| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kun Dong, Qiuchen Zhao, Yaqiang Xue, Yaxun Wei, Yi Zhang, Yan Yan. TCTP participates in hepatic metabolism by regulating gene expression involved in insulin resistance. Gene. vol 768. 2021-01-25. PMID:33122078. |
knock-down of tctp led to 287 differentially expressed genes (degs) that were highly associated with cellular apoptosis and signal response, tnf and nf-κb signaling pathways, glycolysis/gluconeogenesis, insulin resistance, foxo and insulin signaling pathways, adipocytokine and ampk signaling pathways. |
2021-01-25 |
2023-08-13 |
mouse |
| Jinghao Wang, Xu Chen, Wei Huan. MicroRNA-369 attenuates hypoxia-induced cardiomyocyte apoptosis and inflammation via targeting TRPV3. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 3. 2021-01-22. PMID:33470394. |
in addition, we observed that hypoxia significantly promoted apoptosis and the inflammatory response, accompanied by increased caspase-3 activity and the secretion of the cytokines interleukin (il)-6, il-1β, and tumor necrosis factor (tnf)-α. |
2021-01-22 |
2023-08-13 |
rat |
| Roy Xiao, Clint T Allen, Linda Tran, Priya Patel, So-Jin Park, Zhong Chen, Carter Van Waes, Nicole C Schmit. Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer. Oncoimmunology. vol 7. issue 9. 2021-01-12. PMID:30393585. |
nearly 30% of hnsccs overexpress fas-associated death domain (fadd), with or without birc2/3 genes encoding cellular inhibitor of apoptosis proteins 1/2 (ciap1/2), critical components of the tumor necrosis factor (tnf) receptor signaling pathways. |
2021-01-12 |
2023-08-13 |
mouse |
| Yanni Ge, Ran Zhang, Yuqing Feng, Huiling L. Mbd2 Mediates Retinal Cell Apoptosis by Targeting the lncRNA Mbd2-AL1/miR-188-3p/Traf3 Axis in Ischemia/Reperfusion Injury. Molecular therapy. Nucleic acids. vol 19. 2021-01-10. PMID:32074940. |
furthermore, mbd2-al1 sponged microrna (mir)-188-3p, thus preventing tumor necrosis factor (tnf) receptor-associated factor 3 (traf3) downregulation and inducing rgc apoptosis. |
2021-01-10 |
2023-08-13 |
mouse |
| Haiwen Li, Zhiming Yang, Fuping Gao, Ruiqin Zhang, Chanjuan Cha. [Silencing miRNA210 Alleviates Myocardial Cell Damage in Myocarditis by Hypoxia Inducible Factor-vascular Endothelial Growth Factor Pathway]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 42. issue 5. 2021-01-08. PMID:33131511. |
objective to investigate the effect of mirna210 on primary myocardial cells in lipopolysaccharide(lps)-induced myocarditis.methods cck8 method was used to detect the effect of mirna210 on the viability of primary myocardial cells in normal or lps-induced myocarditis rats.elisa was performed to detect the secretion of tumor necrosis factor(tnf)-α and interleukin(il)-1β after mirna210 treatment.flow cytometry was used to detect the apoptosis of primary myocardial cells before and after the intervention.western blotting was used to detect the expression of tnf-α and il-1β.the expression of apoptosis-related proteins bcl-2,bax,caspase-3,and hypoxia inducible factor 1 (hif1)-vascular endothelial growth factor(vegf)were detected by western blotting.results cck8 detection results showed that,compared with the control group,the effect of mirna210 mimic( |
2021-01-08 |
2023-08-13 |
Not clear |
| Aniello Maiese, Alessandra De Matteis, Giorgio Bolino, Emanuela Turillazzi, Paola Frati, Vittorio Finesch. Hypo-Expression of Flice-Inhibitory Protein and Activation of the Caspase-8 Apoptotic Pathways in the Death-Inducing Signaling Complex Due to Ischemia Induced by the Compression of the Asphyxiogenic Tool on the Skin in Hanging Cases. Diagnostics (Basel, Switzerland). vol 10. issue 11. 2020-12-01. PMID:33198065. |
the c-flip plays as an inhibitor of apoptosis induced by a variety of agents, such as tumor necrosis factor (tnf), t cell receptor (tcr), tnf-related apoptosis inducing ligand (trail), fas and death receptor (dr). |
