| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian Hassett, Ena Singh, Ehab Mahgoub, Julie O'Brien, Steven M Vicik, Brian Fitzpatric. Manufacturing history of etanercept (Enbrel mAbs. vol 10. issue 1. 2019-01-07. PMID:29020515. |
based on the key quality attributes of product purity (assessed by hydrophobic interaction chromatography hplc), binding activity (to tnf by elisa), potency (inhibition of tnf-induced apoptosis by cell-based bioassay) and quality (n-linked oligosaccharide map), we show that the integrity of etn ds has remained consistent over time. |
2019-01-07 |
2023-08-13 |
human |
| Rui-Da Xu, Fan Feng, Xiao-Sheng Yu, Zu-De Liu, Li-Feng La. miR-149-5p inhibits cell growth by regulating TWEAK/Fn14/PI3K/AKT pathway and predicts favorable survival in human osteosarcoma. International journal of immunopathology and pharmacology. vol 32. 2018-12-18. PMID:30014744. |
furthermore, we identified tnfrsf12a (tnf receptor superfamily member 12a), also called fibroblast growth factor-inducible 14 (fn14) as a direct target of mir-149, and tnfrsf12a and its ligand tnfsf12 (tnf superfamily member 12), also called tumor necrosis factor-related weak inducer of apoptosis (tweak), were both negatively correlated with mir-149 expression in sarcoma samples. |
2018-12-18 |
2023-08-13 |
human |
| Xu Wu, Shengpeng Wang, Mingxing Li, Anqi Wang, Yangyang Zhou, Peng Li, Yitao Wan. Nanocarriers for TRAIL delivery: driving TRAIL back on track for cancer therapy. Nanoscale. vol 9. issue 37. 2018-12-11. PMID:28914952. |
since its initial identification, tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) has been shown to be capable of selectively inducing apoptosis in cancer cells. |
2018-12-11 |
2023-08-13 |
Not clear |
| Dawei Xu, Wei Zhao, Chengniu Wang, Hao Zhu, Mingqing He, Xinhui Zhu, Wei Liu, Fei Wang, Jianbo Fan, Chu Chen, Daoran Cui, Zhiming Cu. Up-regulation of TNF Receptor-associated Factor 7 after spinal cord injury in rats may have implication for neuronal apoptosis. Neuropeptides. vol 71. 2018-12-11. PMID:30100091. |
up-regulation of tnf receptor-associated factor 7 after spinal cord injury in rats may have implication for neuronal apoptosis. |
2018-12-11 |
2023-08-13 |
rat |
| Xianping Zhu, Lin Wang, Xiao Teng, Qi Chen, Chenshuai Pa. N-Methyl Pyrrolidone (NMP) Alleviates Lipopolysaccharide (LPS)-Induced Inflammatory Injury in Articular Chondrocytes. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-11. PMID:30218608. |
cell viability was measured using cck-8 assay; cell apoptosis was detected using fcm; related protein and mrna expressions were determined using western blot assay and qrt-pcr assay; and inflammatory factors (tumor necrosis factor (tnf)-α, interleukin (il)-1β, il-6, and il-8) productions were measured by performing elisa assay. |
2018-12-11 |
2023-08-13 |
Not clear |
| Andrew T Holdbrooks, Colleen M Britain, Susan L Belli. ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor. The Journal of biological chemistry. vol 293. issue 5. 2018-11-27. PMID:29233887. |
however, upon extended tnf treatment (6-24 h), cells with high st6gal-i levels exhibited resistance to tnf-induced apoptosis, as indicated by morphological evidence of cell death and decreased activation of caspases 8 and 3. |
2018-11-27 |
2023-08-13 |
Not clear |
| Kamal Shaik Fakiruddin, Nadiah Ghazalli, Moon Nian Lim, Zubaidah Zakaria, Syahril Abdulla. Mesenchymal Stem Cell Expressing TRAIL as Targeted Therapy against Sensitised Tumour. International journal of molecular sciences. vol 19. issue 8. 2018-11-21. PMID:30060445. |
engineered mscs expressing tumour necrosis factor (tnf)-related apoptosis inducing ligand (msc-trail) could serve as a platform for an efficient and targeted form of therapy. |
2018-11-21 |
2023-08-13 |
Not clear |
