| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Quanyin Hu, Wujin Sun, Yue Lu, Hunter N Bomba, Yanqi Ye, Tianyue Jiang, Ari J Isaacson, Zhen G. Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots. Nano letters. vol 16. issue 2. 2016-12-13. PMID:26785163. |
equipped with an acid-degradable modality, the resulting cs-ng can substantially release combinational anticancer drugs-tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail) and antiangiogenic cilengitide toward the membrane of cancer cells and endothelial cells at the acidic tumor microenvironment, respectively. |
2016-12-13 |
2023-08-13 |
Not clear |
| Heiko Blaser, Catherine Dostert, Tak W Mak, Dirk Brenne. TNF and ROS Crosstalk in Inflammation. Trends in cell biology. vol 26. issue 4. 2016-12-13. PMID:26791157. |
the role of tnf as a master regulator in balancing cell survival, apoptosis and necroptosis has been extensively studied in various cell types and tissues. |
2016-12-13 |
2023-08-13 |
Not clear |
| Zeynep Kayaoglu Yildirim, Abdullah Sumnu, Neslihan Bademler, Elif Kilic, Gulay Sumnu, Serhat Karadag, Meltem Gursu, Aysegul Ozel, Gonca Batmaz, Seda Ates, Banu Dane, Savas Oztur. Soluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia: A Pilot Clinical Study. Disease markers. vol 2016. 2016-12-13. PMID:26989294. |
soluble tumor necrosis factor-like weak inducer of apoptosis (stweak) was recently introduced as a tnf related cytokine in various inflammatory and noninflammatory disorders. |
2016-12-13 |
2023-08-13 |
Not clear |
| A P Komarov, E A Komarova, K Green, L R Novototskaya, P S Baker, A Eroshkin, A L Osterman, A A Chenchick, C Frangou, A V Gudko. Functional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failure. Cell death & disease. vol 7. 2016-11-14. PMID:26986512. |
by screening a lentiviral shrna library targeting for major components of human signaling pathways and known drug targets, we identified and validated both canonical as well as 52 novel mediators of fas and tnf ligand-induced apoptosis. |
2016-11-14 |
2023-08-13 |
mouse |
| A P Komarov, E A Komarova, K Green, L R Novototskaya, P S Baker, A Eroshkin, A L Osterman, A A Chenchick, C Frangou, A V Gudko. Functional genetics-directed identification of novel pharmacological inhibitors of FAS- and TNF-dependent apoptosis that protect mice from acute liver failure. Cell death & disease. vol 7. 2016-11-14. PMID:26986512. |
remarkably, pharmacological inhibition of either sstr5 or ppp2r5a reduced apoptosis induced by either fasl or tnf in cultured cells and dramatically improved survival in several mouse models of alf. |
2016-11-14 |
2023-08-13 |
mouse |
| Dongsheng Nie, Dong Zhang, Jingbo Dai, Meixing Zhang, Xianglong Zhao, Wangjie Xu, Zhong Chen, Lianyun Wang, Zhaoxia Wang, Zhongdong Qia. Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation. Biology of reproduction. vol 94. issue 2. 2016-11-04. PMID:26607717. |
out of the 86 genes related to apoptosis, tnf (tumor necrosis factor alpha) was screened to be the most significant varied transcript, and the onto-pathway analysis indicated that the tnf apoptotic pathway was especially activated by nicotine exposure. |
2016-11-04 |
2023-08-13 |
mouse |
| Dongsheng Nie, Dong Zhang, Jingbo Dai, Meixing Zhang, Xianglong Zhao, Wangjie Xu, Zhong Chen, Lianyun Wang, Zhaoxia Wang, Zhongdong Qia. Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation. Biology of reproduction. vol 94. issue 2. 2016-11-04. PMID:26607717. |
in summary, our study suggests that nicotine may induce murine spermatozoal apoptosis via the tnf apoptotic pathway through up-regulation of deubiquitinated rip1 by trim27 promoter hypomethylation. |
