| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenshu Zou, Peng Yin, Yaran Shi, Na Jin, Qian Gao, Jiandong Li, Fenghua Li. A Novel Biological Role of α-Mangostin via TAK1-NF-κB Pathway against Inflammatory. Inflammation. vol 42. issue 1. 2019-06-03. PMID:30132203. |
we applied doses of α-mangostin (2.5, 5, and 10 μm) and detected apoptosis by flow cytometry, and the griess reagent and the enzyme-linked immunosorbent assay (elisa) method detected inflammatory factors such as nitric oxide (no), prostaglandin (pg) e2, interleukin (il)-1β, il-6, and tumor necrosis factor (tnf)-α. |
2019-06-03 |
2023-08-13 |
rat |
| Kyoung-Jin Min, Seon Min Woo, Sk Abrar Shahriyar, Taeg Kyu Kwo. Elucidation for modulation of death receptor (DR) 5 to strengthen apoptotic signals in cancer cells. Archives of pharmacal research. vol 42. issue 1. 2019-05-30. PMID:30632113. |
the tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) induces apoptosis via death receptor (dr) 4 or dr5 preferentially in cancer cells, and not in normal cells with relatively high decoy receptor expression. |
2019-05-30 |
2023-08-13 |
Not clear |
| Rosalind L Ang, Adrian T Tin. Detection of RIPK1 in the FADD-Containing Death Inducing Signaling Complex (DISC) During Necroptosis. Methods in molecular biology (Clifton, N.J.). vol 1857. 2019-05-28. PMID:30136234. |
fas-associated protein with death domain (fadd) is a signaling molecule required by members of the tnf receptor superfamily (tnfrsf) such as fas and tnfr1 to induce apoptosis. |
2019-05-28 |
2023-08-13 |
Not clear |
| Kuo-Hao Ho, Chih-Ju Chang, Tzu-Wen Huang, Chwen-Ming Shih, Ann-Jeng Liu, Peng-Hsu Chen, Kur-Ta Cheng, Ku-Chung Che. Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set. PloS one. vol 13. issue 12. 2019-05-17. PMID:30521597. |
we obtained five upregulated signaling pathways from the gene landscape: apoptosis, tumor necrosis factor (tnf)-α signaling via nuclear factor (nf)-κb, apical surface, interferon-α response, and kras signaling. |
2019-05-17 |
2023-08-13 |
Not clear |
| Anusha Chidambaram, Kavya Sundararaju, Ramesh K Chidambaram, Rajasekaran Subbiah, John M Jayaraj, Karthikeyan Muthusamy, Ravikumar Vilwanatha. Design, synthesis, and characterization of α, β-unsaturated carboxylic acid, and its urea based derivatives that explores novel epigenetic modulators in human non-small cell lung cancer A549 cell line. Journal of cellular physiology. vol 233. issue 7. 2019-05-14. PMID:29215703. |
the mechanism of apoptosis is evident, regulating tumor suppressor genes and proteins, thereby facilitating the activation of the death receptor pathway by the tumor necrosis factor (tnf) receptor. |
2019-05-14 |
2023-08-13 |
human |
| Uddin Md Nazim, Sang-Youel Par. Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS. International journal of molecular medicine. vol 43. issue 2. 2019-05-03. PMID:30483736. |
tumor necrosis factor (tnf)‑related apoptosis‑inducing ligand (trail) is a member of the tnf superfamily and is an antitumor drug that induces apoptosis in tumor cells with minimal or no effects on normal cells. |
2019-05-03 |
2023-08-13 |
human |
| Yanjie Ding, Laifang Wang, Qing Zhao, Zhenzhen Wu, Lingli Kon. MicroRNA‑93 inhibits chondrocyte apoptosis and inflammation in osteoarthritis by targeting the TLR4/NF‑κB signaling pathway. International journal of molecular medicine. vol 43. issue 2. 2019-05-03. PMID:30569118. |
using this lps‑induced chondrocyte injury model, the overexpression of mir‑93 enhanced cell viability, improved cell apoptosis and attenuated the inflammatory response, as reflected by reductions in pro‑inflammatory cytokines, including tumor necrosis factor (tnf)‑α, interleukin (il)‑1β and il‑6. |
2019-05-03 |
