| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lance W Peterson, Naomi H Philip, Christopher P Dillon, John Bertin, Peter J Gough, Douglas R Green, Igor E Brodsk. Cell-Extrinsic TNF Collaborates with TRIF Signaling To Promote Yersinia-Induced Apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 197. issue 10. 2017-08-11. PMID:27733552. |
these data demonstrate an important role for collaboration between tnf and pattern recognition receptor signals in promoting maximal apoptosis during bacterial infection, and demonstrate that heterogeneity in virulence factor injection and cellular responses play an important role in promoting anti-yersinia immune defense. |
2017-08-11 |
2023-08-13 |
mouse |
| Alison Roos, Harshil D Dhruv, Ian T Mathews, Landon J Inge, Serdar Tuncali, Lauren K Hartman, Donald Chow, Nghia Millard, Holly H Yin, Jean Kloss, Joseph C Loftus, Jeffrey A Winkles, Michael E Berens, Nhan L Tra. Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells. Oncotarget. vol 8. issue 7. 2017-08-11. PMID:28103571. |
tumor necrosis factor-like weak inducer of apoptosis (tweak), a member of the tumor necrosis factor (tnf) superfamily, can stimulate glioma cell invasion and survival via binding to fibroblast growth factor-inducible 14 (fn14) and subsequent activation of the transcription factor nf-κb. |
2017-08-11 |
2023-08-13 |
Not clear |
| Marta Chesi, Noweeda N Mirza, Victoria M Garbitt, Meaghen E Sharik, Amylou C Dueck, Yan W Asmann, Ilseyar Akhmetzyanova, Heidi E Kosiorek, Arianna Calcinotto, Daniel L Riggs, Niamh Keane, Gregory J Ahmann, Kevin M Morrison, Rafael Fonseca, Martha Q Lacy, David Dingli, Shaji K Kumar, Sikander Ailawadhi, Angela Dispenzieri, Francis Buadi, Morie A Gertz, Craig B Reeder, Yi Lin, Asher A Chanan-Khan, A Keith Stewart, David Fooksman, P Leif Bergsage. IAP antagonists induce anti-tumor immunity in multiple myeloma. Nature medicine. vol 22. issue 12. 2017-08-08. PMID:27841872. |
consequently, small-molecule iap antagonists, such as lcl161, have entered clinical trials for their ability to induce tumor necrosis factor (tnf)-mediated apoptosis of cancer cells. |
2017-08-08 |
2023-08-13 |
mouse |
| Sarah Dawson, Allan Lawri. From bones to blood pressure, developing novel biologic approaches targeting the osteoprotegein pathway for pulmonary vascular disease. Pharmacology & therapeutics. vol 169. 2017-08-07. PMID:27373854. |
opg has subsequently been shown to also be a decoy receptor tnf related apoptosis inducing-ligand (tnfsf10, trail, apo2l). |
2017-08-07 |
2023-08-13 |
human |
| Kate Welsh, Snezana Milutinovic, Robert J Ardecky, Marcos Gonzalez-Lopez, Santhi Reddy Ganji, Peter Teriete, Darren Finlay, Stefan Riedl, Shu-Ichi Matsuzawa, Clemencia Pinilla, Richard Houghten, Kristiina Vuori, John C Reed, Nicholas D P Cosfor. Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis. PloS one. vol 11. issue 9. 2017-08-02. PMID:27617834. |
characterization of potent smac mimetics that sensitize cancer cells to tnf family-induced apoptosis. |
2017-08-02 |
2023-08-13 |
human |
| Kate Welsh, Snezana Milutinovic, Robert J Ardecky, Marcos Gonzalez-Lopez, Santhi Reddy Ganji, Peter Teriete, Darren Finlay, Stefan Riedl, Shu-Ichi Matsuzawa, Clemencia Pinilla, Richard Houghten, Kristiina Vuori, John C Reed, Nicholas D P Cosfor. Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis. PloS one. vol 11. issue 9. 2017-08-02. PMID:27617834. |
members of the inhibitor of apoptosis (iap) protein family suppress apoptosis within tumor cells, particularly in the context of immune cell-mediated killing by the tumor necrosis factor (tnf) superfamily cytokines. |
2017-08-02 |
2023-08-13 |
human |