2016-11-04 |
2023-08-13 |
mouse |
| Ashley R Maiuri, Anna B Breier, Jonathan D Turkus, Patricia E Ganey, Robert A Rot. Calcium Contributes to the Cytotoxic Interaction Between Diclofenac and Cytokines. Toxicological sciences : an official journal of the Society of Toxicology. vol 149. issue 2. 2016-11-02. PMID:26609140. |
dclf synergizes with the cytokines tumor necrosis factor-alpha (tnf) and interferon-gamma (ifn) to cause hepatocellular apoptosis in vitro by a mechanism that involves activation of the endoplasmic reticulum (er) stress response pathway and of the mitogen-activated protein kinases, c-jun n-terminal kinase (jnk), and extracellular signal-regulated kinase (erk). |
2016-11-02 |
2023-08-13 |
Not clear |
| Yue Zhai, Bo Wu, Jia Li, Xi-ying Yao, Ping Zhu, Zhi-nan Che. CD147 promotes IKK/IκB/NF-κB pathway to resist TNF-induced apoptosis in rheumatoid arthritis synovial fibroblasts. Journal of molecular medicine (Berlin, Germany). vol 94. issue 1. 2016-10-19. PMID:26296700. |
we found that overexpressing tnf in synovial tissue did not increase the apoptotic level and, in vitro, tnf-induced mild synovioblast apoptosis and promoted il-6 secretion. |
2016-10-19 |
2023-08-13 |
Not clear |
| Yue Zhai, Bo Wu, Jia Li, Xi-ying Yao, Ping Zhu, Zhi-nan Che. CD147 promotes IKK/IκB/NF-κB pathway to resist TNF-induced apoptosis in rheumatoid arthritis synovial fibroblasts. Journal of molecular medicine (Berlin, Germany). vol 94. issue 1. 2016-10-19. PMID:26296700. |
cd147, which was highly expressed in rheumatoid arthritis synovial fibroblasts (rasfs), increased the resistance of synovioblasts to apoptosis under tnf stimulation. |
2016-10-19 |
2023-08-13 |
Not clear |
| Emilie Hollville, Seamus J Marti. Measuring Apoptosis by Microscopy and Flow Cytometry. Current protocols in immunology. vol 112. 2016-10-19. PMID:26836509. |
numerous physiological as well as pathological stimuli trigger apoptosis such as engagement of fas, trail, or tnf receptors, growth factor deprivation, hypoxia, or exposure to cytotoxic drugs. |
2016-10-19 |
2023-08-13 |
Not clear |
| Fernanda Van Petten Vasconcelos Azevedo, Daiana Silva Lopes, Sarah Natalie Cirilo Gimenes, David Collares Achê, Lara Vecchi, Patrícia Terra Alves, Denise de Oliveira Guimarães, Renata Santos Rodrigues, Luiz Ricardo Goulart, Veridiana de Melo Rodrigues, Kelly Aparecida Geraldo Yoneyam. Human breast cancer cell death induced by BnSP-6, a Lys-49 PLA₂ homologue from Bothrops pauloensis venom. International journal of biological macromolecules. vol 82. 2016-10-13. PMID:26519876. |
apoptosis of mda-mb-231 cells was also confirmed by up-regulation of different genes related to the apoptosis pathway, such as tnf, tnfrsf10b, tnfrsf1a and casp8 and decreased expression of anti-apoptotic genes (bcl2 and bcl2l). |
2016-10-13 |
2023-08-13 |
human |
| Wenshu Lu, Qiongyu Chen, Songmin Ying, Xiaobing Xia, Zhanru Yu, Yuan Lui, George Tranter, Boquan Jin, Chaojun Song, Leonard W Seymour, Shisong Jian. Evolutionarily conserved primary TNF sequences relate to its primitive functions in cell death induction. Journal of cell science. vol 129. issue 1. 2016-10-07. PMID:26729029. |
by screening overlapping peptides derived from human tnf to determine their role in three different tnf-induced processes--apoptosis, necrosis and nf-κb stimulation--we found that tnf conserved regions are mostly related to cell death rather than nf-κb stimulation. |
2016-10-07 |
2023-08-13 |
human |
