| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiong Wu, Jin-Xian Chen, Yu Chen, Li-Li Cai, Xiao-Zhong Wang, Wu-Hua Guo, Jian-Feng Zhen. The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation. Cell death & disease. vol 9. issue 2. 2019-09-11. PMID:29445190. |
transgenic ccr10-knockout (ccr10 ko) in den-treated mice significantly increased hepatocellular apoptosis levels and significantly lowered compensatory hepatocellular proliferation but did not affect upstream tnf expression. |
2019-09-11 |
2023-08-13 |
mouse |
| Stefan M Pasiakos, Claire E Berryman, John W Carbone, Nancy E Murphy, Christopher T Carrigan, Marcas M Bamman, Arny A Ferrando, Andrew J Young, Lee M Margoli. Muscle Fn14 gene expression is associated with fat-free mass retention during energy deficit at high altitude. Physiological reports. vol 6. issue 14. 2019-09-02. PMID:30009538. |
muscle inflammation may contribute to ffm loss at ha by inducing atrophy and inhibiting myogenesis via the tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) and its receptor, fibroblast growth factor-inducible protein 14 (fn14). |
2019-09-02 |
2023-08-13 |
human |
| Mathew S Eapen, Anudeep Kota, Howard Vindin, Kielan D McAlinden, Dia Xenaki, Brian G Oliver, Deepak A Deshpande, Sukhwinder Singh Sohal, Pawan Sharm. Apoptosis signal-regulating kinase 1 inhibition attenuates human airway smooth muscle growth and migration in chronic obstructive pulmonary disease. Clinical science (London, England : 1979). vol 132. issue 14. 2019-08-26. PMID:30006481. |
apoptosis signal-regulating kinase 1 (ask1) is a ubiquitously expressed mitogen-activated protein kinase (mapk) kinase kinase (map3k) activated by various stress stimuli, including reactive oxygen species (ros), tumor necrosis factor (tnf)-α, and lipopolysaccharide (lps) and is known to regulate cell proliferation. |
2019-08-26 |
2023-08-13 |
human |
| Durray Shahwar, Muhammad Javed Iqbal, Mehr-Un Nisa, Milica Todorovska, Rukset Attar, Uteuliyev Yerzhan Sabitaliyevich, Ammad Ahmad Farooqi, Aamir Ahmad, Baojun X. Natural Product Mediated Regulation of Death Receptors and Intracellular Machinery: Fresh from the Pipeline about TRAIL-Mediated Signaling and Natural TRAIL Sensitizers. International journal of molecular sciences. vol 20. issue 8. 2019-08-21. PMID:31022877. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-mediated signaling has emerged as one of the most highly and extensively studied signal transduction cascade that induces apoptosis in cancer cells. |
2019-08-21 |
2023-08-13 |
mouse |
| Yanbo Qu, Zhixin Liao, Xinzhu Wang, Jing Zhang, Chao Li. EFLDO sensitizes liver cancer cells to TNFSF10‑induced apoptosis in a p53‑dependent manner. Molecular medicine reports. vol 19. issue 5. 2019-08-19. PMID:30896802. |
in the present study, efldo was identified to sensitize hepg2 cells to tumor necrosis factor (tnf) superfamily member 10 (tnfsf10)‑induced apoptosis. |
2019-08-19 |
2023-08-13 |
Not clear |
| Yanbo Qu, Zhixin Liao, Xinzhu Wang, Jing Zhang, Chao Li. EFLDO sensitizes liver cancer cells to TNFSF10‑induced apoptosis in a p53‑dependent manner. Molecular medicine reports. vol 19. issue 5. 2019-08-19. PMID:30896802. |
treatment with efldo sensitized liver cancer cells to tnfsf10, and apoptosis was induced via the upregulation of tnf receptor superfamily member 10a (tnfrsf10a) and tnfrsf10b in a tumor protein p53 (p53)‑dependent manner, as detected by reverse transcription‑quantitative polymerase chain reaction and western blot analyses. |
2019-08-19 |
2023-08-13 |
Not clear |
| Abdullah Icli, Medine Cumhur Cure, Erkan Cure, Sevket Arslan, Mehmet Unal, Davut Sakiz, Miyase Ozucan, Aysun Toker, Kultigin Turkmen, Adem Kucu. Soluble Tumor Necrosis Factor (TNF)-Like Weak Inducer of Apoptosis (Tweak) Independently Predicts Subclinical Atherosclerosis in Behcet's Disease. Acta medica (Hradec Kralove). vol 61. issue 3. 2019-07-26. PMID:30543512. |
