| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Q Liu, H Wang, X Wang, M Lu, X Tan, L Peng, F Tan, T Xiao, S Xiao, Y Xi. Experimental atopic dermatitis is dependent on the TWEAK/Fn14 signaling pathway. Clinical and experimental immunology. vol 199. issue 1. 2020-07-21. PMID:31515807. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) acts through its receptor fibroblast growth factor inducible 14 (fn14), and participates in skin inflammation. |
2020-07-21 |
2023-08-13 |
mouse |
| Yutao Wang, Huan Wen, Jiajun Fu, Lin Cai, Peng-Long Li, Chang-Ling Zhao, Zhu-Feng Dong, Jun-Peng Ma, Xi Wang, Han Tian, Yan Zhang, Ye Liu, Jingjing Cai, Zhi-Gang She, Zan Huang, Wenhua Li, Hongliang L. Hepatocyte TNF Receptor-Associated Factor 6 Aggravates Hepatic Inflammation and Fibrosis by Promoting Lysine 6-Linked Polyubiquitination of Apoptosis Signal-Regulating Kinase 1. Hepatology (Baltimore, Md.). vol 71. issue 1. 2020-07-14. PMID:31222801. |
hepatocyte tnf receptor-associated factor 6 aggravates hepatic inflammation and fibrosis by promoting lysine 6-linked polyubiquitination of apoptosis signal-regulating kinase 1. |
2020-07-14 |
2023-08-13 |
Not clear |
| Shima Abdollahi, Amin Salehi-Abargouei, Mahtab Tabatabaie, Mohammad Hasan Sheikhha, Hossein Fallahzadeh, Masoud Rahmanian, Omid Toupchian, Elham Karimi-Nazari, Hassan Mozaffari-Khosrav. The effect of resveratrol supplementation on the expression levels of factors associated with cellular senescence and sCD163/sTWEAK ratio in patients with type 2 diabetes mellitus: study protocol for a double-blind controlled randomised clinical trial. BMJ open. vol 9. issue 7. 2020-07-06. PMID:31278094. |
we will also measure serum levels of cluster of differentiation 163 (cd163) and tumour necrosis factor (tnf)-like weak inducer of apoptosis (tweak) as the indicators of cardiovascular status. |
2020-07-06 |
2023-08-13 |
Not clear |
| Fei Wang, Nan-Nan Sun, Lan-Lan Li, Wan-Wan Zhu, Jianbo Xiu, Yan Shen, Qi X. Hepatic progenitor cell activation is induced by the depletion of the gut microbiome in mice. MicrobiologyOpen. vol 8. issue 10. 2020-06-22. PMID:31094067. |
the mrna expression levels of proinflammatory factors (interleukin [il]-1β, il-6, tumor necrosis factor [tnf]-α, and tnf-like weak inducer of apoptosis [tweak]) were also significantly higher in the antibiotic-treated mice than the levels in the control mice. |
2020-06-22 |
2023-08-13 |
mouse |
| Sohei Ito, Yohei Hashimoto, Ryohei Majima, Eichi Nakao, Hiroki Aoki, Michihide Nishihara, Satoko Ohno-Urabe, Aya Furusho, Saki Hirakata, Norifumi Nishida, Makiko Hayashi, Koichiro Kuwahara, Yoshihiro Fukumot. MRTF-A promotes angiotensin II-induced inflammatory response and aortic dissection in mice. PloS one. vol 15. issue 3. 2020-06-18. PMID:32208430. |
angii infusion for 1 day induced pro-inflammatory response, as demonstrated by expressions of il6, tnf, and ccl2, and apoptosis of aortic wall cells, as detected by tunel staining, in an mrtf-a-dependent manner. |
2020-06-18 |
2023-08-13 |
mouse |
| Jing Zhao, Chao Lv, Qiuling Wu, Huawu Zeng, Xin Guo, Jian Yang, Saisai Tian, Weidong Zhan. Computational systems pharmacology reveals an antiplatelet and neuroprotective mechanism of Deng-Zhan-Xi-Xin injection in the treatment of ischemic stroke. Pharmacological research. vol 147. 2020-06-17. PMID:31348992. |
these target genes were further found to be associated with pathways involved in neuronal apoptosis in ischemic stroke, such as nf-κb signaling, tnf signaling, and pi3k-akt signaling. |
2020-06-17 |
2023-08-13 |
human |
| Touseef Rehan, David MacEwan, Nasrullah Shah, Tabassum Rehan, Riffat Tahira, Sheeba Murad, Mariam Anees, Iram Murtaza, Muhammad Farman, Obaid-Ur-Rahman Abid, Aneesa Sulta. Apoptosis of Leukemia Cells by Ocimum basilicum Fractions Following TNF alpha Induced Activation of JNK and Caspase 3. Current pharmaceutical design. vol 25. issue 34. 2020-06-15. PMID:31604407. |
