| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minami Kumazaki, Haruka Shinohara, Kohei Taniguchi, Tomoaki Takai, Yuki Kuranaga, Nobuhiko Sugito, Yukihiro Aka. Perturbation of the Warburg effect increases the sensitivity of cancer cells to TRAIL-induced cell death. Experimental cell research. vol 347. issue 1. 2017-05-15. PMID:27453209. |
tumor necrosis-factor (tnf)-related apoptosis-inducing ligand (trail) is a member of the tnf-superfamily that selectively induces apoptosis through death receptors (drs) 4 and/ or dr5 in cancer cells, without affecting normal cells. |
2017-05-15 |
2023-08-13 |
human |
| Boren Lin, Da Xu, Douglas W Leama. X-linked inhibitor of apoptosis-associated factor 1 regulates TNF receptor 1 complex stability. FEBS letters. vol 590. issue 23. 2017-05-10. PMID:27768232. |
x-linked inhibitor of apoptosis (xiap)-associated factor 1 (xaf1) is a cytokine-regulated, tumor necrosis factor (tnf) receptor-associated factor (traf) domain-containing protein that has a poorly defined cellular function. |
2017-05-10 |
2023-08-13 |
Not clear |
| Urmi Ro. Structural biology of tumor necrosis factor demonstrated for undergraduates instruction by computer simulation. Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology. vol 44. issue 3. 2017-05-08. PMID:26638199. |
upon binding with tnfr-1, the tnf can activate the nuclear factor kappa b (nf-κb), eventually resulting in apoptosis or cell death. |
2017-05-08 |
2023-08-13 |
human |
| Zhengyuan Xie, Zhihua Xiao, Fenfen Wan. Hepatitis C Virus Nonstructural 5A Protein (HCV-NS5A) Inhibits Hepatocyte Apoptosis through the NF-κb/miR-503/bcl-2 Pathway. Molecules and cells. vol 40. issue 3. 2017-05-05. PMID:28343379. |
to analyse the influence of ns5a on apoptosis, we established an hep-ns5a cell line (hepg2 cells that stably express ns5a) and induced apoptosis using tumour necrosis factor (tnf)-α. |
2017-05-05 |
2023-08-13 |
human |
| Jung-Chin Chang, Ulrich Beuers, Ronald P J Oude Elferin. The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis. Digestive diseases (Basel, Switzerland). vol 35. issue 3. 2017-05-01. PMID:28249274. |
soluble adenylyl cyclase (sac; adcy10) is an evolutionarily conserved bicarbonate sensor that regulates apoptosis, barrier function and tnf signaling. |
2017-05-01 |
2023-08-13 |
Not clear |
| Sandra M McLachlan, Sylvie Lesage, Roxanne Collin, Bianca Banuelos, Holly A Aliesky, Basil Rapopor. Genes Outside the Major Histocompatibility Complex Locus Are Linked to the Development of Thyroid Autoantibodies and Thyroiditis in NOD.H2h4 Mice. Endocrinology. vol 158. issue 4. 2017-04-28. PMID:28323998. |
this locus includes mhc region genes from b10.a(4r) mice (such as i-ak and tnf, the latter involved in thyrocyte apoptosis) and genes from nod mice such as satb1, which most likely plays a role in immune tolerance. |
2017-04-28 |
2023-08-13 |
mouse |
| Ulrike Billmeier, Walburga Dieterich, Markus F Neurath, Raja Atrey. Molecular mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel diseases. World journal of gastroenterology. vol 22. issue 42. 2017-04-24. PMID:27895418. |
apart from neutralization of tnf, influence on the intestinal barrier function, induction of apoptosis in mucosal immune cells, formation of regulatory macrophages as well as other immune modulating properties have been discussed as central features. |
2017-04-24 |
2023-08-13 |
Not clear |
