| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yudong Yin, Li Sun, Lixin Sheng, Liqiong Zhang, Jingjing Liu, Xiaoan Wen, Weibin Mo, Quande Wang, Keguang Chen. (4-Picolylamino)-17β-Estradiol derivative and analogues induce apoptosis with death receptor trail R2/DR5 in MCF-7. Chemico-biological interactions. 2022-12-02. PMID:36460128. |
besides, the human apoptosis array assay demonstrated the expression level of death receptor trail r2/dr5 was upregulated obviously while the expression of tnf r1, iaps and hsp27/60/70 were downregulated. |
2022-12-02 |
2023-08-14 |
human |
| Yusuke Sakamoto, Katsuhiro Sasaki, Mayuki Omatsu, Kensuke Hamada, Yuki Nakanishi, Yoshiro Itatani, Kenji Kawada, Kazutaka Obama, Hiroshi Seno, Kazuhiro Iwa. Differential involvement of LUBAC-mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation. The Journal of pathology. 2022-12-01. PMID:36454102. |
iec death was rescued by an anti-tnf antibody, and tnf (but not lps) induced apoptosis of organoids derived from lubac-defective iecs. |
2022-12-01 |
2023-08-14 |
mouse |
| Woo-Gyun Choi, Na Ri Choi, Eun-Jung Park, Byung Joo Ki. A study of the therapeutic mechanism of Jakyakgamcho-Tang about functional dyspepsia through network pharmacology research. International journal of medical sciences. vol 19. issue 13. 2022-11-28. PMID:36438925. |
and the target is enriched in variety fd-related signaling as follows: mapk, toll-like receptor, nod-like receptor, pi3k-akt, apoptosis and tnf signaling pathway. |
2022-11-28 |
2023-08-14 |
Not clear |
| Zimin Yang, Wei Luo, Zhihong Huang, Min Guo, Xiaochuan He, Zihan Fan, Qing Wang, Qiwei Qin, Min Yang, Xuezhu Le. Genome-Wide Analysis of Differentially Expressed mRNAs and lncRNAs in Koi Carp Infected with Koi Herpesvirus. Viruses. vol 14. issue 11. 2022-11-24. PMID:36423164. |
the kegg analysis showed that degs were significantly enriched in many important immune pathways, such as apoptosis, nod-like receptor signaling pathway, jak-stat signaling pathway, tnf signaling pathway, il-17 signaling pathway, nf-kappa b signaling pathway, and so on. |
2022-11-24 |
2023-08-14 |
Not clear |
| Yanlu Liu, Shiting Gong, Kejian Li, Gong Wu, Xiaohong Zheng, Jingna Zheng, Xiaowei Lu, Luyao Zhang, Jincan Li, Ziren Su, Yuhong Liu, Jianhui Xie, Jiannan Chen, Yucui L. Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-11-22. PMID:36411660. |
meanwhile, coptisine treatment significantly suppressed hyperuricemia induced oxidant stress, inflammatory injury and apoptosis through promoting superoxide dismutase (sod) activity, restraining reactive oxygen species (ros), malondialdehyde (mda), tumor necrosis factor (tnf)-α, interleukin (il)- 1β, il-18 levels, down-regulating protein expressions of cleaved-caspase 3, apoptosis-inducing factor (aif), cyto-cytc, cleaved poly adp-ribose polymerase (parp) and bcl-2-associated x protein (bax), and up-regulating protein expressions of bcl-2 and p-bad. |
2022-11-22 |
2023-08-14 |
mouse |
| Valentina Masola, Nicola Greco, Pamela Tozzo, Luciana Caenazzo, Maurizio Onist. The role of SPATA2 in TNF signaling, cancer, and spermatogenesis. Cell death & disease. vol 13. issue 11. 2022-11-19. PMID:36402749. |
the activation of tnf receptors can lead to cell death with a mechanism of cell necrosis regulated genetically and distinct from apoptosis which is defined as necroptosis. |
2022-11-19 |
2023-08-14 |
mouse |
| Karol Alí Apaza Alccayhuaman, Patrick Heimel, Jung Seok Lee, Stefan Tangl, Ulrike Kuchler, Julie Marchesan, Layla Panahipour, Stefan Lettner, Eva Matalová, Reinhard Grube. FasL is a catabolic factor in alveolar bone homeostasis. Journal of clinical periodontology. 2022-11-17. PMID:36384160. |