2023-08-13 |
mouse |
| Tatiane Karen Cabeça, Alice de Mello Abreu, Rafael Andrette, Vanesca de Souza Lino, Mirian Galliote Morale, Francisco Aguayo, Lara Termini, Luisa Lina Villa, Ana Paula Lepique, Enrique Boccard. HPV-Mediated Resistance to TNF and TRAIL Is Characterized by Global Alterations in Apoptosis Regulatory Factors, Dysregulation of Death Receptors, and Induction of ROS/RNS. International journal of molecular sciences. vol 20. issue 1. 2019-04-26. PMID:30625987. |
hpv-mediated resistance to tnf and trail is characterized by global alterations in apoptosis regulatory factors, dysregulation of death receptors, and induction of ros/rns. |
2019-04-26 |
2023-08-13 |
human |
| Tatiane Karen Cabeça, Alice de Mello Abreu, Rafael Andrette, Vanesca de Souza Lino, Mirian Galliote Morale, Francisco Aguayo, Lara Termini, Luisa Lina Villa, Ana Paula Lepique, Enrique Boccard. HPV-Mediated Resistance to TNF and TRAIL Is Characterized by Global Alterations in Apoptosis Regulatory Factors, Dysregulation of Death Receptors, and Induction of ROS/RNS. International journal of molecular sciences. vol 20. issue 1. 2019-04-26. PMID:30625987. |
we showed that keratinocytes expressing hpv early proteins exhibited global alterations in the expression of proteins involved in apoptosis regulation/execution, including tnf and trail receptors. |
2019-04-26 |
2023-08-13 |
human |
| Xun Yuan, Ambikai Gajan, Qian Chu, Hua Xiong, Kongming Wu, Gen Sheng W. Developing TRAIL/TRAIL death receptor-based cancer therapies. Cancer metastasis reviews. vol 37. issue 4. 2019-04-22. PMID:29541897. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a member of the tnf superfamily that can initiate the apoptosis pathway by binding to its associated death receptors dr4 and dr5. |
2019-04-22 |
2023-08-13 |
human |
| Giulio Giustarini, Laura Kruijssen, Manon van Roest, Rob Bleumink, Richard J Weaver, Marianne Bol-Schoenmakers, Joost Smit, Raymond Pieter. Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin-induced tumor necrosis factor-dependent liver injury in mice. Journal of applied toxicology : JAT. vol 38. issue 5. 2019-04-15. PMID:29377180. |
unlike controls, mice receiving tvx + tnf display severe hepatotoxicity with clear pathology and apoptosis, coagulated hepatic vessels and increased alanine aminotransferase levels and interleukin 6/10 ratios. |
2019-04-15 |
2023-08-13 |
mouse |
| Alice Valentin-Torres, Carine Savarin, Joslyn Barnett, Cornelia C Bergman. Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29690885. |
using a mouse model of progressive ms, this study evaluates the effects of sustained tnf on oligodendrocyte (olg) apoptosis and olg precursor cell (opc) differentiation. |
2019-04-08 |
2023-08-13 |
mouse |
| Yong Tang, Donghyun Joo, Guangna Liu, Hailin Tu, Jeffrey You, Jianping Jin, Xueqiang Zhao, Mien-Chie Hung, Xin Li. Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFα-induced apoptosis. The Journal of biological chemistry. vol 293. issue 52. 2019-04-08. PMID:30361438. |
here, we report that lubac-mediated m1-linked ubiquitination of cellular flice-like inhibitory protein (cflip), an anti-apoptotic molecule, contributes to tumor necrosis factor (tnf) α-induced apoptosis. |
2019-04-08 |
2023-08-13 |
Not clear |
| Yi Sun, Jing Zhou, Ya-Jing Guo, Liu Chen, Tao Li, Yan-Ling Gao, Yu-Ning Wang, Ji-Meng Zhao, Huan-Gan Wu, Yin Sh. [Herbal cake-partitioned moxibustion improves intestinal epithelial barrier dysfunction by suppressing TNF-α-mediated apoptosis pathway of intestinal epithelium in rats with Crohn's disease]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 1. 2019-04-05. PMID:30773854. |