apoptosis of leukemia cells by ocimum basilicum fractions following tnf alpha induced activation of jnk and caspase 3. |
2020-06-15 |
2023-08-13 |
Not clear |
| Xuening Wang, Dan Cheng, Guanglei Hu, Lili Liang, Fei Tan, Tong Xiao, Shengxiang Xiao, Yumin Xi. Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of Apoptosis. Mediators of inflammation. vol 2019. 2020-06-08. PMID:31885495. |
tumor necrosis factor (tnf) receptor expression determines keratinocyte fate upon stimulation with tnf-like weak inducer of apoptosis. |
2020-06-08 |
2023-08-13 |
Not clear |
| Xuening Wang, Dan Cheng, Guanglei Hu, Lili Liang, Fei Tan, Tong Xiao, Shengxiang Xiao, Yumin Xi. Tumor Necrosis Factor (TNF) Receptor Expression Determines Keratinocyte Fate upon Stimulation with TNF-Like Weak Inducer of Apoptosis. Mediators of inflammation. vol 2019. 2020-06-08. PMID:31885495. |
the interaction between tumor necrosis factor- (tnf-) like weak inducer of apoptosis (tweak) and fibroblast growth factor-inducible 14 (fn14) regulates the fate of keratinocytes, depending on the relative expression of tnf receptor (tnfr) 1 or tnfr2. |
2020-06-08 |
2023-08-13 |
Not clear |
| Lopa M Das, Amy M Binko, Zachary P Traylor, Han Peng, Kurt Q L. Vitamin D improves sunburns by increasing autophagy in M2 macrophages. Autophagy. vol 15. issue 5. 2020-05-07. PMID:30661440. |
specifically, pharmacological inhibition of autophagy increased uv-induced apoptosis, suppressed m2 macs recruitment, and prevented vitamin d downregulation of tnf and mmp9 in the skin. |
2020-05-07 |
2023-08-13 |
mouse |
| Xubin Qiu, Ming Zhuang, Ziwen Lu, Zhiwei Liu, Dong Cheng, Chenlei Zhu, Jinbo Li. RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs. Journal of translational medicine. vol 17. issue 1. 2020-04-29. PMID:31029152. |
ripk1 suppresses apoptosis mediated by tnf and caspase-3 in intervertebral discs. |
2020-04-29 |
2023-08-13 |
Not clear |
| David W Vredevoogd, Thomas Kuilman, Maarten A Ligtenberg, Julia Boshuizen, Kelly E Stecker, Beaunelle de Bruijn, Oscar Krijgsman, Xinyao Huang, Juliana C N Kenski, Ruben Lacroix, Riccardo Mezzadra, Raquel Gomez-Eerland, Mete Yildiz, Ilknur Dagidir, Georgi Apriamashvili, Nordin Zandhuis, Vincent van der Noort, Nils L Visser, Christian U Blank, Maarten Altelaar, Ton N Schumacher, Daniel S Peepe. Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Cell. vol 178. issue 3. 2020-04-27. PMID:31303383. |
taking advantage of the genetic screen, we demonstrate that ablation of the top hit, traf2, lowers the tnf cytotoxicity threshold in tumors by redirecting tnf signaling to favor ripk1-dependent apoptosis. |
2020-04-27 |
2023-08-13 |
Not clear |
| Ilias P Doulamis, Panagiotis Konstantopoulos, Aspasia Tzani, Asier Antoranz, Angeliki Minia, Afroditi Daskalopoulou, Anestis Charalampopoulos, Leonidas Alexopoulos, Depsina N Perrea, Evangelos Menenako. Visceral white adipose tissue and serum proteomic alternations in metabolically healthy obese patients undergoing bariatric surgery. Cytokine. vol 115. 2020-04-23. PMID:30472106. |
tnf weak inducer of apoptosis (tweak) (p = 0.043), tnf related apoptosis inducing ligand (trail) (p = 0.037), growth differentiation factor-15 (gdf-15) (p = 0.04), resistin (retn) (p = 0.047), matrix metalloproteinase-9 (mmp-9) (p = 0.011) and c-terminal telopeptide (ictp) (p = 0.022) were up-regulated in the muo group in the visceral white adipose tissue. |
2020-04-23 |
2023-08-13 |
human |
| Jing-Yu Yang, Rui Wang, Tao Jin, Lan Li, Yi-Qin Wang, Qing Xia, Dan D. [Material basis and molecular mechanism of Dachengqi Decoction in treatment of acute pancreatitis based on network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 6. 2020-04-14. PMID:32281357. |
