| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patricia Mendonca, Sumaih Alghamdi, Samia Messeha, Karam F A Solima. Pentagalloyl glucose inhibits TNF-α-activated CXCL1/GRO-α expression and induces apoptosis-related genes in triple-negative breast cancer cells. Scientific reports. vol 11. issue 1. 2021-12-08. PMID:33707603. |
these findings indicate pgg anti-cancer ability in inhibiting tumor cell proliferation and gro-α release and inducing apoptosis by increasing tnf and tnf family receptors' expression. |
2021-12-08 |
2023-08-13 |
Not clear |
| Youzi Dong, Quanlin Zhao, Yuguo Wan. Network pharmacology-based investigation of potential targets of astragalus membranaceous-angelica sinensis compound acting on diabetic nephropathy. Scientific reports. vol 11. issue 1. 2021-12-08. PMID:34593896. |
am-as compound may treat dn by acting on vegfa, tp53, il-6, tnf, mark1, etc., and regulate apoptosis, oxidative stress, inflammation, glucose, and lipid metabolism processes. |
2021-12-08 |
2023-08-13 |
rat |
| Yiming Hu, Haohao Zhang, Ningxia Xie, Dandan Liu, Yuhang Jiang, Zhi Liu, Deji Ye, Sanhong Liu, Xi Chen, Cuifeng Li, Qi Wang, Xingxu Huang, Yongzhong Liu, Yufang Shi, Xiaoren Zhan. Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1. Cell death and differentiation. 2021-12-02. PMID:34853447. |
tumor necrosis factor-α (tnf) is described as a main regulator of cell survival and apoptosis in multiple types of cells, including hepatocytes. |
2021-12-02 |
2023-08-13 |
mouse |
| Guang-Yao Chen, Xiao-Yu Liu, Jia-Qi Chen, Xin-Bo Yu, Jing Luo, Ze-Ran Yan, Qing-Wen Ta. Prediction of Rhizoma Drynariae Targets in the Treatment of Osteoarthritis Based on Network Pharmacology and Experimental Verification. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-11-30. PMID:34840589. |
kegg results indicated that the effects of rhizoma drynariae on oa are associated with the pi3k/akt, tnf, il-17, apoptosis, and hif-1 signaling pathway. |
2021-11-30 |
2023-08-13 |
Not clear |
| Tong Dang, Zhiheng Chang, Jing Meng, Xia Cui, Pei Wang, Jianyuan Cha. TNF antagonizes CCN1 in apoptosis in esophageal adenocarcinoma. Cytokine. vol 149. 2021-11-29. PMID:34634651. |
tnf antagonizes ccn1 in apoptosis in esophageal adenocarcinoma. |
2021-11-29 |
2023-08-13 |
Not clear |
| Tong Dang, Zhiheng Chang, Jing Meng, Xia Cui, Pei Wang, Jianyuan Cha. TNF antagonizes CCN1 in apoptosis in esophageal adenocarcinoma. Cytokine. vol 149. 2021-11-29. PMID:34634651. |
in this study, we examined the relationship between ccn1 and tnf in the context of esophageal adenocarcinoma and found that ccn1 did not help tnf to induce cell death when they were together, instead, it inhibited tnf expression, as well as tnf-induced jnk activation and apoptosis. |
2021-11-29 |
2023-08-13 |
Not clear |
| Tong Dang, Zhiheng Chang, Jing Meng, Xia Cui, Pei Wang, Jianyuan Cha. TNF antagonizes CCN1 in apoptosis in esophageal adenocarcinoma. Cytokine. vol 149. 2021-11-29. PMID:34634651. |
the presence of tnf significantly lowered ccn1 expression and its capability in apoptosis induction. |
2021-11-29 |
2023-08-13 |
Not clear |
| Fu-Jing Liu, Ti-Jun Gu, Dong-Yue We. Emodin alleviates sepsis-mediated lung injury via inhibition and reduction of NF-kB and HMGB1 pathways mediated by SIRT1. The Kaohsiung journal of medical sciences. 2021-11-22. PMID:34806822. |
in lipopolysaccharide (lps) treated cell model, emodin treatment markedly decreased lps-induced release of il-1, il-6, and tumor necrosis factor (tnf)-α, inhibited lps-induced cell apoptosis and suppressed protein levels of p-p65/p65 and hmgb1. |
