, Rita Ferreira, Paula A Oliveir. Lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of prostate carcinogenesis. GeroScience. 2023-05-12. PMID:37171559. |
serum concentrations of c-reactive protein (crp) and tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) were not different among groups. |
2023-05-12 |
2023-08-14 |
rat |
| Meng-Ting Han, Hua Pei, Qi-Qi Sun, Cheng-Long Wang, Peng Li, Ya-Ya Xie, Li-Jun Cao, Xing-Xing Zhang, Zhen-Liang Su. ZY-444 inhibits the growth and metastasis of prostate cancer by targeting TNFAIP3 through TNF signaling pathway. American journal of cancer research. vol 13. issue 4. 2023-05-11. PMID:37168345. |
we found that tnfaip3 inhibited the tnf signaling pathway, which could inhibit cell migration and proliferation and contribute to apoptosis. |
2023-05-11 |
2023-08-14 |
Not clear |
| Zhijing Zhang, Lideng Guo, Fei Yang, Shanpan Peng, Di Wang, Xiawei Lai, Baiqin Su, Haihui Xi. Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats. ACS chemical neuroscience. 2023-05-04. PMID:37141577. |
further experiments indicated that apn could inhibit the toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (myd88)/nuclear factor kappa b (nf-κb) p65 pathway to decrease the degree of oxidative damage (malondialdehyde (mda) and superoxide dismutase (sod)), microglia-mediated neuroinflammation (ionized calcium binding adapter molecule 1 (iba1), caspase-1, tumor necrosis factor (tnf)-α, interleukin-1β (il-1β), and interleukin-6 (il-6)), and apoptosis (p53, bcl2, bax, and caspase 3) in hippocampus. |
2023-05-04 |
2023-08-14 |
rat |
| Wan Zheng, Tianfa Li, Junping Wei, Yani Yan, Shanshan Yan. Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 27. issue 3. 2023-04-20. PMID:37078295. |
lung tissue was collected for histological assessment, apoptosis analysis, and detection of malondialdehyde, superoxide dismutase, tumor necrosis factor (tnf)-α, interleukin (il)-6, and nos3. |
2023-04-20 |
2023-08-14 |
mouse |
| Jing Tong, Stefanie Rufli, Wendy Wei-Lynn Won. Measuring Caspase Activity Using a Fluorometric Assay or Flow Cytometry. Journal of visualized experiments : JoVE. issue 193. 2023-04-10. PMID:37036227. |
using these assays, the simultaneous loss of the inhibitors of apoptosis proteins upon tumor necrosis factor (tnf) stimulation has been identified, which primarily induces apoptosis in macrophages rather than other forms of cell death. |
2023-04-10 |
2023-08-14 |
Not clear |
| N Dianah B Abu Bakar, Rodrigo Carlessi, Jully Gogoi-Tiwari, Julia Köhn-Gaone, Vincent Williams, Marco Falasca, John K Olynyk, Grant A Ramm, Janina E E Tirnitz-Parke. TWEAK/Fn14 Signalling Regulates the Tissue Microenvironment in Chronic Pancreatitis. Cancers. vol 15. issue 6. 2023-03-29. PMID:36980694. |
we established in previous studies that the ligand tumour necrosis factor (tnf)-like weak inducer of apoptosis (tweak) signals through its cognate receptor fibroblast growth factor-inducible 14 (fn14) to regulate these underlying cellular processes in the chronic liver injury niche. |
2023-03-29 |
2023-08-14 |
Not clear |
| Li-Ting Wang, Li-Ru Chen, Kuo-Hu Che. Hormone-Related and Drug-Induced Osteoporosis: A Cellular and Molecular Overview. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982891. |
estrogen promotes apoptosis of osteoclasts and inhibits osteoclastogenesis by stimulating the production of opg and reducing osteoclast differentiation after suppression of il-1 and tnf, and subsequent m-csf, rankl, and il-6 release. |