dcqd may achieve its pharmacological effects through anti-inflammatory and anti-oxidative effects, negative regulation of apoptosis and regulation of pancreatic secretion, involving multiple signals, such as il-17, tnf and nf-κb signaling pathway. |
2020-04-14 |
2023-08-13 |
Not clear |
| Sathya D Unudurthi, Drew M Nassal, Nehal J Patel, Evelyn Thomas, Jane Yu, Curtis G Pierson, Shyam S Bansal, Peter J Mohler, Thomas J Hun. Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction. Life sciences. vol 247. 2020-04-09. PMID:32070706. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is a pro-inflammatory cytokine, which binds to fibroblast growth factor inducible 14 (fn14), a ubiquitously expressed cell-surface receptor. |
2020-04-09 |
2023-08-13 |
Not clear |
| Jessica Michie, Paul A Beavis, Andrew J Freeman, Stephin J Vervoort, Kelly M Ramsbottom, Vignesh Narasimhan, Emily J Lelliott, Najoua Lalaoui, Robert G Ramsay, Ricky W Johnstone, John Silke, Phillip K Darcy, Ilia Voskoboinik, Conor J Kearney, Jane Oliar. Antagonism of IAPs Enhances CAR T-cell Efficacy. Cancer immunology research. vol 7. issue 2. 2020-04-08. PMID:30651288. |
here, we demonstrated that antagonizing the "inhibitor of apoptosis proteins" with the clinical smac-mimetic, birinapant, significantly enhanced the antitumor activity of car t cells in a tumor necrosis factor (tnf)-dependent manner. |
2020-04-08 |
2023-08-13 |
Not clear |
| Sodai Yoshimura, Emiko Sano, Yuya Hanashima, Shun Yamamuro, Koichiro Sumi, Takuya Ueda, Tomohiro Nakayama, Hiroyuki Hara, Atsuo Yoshino, Yoichi Katayam. IFN‑β sensitizes TRAIL‑induced apoptosis by upregulation of death receptor 5 in malignant glioma cells. Oncology reports. vol 42. issue 6. 2020-04-06. PMID:31638255. |
tumor necrosis factor‑related apoptosis‑inducing ligand (trail), a member of the tumor necrosis factor (tnf) family, induces apoptosis in cancer cells by binding to its receptors, death receptor 4 (dr4) and dr5, without affecting normal cells, and is therefore considered to be a promising antitumor agent for use in cancer treatment. |
2020-04-06 |
2023-08-13 |
Not clear |
| Denis Selimovic, Renate U Wahl, Emmanuelle Ruiz, Rizwan Aslam, Thomas W Flanagan, Sofie-Yasmin Hassan, Simeon Santourlidis, Youssef Haikel, Paul Friedlander, Mosaad Megahed, Emad Kandil, Mohamed Hassa. Tumor necrosis factor-α triggers opposing signals in head and neck squamous cell carcinoma and induces apoptosis via mitochondrial- and non-mitochondrial-dependent pathways. International journal of oncology. vol 55. issue 6. 2020-04-02. PMID:31638203. |
the tnf-α-induced survival of hnscc cells is mediated by the tnf receptor-associated factor 2 (traf2)/nuclear factor (nf)-κb-dependent pathway, while tnf-α-induced apoptosis is mediated by mitochondrial and non-mitochondrial-dependent mechanisms through fadd-caspase-8-caspase-3 and ask-jnk-p53-noxa pathways. |
2020-04-02 |
2023-08-13 |
Not clear |
| Yann Estornes, Yves Dondelinger, Kathrin Weber, Inge Bruggeman, Adam Peall, Marion MacFarlane, Serge Lebecque, Peter Vandenabeele, Mathieu J M Bertran. N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis. Cell death & disease. vol 9. issue 5. 2020-03-30. PMID:29717117. |
although cytotoxic in various cancer cells, tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) does not trigger apoptosis in most non-transformed cells. |
2020-03-30 |
2023-08-13 |
mouse |
| James J Zhu, Palaniappan Ramanathan, Elizabeth A Bishop, Vivian O'Donnell, Douglas P Gladue, Manuel V Borc. Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages. PloS one. vol 14. issue 11. 2020-03-19. PMID:31725732. |
our results suggest that the cytokines of tnf family including faslg, lta, ltb, tnf, tnfsf4, tnfsf10, tnfsf13b and tnfsf18 are the major causative cytokine factors in asf pathogenesis via inducing apoptosis. |
2020-03-19 |
2023-08-13 |
Not clear |