| Kate Welsh, Snezana Milutinovic, Robert J Ardecky, Marcos Gonzalez-Lopez, Santhi Reddy Ganji, Peter Teriete, Darren Finlay, Stefan Riedl, Shu-Ichi Matsuzawa, Clemencia Pinilla, Richard Houghten, Kristiina Vuori, John C Reed, Nicholas D P Cosfor. Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis. PloS one. vol 11. issue 9. 2017-08-02. PMID:27617834. |
to further understand the cellular mechanisms of smac mimetics, we focused on iap family members ciap1 and ciap2, which are recruited to tnf receptor complexes where they support cell survival through nf-κb activation while suppressing apoptosis by preventing caspase activation. |
2017-08-02 |
2023-08-13 |
human |
| Aaron Olsen, Yong Chen, Qingzhou Ji, Guofeng Zhu, Aruna Dharshan De Silva, Catherine Vilchèze, Torin Weisbrod, Weimin Li, Jiayong Xu, Michelle Larsen, Jinghang Zhang, Steven A Porcelli, William R Jacobs, John Cha. Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines. mBio. vol 7. issue 3. 2017-07-17. PMID:27247233. |
tumor necrosis factor alpha (tnf) plays a critical role in the control of mycobacterium tuberculosis, in part by augmenting t cell responses through promoting macrophage phagolysosomal fusion (thereby optimizing cd4(+) t cell immunity by enhancing antigen presentation) and apoptosis (a process that can lead to cross-priming of cd8(+) t cells). |
2017-07-17 |
2023-08-13 |
mouse |
| Snehlata Kumari, Manolis Pasparaki. Epithelial Cell Death and Inflammation in Skin. Current topics in microbiology and immunology. vol 403. 2017-07-10. PMID:26275873. |
studies in mouse models showed that sensitization of keratinocytes to apoptosis or necroptosis triggered by tnf and other stimuli causes severe chronic inflammatory skin lesions. |
2017-07-10 |
2023-08-13 |
mouse |
| J G Perez, N L Tran, M G Rosenblum, C S Schneider, N P Connolly, A J Kim, G F Woodworth, J A Winkle. The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics. Oncogene. vol 35. issue 17. 2017-06-23. PMID:26300004. |
fibroblast growth factor-inducible 14 (fn14; tnfrsf12a) is the cell surface receptor for the tumor necrosis factor (tnf) family member tnf-like weak inducer of apoptosis (tweak). |
2017-06-23 |
2023-08-13 |
Not clear |
| Bin Li, Meng Cong, Yanan Zhu, Ying Xiong, Wenyi Jin, Yang Wan, Yunjiao Zhou, Ying Ao, Hui Wan. Indole-3-Carbinol Induces Apoptosis of Hepatic Stellate Cells through K63 De-Ubiquitination of RIP1 in Rats. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 41. issue 4. 2017-06-21. PMID:28395284. |
k63 de-ubiquitinated receptor-interacting protein (rip)1 promotes apoptosis in tumor necrosis factor (tnf)-α signaling pathway. |
2017-06-21 |
2023-08-13 |
rat |
| Anne T Schneider, Jérémie Gautheron, Maria Feoktistova, Christoph Roderburg, Sven H Loosen, Sanchari Roy, Fabian Benz, Peter Schemmer, Markus W Büchler, Ueli Nachbur, Ulf P Neumann, Rene Tolba, Mark Luedde, Jessica Zucman-Rossi, Diana Panayotova-Dimitrova, Martin Leverkus, Christian Preisinger, Frank Tacke, Christian Trautwein, Thomas Longerich, Mihael Vucur, Tom Luedd. RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer. Cancer cell. vol 31. issue 1. 2017-06-13. PMID:28017612. |
ablation of ripk1 in liver parenchymal cells (lpc) did not cause a spontaneous phenotype, but led to tumor necrosis factor (tnf)-dependent hepatocyte apoptosis and liver injury without affecting inducible nuclear factor κb (nf-κb) activation. |
2017-06-13 |
2023-08-13 |
human |
| Collins Waguia Kontchou, Tina Tzivelekidis, Ian E Gentle, Georg Häcke. Infection of epithelial cells with Chlamydia trachomatis inhibits TNF-induced apoptosis at the level of receptor internalization while leaving non-apoptotic TNF-signalling intact. Cellular microbiology. vol 18. issue 11. 2017-06-05. PMID:27062399. |