| Shengpeng Wang, Yingqi Xu, Chenyang Li, Hongxun Tao, Anqi Wang, Chenyu Sun, Zhangfeng Zhong, Xu Wu, Peng Li, Yitao Wan. Gambogic acid sensitizes breast cancer cells to TRAIL-induced apoptosis by promoting the crosstalk of extrinsic and intrinsic apoptotic signalings. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 119. 2018-11-19. PMID:29458160. |
due to the ability of tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) to induce cancer cell apoptosis selectively, trail has attracted significant interest in the treatment of cancer. |
2018-11-19 |
2023-08-13 |
Not clear |
| Alicia M Nevárez-Garza, Uziel Castillo-Velázquez, Adolfo Soto-Domínguez, R Montes-de-Oca-Luna, Diana E Zamora-Ávila, Alfredo Wong-González, Luis E Rodríguez-Tova. Quantitative analysis of TNF-α, IL-4, and IL-10 expression, nitric oxide response, and apoptosis in Encephalitozoon cuniculi-infected rabbits. Developmental and comparative immunology. vol 81. 2018-11-08. PMID:29229442. |
the expression of tumor necrosis factor (tnf) -α, interleukin (il) -4 and il-10, as well as apoptosis and nitric oxide (no) levels were measured in the brain and kidneys of immunocompetent and immunosuppressed new zealand white rabbits infected with encephalitozoon cuniculi. |
2018-11-08 |
2023-08-13 |
Not clear |
| Meng Li, Xiang Yang, Shouchuan Wan. PTEN enhances nasal epithelial cell resistance to TNFα‑induced inflammatory injury by limiting mitophagy via repression of the TLR4‑JNK‑Bnip3 pathway. Molecular medicine reports. vol 18. issue 3. 2018-11-08. PMID:30015897. |
in the present study, tumor necrosis factor (tnf)α was used to induce an inflammatory injury and explore the underlying pathogenesis for nasal epithelial cell apoptosis in vitro, with a focus on mitochondrial homeostasis. |
2018-11-08 |
2023-08-13 |
Not clear |
| Sajad Hassanzadeh, Seyed Behnamedin Jameie, Maryam Soleimani, Mona Farhadi, Mahdieh Kerdari, Navid Danae. Coenzyme Q10 Influences on the Levels of TNF-α and IL-10 and the Ratio of Bax/Bcl2 in a Menopausal Rat Model Following Lumbar Spinal Cord Injury. Journal of molecular neuroscience : MN. vol 65. issue 2. 2018-11-05. PMID:29948851. |
we hypothesized that in the absence of female gonadal steroids, which provide protection following an sci, coq10 could modulate the expression of cytokines, such as tumor necrosis factor (tnf)-α and interleukin (il)-10, besides aquaporin-4 (aqp4) water channels in the cns, which participate in neuroinflammation, as well as the bax and bcl2 proteins that are involved in apoptosis at the site of injury. |
2018-11-05 |
2023-08-13 |
rat |
| Yuguang Wang, Vikki M Abrahams, Guoyang Luo, Nicholas G Norwitz, Victoria V Snegovskikh, Shu-Wing Ng, Errol R Norwit. Progesterone Inhibits Apoptosis in Fetal Membranes by Altering Expression of Both Pro- and Antiapoptotic Proteins. Reproductive sciences (Thousand Oaks, Calif.). vol 25. issue 8. 2018-11-02. PMID:29463188. |
we have previously shown that progesterone inhibits basal and tumor necrosis factor (tnf) α-induced apoptosis in an explant model of human fetal membranes. |
2018-11-02 |
2023-08-13 |
human |
| Zidan Jin, Jie Yao, Nianlin Xie, Libo Cai, Shuai Qi, Zhan Zhang, Bai L. Melittin Constrains the Expression of Identified Key Genes Associated with Bladder Cancer. Journal of immunology research. vol 2018. 2018-10-11. PMID:29854840. |
based on the analysis of articles retrieved in the pubmed database, we found that melittin could induce apoptosis and constrain the progression of tumor cells as a result of regulating critical cancer-related signaling pathways, such as pi3k-akt and tnf signaling pathways. |
2018-10-11 |
2023-08-13 |
Not clear |
| Muzi Zhang, Ming Li, Rixin Wang, Yunxia Qia. Effects of acute ammonia toxicity on oxidative stress, immune response and apoptosis of juvenile yellow catfish Pelteobagrus fulvidraco and the mitigation of exogenous taurine. Fish & shellfish immunology. vol 79. 2018-10-02. PMID:29802884. |
