| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew J McGovern, George E Barret. Network pharmacology identifies IL6 as an important hub and target of tibolone for drug repurposing in traumatic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 140. 2021-08-10. PMID:34058440. |
following protein-protein functional analysis, the top connected proteins were related to kinase activity (mapk1/14/3, akt1 pik3r1), apoptosis (tp53, casp3), growth factors (egfr), estrogen signalling (esr1) and inflammation (il6, tnf), with il6 as an important signalling hub belonging to the top go categories. |
2021-08-10 |
2023-08-13 |
Not clear |
| Youyi Zhang, Chen Xu, Zhengshan Tang, Dewei Guo, Ruojin Yao, Huina Zhao, Zixi Chen, Xin N. Furin is involved in uterine activation for labor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 5. 2021-07-27. PMID:33864414. |
furthermore, d6r and furin sirna treatment reduced the release of soluble form of tumor necrosis factor (tnf)-related weak inducer of apoptosis (tweak), while furin overexpression led to an increase in soluble tweak release in cultured hmsmcs. |
2021-07-27 |
2023-08-13 |
mouse |
| Gertrud Knoll, Martin Ehrenschwende. The non-peptidomimetic IAP antagonist ASTX660 sensitizes colorectal cancer cells for extrinsic apoptosis. FEBS open bio. vol 11. issue 3. 2021-07-23. PMID:33484626. |
astx660 facilitates activation of the extrinsic apoptosis pathway upon stimulation with the death ligands tnf and trail and boosts effector caspase activation and subsequent apoptosis. |
2021-07-23 |
2023-08-13 |
Not clear |
| Dumitru Iacobas, Jing Wen, Sanda Iacobas, Noa Schwartz, Chaim Putterma. Remodeling of Neurotransmission, Chemokine, and PI3K-AKT Signaling Genomic Fabrics in Neuropsychiatric Systemic Lupus Erythematosus. Genes. vol 12. issue 2. 2021-07-23. PMID:33578738. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) and its cognate receptor fn14 have been shown to play an important role in neurocognitive dysfunction in murine lupus. |
2021-07-23 |
2023-08-13 |
Not clear |
| Rania Dagher, Varsha Kumar, Alan M Copenhaver, Sandra Gallagher, Mahboobe Ghaedi, Jonathan Boyd, Paul Newbold, Alison A Humbles, Roland Kolbec. Novel mechanisms of action contributing to Benralizumab's potent anti-eosinophilic activity. The European respiratory journal. 2021-07-22. PMID:34289975. |
through careful observations of cellular co-culture assays we identified a novel role for macrophage derived tnf to further enhance benralizumab-mediated eosinophil apoptosis through activation of tnf-receptor 1 on eosinophils. |
2021-07-22 |
2023-08-13 |
Not clear |
| Wenjie Su, Min Xie, Yao Li, Xinran Gong, Jiacen L. Topiramate Reverses Physiological and Behavioral Alterations by Postoperative Cognitive Dysfunction in Rat Model Through Inhibiting TNF Signaling Pathway. Neuromolecular medicine. vol 22. issue 2. 2021-07-19. PMID:31758388. |
our results revealed that treatment of pocd rats with tpm could suppress neuronal apoptosis in the hippocampus tissues, and the neuroprotective effects of tpm may relate with the regulation of tumor necrosis factor (tnf) signaling pathway. |
2021-07-19 |
2023-08-13 |
rat |
| Gurvinder Kaur, Kandis Wright, Payal Mital, Taylor Hibler, Jonathan M Miranda, Lea Ann Thompson, Katelyn Halley, Jannette M Dufou. Neonatal Pig Sertoli Cells Survive Xenotransplantation by Creating an Immune Modulatory Environment Involving CD4 and CD8 Regulatory T Cells. Cell transplantation. vol 29. 2021-07-19. PMID:32841048. |
additionally, the presence of increased amounts of interleukin 10 (il-10) and transforming growth factor (tgf) β and decreased levels of tumor necrosis factor (tnf) α and apoptosis in the npsc grafts compared to npi grafts suggests the presence of regulatory immune cells in the npsc grafts. |
2021-07-19 |
2023-08-13 |
rat |