2020-12-01 |
2023-08-13 |
human |
| Yubiao Zhang, Weisong Cai, Guangtao Han, Siqi Zhou, Jianping Li, Mao Chen, Haohuan L. Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K‑AKT‑mTOR pathway in osteoarthritic chondrocytes. International journal of molecular medicine. vol 45. issue 4. 2020-11-30. PMID:32124939. |
in the present study, whether pns could limit tumor necrosis factor (tnf)‑α‑induced senescence and apoptosis in chondrocytes and whether they could slow down cartilage degeneration in a surgery‑induced rat osteoarthritis (oa) model by regulating the phosphatidyl inositol 3 kinase (pi3k)‑protein kinase b (akt)‑mammalian target of rapamycin (mtor) signaling pathway was examined. |
2020-11-30 |
2023-08-13 |
rat |
| Kyung-Phil Ko, Seong-In Jeong, Ji-Sun Lim, Kyung-Woo Lee, Min-Goo Lee, Sung-Gil Ch. NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX. Oncogene. vol 39. issue 34. 2020-11-30. PMID:32690868. |
while nore1a suppresses tnf receptor-mediated apoptosis, it activates tnf-induced apoptosis through bax activation by protecting bax from itch binding and ubiquitination. |
2020-11-30 |
2023-08-13 |
human |
| Kyung-Phil Ko, Seong-In Jeong, Ji-Sun Lim, Kyung-Woo Lee, Min-Goo Lee, Sung-Gil Ch. NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX. Oncogene. vol 39. issue 34. 2020-11-30. PMID:32690868. |
collectively, this study uncovers that nore1a directs a substrate switch of itch favoring tnfri over bax to terminate tnf signaling and accelerate apoptosis, illuminating the mechanistic consequence of nore1a inactivation in tumorigenesis. |
2020-11-30 |
2023-08-13 |
human |
| Geun-Young Kim, Hyun-Joung Lim, Won-Ho Kim, Hyun-Young Par. Coronin 1B regulates the TNFα-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD. Biochemical and biophysical research communications. vol 526. issue 4. 2020-11-24. PMID:32303335. |
immunoprecipitation and in situ proximity ligation assays showed that coronin 1b depletion diminished the interaction between tnfα-induced tnf receptor-1-associated death domain protein (tradd) and fadd, suggesting that coronin 1b is required for the tnfα-induced tradd and fadd interaction and subsequent caspase-8/caspase-3 cascade activation, ultimately leading to apoptosis. |
2020-11-24 |
2023-08-13 |
human |
| Tong Lin, Caijun Liang, Wenya Peng, Yuqin Qiu, Lisheng Pen. Mechanisms of Core Chinese Herbs against Colorectal Cancer: A Study Based on Data Mining and Network Pharmacology. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-11-17. PMID:33193800. |
various cancer-associated signaling pathways, including micrornas, tnf, apoptosis, pi3k-akt, and p53, were involved. |
2020-11-17 |
2023-08-13 |
Not clear |
| Burhan Engin, Ali Tanakol, Huri Bulut, Abdullah Songür, Hayriye E Vehid, Eral Gökalp, Zekayi Kutlubay, Defne Özkoca, Yalçın Tüzün, Server Serdaroğl. Changes in serum TNF-like weak inducer of apoptosis (TWEAK) levels and Psoriasis Area Severity Index (PASI) scores in plaque psoriasis patients treated with conventional versus anti-TNF treatments. International journal of dermatology. vol 59. issue 2. 2020-11-16. PMID:31531981. |
tumour necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is a newly defined member of the tnf family. |
2020-11-16 |
2023-08-13 |
Not clear |
| Bo Liu, Zhenyan Song, Jingping Yu, Ping Li, Yuan Tang, Jinwen G. The atherosclerosis-ameliorating effects and molecular mechanisms of BuYangHuanWu decoction. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 123. 2020-11-16. PMID:31887542. |
our results revealed the mechanisms of byhwd in treating as, which is highly related to inflammation and apoptosis pathways, moreover, the genes including il1β, tgfb1, tnf, il6, nfκb1 are proved to be the key pharmacological targets for the treatment of as. |
2020-11-16 |
2023-08-13 |
rat |