in addition, ammonia poisoning could induce up-regulation of antioxidant enzymes (cu/zn-sod, cat, gpx and gr), inflammatory cytokines (tnf, il-1 and il-8) and apoptosis (p53, bax, caspase 3 and caspase 9) genes transcription, suggesting that cell apoptotic and inflammation may relate to oxidative stress. |
2018-10-02 |
2023-08-13 |
cat |
| Hao Lin, Yifan Wang, Haoqiang Lai, Xiaoling Li, Tianfeng Che. Iron(II)-Polypyridyl Complexes Inhibit the Growth of Glioblastoma Tumor and Enhance TRAIL-Induced Cell Apoptosis. Chemistry, an Asian journal. vol 13. issue 18. 2018-10-01. PMID:29963768. |
a promising cancer-targeting agent for the induction of apoptosis in tumor necrosis factor (tnf) proteins, the tnf-related apoptosis-inducing ligand (trail) ligand, has found limited applications in the treatment of cancer cells, owing to its resistance by cancer cell lines. |
2018-10-01 |
2023-08-13 |
mouse |
| Burcu Kasap, Ümmühani Özel Türkçü, Eren Akbaba, Behiye Sarıyıldız, Mert Küçük, Nilgün Öztürk Turhan, Gökalp Öner, Aykut Özca. The predictive role of sTWEAK levels in pregnant women with first-trimester vaginal bleeding The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. vol 31. issue 13. 2018-09-26. PMID:28462593. |
the predictive role of stweak levels in pregnant women with first-trimester vaginal bleeding to investigate the relationships of tnf-related weak inducer of apoptosis (stweak), a cytokine related to the tnf superfamily, its newly described soluble receptor scd163, and the stweak/scd163 ratio with perinatal outcomes in women with first-trimester vaginal bleeding. |
2018-09-26 |
2023-08-13 |
Not clear |
| Zhiying Qi, Lirong Yin, Yanying Xu, Fang Wan. Pegylated liposomal‑paclitaxel induces ovarian cancer cell apoptosis via TNF‑induced ERK/AKT signaling pathway. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29620264. |
the observations of the present study revealed that pl‑ptx induced ovarian cell apoptosis via the tnf‑dependent pathway, which was significantly inhibited with the employment of antibodies against tnf. |
2018-09-26 |
2023-08-13 |
mouse |
| Shanshan Shen, Chunyang Li, Mingjia Dai, Xuebing Ya. Induction of Huh‑7 cell apoptosis by HCV core proteins via CK1α‑p53‑Bid signaling pathway. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29620268. |
hepatitis c virus (hcv)‑infected liver cells sensitize host cells to tumor necrosis factor (tnf)‑related apoptosis‑inducing ligand (trail)‑induced cell apoptosis; however, the precise mechanisms are unknown. |
2018-09-26 |
2023-08-13 |
human |
| Chunlei Wan, Xiaozhen Liu, Baoling Bai, Haiyan Cao, Huili Li, Qin Zhan. Regulation of the expression of tumor necrosis factor‑related genes by abnormal histone H3K27 acetylation: Implications for neural tube defects. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29693124. |
among 84 key genes involved in programmed cell death, 13 genes, including tumor necrosis factor (tnf), annexin a5, apoptosis inhibitor 5, bcl2‑associated athanogene 3, baculoviral iap repeat‑containing 3, caspase (casp)12, casp4, casp8, lymphotoxin β receptor, nlr family, apoptosis inhibitory protein 2, tnf receptor superfamily (tnfrsf)1a, tnf superfamily (tnfs)f10 and tnfsf12, were downregulated, whereas nucleolar protein 3 was upregulated in the ra‑induced ntd mice. |
2018-09-26 |
2023-08-13 |
mouse |
| Shaowen Zhu, Wanfu Wei, Zhiwei Liu, Yang Yang, Haobo Ji. Tanshinone‑IIA attenuates the deleterious effects of oxidative stress in osteoporosis through the NF‑κB signaling pathway. Molecular medicine reports. vol 17. issue 5. 2018-09-21. PMID:29568934. |
in addition, tan‑iia inhibited the activation of nuclear factor (nf)‑κb and its target genes, tumor necrosis factor (tnf)‑α, inducible nitric oxide synthase and cyclooxygenase 2, and increased the levels of tnf receptor‑associated factor 1 and inhibitor of apoptosis protein‑1/2 in the osteocytes. |
2018-09-21 |
2023-08-13 |
mouse |