the pro-apoptotic signal of tnf involves the activation of caspase-8 and is controlled by inhibitor of apoptosis proteins. |
2017-06-05 |
2023-08-13 |
Not clear |
| Collins Waguia Kontchou, Tina Tzivelekidis, Ian E Gentle, Georg Häcke. Infection of epithelial cells with Chlamydia trachomatis inhibits TNF-induced apoptosis at the level of receptor internalization while leaving non-apoptotic TNF-signalling intact. Cellular microbiology. vol 18. issue 11. 2017-06-05. PMID:27062399. |
these results identify a dichotomy of tnf signalling in c. trachomatis-infected cells: apoptosis is blocked at the internalization of the tnf receptor, but non-apoptotic signalling through this receptor remains intact, permitting a response to this cytokine at sites of infection. |
2017-06-05 |
2023-08-13 |
Not clear |
| Yuchen Zhang, Junjun Cheng, Junmeng Zhang, Xiaofan Wu, Fang Chen, Xuejun Ren, Yunlong Wang, Quan Li, Yu L. Proteasome inhibitor PS-341 limits macrophage necroptosis by promoting cIAPs-mediated inhibition of RIP1 and RIP3 activation. Biochemical and biophysical research communications. vol 477. issue 4. 2017-05-15. PMID:27363341. |
the results showed that ps-341 could not induce macrophage apoptosis or promote tnf-induced macrophage apoptosis, on the other hand, ps-341 could significantly inhibit macrophage necroptosis induced by tnf and pan-caspase inhibitor z-vad treatment. |
2017-05-15 |
2023-08-13 |
Not clear |
| Minami Kumazaki, Haruka Shinohara, Kohei Taniguchi, Tomoaki Takai, Yuki Kuranaga, Nobuhiko Sugito, Yukihiro Aka. Perturbation of the Warburg effect increases the sensitivity of cancer cells to TRAIL-induced cell death. Experimental cell research. vol 347. issue 1. 2017-05-15. PMID:27453209. |
tumor necrosis-factor (tnf)-related apoptosis-inducing ligand (trail) is a member of the tnf-superfamily that selectively induces apoptosis through death receptors (drs) 4 and/ or dr5 in cancer cells, without affecting normal cells. |
2017-05-15 |
2023-08-13 |
human |
| Boren Lin, Da Xu, Douglas W Leama. X-linked inhibitor of apoptosis-associated factor 1 regulates TNF receptor 1 complex stability. FEBS letters. vol 590. issue 23. 2017-05-10. PMID:27768232. |
x-linked inhibitor of apoptosis (xiap)-associated factor 1 (xaf1) is a cytokine-regulated, tumor necrosis factor (tnf) receptor-associated factor (traf) domain-containing protein that has a poorly defined cellular function. |
2017-05-10 |
2023-08-13 |
Not clear |
| Urmi Ro. Structural biology of tumor necrosis factor demonstrated for undergraduates instruction by computer simulation. Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology. vol 44. issue 3. 2017-05-08. PMID:26638199. |
upon binding with tnfr-1, the tnf can activate the nuclear factor kappa b (nf-κb), eventually resulting in apoptosis or cell death. |
2017-05-08 |
2023-08-13 |
human |
| Zhengyuan Xie, Zhihua Xiao, Fenfen Wan. Hepatitis C Virus Nonstructural 5A Protein (HCV-NS5A) Inhibits Hepatocyte Apoptosis through the NF-κb/miR-503/bcl-2 Pathway. Molecules and cells. vol 40. issue 3. 2017-05-05. PMID:28343379. |
to analyse the influence of ns5a on apoptosis, we established an hep-ns5a cell line (hepg2 cells that stably express ns5a) and induced apoptosis using tumour necrosis factor (tnf)-α. |
2017-05-05 |
2023-08-13 |
human |
| Jung-Chin Chang, Ulrich Beuers, Ronald P J Oude Elferin. The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis. Digestive diseases (Basel, Switzerland). vol 35. issue 3. 2017-05-01. PMID:28249274. |
soluble adenylyl cyclase (sac; adcy10) is an evolutionarily conserved bicarbonate sensor that regulates apoptosis, barrier function and tnf signaling. |
2017-05-01 |
2023-08-13 |
Not clear |