| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Yu Liang, Wei Huang, Qing Chang, Yan-Qiang Ho. ShDcR3 sensitizes TRAIL-resistant HCC cells by inducing caspase-dependent apoptosis while suppressing NF-κB dependent cFLIPL expression. PloS one. vol 13. issue 2. 2018-03-13. PMID:29444104. |
evidence has shown that most hepatocellular carcinoma (hcc) cells are resistant to tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-mediated apoptosis. |
2018-03-13 |
2023-08-13 |
Not clear |
| Lili Pei, Weijing Zhang, Jia Lu, Fang Huang, Qianqian Cao, Wenhua Re. [Molecular cloning, in vitro expression and bioactivity of TRAIL (TNFSF10) gene from finless porpoises]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 32. issue 5. 2018-03-12. PMID:29019199. |
to construct soluble tnf related apoptosis inducing ligand (trail) expression system and investigate the effect of the expression product on tumor cell. |
2018-03-12 |
2023-08-13 |
Not clear |
| Ximena Terra, David Gómez, Jacinto García-Lorenzo, Joan Carles Flores, Enric Figuerola, Josefina Mora, Matilde R Chacón, Miquel Quer, Mercedes Camacho, Xavier León, Francesc Xavier Avilés-Jurad. External validation of sTWEAK as a prognostic noninvasive biomarker for head and neck squamous cell carcinoma. Head & neck. vol 38 Suppl 1. 2018-02-28. PMID:26676381. |
the main purpose of this study was to validate the prognostic significance of tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) in head and neck squamous cell carcinoma (hnscc) using an independent cohort. |
2018-02-28 |
2023-08-13 |
Not clear |
| Jürgen Fritsch, Ricarda Fickers, Jan Klawitter, Vinzenz Särchen, Philipp Zingler, Dieter Adam, Ottmar Janssen, Eberhard Krause, Stefan Schütz. TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death. Oncotarget. vol 7. issue 46. 2018-02-26. PMID:27716614. |
during apoptosis induction by tnf, the extrinsic and intrinsic apoptosis pathways converge at the lysosomal-mitochondrial interface. |
2018-02-26 |
2023-08-13 |
Not clear |
| Julien Beyrath, Neila Chekkat, Cristian R Smulski, Caterina M Lombardo, Marie-Charlotte Lechner, Cendrine Seguin, Marion Decossas, Maria Vittoria Spanedda, Benoît Frisch, Gilles Guichard, Sylvie Fourne. Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels. Oncotarget. vol 7. issue 40. 2018-02-22. PMID:27409341. |
dr4 (death receptor 4) and dr5 (death receptor 5) are two potential targets for cancer therapy due to their ability to trigger apoptosis of cancer cells, but not normal ones, when activated by their cognate ligand trail (tnf related apoptosis-inducing ligand). |
2018-02-22 |
2023-08-13 |
Not clear |
| Bart Tummers, Douglas R Gree. Caspase-8: regulating life and death. Immunological reviews. vol 277. issue 1. 2018-02-15. PMID:28462525. |
of the two best understood pathways of apoptosis, the extrinsic and intrinsic (mitochondrial) pathways, the former is induced by the ligation of death receptors, a subset of the tnf receptor (tnfr) superfamily. |
2018-02-15 |
2023-08-13 |
mouse |
| Jason C Lim, Kang I Ko, Marcelo Mattos, Miao Fang, Citong Zhang, Daniel Feinberg, Hisham Sindi, Shuai Li, Jazia Alblowi, Rayyan A Kayal, Thomas A Einhorn, Louis C Gerstenfeld, Dana T Grave. TNFα contributes to diabetes impaired angiogenesis in fracture healing. Bone. vol 99. 2018-02-12. PMID:28285015. |
in addition, the tnf inhibitor rescued the negative effect of diabetes on endothelial cell proliferation and endothelial cell apoptosis. |
2018-02-12 |
2023-08-13 |
mouse |
| Adeeb Derakhshan, Zhong Chen, Carter Van Wae. Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 23. issue 6. 2018-02-08. PMID:28039268. |
such alterations are particularly common in head and neck squamous cell carcinomas (hnscc), which frequently display amplification and overexpression of the fas-associated via death domain (fadd) and inhibitor of apoptosis proteins (iap) that complex with members of the tnf receptor family. |
2018-02-08 |
2023-08-13 |
Not clear |
| Seong Hye Park, Dae-Hee Lee, Jung Lim Kim, Bo Ram Kim, Yoo Jin Na, Min Jee Jo, Yoon A Jeong, Suk-Young Lee, Sun Il Lee, Yong Yook Lee, Sang Cheul O. Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells. Oncotarget. vol 7. issue 37. 2018-01-30. PMID:27517746. |
in this study, we show that subtoxic doses of metformin effectively sensitize human colorectal cancer (crc) cells to tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail), which induces apoptosis. |
2018-01-30 |
2023-08-13 |
human |
| Jie Xu, Yan Sun, Yize Li, Gordon Ruthel, Susan R Weiss, Arjun Raj, Daniel Beiting, Carolina B Lópe. Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence. Nature communications. vol 8. issue 1. 2018-01-24. PMID:28986577. |
we find that during sendai virus infection this phenotype results from dvgs stimulating a mitochondrial antiviral-signaling (mavs)-mediated tnf response that drives apoptosis of highly infected cells while extending the survival of cells enriched in dvgs. |
2018-01-24 |
2023-08-13 |
Not clear |
