| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoqin Ma, Chenxia Hao, Meixiang Yu, Zhaokang Zhang, Jingjing Huang, Wanhua Yan. Investigating the Molecular Mechanism of Quercetin Protecting against Podocyte Injury to Attenuate Diabetic Nephropathy through Network Pharmacology, MicroarrayData Analysis, and Molecular Docking. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-05-26. PMID:35615688. |
this study revealed that que could protect against podocyte injury in dn through the following mechanisms: downregulating inflammatory cytokine of tnf, reducing vegf-induced vascular permeability, inhibiting apoptosis by stimulating akt1 phosphorylation, and suppressing the age-induced oxidative stress via the age-rage signaling pathway. |
2022-05-26 |
2023-08-13 |
rat |
| Rui Tao, Qi Liu, Ruoyu Huang, Kuanyu Wang, Zhiyan Sun, Pei Yang, Jiangfei Wan. A Novel TNFSF-Based Signature Predicts the Prognosis and Immunosuppressive Status of Lower-Grade Glioma. BioMed research international. vol 2022. 2022-05-20. PMID:35592520. |
tumour necrosis factor (tnf) superfamilies play important roles in cell proliferation, migration, differentiation, and apoptosis. |
2022-05-20 |
2023-08-13 |
Not clear |
| Xiang Li, Zhi-Qiang Dong, Hong Chang, Hong-Bing Zhou, Jia Wang, Zhan-Jun Yang, Min Qiu, Wan-Fu Bai, Song-Li Sh. Screening and identification of key microRNAs and regulatory pathways associated with the renal fibrosis process. Molecular omics. 2022-05-13. PMID:35551348. |
the putative target genes of these de-mirnas were enriched in metabolic processes, apoptosis, pyrimidine metabolism, and tnf and vegf signalling pathways. |
2022-05-13 |
2023-08-13 |
rat |
| Sho Masaki, Tomohiro Watanabe, Yasuyuki Arai, Ikue Sekai, Akane Hara, Masayuki Kurimoto, Yasuo Otsuka, Yasuhiro Masuta, Tomoe Yoshikawa, Ryutaro Takada, Ken Kamata, Kosuke Minaga, Kouhei Yamashita, Masatoshi Kud. Expression levels of cellular inhibitor of apoptosis proteins and colitogenic cytokines are inversely correlated with the activation of interferon regulatory factor 4. Clinical and experimental immunology. vol 207. issue 3. 2022-05-13. PMID:35553628. |
cellular inhibitors of apoptosis proteins 1 (ciap1) and 2 (ciap2) are involved in signaling pathways mediated by toll-like receptors (tlrs) and tumor necrosis factor (tnf)-α. |
2022-05-13 |
2023-08-13 |
mouse |
| Jieun Kim, Seungbok Lee, Jaemeun Lee, Jong-Chan Park, Kyung Hyun Kim, Jung Min Ko, Sun-Hyun Park, Seung-Ki Kim, Inhee Mook-Jung, Ji Yeoun Le. Neurotoxicity of phenylalanine on human iPSC-derived cerebral organoids. Molecular genetics and metabolism. 2022-05-13. PMID:35562278. |
rna-seq of phenylalanine-treated organoids revealed that gene sets related to apoptosis, p53 signaling pathway, and tnf signaling pathway via nf-kb were enriched in upregulated genes, while those related to cell cycle and amino acid metabolism were enriched in downregulated genes. |
2022-05-13 |
2023-08-13 |
human |
| Rui Meng, Junxian Song, Lina Guan, Qian Li, Cuige Shi, Dongmei Su, Xu M. Genome-wide analysis of methylation in rat fetal heart under hyperglycemia by methylation-dependent restriction site-associated DNA sequencing. PloS one. vol 17. issue 5. 2022-05-11. PMID:35544480. |
ccngg-based dmgs were involved in the tnf signaling and apoptosis pathways. |
2022-05-11 |
2023-08-13 |
rat |
| Xuxu Wang, Tao Sun, Xiaohua Ma. mascRNA promotes macrophage apoptosis, inhibits osteoclast differentiation and attenuates disease progression in a murine model of arthritis. Biochemical and biophysical research communications. vol 611. 2022-04-30. PMID:35489201. |
here we show that mascrna, a trna-like cytoplasmic small noncoding rna, promoted ripk1-dependent apoptosis (rda) in raw267.4 macrophages in response to the tak1 inhibitor 5z-7-oxozeaenol (5z-7) alone as well as in combination with tnf. |
