| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongbo Ma, Yanjiao Dong, Kun Sun, Shuo Wang, Zheng Zhan. Protective Effect of MiR-146 on Renal Injury Following Cardiopulmonary Bypass in Rats Through Mediating NF-κB Signaling Pathway. Bioengineered. 2021-12-13. PMID:34898360. |
it is found that the contents of cr, bun and mda in blood =, serum il-1, il-6 and tnf in mimics group are higher than those in the other two groups- α content, apoptosis rate, icam-1, tnf- α, nf- κ b mrna and nf- κ b protein decreased significantly (p < 0.05), while the content of sod in kidney increased significantly (p < 0.05). |
2021-12-13 |
2023-08-13 |
rat |
| Fei Huang, Carmine M Pariante, Alessandra Borsin. From dried bear bile to molecular investigation: A systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across pre-clinical models of neurological, neurodegenerative and neuropsychiatric disorders. Brain, behavior, and immunity. vol 99. 2021-12-11. PMID:34601012. |
findings show that udca reduces apoptosis, reactive oxygen species (ros) and tumour necrosis factor (tnf)-α production in neurodegenerative models, and reduces nitric oxide (no) and interleukin (il)-1β production in neuropsychiatric models; gudca decreases lactate dehydrogenase, tnf-α and il-1β production in neurological models, and also reduces cytochrome c peroxidase production in neurodegenerative models; tudca decreases apoptosis in neurological models, reduces ros and il-1β production in neurodegenerative models, and decreases apoptosis and tnf-α production, and increases glutathione production in neuropsychiatric models. |
2021-12-11 |
2023-08-13 |
Not clear |
| Beatriz Abós, Elena Pérez-Fernández, Esther Morel, Pedro Perdiguero, Carolina Tafall. Pro-Inflammatory and B Cell Regulating Capacities of TWEAK in Rainbow Trout ( Frontiers in immunology. vol 12. 2021-12-10. PMID:34659247. |
pro-inflammatory and b cell regulating capacities of tweak in rainbow trout ( tumor necrosis factor (tnf)-like weak inducer of apoptosis or tweak is a member of the tnf superfamily involved in the regulation of many biological processes. |
2021-12-10 |
2023-08-13 |
Not clear |
| Xingyu Chen, Yue Wang, Ying Ma, Ruonan Wang, Dexi Zha. To explore the Radix Paeoniae Rubra-Flos Carthami herb pair's potential mechanism in the treatment of ischemic stroke by network pharmacology and molecular docking technology. Medicine. vol 100. issue 49. 2021-12-10. PMID:34889224. |
kegg pathway enrichment analysis was mainly related to the nf-kappa b signaling pathway, the tnf signaling pathway, apoptosis, the mapk signaling pathway, the pi3k-akt signaling pathway, the vegf signaling pathway, etc. |
2021-12-10 |
2023-08-13 |
Not clear |
| Patricia Mendonca, Sumaih Alghamdi, Samia Messeha, Karam F A Solima. Pentagalloyl glucose inhibits TNF-α-activated CXCL1/GRO-α expression and induces apoptosis-related genes in triple-negative breast cancer cells. Scientific reports. vol 11. issue 1. 2021-12-08. PMID:33707603. |
moreover, pgg induced apoptosis, modulating caspases, and tnf superfamily receptor genes. |
2021-12-08 |
2023-08-13 |
Not clear |
| Patricia Mendonca, Sumaih Alghamdi, Samia Messeha, Karam F A Solima. Pentagalloyl glucose inhibits TNF-α-activated CXCL1/GRO-α expression and induces apoptosis-related genes in triple-negative breast cancer cells. Scientific reports. vol 11. issue 1. 2021-12-08. PMID:33707603. |
these findings indicate pgg anti-cancer ability in inhibiting tumor cell proliferation and gro-α release and inducing apoptosis by increasing tnf and tnf family receptors' expression. |
2021-12-08 |
2023-08-13 |
Not clear |