| Xiaoning Feng, Jingjin Jiang, Shaohua Shi, Haiyang Xie, Lin Zhou, Shusen Zhen. Knockdown of miR-25 increases the sensitivity of liver cancer stem cells to TRAIL-induced apoptosis via PTEN/PI3K/Akt/Bad signaling pathway. International journal of oncology. vol 49. issue 6. 2017-04-17. PMID:27840896. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is considered as a promising anticancer agent, it induced apoptosis in cancer cells selectively without damaging the normal tissue cells. |
2017-04-17 |
2023-08-13 |
Not clear |
| Yu-Ping Liu, Chong-Ming Yuan, Shuai-Gong Zhang, Qing-Hai Hao, Ming-Ming Wang, Zhong Zhang, Qian Meng, Ming Li, Yue-Dong Ha. TWEAK/Fn14 signaling: a promising target in intervertebral disc degeneration. Histology and histopathology. vol 31. issue 9. 2017-04-14. PMID:26907852. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is a potent chemoattractant cytokine with various biological functions, such as stimulation of angiogenesis, induction of proinflammatory cytokines, regulation of cellular proliferation and apoptosis. |
2017-04-14 |
2023-08-13 |
Not clear |
| L Manta, N Suciu, O Toader, R M Purcărea, A Constantin, F Pop. The etiopathogenesis of uterine fibromatosis. Journal of medicine and life. vol 9. issue 1. 2017-04-07. PMID:27974911. |
proliferative effects of estrogen and progesterone may be exercised through proinflammatory factors (tnf alpha), growth factors (igf1, igf2, tgfbeta3 and betafgf) or inhibitors of apoptosis (p53 suppression). |
2017-04-07 |
2023-08-13 |
Not clear |
| Xiuqin Wang, Yanqing Guo, Chunyan Wang, Hong Yu, Xiuxiang Yu, Hongbo Y. MicroRNA-142-3p Inhibits Chondrocyte Apoptosis and Inflammation in Osteoarthritis by Targeting HMGB1. Inflammation. vol 39. issue 5. 2017-03-30. PMID:27447821. |
moreover, the overexpression of mir-142-3p significantly inhibited cell apoptosis, nuclear factor (nf)-kb, and the production of proinflammatory cytokines, including interleukin (il)-1, il-6, and tumor necrosis factor (tnf)-α induced by lps. |
2017-03-30 |
2023-08-13 |
mouse |
| Xinran Ji, Yiling Zhang, Lihai Zhang, Hua Chen, Ye Peng, Peifu Tan. Inhibition of p21-Activated Kinase 1 by IPA-3 Promotes Locomotor Recovery After Spinal Cord Injury in Mice. Spine. vol 41. issue 11. 2017-03-20. PMID:26863260. |
expression of matrix metalloproteinase (mmp)-2 and mmp-9, production of tumor necrosis factors (tnf)-α and interleukin (il)-1β, tissue edema, blood-spinal cord barrier penetrability, neural cell apoptosis, and neurological function recovery were measured. |
2017-03-20 |
2023-08-13 |
mouse |
| b' Yves Claude Guillaume, Lydie Lethier, Claire Andr\\xc3\\xa. An HPLC method associated with a thermodynamic analysis to compare the binding of TRAIL and its nanovectorized form to death receptors DR4 and DR5 and their relationship to cytotoxicity. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1036-1037. 2017-03-17. PMID:27750195.' |
trail is a member of the tnf family of cytokines which induces apoptosis of cancer cells via its binding to its cognate receptors, dr5 a high affinity site and dr4 a site of low affinity. |
2017-03-17 |
2023-08-13 |
human |
| Giovanni Luca Gravina, Francesco Marampon, Patrizia Sanità, Andrea Mancini, Alessandro Colapietro, Luca Scarsella, Ana Jitariuc, Leda Biordi, Corrado Ficorella, Claudio Festucci. Increased expression and activity of p75NTR are crucial events in azacitidine-induced cell death in prostate cancer. Oncology reports. vol 36. issue 1. 2017-03-13. PMID:27222100. |
the high affinity nerve growth factor (ngf) ngf receptor, p75ntr, is a member of the tumor necrosis factor (tnf) receptor superfamily that shares a conserved intracellular death domain capable of inducing apoptosis and suppressing growth in prostate epithelial cells. |
2017-03-13 |
2023-08-13 |
Not clear |