soluble tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) independently predicts subclinical atherosclerosis in behcet's disease. |
2019-07-26 |
2023-08-13 |
Not clear |
| Abdullah Icli, Medine Cumhur Cure, Erkan Cure, Sevket Arslan, Mehmet Unal, Davut Sakiz, Miyase Ozucan, Aysun Toker, Kultigin Turkmen, Adem Kucu. Soluble Tumor Necrosis Factor (TNF)-Like Weak Inducer of Apoptosis (Tweak) Independently Predicts Subclinical Atherosclerosis in Behcet's Disease. Acta medica (Hradec Kralove). vol 61. issue 3. 2019-07-26. PMID:30543512. |
soluble tumor necrosis factor-like (tnf) weak inducer of apoptosis (tweak) is known as a good marker of the inflammation in vascular tree. |
2019-07-26 |
2023-08-13 |
Not clear |
| Amir Daei Farshchi Adli, Rana Jahanban-Esfahlan, Khaled Seidi, Sonia Samandari-Rad, Nosratollah Zargham. An overview on Vadimezan (DMXAA): The vascular disrupting agent. Chemical biology & drug design. vol 91. issue 5. 2019-07-22. PMID:29288534. |
the exact mechanism of vascular disruption is unknown; however, proposed direct and indirect mechanisms of action for dmxaa comprises (i) inducing apoptosis in endothelial cells; (ii) hemorrhagic necrosis and ischemia in tumor; (iii) release of serotonin (5-ht); (vi) stimulation of innate immune system; (v) production of inflammatory cytokines, for example tnf, il-6, gcsf, kc, ip-10, and mcp-1; (vi) activation of nfκb and p38 (mapk); (vii) production of nitric oxide; and (viii) reducing tumor energetics and membrane turnover. |
2019-07-22 |
2023-08-13 |
mouse |
| Sevil Arabaci Tamer, Alper Yildirim, M Kutay Köroğlu, Özge Çevik, Feriha Ercan, Berrak Ç Yeğe. Nesfatin-1 ameliorates testicular injury and supports gonadal function in rats induced with testis torsion. Peptides. vol 107. 2019-07-15. PMID:30031042. |
the levels of 8-ohdg, tumor necrosis factor (tnf)-alpha, interleukin (il)-6, caspase-3 were increased in the saline-treated torsion/detorsion group as compared to sham-operated group, while nesfatin-1 pre-treatment significantly decreased the expressions of the pro-inflammatory cytokines, depressed apoptosis, and also reduced the tubular degeneration. |
2019-07-15 |
2023-08-13 |
rat |
| Kei Matsuno, Norihiro Harada, Sonoko Harada, Tomohito Takeshige, Ayako Ishimori, Yukinari Itoigawa, Yoko Katsura, Yuzo Kodama, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahash. Combination of TWEAK and TGF-β1 induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition. Experimental lung research. vol 44. issue 7. 2019-07-15. PMID:30676129. |
previous reports show that tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is a cytokine of the tnf superfamily, exerts pro-inflammatory effects, and enhances transforming growth factor (tgf)-β-induced emt in bronchial epithelial cells. |
2019-07-15 |
2023-08-13 |
human |
| Xixi Chang, Lili Wang, Zicheng Wang, Shuai Wu, Xiaoming Zhu, Shiping Hu, Yu Wang, Jiyun Yu, Guozhu Che. TRADD mediates the tumor necrosis factor-induced apoptosis of L929 cells in the absence of RIP3. Scientific reports. vol 7. issue 1. 2019-07-03. PMID:29170425. |
although both tnf receptor type 1-associated death domain protein (tradd) and rip1 have been reported to mediate tnfα-induced apoptosis, the knockdown of tradd, but not rip1, suppressed tnfα-induced activation of the caspase pathway and subsequent apoptosis in rip3 knockdown l929 cells. |
2019-07-03 |
2023-08-13 |
Not clear |
| I V Kurbatova, L V Topchieva, O P Dudanova, A A Shipovskay. Biochemical and molecular-genetic indicators of inflammation and apoptosis in liver cirrhosis as an outcome of the progression of non-alcoholic steatohepatitis. Terapevticheskii arkhiv. vol 91. issue 4. 2019-07-01. PMID:31094472. |