2021-11-22 |
2023-08-13 |
rat |
| Sule Cilekar, Selvihan Beysel, Savas Karatas, Aydin Balci, Kursad Akaslan, Ali Unc. Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome. Scientific reports. vol 11. issue 1. 2021-11-18. PMID:34764367. |
circulating soluble tumor necrosis factor (tnf)-like weak inducer of apoptosis (stweak) is a cytokine that regulates inflammation and insulin resistance in adipose tissue. |
2021-11-18 |
2023-08-13 |
Not clear |
| Maria C Tanzer, Isabell Bludau, Che A Stafford, Veit Hornung, Matthias Man. Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling. Nature communications. vol 12. issue 1. 2021-11-17. PMID:34663829. |
phosphoproteome analysis of tnf-induced apoptosis and necroptosis uncovers a key role for transcriptional cyclin-dependent kinase activity to promote cytokine production and prevent excessive cell death downstream of the tnf signaling receptor. |
2021-11-17 |
2023-08-13 |
Not clear |
| Carmen Picon, Anusha Jayaraman, Rachel James, Catriona Beck, Patricia Gallego, Maarten E Witte, Jack van Horssen, Nicholas D Mazarakis, Richard Reynold. Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter. Acta neuropathologica. vol 141. issue 4. 2021-11-15. PMID:33569629. |
exposure of cultured primary rat cortical neurons to tnf induced necroptosis when apoptosis was inhibited. |
2021-11-15 |
2023-08-13 |
human |
| Xuezhe Piao, Hee Sun Byun, So-Ra Lee, Eunjin Ju, Kyeong Ah Park, Kyung-Cheol Sohn, Khong Trong Quan, Jinbae Lee, MinKyun Na, Gang Min Hu. 8-Geranylumbelliferone isolated from Paramignya trimera triggers RIPK1/RIPK3-dependent programmed cell death upon TNFR1 ligation. Biochemical pharmacology. vol 192. 2021-11-15. PMID:34411570. |
in this study, we propose that two major gernaylated 7-hydroxy coumarins, 6-geranyl-7-hydroxycoumarin (ostruthin) and 8-geranyl-7-hydroxycoumarin (8-geranylumbelliferone, 8-gu) isolated from paramignya timera, facilitate ripk1-dependent dual modes of apoptosis and necroptosis by targeting ikkβ upon tnf receptor1 (tnfr1) ligation. |
2021-11-15 |
2023-08-13 |
Not clear |
| Andrew J Freeman, Stephin J Vervoort, Jessica Michie, Kelly M Ramsbottom, John Silke, Conor J Kearney, Jane Oliar. HOIP limits anti-tumor immunity by protecting against combined TNF and IFN-gamma-induced apoptosis. EMBO reports. vol 22. issue 11. 2021-11-13. PMID:34467615. |
hoip limits anti-tumor immunity by protecting against combined tnf and ifn-gamma-induced apoptosis. |
2021-11-13 |
2023-08-13 |
Not clear |
| Sandra Lampl, Marianne K Janas, Sainitin Donakonda, Marcus Brugger, Kerstin Lohr, Annika Schneider, Katrin Manske, Laura E Sperl, Susan Kläger, Bernhard Küster, Jennifer Wettmarshausen, Constanze Müller, Melanie Laschinger, Daniel Hartmann, Norber Hüser, Fabiana Perocchi, Philippe Schmitt-Kopplin, Franz Hagn, Lars Zender, Veit Hornung, Christoph Borner, Andreas Pichlmair, Hamid Kashkar, Martin Klingenspor, Marco Prinz, Sabrina Schreiner, Marcus Conrad, Philipp J Jost, Hans Zischka, Katja Steiger, Martin Krönke, Dietmar Zehn, Ulrike Protzer, Mathias Heikenwälder, Percy A Knolle, Dirk Wohllebe. Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes. Journal of hepatology. vol 73. issue 6. 2021-11-11. PMID:32598967. |
reduced mitochondrial resilience enables non-canonical induction of apoptosis after tnf receptor signaling in virus-infected hepatocytes. |
2021-11-11 |
2023-08-13 |
Not clear |