| Reza Badalzadeh, Ako Azimi, Alireza Alihemmati, Bahman Yousef. Chronic type-I diabetes could not impede the anti-inflammatory and anti-apoptotic effects of combined postconditioning with ischemia and cyclosporine A in myocardial reperfusion injury. Journal of physiology and biochemistry. vol 73. issue 1. 2017-03-09. PMID:27771871. |
the concentration of creatine kinase (ck), tumor necrosis factor (tnf)-α, interleukin (il)-1β, and il-6 were determined; the levels of total and phosphorylated glycogen synthase kinase 3 beta (p-gsk3β) and b-cell lymphoma 2 (bcl-2) were quantified by western blotting, and the rate of apoptosis was assessed by terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling (tunel) staining. |
2017-03-09 |
2023-08-13 |
rat |
| Jianlin Liu, Lin Yang, Hongyan Tian, Qiang M. Cathepsin D is involved in the oxygen and glucose deprivation/reperfusion-induced apoptosis of astrocytes. International journal of molecular medicine. vol 38. issue 4. 2017-03-06. PMID:27573911. |
we found that ogd/r markedly increased cell apoptosis and the production of inflammatory cytokines, namely il-6, tumor necrosis factor (tnf)-α and fasl in a reperfusion time‑dependent manner and their elevation peaked at 24 h after reperfusion. |
2017-03-06 |
2023-08-13 |
Not clear |
| Mahmut Yuksel, Mustafa Kaplan, Ihsan Ates, Zeki Mesut Yaln Kilic, Hasan Kilic, Nuretdin Suna, Hale Ates, Ertugrul Kayaceti. The role of soluble tumor necrosis factor like weak inducer of apoptosis and interleukin-17A in the etiopathogenesis of celiac disease: A cross-sectional study. Medicine. vol 95. issue 26. 2017-02-22. PMID:27367991. |
our aim in this study was to determine soluble tumor necrosis factor (tnf)-like weak inducer of apoptosis (stweak) and interleukin-17a (il-17a) levels in celiac disease, and their association with the gluten diet and autoantibodies. |
2017-02-22 |
2023-08-13 |
Not clear |
| Christoph Roderburg, Fabian Benz, Florian Schüller, Ines Pombeiro, Hans-Joerg Hippe, Norbert Frey, Christian Trautwein, Tom Luedde, Alexander Koch, Frank Tacke, Mark Luedd. Serum Levels of TNF Receptor Ligands Are Dysregulated in Sepsis and Predict Mortality in Critically Ill Patients. PloS one. vol 11. issue 4. 2017-02-21. PMID:27124414. |
tnf superfamily members, including tnf-related weak inducer of apoptosis (tweak) and glucocorticoid-induced tnfr-related protein ligand (gitrl) have been described as serum based biomarkers for inflammatory and immune mediated diseases. |
2017-02-21 |
2023-08-13 |
Not clear |
| Yağmur Kiraz, Aysun Adan, Melis Kartal Yandim, Yusuf Bara. Major apoptotic mechanisms and genes involved in apoptosis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 7. 2017-02-09. PMID:27059734. |
different gene families such as caspases, inhibitor of apoptosis proteins, b cell lymphoma (bcl)-2 family of genes, tumor necrosis factor (tnf) receptor gene superfamily, or p53 gene are involved and/or collaborate in the process of apoptosis. |
2017-02-09 |
2023-08-13 |
Not clear |
| Sung-Moo Kim, Eun-Jung Lee, Jong Hyun Lee, Woong Mo Yang, Dongwoo Nam, Jun-Hee Lee, Seok-Geun Lee, Jae-Young Um, Bum Sang Shim, Kwang Seok Ah. Simvastatin in combination with bergamottin potentiates TNF-induced apoptosis through modulation of NF-κB signalling pathway in human chronic myelogenous leukaemia. Pharmaceutical biology. vol 54. issue 10. 2017-02-07. PMID:26911804. |
results we found that the combination treatment enhanced cytotoxicity and potentiated the apoptosis induced by tnf as indicated by intracellular esterase activity, annexin v staining and caspase activation. |
2017-02-07 |
2023-08-13 |
human |