| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Vomero, V Manganelli, C Barbati, T Colasanti, A Capozzi, A Finucci, F R Spinelli, F Ceccarelli, C Perricone, S Truglia, S Morrone, R Maggio, R Misasi, M Bombardieri, M Di Franco, F Conti, M Sorice, G Valesini, C Alessandr. Reduction of autophagy and increase in apoptosis correlates with a favorable clinical outcome in patients with rheumatoid arthritis treated with anti-TNF drugs. Arthritis research & therapy. vol 21. issue 1. 2020-03-16. PMID:30696478. |
to investigate whether the relationship between autophagy and apoptosis may impact the response to the therapy, we analyzed ex vivo spontaneous autophagy and apoptosis in patients with ra subjected to treatment with anti-tumor necrosis factor (tnf) drugs and in vitro the effects of tnfα and anti-tnf drugs on cell fate. |
2020-03-16 |
2023-08-13 |
Not clear |
| João Pedro Ferreira, Job Verdonschot, Timothy Collier, Ping Wang, Anne Pizard, Christian Bär, Jens Björkman, Alessandro Boccanelli, Javed Butler, Andrew Clark, John G Cleland, Christian Delles, Javier Diez, Nicolas Girerd, Arantxa González, Mark Hazebroek, Anne-Cécile Huby, Wouter Jukema, Roberto Latini, Joost Leenders, Daniel Levy, Alexandre Mebazaa, Harald Mischak, Florence Pinet, Patrick Rossignol, Naveed Sattar, Peter Sever, Jan A Staessen, Thomas Thum, Nicolas Vodovar, Zhen-Yu Zhang, Stephane Heymans, Faiez Zanna. Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure. Circulation. Heart failure. vol 12. issue 5. 2020-03-09. PMID:31104495. |
these 38 proteins pointed to 4 main network clusters underlying incident hf: (1) inflammation and apoptosis, indicated by the expression of the tnf (tumor necrosis factor)-family members; (2) extracellular matrix remodeling, angiogenesis and growth, indicated by the expression of proteins associated with collagen metabolism, endothelial function, and vascular homeostasis; (3) blood pressure regulation, indicated by the expression of natriuretic peptides and proteins related to the renin-angiotensin-aldosterone system; and (4) metabolism, associated with cholesterol and atherosclerosis. |
2020-03-09 |
2023-08-13 |
Not clear |
| Isabel Gonçalves, Pratibha Singh, Christoffer Tengryd, Michele Cavalera, Ingrid Yao Mattisson, Mihaela Nitulescu, Ana Flor Persson, Petr Volkov, Gunnar Engström, Marju Orho-Melander, Jan Nilsson, Andreas Edsfeld. sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events. Stroke. vol 50. issue 8. 2020-03-06. PMID:31272321. |
strail-r2 (soluble tnf [tumor necrosis factor]-related apoptosis-inducing ligand receptor 2) a marker of plaque cell apoptosis and cardiovascular events. |
2020-03-06 |
2023-08-13 |
human |
| Isabel Gonçalves, Pratibha Singh, Christoffer Tengryd, Michele Cavalera, Ingrid Yao Mattisson, Mihaela Nitulescu, Ana Flor Persson, Petr Volkov, Gunnar Engström, Marju Orho-Melander, Jan Nilsson, Andreas Edsfeld. sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events. Stroke. vol 50. issue 8. 2020-03-06. PMID:31272321. |
activation of the death receptor trail-r2 (tnf [tumor necrosis factor]-related apoptosis-inducing ligand receptor 2) through its ligand tumor necrosis factor-relate apoptosis-inducing ligand (trail), induces apoptosis in cells in vitro. |
2020-03-06 |
2023-08-13 |
human |
| Elena Brin, Katherine Wu, Eleanor Dagostino, Mario Meng-Chiang Kuo, Yudou He, Wei-Jong Shia, Li-Chang Chen, Mariusz Stempniak, Richard Hickey, Robert Almassy, Richard Showalter, James Thomso. TRAIL stabilization and cancer cell sensitization to its pro-apoptotic activity achieved through genetic fusion with arginine deiminase. Oncotarget. vol 9. issue 97. 2020-02-25. PMID:30651925. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) binds to death receptors and induces apoptosis in various cancer cell lines while sparing normal cells. |
2020-02-25 |
2023-08-13 |
Not clear |
| Mengfang Li, Jingjing Ye, Guangju Zhao, Guangliang Hong, Xiyi Hu, Kaiqiang Cao, You Wu, Zhongqiu L. Gas6 attenuates lipopolysaccharide‑induced TNF‑α expression and apoptosis in H9C2 cells through NF‑κB and MAPK inhibition via the Axl/PI3K/Akt pathway. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524235. |