to observe the effect of herbal cake-partitioned moxibustion (moxi) on tumor necrosis factor (tnf)-α/ tnf receptor 1 (tnfr1)-associated death domain (tradd) / fas-associated death domain (fadd) pathway-mediated apoptosis of intestinal epithelial cells in crohn's disease (cd) rats, so as to explore its underlying mechanisms in the treatment of cd. |
2019-04-05 |
2023-08-13 |
rat |
| Jeremy M Hugh, Jeffrey M Weinber. Update on the pathophysiology of psoriasis. Cutis. vol 102. issue 5S. 2019-04-01. PMID:30566550. |
through various cytokines, such as tumor necrosis factor (tnf) α, these cells cause a chronic inflammatory state and alter epidermal hyperproliferation, differentiation, apoptosis, and neoangiogenesis that produce the cutaneous findings seen in this disease. |
2019-04-01 |
2023-08-13 |
Not clear |
| W K M Omeka, D S Liyanage, Thanthrige Thiunuwan Priyathilaka, Hyukjae Kwon, Seongdo Lee, Jehee Le. Characterization of four C1q/TNF-related proteins (CTRPs) from red-lip mullet (Liza haematocheila) and their transcriptional modulation in response to bacterial and pathogen-associated molecular pattern stimuli. Fish & shellfish immunology. vol 84. 2019-03-22. PMID:30287348. |
the structural and evolutionary linkage between tumor necrosis factor (tnf) and the globular c1q (gc1q) domain defines the c1q and tnf-related proteins (ctrps), which are involved in diverse functions such as immune defense, inflammation, apoptosis, autoimmunity, and cell differentiation. |
2019-03-22 |
2023-08-13 |
Not clear |
| Gabriel Virella, Kelsey Wilson, Johnathon Elkes, Samar M Hammad, Hussein A Rajab, Yanchun Li, Charlyne Chassereau, Yan Huang, Maria Lopes-Virell. Immune complexes containing malondialdehyde (MDA) LDL induce apoptosis in human macrophages. Clinical immunology (Orlando, Fla.). vol 187. 2019-03-18. PMID:28689783. |
mda-ldl ic induced higher degrees of apoptosis, higher levels of caspase-3 expression, and increased expression and release of mmp-1 and tnf compared to mda-ldl, oxldl, and oxldl ic. |
2019-03-18 |
2023-08-13 |
human |
| Gabriel Virella, Kelsey Wilson, Johnathon Elkes, Samar M Hammad, Hussein A Rajab, Yanchun Li, Charlyne Chassereau, Yan Huang, Maria Lopes-Virell. Immune complexes containing malondialdehyde (MDA) LDL induce apoptosis in human macrophages. Clinical immunology (Orlando, Fla.). vol 187. 2019-03-18. PMID:28689783. |
in conclusion, the interaction of mda-ldl ic with fcγri triggers macrophage apoptosis and increased expression and release of tnf and mmp-1, which can lead to the rupture of unstable plaques. |
2019-03-18 |
2023-08-13 |
human |
| Verena Wieser, Irina Tsibulak, Christine Degasper, Hannah Welponer, Katharina Leitner, Walther Parson, Alain G Zeimet, Christian Marth, Heidelinde Fieg. Tumor necrosis factor receptor modulator spermatogenesis-associated protein 2 is a novel predictor of outcome in ovarian cancer. Cancer science. vol 110. issue 3. 2019-03-08. PMID:30697874. |
recently, spermatogenesis-associated protein 2 (spata2) was identified as a tnf receptor modulator which is required for tnf-induced inflammation and apoptosis. |
2019-03-08 |
2023-08-13 |
Not clear |
| Stephane J de M Escobar, Genevieve M Fong, Sheila M B Winnischofer, Martin Simone, Lenka Munoz, Joanne M Dennis, Maria Eliane M Rocha, Paul K Wittin. Anti-proliferative and cytotoxic activities of the flavonoid isoliquiritigenin in the human neuroblastoma cell line SH-SY5Y. Chemico-biological interactions. vol 299. 2019-02-04. PMID:30502331. |
isl-mediated cell toxicity did not involve intracellular caspase 3/7 activation, externalization of phosphatidylserine on the cell membrane or stimulation of tnf and il-1β release, all indicating that the flavonoid did not induce apoptosis. |
2019-02-04 |
2023-08-13 |
human |