| Youzi Dong, Quanlin Zhao, Yuguo Wan. Network pharmacology-based investigation of potential targets of astragalus membranaceous-angelica sinensis compound acting on diabetic nephropathy. Scientific reports. vol 11. issue 1. 2021-12-08. PMID:34593896. |
am-as compound may treat dn by acting on vegfa, tp53, il-6, tnf, mark1, etc., and regulate apoptosis, oxidative stress, inflammation, glucose, and lipid metabolism processes. |
2021-12-08 |
2023-08-13 |
rat |
| Yiming Hu, Haohao Zhang, Ningxia Xie, Dandan Liu, Yuhang Jiang, Zhi Liu, Deji Ye, Sanhong Liu, Xi Chen, Cuifeng Li, Qi Wang, Xingxu Huang, Yongzhong Liu, Yufang Shi, Xiaoren Zhan. Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1. Cell death and differentiation. 2021-12-02. PMID:34853447. |
tumor necrosis factor-α (tnf) is described as a main regulator of cell survival and apoptosis in multiple types of cells, including hepatocytes. |
2021-12-02 |
2023-08-13 |
mouse |
| Guang-Yao Chen, Xiao-Yu Liu, Jia-Qi Chen, Xin-Bo Yu, Jing Luo, Ze-Ran Yan, Qing-Wen Ta. Prediction of Rhizoma Drynariae Targets in the Treatment of Osteoarthritis Based on Network Pharmacology and Experimental Verification. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-11-30. PMID:34840589. |
kegg results indicated that the effects of rhizoma drynariae on oa are associated with the pi3k/akt, tnf, il-17, apoptosis, and hif-1 signaling pathway. |
2021-11-30 |
2023-08-13 |
Not clear |
| Tong Dang, Zhiheng Chang, Jing Meng, Xia Cui, Pei Wang, Jianyuan Cha. TNF antagonizes CCN1 in apoptosis in esophageal adenocarcinoma. Cytokine. vol 149. 2021-11-29. PMID:34634651. |
tnf antagonizes ccn1 in apoptosis in esophageal adenocarcinoma. |
2021-11-29 |
2023-08-13 |
Not clear |
| Tong Dang, Zhiheng Chang, Jing Meng, Xia Cui, Pei Wang, Jianyuan Cha. TNF antagonizes CCN1 in apoptosis in esophageal adenocarcinoma. Cytokine. vol 149. 2021-11-29. PMID:34634651. |
in this study, we examined the relationship between ccn1 and tnf in the context of esophageal adenocarcinoma and found that ccn1 did not help tnf to induce cell death when they were together, instead, it inhibited tnf expression, as well as tnf-induced jnk activation and apoptosis. |
2021-11-29 |
2023-08-13 |
Not clear |
| Tong Dang, Zhiheng Chang, Jing Meng, Xia Cui, Pei Wang, Jianyuan Cha. TNF antagonizes CCN1 in apoptosis in esophageal adenocarcinoma. Cytokine. vol 149. 2021-11-29. PMID:34634651. |
the presence of tnf significantly lowered ccn1 expression and its capability in apoptosis induction. |
2021-11-29 |
2023-08-13 |
Not clear |
| Fu-Jing Liu, Ti-Jun Gu, Dong-Yue We. Emodin alleviates sepsis-mediated lung injury via inhibition and reduction of NF-kB and HMGB1 pathways mediated by SIRT1. The Kaohsiung journal of medical sciences. 2021-11-22. PMID:34806822. |
in lipopolysaccharide (lps) treated cell model, emodin treatment markedly decreased lps-induced release of il-1, il-6, and tumor necrosis factor (tnf)-α, inhibited lps-induced cell apoptosis and suppressed protein levels of p-p65/p65 and hmgb1. |
2021-11-22 |
2023-08-13 |
rat |
| Sule Cilekar, Selvihan Beysel, Savas Karatas, Aydin Balci, Kursad Akaslan, Ali Unc. Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome. Scientific reports. vol 11. issue 1. 2021-11-18. PMID:34764367. |
circulating soluble tumor necrosis factor (tnf)-like weak inducer of apoptosis (stweak) is a cytokine that regulates inflammation and insulin resistance in adipose tissue. |
2021-11-18 |
2023-08-13 |
Not clear |
| Maria C Tanzer, Isabell Bludau, Che A Stafford, Veit Hornung, Matthias Man. Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling. Nature communications. vol 12. issue 1. 2021-11-17. PMID:34663829. |