| Tomiyasu Murata, Kazunori Hashimoto, Susumu Kohno, Chiaki Takahashi, Masayoshi Yamaguchi, Chihiro Ito, Itoigawa Masataka, Roji Kojima, Kiyomi Hikita, Norio Kaned. Chemical inducer of regucalcin attenuates lipopolysaccharide-induced inflammatory responses in pancreatic MIN6 β-cells and RAW264.7 macrophages. FEBS open bio. 2021-11-09. PMID:34709731. |
induction of rgn expression by derrisfolin a or retrovirus-mediated gene transfer in min6 cells and raw264.7 macrophages significantly decreased lipopolysaccharide (lps)-induced mrna expression of nos2, il1b, and tnf via nuclear factor-κb activation; reduced lps-induced apoptosis in min6 cells, accompanied by decreased production of nitric oxide, interleukin-1β, and tumor necrosis factor-α; and attenuated generation of lps-induced reactive oxygen species, malondialdehyde, and 3-nitrotyrosine in min6 cells. |
2021-11-09 |
2023-08-13 |
Not clear |
| Nicholas Chun, Rosalind L Ang, Mark Chan, Robert L Fairchild, William M Baldwin Iii, Julian K Horwitz, Jesse D Gelles, Jerry Edward Chipuk, Michelle A Kelliher, Vasile I Pavlov, Yansui Li, Dirk Homann, Peter S Heeger, Adrian T Tin. T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death. JCI insight. 2021-11-09. PMID:34752416. |
tumor necrosis factor (tnf) ligation of tnf receptor 1 (tnfr1) promotes either inflammation and cell survival by inhibiting ripk1's death-signaling function and activating nf-kb, or causes ripk1 to associate with the death-inducing signaling complex to initiate apoptosis or necroptosis. |
2021-11-09 |
2023-08-13 |
Not clear |
| Anusha Jayaraman, Thein Than Htike, Rachel James, Carmen Picon, Richard Reynold. TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34625123. |
exposure of human ipsc-derived glutamatergic neurons to tnf increased necroptotic cell death when apoptosis was inhibited, which was significantly reversed by small molecule inhibitors of ripk1, ripk3, and mlkl. |
2021-11-05 |
2023-08-13 |
human |
| Mohammed M H Al-Gayyar, Abdullah Alattar, Reem Alshaman, Ahmed M Hamda. QNZ alleviated hepatocellular carcinoma by targeting inflammatory pathways in a rat model. Cytokine. vol 148. 2021-11-02. PMID:34564023. |
the expression levels of nuclear factor (nf)κb, tumor necrosis factor (tnf)-α, apoptosis signal regulating kinase (ask)-1, β-catenin, glycogen synthase kinase (gsk)-3 and tnf receptor-associated factor (traf) were examined in hepatic samples. |
2021-11-02 |
2023-08-13 |
rat |
| Minggang Zhang, Zeguo Zhao, Yuri Pritykin, Margaret Hannum, Andrew C Scott, Fengshen Kuo, Viraj Sanghvi, Timothy A Chan, Venkatraman Seshan, Hans-Guido Wendel, Andrea Schietinger, Michel Sadelain, Morgan Hus. Ectopic activation of the miR-200c-EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy. Science translational medicine. vol 13. issue 611. 2021-11-01. PMID:34524864. |
ctls transduced with mir-200c exhibited reduced apoptosis during engraftment and enhanced in vivo persistence, accompanied by up-regulation of the transcriptional regulator t cell factor 1 (tcf1) and the inflammatory cytokine tumor necrosis factor (tnf). |
2021-11-01 |
2023-08-13 |
mouse |
| Yuan Xu, Hui-Ting Wei, Hao-Yue Jing, Xiao-Yang Tan, Xiao-Tao Zhou, Yue-Rong M. Emerging role of TWEAK-Fn14 axis in lupus, a disease related to autoimmunity and fibrosis. International journal of rheumatic diseases. 2021-10-30. PMID:34716660. |
as an important marker in the tumor necrosis factor (tnf) superfamily, tnf-like weak inducer of apoptosis (tweak) has been given much attention with respect to its role in regulating pro-inflammatory immune response. |
2021-10-30 |
2023-08-13 |
Not clear |