| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Zhao, Chao Lv, Qiuling Wu, Huawu Zeng, Xin Guo, Jian Yang, Saisai Tian, Weidong Zhan. Computational systems pharmacology reveals an antiplatelet and neuroprotective mechanism of Deng-Zhan-Xi-Xin injection in the treatment of ischemic stroke. Pharmacological research. vol 147. 2020-06-17. PMID:31348992. |
these target genes were further found to be associated with pathways involved in neuronal apoptosis in ischemic stroke, such as nf-κb signaling, tnf signaling, and pi3k-akt signaling. |
2020-06-17 |
2023-08-13 |
human |
| Touseef Rehan, David MacEwan, Nasrullah Shah, Tabassum Rehan, Riffat Tahira, Sheeba Murad, Mariam Anees, Iram Murtaza, Muhammad Farman, Obaid-Ur-Rahman Abid, Aneesa Sulta. Apoptosis of Leukemia Cells by Ocimum basilicum Fractions Following TNF alpha Induced Activation of JNK and Caspase 3. Current pharmaceutical design. vol 25. issue 34. 2020-06-15. PMID:31604407. |
apoptosis of leukemia cells by ocimum basilicum fractions following tnf alpha induced activation of jnk and caspase 3. |
2020-06-15 |
2023-08-13 |
Not clear |
| Xuening Wang, Dan Cheng, Guanglei Hu, Lili Liang, Fei Tan, Tong Xiao, Shengxiang Xiao, Yumin Xi. Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of Apoptosis. Mediators of inflammation. vol 2019. 2020-06-08. PMID:31885495. |
tumor necrosis factor (tnf) receptor expression determines keratinocyte fate upon stimulation with tnf-like weak inducer of apoptosis. |
2020-06-08 |
2023-08-13 |
Not clear |
| Xuening Wang, Dan Cheng, Guanglei Hu, Lili Liang, Fei Tan, Tong Xiao, Shengxiang Xiao, Yumin Xi. Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of Apoptosis. Mediators of inflammation. vol 2019. 2020-06-08. PMID:31885495. |
the interaction between tumor necrosis factor- (tnf-) like weak inducer of apoptosis (tweak) and fibroblast growth factor-inducible 14 (fn14) regulates the fate of keratinocytes, depending on the relative expression of tnf receptor (tnfr) 1 or tnfr2. |
2020-06-08 |
2023-08-13 |
Not clear |
| Lopa M Das, Amy M Binko, Zachary P Traylor, Han Peng, Kurt Q L. Vitamin D improves sunburns by increasing autophagy in M2 macrophages. Autophagy. vol 15. issue 5. 2020-05-07. PMID:30661440. |
specifically, pharmacological inhibition of autophagy increased uv-induced apoptosis, suppressed m2 macs recruitment, and prevented vitamin d downregulation of tnf and mmp9 in the skin. |
2020-05-07 |
2023-08-13 |
mouse |
| Xubin Qiu, Ming Zhuang, Ziwen Lu, Zhiwei Liu, Dong Cheng, Chenlei Zhu, Jinbo Li. RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs. Journal of translational medicine. vol 17. issue 1. 2020-04-29. PMID:31029152. |
ripk1 suppresses apoptosis mediated by tnf and caspase-3 in intervertebral discs. |
2020-04-29 |
2023-08-13 |
Not clear |
| David W Vredevoogd, Thomas Kuilman, Maarten A Ligtenberg, Julia Boshuizen, Kelly E Stecker, Beaunelle de Bruijn, Oscar Krijgsman, Xinyao Huang, Juliana C N Kenski, Ruben Lacroix, Riccardo Mezzadra, Raquel Gomez-Eerland, Mete Yildiz, Ilknur Dagidir, Georgi Apriamashvili, Nordin Zandhuis, Vincent van der Noort, Nils L Visser, Christian U Blank, Maarten Altelaar, Ton N Schumacher, Daniel S Peepe. Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Cell. vol 178. issue 3. 2020-04-27. PMID:31303383. |
taking advantage of the genetic screen, we demonstrate that ablation of the top hit, traf2, lowers the tnf cytotoxicity threshold in tumors by redirecting tnf signaling to favor ripk1-dependent apoptosis. |
2020-04-27 |
2023-08-13 |
Not clear |
| Ilias P Doulamis, Panagiotis Konstantopoulos, Aspasia Tzani, Asier Antoranz, Angeliki Minia, Afroditi Daskalopoulou, Anestis Charalampopoulos, Leonidas Alexopoulos, Depsina N Perrea, Evangelos Menenako. Visceral white adipose tissue and serum proteomic alternations in metabolically healthy obese patients undergoing bariatric surgery. Cytokine. vol 115. 2020-04-23. PMID:30472106. |