phosphoproteome analysis of tnf-induced apoptosis and necroptosis uncovers a key role for transcriptional cyclin-dependent kinase activity to promote cytokine production and prevent excessive cell death downstream of the tnf signaling receptor. |
2021-11-17 |
2023-08-13 |
Not clear |
| Carmen Picon, Anusha Jayaraman, Rachel James, Catriona Beck, Patricia Gallego, Maarten E Witte, Jack van Horssen, Nicholas D Mazarakis, Richard Reynold. Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter. Acta neuropathologica. vol 141. issue 4. 2021-11-15. PMID:33569629. |
exposure of cultured primary rat cortical neurons to tnf induced necroptosis when apoptosis was inhibited. |
2021-11-15 |
2023-08-13 |
human |
| Xuezhe Piao, Hee Sun Byun, So-Ra Lee, Eunjin Ju, Kyeong Ah Park, Kyung-Cheol Sohn, Khong Trong Quan, Jinbae Lee, MinKyun Na, Gang Min Hu. 8-Geranylumbelliferone isolated from Paramignya trimera triggers RIPK1/RIPK3-dependent programmed cell death upon TNFR1 ligation. Biochemical pharmacology. vol 192. 2021-11-15. PMID:34411570. |
in this study, we propose that two major gernaylated 7-hydroxy coumarins, 6-geranyl-7-hydroxycoumarin (ostruthin) and 8-geranyl-7-hydroxycoumarin (8-geranylumbelliferone, 8-gu) isolated from paramignya timera, facilitate ripk1-dependent dual modes of apoptosis and necroptosis by targeting ikkβ upon tnf receptor1 (tnfr1) ligation. |
2021-11-15 |
2023-08-13 |
Not clear |
| Andrew J Freeman, Stephin J Vervoort, Jessica Michie, Kelly M Ramsbottom, John Silke, Conor J Kearney, Jane Oliar. HOIP limits anti-tumor immunity by protecting against combined TNF and IFN-gamma-induced apoptosis. EMBO reports. vol 22. issue 11. 2021-11-13. PMID:34467615. |
hoip limits anti-tumor immunity by protecting against combined tnf and ifn-gamma-induced apoptosis. |
2021-11-13 |
2023-08-13 |
Not clear |
| Sandra Lampl, Marianne K Janas, Sainitin Donakonda, Marcus Brugger, Kerstin Lohr, Annika Schneider, Katrin Manske, Laura E Sperl, Susan Kläger, Bernhard Küster, Jennifer Wettmarshausen, Constanze Müller, Melanie Laschinger, Daniel Hartmann, Norber Hüser, Fabiana Perocchi, Philippe Schmitt-Kopplin, Franz Hagn, Lars Zender, Veit Hornung, Christoph Borner, Andreas Pichlmair, Hamid Kashkar, Martin Klingenspor, Marco Prinz, Sabrina Schreiner, Marcus Conrad, Philipp J Jost, Hans Zischka, Katja Steiger, Martin Krönke, Dietmar Zehn, Ulrike Protzer, Mathias Heikenwälder, Percy A Knolle, Dirk Wohllebe. Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes. Journal of hepatology. vol 73. issue 6. 2021-11-11. PMID:32598967. |
reduced mitochondrial resilience enables non-canonical induction of apoptosis after tnf receptor signaling in virus-infected hepatocytes. |
2021-11-11 |
2023-08-13 |
Not clear |
| Tomiyasu Murata, Kazunori Hashimoto, Susumu Kohno, Chiaki Takahashi, Masayoshi Yamaguchi, Chihiro Ito, Itoigawa Masataka, Roji Kojima, Kiyomi Hikita, Norio Kaned. Chemical inducer of regucalcin attenuates lipopolysaccharide-induced inflammatory responses in pancreatic MIN6 β-cells and RAW264.7 macrophages. FEBS open bio. 2021-11-09. PMID:34709731. |
induction of rgn expression by derrisfolin a or retrovirus-mediated gene transfer in min6 cells and raw264.7 macrophages significantly decreased lipopolysaccharide (lps)-induced mrna expression of nos2, il1b, and tnf via nuclear factor-κb activation; reduced lps-induced apoptosis in min6 cells, accompanied by decreased production of nitric oxide, interleukin-1β, and tumor necrosis factor-α; and attenuated generation of lps-induced reactive oxygen species, malondialdehyde, and 3-nitrotyrosine in min6 cells. |
2021-11-09 |
2023-08-13 |
Not clear |