fas ligand (fasl) belongs to the tumor necrosis factor (tnf) superfamily regulating bone turnover, inflammation, and apoptosis. |
2022-11-17 |
2023-08-14 |
Not clear |
| Olena Zaitseva, Annett Hoffmann, Christoph Otto, Harald Wajan. Targeting fibroblast growth factor (FGF)-inducible 14 (Fn14) for tumor therapy. Frontiers in pharmacology. vol 13. 2022-11-07. PMID:36339601. |
fibroblast growth factor-inducible 14 (fn14) is a member of the tumor necrosis factor (tnf) receptor superfamily (tnfrsf) and is activated by its ligand tnf-like weak inducer of apoptosis (tweak). |
2022-11-07 |
2023-08-14 |
Not clear |
| Zhaoqun Liu, Mingxun An, Xinxing Geng, Zhongjie Wu, Wenqi Cai, Jia Tang, Kaidian Zhang, Zhi Zho. The scleractinian coral Pocillopora damicornis relies on neuroendocrine regulation to cope with polycyclic aromatic hydrocarbons under heat stress. Environmental pollution (Barking, Essex : 1987). 2022-11-04. PMID:36332711. |
results from the transcriptome data further indicated that corals might perform stress responses upon pahs and heat challenges through the tnf and apoptosis pathways, which perhaps was modulated by the neuroendocrine system of corals. |
2022-11-04 |
2023-08-14 |
Not clear |
| Khalidah Ibraheem, Albashir M A Yhmed, Mohamed M Nasef, Nikolaos T Georgopoulo. TRAF3/p38-JNK Signalling Crosstalk with Intracellular-TRAIL/Caspase-10-Induced Apoptosis Accelerates ROS-Driven Cancer Cell-Specific Death by CD40. Cells. vol 11. issue 20. 2022-10-27. PMID:36291141. |
the capacity to induce tumour-cell specific apoptosis represents the most unique feature of the tnf receptor (tnfr) family member cd40. |
2022-10-27 |
2023-08-14 |
Not clear |
| Delphine Stephan, Anais Roger, Jehanne Aghzadi, Sylvie Carmona, Christophe Picard, Jean-Philippe Dales, Sophie Desplat-Jég. TWEAK and TNFα, Both TNF Ligand Family Members and Multiple Sclerosis-Related Cytokines, Induce Distinct Gene Response in Human Brain Microvascular Endothelial Cells. Genes. vol 13. issue 10. 2022-10-27. PMID:36292599. |
tumor necrosis factor-like weak inducer of apoptosis (tweak) is a member of the tnf ligand family involved in various diseases including brain inflammatory pathologies such as multiple sclerosis. |
2022-10-27 |
2023-08-14 |
human |
| Yi-Fan Liao, Feng-Lin Luo, Shan-Shan Tang, Jing-Wei Huang, Ying Yang, Shuang Wang, Tang-Yu Jiang, Qiong Man, Sha Liu, Yi-Ying W. Network analysis and experimental pharmacology study explore the protective effects of Isoliquiritigenin on 5-fluorouracil-Induced intestinal mucositis. Frontiers in pharmacology. vol 13. 2022-10-24. PMID:36278232. |
in addition, kegg and go enrichment analysis revealed that the hif-1, tnf, mapk, il-17, pi3k-akt, ras, nf-kappa b signaling pathway, and biological processes of the inflammatory response, apoptosis regulation, no production and nf-kappa b transcription factor activity might be involved in the mechanism of isl against intestinal mucositis. |
2022-10-24 |
2023-08-14 |
mouse |
| Zeze Wang, Xue Luo, Zhen Luo, Yulong Tan, Genlin He, Ping Li, Xuesen Yan. Transcriptome sequencing reveals neurotoxicity in embryonic neural stem/progenitor cells under heat stress. Toxicology in vitro : an international journal published in association with BIBRA. 2022-10-22. PMID:36272530. |
pcr arrays confirmed that the tnf receptor family plays an important role in the apoptosis of nspcs during heat stress. |
2022-10-22 |
2023-08-14 |
mouse |