tnf weak inducer of apoptosis (tweak) (p = 0.043), tnf related apoptosis inducing ligand (trail) (p = 0.037), growth differentiation factor-15 (gdf-15) (p = 0.04), resistin (retn) (p = 0.047), matrix metalloproteinase-9 (mmp-9) (p = 0.011) and c-terminal telopeptide (ictp) (p = 0.022) were up-regulated in the muo group in the visceral white adipose tissue. |
2020-04-23 |
2023-08-13 |
human |
| Jing-Yu Yang, Rui Wang, Tao Jin, Lan Li, Yi-Qin Wang, Qing Xia, Dan D. [Material basis and molecular mechanism of Dachengqi Decoction in treatment of acute pancreatitis based on network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 6. 2020-04-14. PMID:32281357. |
dcqd may achieve its pharmacological effects through anti-inflammatory and anti-oxidative effects, negative regulation of apoptosis and regulation of pancreatic secretion, involving multiple signals, such as il-17, tnf and nf-κb signaling pathway. |
2020-04-14 |
2023-08-13 |
Not clear |
| Sathya D Unudurthi, Drew M Nassal, Nehal J Patel, Evelyn Thomas, Jane Yu, Curtis G Pierson, Shyam S Bansal, Peter J Mohler, Thomas J Hun. Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction. Life sciences. vol 247. 2020-04-09. PMID:32070706. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is a pro-inflammatory cytokine, which binds to fibroblast growth factor inducible 14 (fn14), a ubiquitously expressed cell-surface receptor. |
2020-04-09 |
2023-08-13 |
Not clear |
| Jessica Michie, Paul A Beavis, Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Vignesh Narasimhan, Emily J Lelliott, Najoua Lalaoui, Robert G Ramsay, Ricky W Johnstone, John Silke, Phillip K Darcy, Ilia Voskoboinik, Conor J Kearney, Jane Oliar. Antagonism of IAPs Enhances CAR T-cell Efficacy. Cancer immunology research. vol 7. issue 2. 2020-04-08. PMID:30651288. |
here, we demonstrated that antagonizing the "inhibitor of apoptosis proteins" with the clinical smac-mimetic, birinapant, significantly enhanced the antitumor activity of car t cells in a tumor necrosis factor (tnf)-dependent manner. |
2020-04-08 |
2023-08-13 |
Not clear |
| Sodai Yoshimura, Emiko Sano, Yuya Hanashima, Shun Yamamuro, Koichiro Sumi, Takuya Ueda, Tomohiro Nakayama, Hiroyuki Hara, Atsuo Yoshino, Yoichi Katayam. IFN‑β sensitizes TRAIL‑induced apoptosis by upregulation of death receptor 5 in malignant glioma cells. Oncology reports. vol 42. issue 6. 2020-04-06. PMID:31638255. |
tumor necrosis factor‑related apoptosis‑inducing ligand (trail), a member of the tumor necrosis factor (tnf) family, induces apoptosis in cancer cells by binding to its receptors, death receptor 4 (dr4) and dr5, without affecting normal cells, and is therefore considered to be a promising antitumor agent for use in cancer treatment. |
2020-04-06 |
2023-08-13 |
Not clear |
| Denis Selimovic, Renate U Wahl, Emmanuelle Ruiz, Rizwan Aslam, Thomas W Flanagan, Sofie-Yasmin Hassan, Simeon Santourlidis, Youssef Haikel, Paul Friedlander, Mosaad Megahed, Emad Kandil, Mohamed Hassa. Tumor necrosis factor-α triggers opposing signals in head and neck squamous cell carcinoma and induces apoptosis via mitochondrial- and non-mitochondrial-dependent pathways. International journal of oncology. vol 55. issue 6. 2020-04-02. PMID:31638203. |
the tnf-α-induced survival of hnscc cells is mediated by the tnf receptor-associated factor 2 (traf2)/nuclear factor (nf)-κb-dependent pathway, while tnf-α-induced apoptosis is mediated by mitochondrial and non-mitochondrial-dependent mechanisms through fadd-caspase-8-caspase-3 and ask-jnk-p53-noxa pathways. |
2020-04-02 |
2023-08-13 |
Not clear |
| Yann Estornes, Yves Dondelinger, Kathrin Weber, Inge Bruggeman, Adam Peall, Marion MacFarlane, Serge Lebecque, Peter Vandenabeele, Mathieu J M Bertran. N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis. Cell death & disease. vol 9. issue 5. 2020-03-30. PMID:29717117. |
although cytotoxic in various cancer cells, tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) does not trigger apoptosis in most non-transformed cells. |
2020-03-30 |
2023-08-13 |
mouse |
| James J Zhu, Palaniappan Ramanathan, Elizabeth A Bishop, Vivian O'Donnell, Douglas P Gladue, Manuel V Borc. Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages. PloS one. vol 14. issue 11. 2020-03-19. PMID:31725732. |