therapeutic agents used to treat sepsis‑induced cardiac dysfunction are designed to suppress tumor necrosis factor (tnf)‑α release and inhibit cell apoptosis. |
2020-02-04 |
2023-08-13 |
Not clear |
| Shaoshuai Liang, Danwen Liu, Xixi Li, Maokai Wei, Xiaohan Yu, Qi Li, Huixin Ma, Zhifeng Zhang, Zhenkui Qi. SOX2 participates in spermatogenesis of Zhikong scallop Chlamys farreri. Scientific reports. vol 9. issue 1. 2020-01-20. PMID:30635613. |
go and kegg analysis showed that most degs were related to cell apoptosis (casp2, casp3, casp8), cell proliferation (samd9, crebzf, iqsec1) and spermatogenesis (htt, tusc3, zmynd10, nipbl, mfge8), and enriched in p53, tnf and apoptosis pathways. |
2020-01-20 |
2023-08-13 |
Not clear |
| Rosalind L Ang, Adrian T Tin. Tumor necrosis factor-driven cell death in donor organ as a barrier to immunological tolerance. Current opinion in organ transplantation. vol 24. issue 1. 2020-01-15. PMID:30507704. |
a well-known trigger of regulated cell death is tumor necrosis factor-alpha (tnf), which activates both caspase-dependent apoptosis and caspase-independent necroptosis. |
2020-01-15 |
2023-08-13 |
Not clear |
| Jie Zhang, De-Ling Kong, Bin Xiao, Hong-Jie Yuan, Qiao-Qiao Kong, Xiao Han, Ming-Jiu Luo, Jing-He Ta. Restraint stress of male mice triggers apoptosis in spermatozoa and spermatogenic cells via activating the TNF-α system. Zygote (Cambridge, England). 2020-01-14. PMID:31933449. |
using a psychological (restraint) stress mouse model, we tested whether male psychological stress triggers apoptosis of spermatozoa and spermatogenic cells through activating tumour necrosis factor (tnf)-α signalling. |
2020-01-14 |
2023-08-13 |
mouse |
| Jie Zhang, De-Ling Kong, Bin Xiao, Hong-Jie Yuan, Qiao-Qiao Kong, Xiao Han, Ming-Jiu Luo, Jing-He Ta. Restraint stress of male mice triggers apoptosis in spermatozoa and spermatogenic cells via activating the TNF-α system. Zygote (Cambridge, England). 2020-01-14. PMID:31933449. |
wild-type or tnf-α-/- male mice were restrained for 48 h before examination for apoptosis and expression of tnf-α and tnf receptor 1 (tnfr1) in spermatozoa, epididymis, seminiferous tubules and spermatogenic cells. |
2020-01-14 |
2023-08-13 |
mouse |
| Lei Cao, Zhe Zhang, Yong Li, Peiyong Zhao, Yuguo Che. LncRNA H19/miR-let-7 axis participates in the regulation of ox-LDL-induced endothelial cell injury via targeting periostin. International immunopharmacology. vol 72. 2020-01-07. PMID:31054453. |
h19 knockdown by transfection with h19 sirnas in ox-ldl-treated huvecs remarkably promoted cell viability, suppressed the secretion of interleukin (il)-1β, il-6, and tumour necrosis factor (tnf)-α, decreased the expression of vascular cell adhesion molecule 1 (vcam1), intercellular adhesion molecule 1 (icam1) and e-selectin, reduced levels of reactive oxygen species (ros) and malondialdehyde (mda), increased superoxide dismutase (sod) levels, and reduced cell apoptosis. |
2020-01-07 |
2023-08-13 |
human |
| Jianguo Wu, Yulan Zhao, Young-Ki Park, Ji-Young Lee, Ling Gao, Jiajun Zhao, Li Wan. Loss of PDK4 switches the hepatic NF-κB/TNF pathway from pro-survival to pro-apoptosis. Hepatology (Baltimore, Md.). vol 68. issue 3. 2019-12-27. PMID:29603325. |
it has been established that nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) members promote survival by upregulating antiapoptotic genes and that genetic and pharmacological inhibition of nf-κb is required for tumor necrosis factor (tnf)-induced hepatocyte apoptosis. |
2019-12-27 |
2023-08-13 |
Not clear |
| Kaito Nihira, Ken-Ichiro Nan-Ya, Masakazu Kakuni, Yoko Ono, Yukitaka Yoshikawa, Toshio Ota, Masanori Hiura, Kouichi Yoshinar. Chimeric Mice With Humanized Livers Demonstrate Human-Specific Hepatotoxicity Caused by a Therapeutic Antibody Against TRAIL-Receptor 2/Death Receptor 5. Toxicological sciences : an official journal of the Society of Toxicology. vol 167. issue 1. 2019-12-19. PMID:30202993. |
the activation of tumor necrosis factor (tnf)-related apoptosis-inducing ligand receptor 2 (trail-r2)/death receptor 5 (dr5) induces apoptosis in various tumor cells but not in normal human cells. |