| Xiushen Li, Weizheng Liang, Chengwei Yu, Qingxue Meng, Weiwen Zhang, Xueliang Wu, Jun Xue, Shoulong Deng, Hao Wan. Potential therapeutic strategies for quercetin targeting critical pathological mechanisms associated with colon adenocarcinoma and COVID-19. Frontiers in pharmacology. vol 13. 2022-10-17. PMID:36249762. |
bioinformatic analysis of these 105 genes revealed that the mechanisms for quercetin the treatment of coad/covid-19 may be associated with oxidative stress, apoptosis, anti-inflammatory, immune, anti-viral and multiple pathways containing il-17, tnf, hif-1. |
2022-10-17 |
2023-08-14 |
Not clear |
| Dong-Xu Hua, Kai-Shu Ma, Jia-Yi Cheng, Ying Liu, Jing Sun, Qi-Yuan He, You-Peng Deng, Jin Yang, Lin Fu, Hui Zha. Serum TRAIL predicts severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study. Internal and emergency medicine. 2022-10-14. PMID:36241932. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) can trigger the apoptosis pathways through binding to relative death receptors. however, the relationship of trail with community-acquired pneumonia (cap) was unclear. |
2022-10-14 |
2023-08-14 |
Not clear |
| Antonella Montinaro, Henning Walcza. Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries. Cell death and differentiation. 2022-10-04. PMID:36195672. |
tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail) can induce apoptosis in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any essential normal cells. |
2022-10-04 |
2023-08-14 |
Not clear |
| Simeng Hou, Haotian Wu, Si Chen, Xubo Li, Zhenxing Zhang, Yiwen Cheng, Yuanyuan Chen, Meirong He, Qi An, Churiga Man, Li Du, Qiaoling Chen, Fengyang Wan. Bovine skin fibroblasts mediated immune responses to defend against bovine Acinetobacter baumannii infection. Microbial pathogenesis. 2022-09-30. PMID:36179976. |
kyoto encyclopedia of genes and genomes (kegg) enrichment showed that innate immune pathways were significantly enriched, such as tnf, il-17, nlr, mapk, nf-κb, endocytosis, apoptosis and hif-1 signaling pathways. |
2022-09-30 |
2023-08-14 |
cattle |
| Jun Li, Kaiping Yang, Yunhui Guo, Lukang Cao, Fangling Cheng, Nannan Zhan. Material basis and action mechanism of Euryale Ferox Salisb in preventing and treating diabetic kidney disease. Journal of food biochemistry. 2022-09-27. PMID:36165567. |
they are involved primarily in signal transduction, inflammatory responses, tnf regulation, apoptosis, mapk, and other signaling pathways. |
2022-09-27 |
2023-08-14 |
Not clear |
| Jun Li, Kaiping Yang, Yunhui Guo, Lukang Cao, Fangling Cheng, Nannan Zhan. Material basis and action mechanism of Euryale Ferox Salisb in preventing and treating diabetic kidney disease. Journal of food biochemistry. 2022-09-27. PMID:36165567. |
in general, this approach provides an effective strategy in which es acts primarily against dkd through oleic acid and vitamin e, targeting the protein encoded by ppara, lpl, fabp1, mapk1 to regulate tnf, apoptosis, mapk, and other signaling pathways. |
2022-09-27 |
2023-08-14 |
Not clear |
| Song-Hee Kim, Seung-Il Baek, Jihye Jung, Eung-Seok Lee, Younghwa Na, Bang Yeon Hwang, Yoon-Seok Roh, Jin Tae Hong, Sang-Bae Han, Youngsoo Ki. Chemical inhibition of TRAF6-TAK1 axis as therapeutic strategy of endotoxin-induced liver disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-09-23. PMID:36150308. |
following exposure to endotoxin lps, tlr4-mediated phosphorylation of tak1 and transcription of cell-death cytokine tnf-α were triggered in kupffer cells but not in hepatocytes as well as tnf receptor-mediated and caspase-3-executed apoptosis was occurred in d-galactosamine (galn)-sensitized hepatocytes under co-culture with kupffer cells. |
2022-09-23 |
2023-08-14 |
mouse |