| Maria C Tanzer, Nufail Khan, James A Rickard, Nima Etemadi, Najoua Lalaoui, Sukhdeep Kaur Spall, Joanne M Hildebrand, David Segal, Maria Miasari, Diep Chau, WendyWei-Lynn Wong, Mark McKinlay, Srinivas K Chunduru, Christopher A Benetatos, Stephen M Condon, James E Vince, Marco J Herold, John Silk. Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways. Cell death and differentiation. vol 24. issue 3. 2018-01-19. PMID:28106882. |
peptido-mimetic inhibitor of apoptosis protein (iap) antagonists (smac mimetics (sms)) can kill tumour cells by depleting endogenous iaps and thereby inducing tumour necrosis factor (tnf) production. |
2018-01-19 |
2023-08-13 |
Not clear |
| K Newton, D L Dugger, A Maltzman, J M Greve, M Hedehus, B Martin-McNulty, R A D Carano, T C Cao, N van Bruggen, L Bernstein, W P Lee, X Wu, J DeVoss, J Zhang, S Jeet, I Peng, B S McKenzie, M Roose-Girma, P Caplazi, L Diehl, J D Webster, D Vuci. RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury. Cell death and differentiation. vol 23. issue 9. 2018-01-16. PMID:27177019. |
combined loss of ripk3 (or mlkl) and caspase-8 largely prevented the cytokine storm, hypothermia, and morbidity induced by tnf, suggesting that the triggering event in this model is a combination of apoptosis and necroptosis. |
2018-01-16 |
2023-08-13 |
mouse |
| O H Minchenko, D O Tsymbal, D O Minchenko, O O Ratushn. The role of the TNF receptors and apoptosis inducing ligands in tumor growth. Ukrainian biochemical journal. vol 88. issue 5. 2018-01-16. PMID:29235796. |
the role of the tnf receptors and apoptosis inducing ligands in tumor growth. |
2018-01-16 |
2023-08-13 |
Not clear |
| O H Minchenko, D O Tsymbal, D O Minchenko, O O Ratushn. The role of the TNF receptors and apoptosis inducing ligands in tumor growth. Ukrainian biochemical journal. vol 88. issue 5. 2018-01-16. PMID:29235796. |
tumor necrosis factor (tnf) superfamily receptors and tnf apoptosis inducing ligands play an important role in the realization of tnf function and control tumor growth. |
2018-01-16 |
2023-08-13 |
Not clear |
| O H Minchenko, D O Tsymbal, D O Minchenko, O O Ratushn. The role of the TNF receptors and apoptosis inducing ligands in tumor growth. Ukrainian biochemical journal. vol 88. issue 5. 2018-01-16. PMID:29235796. |
furthermore, the inhibition of ire1 (inositol requiring enzyme-1), which is a central mediator of endoplasmic reticulum stress sand mainly responsible for cell proliferation and apoptosis, leads to suppression of tumor growth through specific changes in the expression of genes encoding transcription factors, tumor suppressors, angiogenesis and apoptosis related proteins, including tnf superfamily receptors and tnf apoptosis inducing ligands. |
2018-01-16 |
2023-08-13 |
Not clear |
| O H Minchenko, D O Tsymbal, D O Minchenko, O O Ratushn. The role of the TNF receptors and apoptosis inducing ligands in tumor growth. Ukrainian biochemical journal. vol 88. issue 5. 2018-01-16. PMID:29235796. |
therefore, changes in the expression level of tnf-related genes encoding tnf superfamily receptors and apoptosis inducing ligands possibly reflect metabolic reprogramming of cancer cells upon inhibition of ire1-mediated endoplasmic reticulum stress signaling and correlate with suppression of glioma cell proliferation. |
2018-01-16 |
2023-08-13 |
Not clear |
| Sudeshna Goswami, Neelam Sharma-Wali. Osteoprotegerin rich tumor microenvironment: implications in breast cancer. Oncotarget. vol 7. issue 27. 2018-01-15. PMID:27072583. |
osteoprotegerin (opg) is a soluble decoy receptor for tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail). |
2018-01-15 |
2023-08-13 |
Not clear |
| T Chen, Z-P Guo, L-X Fu, N Cao, S Qi. Anti-TWEAK monoclonal antibodies reduce vascular damage and leucocyte infiltration in a mouse model of cutaneous reverse passive Arthus reaction. Clinical and experimental dermatology. vol 41. issue 8. 2018-01-12. PMID:27753135. |
tumour necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is a pro-inflammatory cytokine, which is closely associated with the pathogenesis of various types of cutaneous vasculitis (cv). |
2018-01-12 |
2023-08-13 |
mouse |
| H Chung, A Vilaysane, A Lau, M Stahl, V Morampudi, A Bondzi-Simpson, J M Platnich, N A Bracey, M-C French, P L Beck, J Chun, B A Vallance, D A Muruv. NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis. Cell death and differentiation. vol 23. issue 8. 2018-01-08. PMID:26891693. |
primary mouse tubular epithelial cells (tec) lacking nlrp3 displayed reduced apoptosis downstream of the tumor necrosis factor (tnf) receptor and cd95. |
2018-01-08 |
2023-08-13 |
mouse |
| Qing Xu, Siriporn Jitkaew, Swati Choksi, Chamila Kadigamuwa, Jianhui Qu, Moran Choe, Jonathan Jang, Chengyu Liu, Zheng-Gang Li. The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited. Nature communications. vol 8. issue 1. 2018-01-08. PMID:28871172. |
tumor necrosis factor (tnf) has a critical role in diverse cellular events including inflammation, apoptosis and necroptosis through different signaling complexes. |
2018-01-08 |
2023-08-13 |
Not clear |