| Mina Moeini, Nafiseh Esmaeil, Hamid Reza Mokhtari, Nahid Eskandari, Hamid Reza Banafsh. Neuro-Immuno-Endocrine Interactions in Early Life Stress and Heroin Withdrawal Timeline. European addiction research. vol 26. issue 1. 2020-11-02. PMID:31630140. |
also, apoptosis markers including tumor necrosis factor (tnf)-related weak inducer of apoptosis, tnf-related apoptosis-inducing ligand, soluble tumor necrosis factor receptor type i as apoptosis markers were detected by enzyme-linked immunosorbent assay. |
2020-11-02 |
2023-08-13 |
Not clear |
| Claudia Tandler, Moritz Schmidt, Jonas S Heitmann, Julia Hierold, Jonas Schmidt, Pascal Schneider, Daniela Dörfel, Juliane Walz, Helmut R Sali. Neutralization of B-Cell Activating Factor (BAFF) by Belimumab Reinforces Small Molecule Inhibitor Treatment in Chronic Lymphocytic Leukemia. Cancers. vol 12. issue 10. 2020-10-31. PMID:32977449. |
here we report that the tnf family member b-cell activating factor (baff) mediates resistance of cll cells to idelalisib, ibrutinib and venetoclax by sustaining survival and preventing apoptosis of the malignant b cells as revealed by analysis of cellular atp levels and mitochondrial membrane integrity as well as caspase activation, respectively. |
2020-10-31 |
2023-08-13 |
Not clear |
| Arnaud Sans, Stéphanie Bonnafous, Déborah Rousseau, Stéphanie Patouraux, Clémence M Canivet, Pierre S Leclere, Jeanne Tran-Van-Nhieu, Carmelo Luci, Béatrice Bailly-Maitre, Xu Xu, Ann-Hwee Lee, Kaori Minehira, Rodolphe Anty, Albert Tran, Antonio Iannelli, Philippe Gua. The Differential Expression of Cide Family Members is Associated with Nafld Progression from Steatosis to Steatohepatitis. Scientific reports. vol 9. issue 1. 2020-10-14. PMID:31097771. |
this, in turn, sensitized cells to apoptosis in response to tnf α and saturated fatty acid. |
2020-10-14 |
2023-08-13 |
mouse |
| Bingqing Shi, Yuqiu Hao, Wei Li, Hongna Dong, Mengting Xu, Peng Ga. The enigmatic role of TIPE2 in asthma. American journal of physiology. Lung cellular and molecular physiology. vol 319. issue 1. 2020-10-06. PMID:32493031. |
unlike other members of the tumor necrosis factor (tnf)-α-induced protein 8 (tnfaip8/tipe) family that play a carcinogenic role and regulate apoptosis, tnfaip8-like 2 (tipe2) can not only maintain immune homeostasis but also regulate inflammation. |
2020-10-06 |
2023-08-13 |
human |
| Sung-Chul Lim, Song Iy Ha. MDL-12330A potentiates TRAIL-induced apoptosis in gastric cancer cells through CHOP-mediated DR5 upregulation. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 21. issue 4. 2020-10-01. PMID:28706453. |
more importantly, low concentrations of mdl-12330a effectively enhanced recombinant human tumor necrosis factor (tnf)-related apoptosis-inducing ligand (rhtrail)-induced apoptosis and clonogenicity in these gastric cancer cells. |
2020-10-01 |
2023-08-13 |
human |
| Federico Pinna, Michaela Bissinger, Katharina Beuke, Nicolas Huber, Thomas Longerich, Ursula Kummer, Peter Schirmacher, Sven Sahle, Kai Breuhah. A20/TNFAIP3 Discriminates Tumor Necrosis Factor (TNF)-Induced NF-κB from JNK Pathway Activation in Hepatocytes. Frontiers in physiology. vol 8. 2020-10-01. PMID:28878689. |
in the liver tumor necrosis factor (tnf)-induced signaling critically regulates the immune response of non-parenchymal cells as well as proliferation and apoptosis of hepatocytes |
2020-10-01 |
2023-08-13 |
Not clear |
| Yan Jiang, Wei Wang, Zong-Yang Liu, Yi Xie, Yuan Qian, Xue-Ni Ca. Overexpression of miR-130a-3p/301a-3p attenuates high glucose-induced MPC5 podocyte dysfunction through suppression of TNF-α signaling. Experimental and therapeutic medicine. vol 15. issue 1. 2020-10-01. PMID:29434693. |
tumor necrosis factor (tnf)-α has been reported to be important in glomerulonephritis, which is closely associated with podocyte dysfunction and apoptosis. |
2020-10-01 |
2023-08-13 |
mouse |