| Pan Huang, Weihong Tang, Rong Shen, Xiaoli Ju, Genbao Shao, Xiao Xu, Anqi Jiang, Xiaobin Qian, Miao Chen, Zhengrong Zhou, Caifang Re. Analysis of candidate biomarkers and related transcription factors involved in the development and restoration of stress-induced gastric ulcer by transcriptomics. Cell stress & chaperones. vol 25. issue 2. 2021-07-07. PMID:32088906. |
pathway analysis suggested that degs were enriched in tnf signaling pathway, ppar signaling pathway, apoptosis, and il-17 signaling pathway. |
2021-07-07 |
2023-08-13 |
human |
| Mengying Li, Panpan Liu, Yucong Xue, Yingran Liang, Jing Shi, Xue Han, Jianping Zhang, Xi Chu, Li Ch. Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats. Oncology reports. vol 44. issue 5. 2021-07-06. PMID:33000240. |
in addition, ta treatment inhibited ato‑induced liver apoptosis and inflammatory responses, increased bcl‑2 protein expression level and reduced the levels of bax, caspase‑3, interleukin (il)‑1β, il‑6 and tumor necrosis factor (tnf)‑α. |
2021-07-06 |
2023-08-13 |
rat |
| b' Bindu Thapa, Remant Kc, Hasan Uluda\\xc4\\x9. TRAIL therapy and prospective developments for cancer treatment. Journal of controlled release : official journal of the Controlled Release Society. vol 326. 2021-06-17. PMID:32682900.' |
tumor necrosis factor (tnf) related apoptosis-inducing ligand (trail), an immune cytokine of tnf-family, has received much attention in late 1990s as a potential cancer therapeutics due to its selective ability to induce apoptosis in cancer cells. |
2021-06-17 |
2023-08-13 |
human |
| Federica Cossu, Luca Sorrentino, Elisa Fagnani, Mattia Zaffaroni, Mario Milani, Toni Giorgino, Eloise Mastrangel. Computational and Experimental Characterization of NF023, A Candidate Anticancer Compound Inhibiting cIAP2/TRAF2 Assembly. Journal of chemical information and modeling. vol 60. issue 10. 2021-06-17. PMID:32820924. |
in this context, inhibitor of apoptosis proteins (iaps)-mediated interactions are pivotal for cancer cell survival; the interaction of the bir1 domain of ciap2 with traf2 was shown to lead the recruitment of ciaps to the tnf receptor, promoting the activation of the nf-κb survival pathway. |
2021-06-17 |
2023-08-13 |
Not clear |
| D L Zhu, L Y Shua. Effects of Birinapant on Proliferation and Invasion of MGC-803 Gastric Cancer Cells and Mechanism Underlying These Effects. Bulletin of experimental biology and medicine. vol 171. issue 1. 2021-06-08. PMID:34050412. |
the expression of cellular inhibitor of apoptosis 1 (ciap1) and tnf receptor-associated factor 3 (traf3) in gastric cancer cell line mgc-803 and normal gastric mucosa ges-1 cells were analyzed by western blotting and cell immunofluorescence assay. |
2021-06-08 |
2023-08-13 |
mouse |
| Fa-Li Zhang, Li Kong, Ai-Hong Zhao, Wei Ge, Zi-Hui Yan, Lan Li, Massimo De Felici, Wei She. Inflammatory cytokines as key players of apoptosis induced by environmental estrogens in the ovary. Environmental research. vol 198. 2021-06-03. PMID:33971129. |
by reviewing and elaborating these studies, we propose inflammatory factors, centered on the production of tumor necrosis factor (tnf), as a major cause of the induction of apoptosis by ees in the mammalian ovary. |
2021-06-03 |
2023-08-13 |
human |
| Haruki Jimbo, Hiroshi Nagai, Susumu Fujiwara, Noriko Shimoura, Chikako Nishigor. Fas-FasL interaction in cytotoxic T cell-mediated vitiligo: The role of lesional expression of tumor necrosis factor-α and interferon-γ in Fas-mediated melanocyte apoptosis. Experimental dermatology. vol 29. issue 1. 2021-06-01. PMID:31675451. |
tumor necrosis factor (tnf)-α and interferon (ifn)-γ, the expression levels of which have been reported to be elevated in lesional skin of patients with vitiligo, synergistically upregulated fas expression on human melanocytes but inhibited the fas-mediated apoptosis. |
2021-06-01 |
2023-08-13 |
mouse |
| D V Novikov, S G Selivanova, N V Krasnogorova, E N Gorshkova, S N Pleskova, V V Novikov, A V Karaulo. Serum Protein Corona Abolishes Changes in the Expression of Proinflammatory Genes Induced by Quantum Dots in Human Blood Mononuclear Cell. Bulletin of experimental biology and medicine. vol 169. issue 1. 2021-06-01. PMID:32495165. |
