| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pratyusha Mandal, A Louise McCormick, Edward S Mocarsk. TNF Signaling Dictates Myeloid and Non-Myeloid Cell Crosstalk to Execute MCMV-Induced Extrinsic Apoptosis. Viruses. vol 12. issue 11. 2021-03-05. PMID:33126536. |
tnf signaling dictates myeloid and non-myeloid cell crosstalk to execute mcmv-induced extrinsic apoptosis. |
2021-03-05 |
2023-08-13 |
mouse |
| Pratyusha Mandal, A Louise McCormick, Edward S Mocarsk. TNF Signaling Dictates Myeloid and Non-Myeloid Cell Crosstalk to Execute MCMV-Induced Extrinsic Apoptosis. Viruses. vol 12. issue 11. 2021-03-05. PMID:33126536. |
in this manner, vica has long been known to prevent apoptosis triggered via tumor necrosis factor (tnf) family death receptor-dependent extrinsic signaling. |
2021-03-05 |
2023-08-13 |
mouse |
| Pratyusha Mandal, A Louise McCormick, Edward S Mocarsk. TNF Signaling Dictates Myeloid and Non-Myeloid Cell Crosstalk to Execute MCMV-Induced Extrinsic Apoptosis. Viruses. vol 12. issue 11. 2021-03-05. PMID:33126536. |
here, we employ fully wild-type murine cytomegalovirus (mcmv) and vica-deficient mcmv (∆m36) to investigate the contribution of tnf signaling to apoptosis during infection of different cell types. |
2021-03-05 |
2023-08-13 |
mouse |
| Pratyusha Mandal, A Louise McCormick, Edward S Mocarsk. TNF Signaling Dictates Myeloid and Non-Myeloid Cell Crosstalk to Execute MCMV-Induced Extrinsic Apoptosis. Viruses. vol 12. issue 11. 2021-03-05. PMID:33126536. |
human and murine fibroblasts or murine endothelial cells (svec4-10) normally insensitive to tnf become sensitized to ∆m36-induced apoptosis when treated with tnf or tnf-containing bmdm-conditioned medium. |
2021-03-05 |
2023-08-13 |
mouse |
| Pratyusha Mandal, A Louise McCormick, Edward S Mocarsk. TNF Signaling Dictates Myeloid and Non-Myeloid Cell Crosstalk to Execute MCMV-Induced Extrinsic Apoptosis. Viruses. vol 12. issue 11. 2021-03-05. PMID:33126536. |
we demonstrate that myeloid cells are the natural source of tnf that triggers apoptosis in either myeloid (autocrine) or non-myeloid cells (paracrine) during ∆m36 infection of mice. |
2021-03-05 |
2023-08-13 |
mouse |
| Yung-Che Chen, Chiu Ping Lee, Chang-Chun Hsiao, Po-Yuan Hsu, Ting-Ya Wang, Chao-Chien Wu, Tung-Ying Chao, Sum-Yee Leung, Yu-Ping Chang, Meng-Chih Li. MicroRNA-23a-3p Down-Regulation in Active Pulmonary Tuberculosis Patients with High Bacterial Burden Inhibits Mononuclear Cell Function and Phagocytosis through TLR4/TNF-α/TGF-β1/IL-10 Signaling via Targeting IRF1/SP1. International journal of molecular sciences. vol 21. issue 22. 2021-03-04. PMID:33202583. |
mir-23a-3p mimic transfection reversed esat6-induced reduction of reactive oxygen species generation, and augmented esat6-induced late apoptosis and phagocytosis, in association with down-regulations of the predicted target genes, including tumor necrosis factor (tnf)-α, tlr4, tlr2, il6, il10, notch1, il6r, bcl2, tgf-β1, sp1, and irf1. |
2021-03-04 |
2023-08-13 |
human |
| Maria Feoktistova, Roman Makarov, Martin Leverkus, Amir S Yazdi, Diana Panayotova-Dimitrov. TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP. International journal of molecular sciences. vol 21. issue 22. 2021-03-03. PMID:33238518. |
moreover, the lack of tnf in these animals strongly reduced and delayed the epidermal hyperkeratosis and the increased apoptosis in keratinocytes. |
2021-03-03 |
2023-08-13 |
mouse |
| Xingyue Qin, Chen Huang, Ka Wu, Yu Li, Xiao Liang, Min Su, Rong L. Anti-coronavirus disease 2019 (COVID-19) targets and mechanisms of puerarin. Journal of cellular and molecular medicine. vol 25. issue 2. 2021-02-26. PMID:33241658. |