a comparative analysis of the complex of clinical and laboratory indicators (including the content of cytokines in blood plasma and the level of expression of tnf and il6 genes in peripheral leukocytes, as well as the level of biochemical and molecular-genetic indicators of apoptosis, such as the content of tissue polypeptide-specific antigen (tps) in the blood, the activity of caspases 3, 8 and 9 and the expression level of the encoding genes in peripheral blood leukocytes) in patients with non-alcoholic fatty liver disease (nafld) with non-alcoholic steatohepatitis (nash) of different activity, liver cirrhosis (lc) classes a and b and in the donors of control group. |
2019-07-01 |
2023-08-13 |
Not clear |
| Allison E Songstad, Kristan S Worthington, Kathleen R Chirco, Joseph C Giacalone, S Scott Whitmore, Kristin R Anfinson, Dalyz Ochoa, Cathryn M Cranston, Megan J Riker, Maurine Neiman, Edwin M Stone, Robert F Mullins, Budd A Tucke. Connective Tissue Growth Factor Promotes Efficient Generation of Human Induced Pluripotent Stem Cell-Derived Choroidal Endothelium. Stem cells translational medicine. vol 6. issue 6. 2019-06-27. PMID:28474838. |
a second factor tumor necrosis factor (tnf)-related weak inducer of apoptosis receptor was also found to promote ipsc to cec differentiation by inducing endogenous ctgf secretion. |
2019-06-27 |
2023-08-13 |
human |
| Nikolai Genov, Alireza Basti, Mónica Abreu, Angela Relógi. Temporal Splicing Switches in Elements of the TNF-Pathway Identified by Computational Analysis of Transcriptome Data for Human Cell Lines. International journal of molecular sciences. vol 20. issue 5. 2019-06-24. PMID:30857150. |
our data indicate that elements within the tnf pathway undergo a time-dependent variation in isoform production with a putative impact on cell migration, proliferation and apoptosis. |
2019-06-24 |
2023-08-13 |
human |
| Xenia A Glukhova, Julia A Trizna, Olga V Proussakova, Vladimir Gogvadze, Igor P Beletsk. Impairment of Fas-ligand-caveolin-1 interaction inhibits Fas-ligand translocation to rafts and Fas-ligand-induced cell death. Cell death & disease. vol 9. issue 2. 2019-06-18. PMID:29358576. |
fas-ligand/cd178 belongs to the tnf family proteins and can induce apoptosis through death receptor fas/cd95. |
2019-06-18 |
2023-08-13 |
Not clear |
| Maria F Lopes-Virella, Gabriel Virell. Modified LDL Immune Complexes and Cardiovascular Disease. Current medicinal chemistry. vol 26. issue 9. 2019-06-17. PMID:29792135. |
high levels of tnf are likely to be a major factor leading to apoptosis and high levels of metalloproteinases are likely to play a role in the thinning of the fibrous cap of the atheromatous plaque. |
2019-06-17 |
2023-08-13 |
Not clear |
| Vangelis Kondylis, Manolis Pasparaki. RIP Kinases in Liver Cell Death, Inflammation and Cancer. Trends in molecular medicine. vol 25. issue 1. 2019-06-17. PMID:30455045. |
recent genetic studies have suggested that receptor-interacting protein kinase (ripk)1 is implicated in liver disease pathogenesis by regulating caspase-dependent hepatocyte apoptosis induced by tumor necrosis factor (tnf) or other stimuli. |
2019-06-17 |
2023-08-13 |
Not clear |
| Fang Liu, Zhuanzi Wang, Wenjian Li, Yanting We. Transcriptional response of murine bone marrow cells to total-body carbon-ion irradiation. Mutation research. Genetic toxicology and environmental mutagenesis. vol 839. 2019-06-10. PMID:30744812. |
kyoto encyclopedia of genes and genomes pathway analysis indicated that these functions are regulated by the p38 mapk, tnf, and apoptosis pathways. |
2019-06-10 |
2023-08-13 |
mouse |
| Xuefu Li, Wei Wei, Zhongquan Zhao, Shuzhen L. Tripterine up-regulates miR-223 to alleviate lipopolysaccharide-induced damage in murine chondrogenic ATDC5 cells. International journal of immunopathology and pharmacology. vol 33. 2019-06-10. PMID:30791741. |
lps stimulation significantly reduced atdc5 cells viability, induced apoptosis, and increased the release of interleukin (il)-6 and tumor necrosis factor (tnf)-α. |
2019-06-10 |
2023-08-13 |
Not clear |