we studied changes in the transcription of genes encoding cytokines (tnf, il-6, il-10, and il-32), cell activation markers (icam1, cd38, fas, and fcgriii), ros production catalyst (nox2), autophagy (beclin 1, lc3b, and p62) and apoptosis (bax, bcl2) regulators in peripheral blood mononuclear cells upon contact with quantum dots cdse/zns-mpa and cdse/cdsezns/zns-ptvp. |
2021-06-01 |
2023-08-13 |
human |
| Cristiana Barbati, Tania Colasanti, Marta Vomero, Fulvia Ceccarelli, Alessandra Ida Celia, Carlo Perricone, Francesca Romana Spinelli, Fabrizio Conti, Guido Valesini, Cristiano Alessandr. Up-regulation of autophagy by etanercept treatment results in TNF-induced apoptosis reduction in EA.hy926 endothelial cell line. Clinical and experimental rheumatology. vol 39. issue 3. 2021-05-25. PMID:32896251. |
we investigated the contribution of tnf to endothelial dysfunction and the effect of in vitro treatment with etanercept, with a special focus on autophagy and apoptosis pathways. |
2021-05-25 |
2023-08-13 |
Not clear |
| Érica Leandro Marciano Vieira, Paulo Caramelli, Natalia Pessoa Rocha, Maíra da Glória Freitas Cardoso, Aline Silva de Miranda, Antônio Lúcio Teixeira, Leonardo Cruz de Souz. Tumor necrosis factor superfamily molecules are increased in behavioral variant frontotemporal dementia and correlate with cortical atrophy: An exploratory investigation. Journal of neuroimmunology. vol 354. 2021-05-25. PMID:33711696. |
the aim of this study was to investigate tnf superfamily molecules (tnf, tnf-related weak inducer of apoptosis [tweak], soluble tnf receptor type 1 [stnfri] and soluble tnf receptor type 2 [stnfrii]) in patients with behavioral variant ftd (bvftd) and controls, and to explore potential associations with clinical parameters and brain atrophy. |
2021-05-25 |
2023-08-13 |
human |
| Masahiro Watanabe, Takao Toyomura, Mayuko Tomiyama, Hidenori Wake, Keyue Liu, Kiyoshi Teshigawara, Hideo Takahashi, Masahiro Nishibori, Shuji Mor. Advanced glycation end products (AGEs) synergistically potentiated the proinflammatory action of lipopolysaccharide (LPS) and high mobility group box-1 (HMGB1) through their direct interactions. Molecular biology reports. vol 47. issue 9. 2021-05-18. PMID:32885364. |
previously, we found that advanced glycation endproducts (ages) directly interact with tumor necrosis factor (tnf)-like weak inducer of apoptosis, a cytokine that controls inflammation, and that this interaction inhibited its action. |
2021-05-18 |
2023-08-13 |
Not clear |
| Elisabeth Zechendorf, Caroline E O'Riordan, Lara Stiehler, Natalie Wischmeyer, Fausto Chiazza, Debora Collotta, Bernd Denecke, Sabrina Ernst, Gerhard Müller-Newen, Sina M Coldewey, Bianka Wissuwa, Massimo Collino, Tim-Philipp Simon, Tobias Schuerholz, Christian Stoppe, Gernot Marx, Christoph Thiemermann, Lukas Marti. Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis. JCI insight. vol 5. issue 8. 2021-05-17. PMID:32213712. |
treatment with rnase 1 resulted in a significant decrease of apoptosis, induced by the intrinsic pathway, and tnf expression in murine cardiomyocytes exposed to either necrotic cardiomyocytes or serum of septic patients for 16 hours. |
2021-05-17 |
2023-08-13 |
mouse |
| Elisabeth Zechendorf, Caroline E O'Riordan, Lara Stiehler, Natalie Wischmeyer, Fausto Chiazza, Debora Collotta, Bernd Denecke, Sabrina Ernst, Gerhard Müller-Newen, Sina M Coldewey, Bianka Wissuwa, Massimo Collino, Tim-Philipp Simon, Tobias Schuerholz, Christian Stoppe, Gernot Marx, Christoph Thiemermann, Lukas Marti. Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis. JCI insight. vol 5. issue 8. 2021-05-17. PMID:32213712. |
additionally, treatment of septic mice with rnase 1 resulted in a reduction in cardiac apoptosis, tnf expression, and septic cardiomyopathy. |
2021-05-17 |
2023-08-13 |
mouse |