the signalling pathways of puerarin to treat covid-19 included modulation of the pathways of apoptosis, il-17 signalling, mitogen-activated protein kinase (mapk) signalling and tnf signalling. |
2021-02-26 |
2023-08-13 |
Not clear |
| Usman Hyder, Jennifer L McCann, Jinli Wang, Victor Fung, Juan Bayo, Iván D'Ors. The ARF tumor suppressor targets PPM1G/PP2Cγ to counteract NF-κB transcription tuning cell survival and the inflammatory response. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 51. 2021-02-19. PMID:33288725. |
consistently, loss of arf in colon epithelial cells leads to up-regulation of nf-κb antiapoptotic genes upon tnf stimulation and renders cells partially resistant to tnf-induced apoptosis in the presence of agents blocking the antiapoptotic program. |
2021-02-19 |
2023-08-13 |
Not clear |
| Yoshimasa Ando, Yasuhiko Sato, Akihiko Kudo, Takayo Watanabe, Akito Hirakata, Annabelle A Okada, Kazuo Umezawa, Hiroshi Kein. Anti‑inflammatory effects of the NF‑κB inhibitor dehydroxymethylepoxyquinomicin on ARPE‑19 cells. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377746. |
it was revealed that high concentrations of dhmeq (100 µg/ml) induced apoptosis and necrosis of tumor necrosis factor (tnf)‑α‑stimulated arpe‑19 cells. |
2021-02-16 |
2023-08-13 |
human |
| Srirupa Bhattacharyya, Siddhartha Sankar Ghos. Deciphering insights of novel recombinant tmTNFα in cell growth inhibition. Molecular biology reports. vol 47. issue 5. 2021-02-16. PMID:32385773. |
soluble tnfα, a member of tnf superfamily attributes dual roles in apoptosis and cell proliferation whereas its precursor transmembrane tnfα (tmtnfα) has potential for tumor reduction without initiating proliferation. |
2021-02-16 |
2023-08-13 |
Not clear |
| Atilla Engi. Protein Kinase-Mediated Decision Between the Life and Death. Advances in experimental medicine and biology. vol 1275. 2021-02-15. PMID:33539010. |
while the interaction of tnf with tnf receptor 1 (tnfr1) activates various signal transduction pathways, different death receptors activate three main signal transduction pathways: nuclear factor kappa b (nf-ĸb)-mediated differentiation or pro-inflammatory cytokine synthesis, mitogen-activated protein kinase (mapk)-mediated stress response and caspase-mediated apoptosis. |
2021-02-15 |
2023-08-13 |
human |
| Uddin Md Nazim, Honghua Yin, Sang-Youel Par. Neferine treatment enhances the TRAIL‑induced apoptosis of human prostate cancer cells via autophagic flux and the JNK pathway. International journal of oncology. vol 56. issue 5. 2021-02-08. PMID:32319589. |
tumor necrosis factor‑related apoptosis‑inducing ligand (trail), a member of the tumor necrosis factor (tnf) family, initiates the apoptosis of certain cancer cells. |
2021-02-08 |
2023-08-13 |
human |
| Han-Ze Wang, Ge Gao, Qian-Qian Yang, Xiao-Meng Hou, Bing-Qi Li, Qiang Li, Yin-Chu S. [Study on therapeutic mechanism of Rehmanniae Radix Praeparata- Corni Fructus in sequelae of ischemic stroke based on network pharmacology technology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 24. 2021-01-27. PMID:33496143. |
kegg pathway analysis showed that rehmanniae radix praeparata-corni fructus could inhibit inflammatory response and apoptosis signaling pathway by regulating hif-vegfa signaling pathway in neural stem cell proliferation, tnf signaling pathway and nf-kappab signaling pathway. |
2021-01-27 |
2023-08-13 |
Not clear |