2022-04-30 |
2023-08-13 |
mouse |
| Almas Jabeen, Nadeem Ahmad, Khalid Raz. Global Gene Expression and Docking Profiling of COVID-19 Infection. Frontiers in genetics. vol 13. 2022-04-28. PMID:35480316. |
the functional changes are mainly associated with these pathways tnf, cytokine, nf-kb, tlr, tcr, bcr, foxo, and tgf signaling pathways are among them and there are additional pathways such as hippo signaling, apoptosis, estrogen signaling, regulating pluropotency of stem cells, erbb, wnt, p53, camp, mapk, pi3k-akt, oxidative phosphorylation, protein processing in endoplasmic reticulum, prolactin signaling, adipocytokine, neurotrophine signaling, and longevity regulating pathways. |
2022-04-28 |
2023-08-13 |
Not clear |
| Xue Zhong, Jin Huk Choi, Sara Hildebrand, Sara Ludwig, Jianhui Wang, Evan Nair-Gill, Tzu-Chieh Liao, James J Moresco, Aijie Liu, Jiexia Quan, Qihua Sun, Duanwu Zhang, Xiaoming Zhan, Mihwa Choi, Xiaohong Li, Junmei Wang, Thomas Gallagher, Eva Marie Y Moresco, Bruce Beutle. RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 18. 2022-04-28. PMID:35482923. |
homozygous mutant mice displayed altered immune cell development due to excessive tumor necrosis factor (tnf)-dependent immune cell apoptosis. |
2022-04-28 |
2023-08-13 |
mouse |
| Dongjuan Wang, Kun Liu, Jinyan Zhong, Xin Li, Jie Zhang, Gongxin Wang, Ni Li, Tianwen Li, Harvey Davis, Ibrahim El-Gaby, Guoliang Hao, Honghua Ye, Dan L. Molecular Correlates of Early Onset of Diabetic Cardiomyopathy: Possible Therapeutic Targets. Oxidative medicine and cellular longevity. vol 2022. 2022-04-25. PMID:35464763. |
rna-sequencing analysis of ventricular tissue revealed a differential transcriptome profile and abnormal activation of pathways involved in fatty acid metabolism, oxidative phosphorylation, cardiac structure and function, insulin resistance, calcium signalling, apoptosis, and tnf signalling. |
2022-04-25 |
2023-08-13 |
human |
| Wei Zhang, Qi Zh. Punicalagin suppresses inflammation in ventilator-induced lung injury through PAR2 inhibition-induced inhibition of NLRP3 inflammasome activation. Chemical biology & drug design. 2022-04-18. PMID:35434894. |
the levels of inflammatory cytokines (tumor necrosis factor (tnf)-α, interleukin (il)-1β, and il-6), par2, nlr family pyrin domain containing-3 (nlrp3) and apoptosis associated speck-like protein containing a card (asc) in the balf lungs or cells were analyzed by enzyme-linked immune-sorbent assay (elisa), qrt-pcr or/and western blot. |
2022-04-18 |
2023-08-13 |
mouse |
| Shima Lotfollahzadeh, Elaheh Sadat Hosseini, Hooman Mahmoudi Aznaveh, Maryam Nikkhah, Saman Hosseinkhan. TRAIL/S-layer/graphene quantum dot nanohybrid enhanced stability and anticancer activity of TRAIL on colon cancer cells. Scientific reports. vol 12. issue 1. 2022-04-08. PMID:35393438. |
tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail), known as a cytokine of the tnf superfamily, is considered a promising antitumor agent due to its ability to selectively induce apoptosis in a wide variety of cancer cells. |
2022-04-08 |
2023-08-13 |
human |
| Yingying Ma, Li Wang, Xiaoxia Jiang, Xin Yao, Xinning Huang, Kun Zhou, Yaqi Yang, Yixin Wang, Xiaobo Sun, Xueting Guan, Yigang X. Integrative Transcriptomics and Proteomics Analysis Provide a Deep Insight Into Bovine Viral Diarrhea Virus-Host Interactions During BVDV Infection. Frontiers in immunology. vol 13. 2022-04-04. PMID:35371109. |
following gene ontology (go) annotation and kegg enrichment analysis, we determined that these degs and deps were significantly enriched in multiple important cellular signaling pathways including nod-like receptor, toll-like receptor, tnf, nf-κb, mapk, camp, lysosome, protein processing in endoplasmic reticulum, lipid metabolism, and apoptosis signaling pathways. |