2019-12-19 |
2023-08-13 |
mouse |
| Junying Yuan, Palak Amin, Dimitry Ofengei. Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases. Nature reviews. Neuroscience. vol 20. issue 1. 2019-12-16. PMID:30467385. |
however, under pathological conditions, upregulation of death receptor family ligands, such as tumour necrosis factor (tnf), can sensitize cells in the cns to apoptosis and a form of regulated necrotic cell death known as necroptosis that is mediated by receptor-interacting protein kinase 1 (ripk1), ripk3 and mixed lineage kinase domain-like protein (mlkl). |
2019-12-16 |
2023-08-13 |
Not clear |
| Leema George, Tamizhselvi Ramasamy, Kns Sirajudeen, Venkatraman Manicka. LPS-induced Apoptosis is Partially Mediated by Hydrogen Sulphide in RAW 264.7 Murine Macrophages. Immunological investigations. vol 48. issue 5. 2019-12-12. PMID:30689461. |
lipopolysaccharide (lps) induces apoptosis in murine macrophages through the autocrine secretion of tumor necrosis factor (tnf)-α and nitric oxide (no). |
2019-12-12 |
2023-08-13 |
Not clear |
| L Peng, Q Li, H Wang, J Wu, C Li, Y Liu, J Liu, L Xia, Y Xi. Fn14 deficiency ameliorates psoriasis-like skin disease in a murine model. Cell death & disease. vol 9. issue 8. 2019-12-03. PMID:30038329. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is a multifunctional cytokine that acts through its receptor fibroblast growth factor-inducible 14 (fn14). |
2019-12-03 |
2023-08-13 |
mouse |
| Xiaoxin Jin, Lifeng Cai, Changfa Wang, Xiaofeng Deng, Shengen Yi, Zhao Lei, Qiangsheng Xiao, Hongbo Xu, Hongwu Luo, Jichun Su. CASC2/miR-24/miR-221 modulates the TRAIL resistance of hepatocellular carcinoma cell through caspase-8/caspase-3. Cell death & disease. vol 9. issue 3. 2019-11-25. PMID:29476051. |
tnf related apoptosis inducing ligand (trail), an attractive anticancer agent, exerts its effect of selectively inducing apoptosis in tumor cells through death receptors and the formation of the downstream death-inducing signaling complex, which activates apical caspases 3/8 and leads to apoptosis. |
2019-11-25 |
2023-08-13 |
Not clear |
| Sabrina Daniela da Silva, Bin Xu, Mariana Maschietto, Fabio Albuquerque Marchi, Maisa I Alkailani, Krikor Bijian, Dingzhang Xiao, Moulay A Alaoui-Jamal. TRAF2 Cooperates with Focal Adhesion Signaling to Regulate Cancer Cell Susceptibility to Anoikis. Molecular cancer therapeutics. vol 18. issue 1. 2019-11-25. PMID:30373932. |
traf2, a ring finger adaptor protein, plays an important function in tumor necrosis factor (tnf)- and tnf-like weak inducer of apoptosis (tweak)-dependent signaling, in particular during inflammatory and immune responses. |
2019-11-25 |
2023-08-13 |
Not clear |
| Mahnaz Ramezani, Mahin Ramezani, Ali Darekordi, Gholamhossein Hassanshahi, Mohammad Reza Mirzae. The New Compound of (2R, 4S)-N-(2, 5-difluorophenyl)-4-Hydroxy-1-(2, 2, 2-Trifluoroacetyl) Pyrrolidine-2-Carboxamide to Mediate the Expression of Some Apoptosis Genes by the HepG2 Cell Line Asian Pacific journal of cancer prevention : APJCP. vol 20. issue 5. 2019-11-22. PMID:31127908. |
after 48 hours from theculture, the expressional profiles of apoptosis pathway genes (84 genes) were studied using the pcr array method.results: the findings demonstrated that the expression of some apoptosis-related genes pertaining to tnf, bcl2,iap, and caspase families was regulated by (2r, 4s)-n-(2, 5-difluorophenyl)-4-hydroxy-1-(2, 2, 2-trifluoroacetyl)pyrrolidine-2-carboxamide. |
2019-11-22 |
2023-08-13 |
Not clear |
| Nima Etemadi, Michael Chopin, Holly Anderton, Maria C Tanzer, James A Rickard, Waruni Abeysekera, Cathrine Hall, Sukhdeep K Spall, Bing Wang, Yuquan Xiong, Timothy Hla, Stuart M Pitson, Claudine S Bonder, Wendy Wei-Lynn Wong, Matthias Ernst, Gordon K Smyth, David L Vaux, Stephen L Nutt, Ueli Nachbur, John Silk. Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. eLife. vol 6. 2019-11-20. PMID:28654421. |
correction: traf2 regulates tnf and nf-κb signalling to suppress apoptosis and skin inflammation independently of sphingosine kinase 1. |
2019-11-20 |
2023-08-13 |
Not clear |