| Jia Chen, Shuhua Yang, Sheng Huang, Rong Yan, Mingyang Wang, Si Chen, Jing Cai, Miao Long, Peng L. Transcriptome study reveals apoptosis of porcine kidney cells induced by fumonisin B1 via TNF signalling pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 139. 2021-01-25. PMID:32198028. |
transcriptome study reveals apoptosis of porcine kidney cells induced by fumonisin b1 via tnf signalling pathway. |
2021-01-25 |
2023-08-13 |
Not clear |
| Kun Dong, Qiuchen Zhao, Yaqiang Xue, Yaxun Wei, Yi Zhang, Yan Yan. TCTP participates in hepatic metabolism by regulating gene expression involved in insulin resistance. Gene. vol 768. 2021-01-25. PMID:33122078. |
knock-down of tctp led to 287 differentially expressed genes (degs) that were highly associated with cellular apoptosis and signal response, tnf and nf-κb signaling pathways, glycolysis/gluconeogenesis, insulin resistance, foxo and insulin signaling pathways, adipocytokine and ampk signaling pathways. |
2021-01-25 |
2023-08-13 |
mouse |
| Jinghao Wang, Xu Chen, Wei Huan. MicroRNA-369 attenuates hypoxia-induced cardiomyocyte apoptosis and inflammation via targeting TRPV3. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 3. 2021-01-22. PMID:33470394. |
in addition, we observed that hypoxia significantly promoted apoptosis and the inflammatory response, accompanied by increased caspase-3 activity and the secretion of the cytokines interleukin (il)-6, il-1β, and tumor necrosis factor (tnf)-α. |
2021-01-22 |
2023-08-13 |
rat |
| Roy Xiao, Clint T Allen, Linda Tran, Priya Patel, So-Jin Park, Zhong Chen, Carter Van Waes, Nicole C Schmit. Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer. Oncoimmunology. vol 7. issue 9. 2021-01-12. PMID:30393585. |
nearly 30% of hnsccs overexpress fas-associated death domain (fadd), with or without birc2/3 genes encoding cellular inhibitor of apoptosis proteins 1/2 (ciap1/2), critical components of the tumor necrosis factor (tnf) receptor signaling pathways. |
2021-01-12 |
2023-08-13 |
mouse |
| Yanni Ge, Ran Zhang, Yuqing Feng, Huiling L. Mbd2 Mediates Retinal Cell Apoptosis by Targeting the lncRNA Mbd2-AL1/miR-188-3p/Traf3 Axis in Ischemia/Reperfusion Injury. Molecular therapy. Nucleic acids. vol 19. 2021-01-10. PMID:32074940. |
furthermore, mbd2-al1 sponged microrna (mir)-188-3p, thus preventing tumor necrosis factor (tnf) receptor-associated factor 3 (traf3) downregulation and inducing rgc apoptosis. |
2021-01-10 |
2023-08-13 |
mouse |
| Haiwen Li, Zhiming Yang, Fuping Gao, Ruiqin Zhang, Chanjuan Cha. [Silencing miRNA210 Alleviates Myocardial Cell Damage in Myocarditis by Hypoxia Inducible Factor-vascular Endothelial Growth Factor Pathway]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 42. issue 5. 2021-01-08. PMID:33131511. |
objective to investigate the effect of mirna210 on primary myocardial cells in lipopolysaccharide(lps)-induced myocarditis.methods cck8 method was used to detect the effect of mirna210 on the viability of primary myocardial cells in normal or lps-induced myocarditis rats.elisa was performed to detect the secretion of tumor necrosis factor(tnf)-α and interleukin(il)-1β after mirna210 treatment.flow cytometry was used to detect the apoptosis of primary myocardial cells before and after the intervention.western blotting was used to detect the expression of tnf-α and il-1β.the expression of apoptosis-related proteins bcl-2,bax,caspase-3,and hypoxia inducible factor 1 (hif1)-vascular endothelial growth factor(vegf)were detected by western blotting.results cck8 detection results showed that,compared with the control group,the effect of mirna210 mimic( |
2021-01-08 |
2023-08-13 |
Not clear |