2022-04-04 |
2023-08-13 |
cattle |
| Xia Cui, Zhiheng Chang, Tong Dang, Jing Meng, Pei Wang, Jinbao Wu, Jianyuan Cha. TNF upregulates peptidoglycan recognition protein 1 in esophageal cancer cells to clear the path to its signaling: Making the "enemy" a friend. Archives of biochemistry and biophysics. 2022-04-03. PMID:35367194. |
in fibroblasts, ccn1 was reported to support tnf in apoptosis induction while pglyrp1 was found to compete with tnf for binding to tnfr1. |
2022-04-03 |
2023-08-13 |
Not clear |
| Hai Duc Nguyen, Min-Sun Ki. Exposure to a mixture of heavy metals induces cognitive impairment: genes and microRNAs involved. Toxicology. 2022-03-29. PMID:35346790. |
the mixed heavy metals altered the genes bax, casp3, bcl2, tnf, and il-1b, indicating the significance of apoptosis and pro-inflammatory cytokines in the pathogenesis of cognitive impairment and the possibility of targeting these genes in future neuroprotective therapy. |
2022-03-29 |
2023-08-13 |
Not clear |
| Yuan Ren, Gedan Cui, Yongxiang Ga. Research progress on inflammatory mechanism of primary Sjögren syndrome. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 50. issue 6. 2022-03-29. PMID:35347914. |
long-term inflammation leads to accelerated apoptosis of epithelial cells, disordered gland structure, increased expression of proinflammatory cytokine such as cxc subfamily ligand (cxcl) 12, cxcl13, b cell-activating factor (baf), interleukin (il)-6, interferon (ifn)-γ and tumor necrosis factor (tnf)-α in submandibular gland. |
2022-03-29 |
2023-08-13 |
Not clear |
| Bao Zhao, Qingyue Fan, Jintong Liu, Aihua Yin, Pingping Wang, Wenxin Zhan. Identification of Key Modules and Genes Associated with Major Depressive Disorder in Adolescents. Genes. vol 13. issue 3. 2022-03-25. PMID:35328018. |
several gene ontology (go) terms and kyoto encyclopedia of genes and genomes (kegg) pathways associated with stress and inflammation were identified in this module, including histone methylation, apoptosis, nf-kappa β signaling pathway, and tnf signaling pathway. |
2022-03-25 |
2023-08-13 |
human |
| Valéria Bumiller-Bini Hoch, Larissa Schneider, Anna Elisabeth Pumpe, Emelie Lüders, Jennifer Elisabeth Hundt, Angelica Beate Winter Bold. Marked to Die-Cell Death Mechanisms for Keratinocyte Acantholysis in Pemphigus Diseases. Life (Basel, Switzerland). vol 12. issue 3. 2022-03-25. PMID:35330080. |
among the molecules, most investigated were pleiotropic molecules such as tnf and casp3, followed by fasl and casp8, and then by fas, bax, bcl2, and tp53, all involved in more than one pathway but interpreted to function only within apoptosis. |
2022-03-25 |
2023-08-13 |
mouse |
| Liyuan Yi, Caiyun Sun, Jinying Wu, Zengxin Hou, Wensheng L. Molecular cloning, expressional analyses and functional identification of TRAIL in tilapia, Oreochromis niloticus. Journal of fish diseases. 2022-03-17. PMID:35298837. |
tnfsf10 (trail or apol-2) belongs to the tumour necrosis factor (tnf) cytokine family and induces rapid apoptosis in a wide variety of tumour cell lines upon binding to death-inducing signalling receptors. |
2022-03-17 |
2023-08-13 |
Not clear |
| Zhuohui Luo, Jiawen Huang, Ennian Li, Xinqian He, Qiqi Meng, Xinan Huang, Xiaoling Shen, Changkai Ya. An Integrated Pharmacology-Based Strategy to Investigate the Potential Mechanism of Xiebai San in Treating Pediatric Pneumonia. Frontiers in pharmacology. vol 13. 2022-03-03. PMID:35237157. |
il-17 signaling pathway, tnf signaling pathway and pi3k-akt signaling pathway, which are involved in anti-inflammation processes, immune responses and apoptosis, showed to be the most probable pathways regulated by xbs. |
2022-03-03 |
2023-08-13 |
Not clear |