| Wenshu Lu, Qiongyu Chen, Songmin Ying, Xiaobing Xia, Zhanru Yu, Yuan Lui, George Tranter, Boquan Jin, Chaojun Song, Leonard W Seymour, Shisong Jian. Evolutionarily conserved primary TNF sequences relate to its primitive functions in cell death induction. Journal of cell science. vol 129. issue 1. 2016-10-07. PMID:26729029. |
finally, using a monoclonal antibody and a mutant tnf protein, we show that tnf-induced apoptosis is determined by a conserved linear sequence that corresponds to that within p1213. |
2016-10-07 |
2023-08-13 |
human |
| Wenshu Lu, Qiongyu Chen, Songmin Ying, Xiaobing Xia, Zhanru Yu, Yuan Lui, George Tranter, Boquan Jin, Chaojun Song, Leonard W Seymour, Shisong Jian. Evolutionarily conserved primary TNF sequences relate to its primitive functions in cell death induction. Journal of cell science. vol 129. issue 1. 2016-10-07. PMID:26729029. |
our results reveal the determinant sequence that is key to the tnf primitive function of inducing apoptosis. |
2016-10-07 |
2023-08-13 |
human |
| Yoko Hari, Nanae Harashima, Yoshitsugu Tajima, Mamoru Harad. Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL. Oncotarget. vol 6. issue 39. 2016-09-28. PMID:26506422. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) induces apoptosis in various types of cancer cells without damaging normal cells. |
2016-09-28 |
2023-08-13 |
mouse |
| Mo-fei Li, Jian Zhan. CsTNF1, a teleost tumor necrosis factor that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved receptor binding site. Developmental and comparative immunology. vol 55. 2016-09-26. PMID:26478190. |
tumor necrosis factor (tnf) is one of the most important cytokines involved in inflammation, apoptosis, cell proliferation, and stimulation of the immune system. |
2016-09-26 |
2023-08-13 |
Not clear |
| Sebastian Czaplinski, Behnaz Ahangarian Abhari, Alica Torkov, Dominik Seggewiß, Manuela Hugle, Simone Fuld. Differential role of RIP1 in Smac mimetic-mediated chemosensitization of neuroblastoma cells. Oncotarget. vol 6. issue 39. 2016-09-26. PMID:26575016. |
while bv6 causes rapid downregulation of cellular iap (ciap)1 protein and nuclear factor-kappab (nf-κb) activation, dox/bv6- or vcr/bv6-induced apoptosis occurs independently of nf-κb or tnfα signaling, since overexpression of dominant-negative iκbα superrepressor or the tumor necrosis factor (tnf)α-blocking antibody enbrel fail to block cell death. |
2016-09-26 |
2023-08-13 |
Not clear |
| Imtiaj Hasan, Shigeki Sugawara, Yuki Fujii, Yasuhiro Koide, Daiki Terada, Naoya Iimura, Toshiyuki Fujiwara, Keisuke G Takahashi, Nobuhiko Kojima, Sultana Rajia, Sarkar M A Kawsar, Robert A Kanaly, Hideho Uchiyama, Masahiro Hosono, Yukiko Ogawa, Hideaki Fujita, Jiharu Hamako, Taei Matsui, Yasuhiro Ozek. MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt's Lymphoma Cells to Trigger Apoptosis through Multiple Pathways. Marine drugs. vol 13. issue 12. 2016-09-26. PMID:26694420. |
in the cells, mytilec treatment triggered expression of tumor necrosis factor (tnf)-α (a ligand of death receptor-dependent apoptosis) and activation of mitochondria-controlling caspase-9 (initiator caspase) and caspase-3 (activator caspase). |
2016-09-26 |
2023-08-13 |
Not clear |
| Anuja Chattopadhyay, Irina Abecassis, Robert L Redne. NPM-RAR binding to TRADD selectively inhibits caspase activation, while allowing activation of NFκB and JNK. Leukemia & lymphoma. vol 56. issue 12. 2016-09-20. PMID:25791120. |
we have previously shown that npm-rar interaction with tradd blocks tnf activation of caspase 3, caspase 8, poly(adp-ribose) polymerase (parp) cleavage and, ultimately, apoptosis. |
2016-09-20 |
2023-08-13 |
Not clear |