2023-03-29 |
2023-08-14 |
Not clear |
| Kangyong Chen, Qianzi Xiu, Qingyu Min, Xingxing Cheng, Hehe Xiao, Zhao Jia, Jianhua Feng, Yanjie Shi, Qianli Zhuo, Junya Wang, Jun Zo. TL1A induces apoptosis via DR3 in grass carp ( Fish and shellfish immunology reports. vol 4. 2023-03-27. PMID:36970231. |
tl1a induces apoptosis via dr3 in grass carp ( tumor necrosis factor like ligand 1a (tl1a), a member of tnf superfamily, regulates inflammatory response and immune defense. |
2023-03-27 |
2023-08-14 |
Not clear |
| Mengge Yang, Huizhen Ge, Suqiong Ji, Yue Li, Li Xu, Zhuajin Bi, Bitao B. TWEAK and Fn14 is overexpressed in immune-mediated necrotizing myopathy: implications for muscle damage and repair. Rheumatology (Oxford, England). 2023-03-14. PMID:36916753. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) and its sole receptor fibroblast growth factor-inducible 14 (fn14), are involved in various inflammatory conditions. |
2023-03-14 |
2023-08-14 |
Not clear |
| Hina Agraval, Taylor Crue, Niccolette Schaunaman, Mari Numata, Brian J Day, Hong Wei Ch. Electronic Cigarette Exposure Increases the Severity of Influenza a Virus Infection via TRAIL Dysregulation in Human Precision-Cut Lung Slices. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901724. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail), a protein of the tnf family involved in cell apoptosis, is upregulated in copd patients and during influenza a virus (iav) infections, but its role in viral infection during ec exposures remains unclear. |
2023-03-11 |
2023-08-14 |
human |
| Katherine S Ventre, Kevin Roehle, Elisa Bello, Aladdin M Bhuiyan, Tamara Biary, Stephanie J Crowley, Patrick T Bruck, Max Heckler, Patrick J Lenehan, Lestat R Ali, Courtney T Stump, Victoria Lippert, Eleanor Clancy-Thompson, Winiffer D Conce Alberto, Megan T Hoffman, Li Qiang, Marc Pelletier, James J Akin, Michael Dougan, Stephanie K Douga. cIAP1/2 Antagonism Induces Antigen-Specific T Cell-Dependent Immunity. Journal of immunology (Baltimore, Md. : 1950). 2023-03-07. PMID:36881882. |
in tumor cells, ciap1/2 antagonists can increase tnf production and tnf-mediated apoptosis; however, pancreatic cancer cells are resistant to cytokine-mediated apoptosis, even in the presence of ciap1/2 antagonism. |
2023-03-07 |
2023-08-14 |
mouse |
| Mai Sakai, Zhiqian Yu, Masayuki Taniguchi, Rosanne Picotin, Nanami Oyama, David Stellwagen, Chiaki Ono, Yoshie Kikuchi, Ko Matsui, Miharu Nakanishi, Hatsumi Yoshii, Tomoyuki Furuyashiki, Takaaki Abe, Hiroaki Tomit. N-Acetylcysteine Suppresses Microglial Inflammation and Induces Mortality Dose-Dependently via Tumor Necrosis Factor-α Signaling. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835209. |
n-acetylcysteine (nac) is an antioxidant that prevents tumor necrosis factor (tnf)-α-induced cell death, but it also acts as a pro-oxidant, promoting reactive oxygen species independent apoptosis. |
2023-02-25 |
2023-08-14 |
mouse |
| Zimo Liu, Xuefei Zhou, Qi Li, Youqing Shen, Tianhua Zhou, Xiangrui Li. Macrophage-evading and tumor-specific apoptosis inducing nanoparticles for targeted cancer therapy. Acta pharmaceutica Sinica. B. vol 13. issue 1. 2023-02-23. PMID:36815044. |
the fabricated nanoparticles (tm-cq/nps) were coated with fibroblast cell membrane expressing tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail). |
2023-02-23 |
2023-08-14 |
Not clear |