our results suggest that the cytokines of tnf family including faslg, lta, ltb, tnf, tnfsf4, tnfsf10, tnfsf13b and tnfsf18 are the major causative cytokine factors in asf pathogenesis via inducing apoptosis. |
2020-03-19 |
2023-08-13 |
Not clear |
| M Vomero, V Manganelli, C Barbati, T Colasanti, A Capozzi, A Finucci, F R Spinelli, F Ceccarelli, C Perricone, S Truglia, S Morrone, R Maggio, R Misasi, M Bombardieri, M Di Franco, F Conti, M Sorice, G Valesini, C Alessandr. Reduction of autophagy and increase in apoptosis correlates with a favorable clinical outcome in patients with rheumatoid arthritis treated with anti-TNF drugs. Arthritis research & therapy. vol 21. issue 1. 2020-03-16. PMID:30696478. |
to investigate whether the relationship between autophagy and apoptosis may impact the response to the therapy, we analyzed ex vivo spontaneous autophagy and apoptosis in patients with ra subjected to treatment with anti-tumor necrosis factor (tnf) drugs and in vitro the effects of tnfα and anti-tnf drugs on cell fate. |
2020-03-16 |
2023-08-13 |
Not clear |
| João Pedro Ferreira, Job Verdonschot, Timothy Collier, Ping Wang, Anne Pizard, Christian Bär, Jens Björkman, Alessandro Boccanelli, Javed Butler, Andrew Clark, John G Cleland, Christian Delles, Javier Diez, Nicolas Girerd, Arantxa González, Mark Hazebroek, Anne-Cécile Huby, Wouter Jukema, Roberto Latini, Joost Leenders, Daniel Levy, Alexandre Mebazaa, Harald Mischak, Florence Pinet, Patrick Rossignol, Naveed Sattar, Peter Sever, Jan A Staessen, Thomas Thum, Nicolas Vodovar, Zhen-Yu Zhang, Stephane Heymans, Faiez Zanna. Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure. Circulation. Heart failure. vol 12. issue 5. 2020-03-09. PMID:31104495. |
these 38 proteins pointed to 4 main network clusters underlying incident hf: (1) inflammation and apoptosis, indicated by the expression of the tnf (tumor necrosis factor)-family members; (2) extracellular matrix remodeling, angiogenesis and growth, indicated by the expression of proteins associated with collagen metabolism, endothelial function, and vascular homeostasis; (3) blood pressure regulation, indicated by the expression of natriuretic peptides and proteins related to the renin-angiotensin-aldosterone system; and (4) metabolism, associated with cholesterol and atherosclerosis. |
2020-03-09 |
2023-08-13 |
Not clear |
| Isabel Gonçalves, Pratibha Singh, Christoffer Tengryd, Michele Cavalera, Ingrid Yao Mattisson, Mihaela Nitulescu, Ana Flor Persson, Petr Volkov, Gunnar Engström, Marju Orho-Melander, Jan Nilsson, Andreas Edsfeld. sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events. Stroke. vol 50. issue 8. 2020-03-06. PMID:31272321. |
strail-r2 (soluble tnf [tumor necrosis factor]-related apoptosis-inducing ligand receptor 2) a marker of plaque cell apoptosis and cardiovascular events. |
2020-03-06 |
2023-08-13 |
human |
| Isabel Gonçalves, Pratibha Singh, Christoffer Tengryd, Michele Cavalera, Ingrid Yao Mattisson, Mihaela Nitulescu, Ana Flor Persson, Petr Volkov, Gunnar Engström, Marju Orho-Melander, Jan Nilsson, Andreas Edsfeld. sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events. Stroke. vol 50. issue 8. 2020-03-06. PMID:31272321. |
activation of the death receptor trail-r2 (tnf [tumor necrosis factor]-related apoptosis-inducing ligand receptor 2) through its ligand tumor necrosis factor-relate apoptosis-inducing ligand (trail), induces apoptosis in cells in vitro. |
2020-03-06 |
2023-08-13 |
human |
| Elena Brin, Katherine Wu, Eleanor Dagostino, Mario Meng-Chiang Kuo, Yudou He, Wei-Jong Shia, Li-Chang Chen, Mariusz Stempniak, Richard Hickey, Robert Almassy, Richard Showalter, James Thomso. TRAIL stabilization and cancer cell sensitization to its pro-apoptotic activity achieved through genetic fusion with arginine deiminase. Oncotarget. vol 9. issue 97. 2020-02-25. PMID:30651925. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) binds to death receptors and induces apoptosis in various cancer cell lines while sparing normal cells. |
2020-02-25 |
2023-08-13 |
Not clear |