| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simone Fuld. Safety and tolerability of TRAIL receptor agonists in cancer treatment. European journal of clinical pharmacology. vol 71. issue 5. 2016-01-20. PMID:25704217. |
the tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) receptor/ligand system is of particular interest among the death receptor superfamily for therapeutic targeting in cancer, since trail has been reported to preferentially induce apoptosis in cancer cells, while sparing non-malignant cells. |
2016-01-20 |
2023-08-13 |
Not clear |
| Qiao-Li Ma, Ai-Cui Liu, Xiao-Juan Ma, Yan-Bai Wang, Yu-Ting Hou, Zhen-Hai Wan. Brucella outer membrane protein Omp25 induces microglial cells in vitro to secrete inflammatory cytokines and inhibit apoptosis. International journal of clinical and experimental medicine. vol 8. issue 10. 2016-01-15. PMID:26770344. |
mouse bv2 microglial cells were incubated with different concentrations of omp25 for 24 h, and an enzyme-linked immunosorbent assay (elisa) was used to detect the secretion of the inflammatory cytokines interleukin (il)-6, tumour necrosis factor (tnf)-α and hmgb1 (high mobility group box-1 protein); reverse transcription polymerase chain reaction (rt-pcr) was used to detect the expression of tlr4 (toll-like receptor 4) mrna; annexin v-fluorescein isothiocyanate (fitc) double staining was used to detect apoptosis in the bv2 cells. |
2016-01-15 |
2023-08-13 |
mouse |
| Ya-Ping Zhang, Qing-Hong Kong, Ying Huang, Guan-Lin Wang, Kwen-Jen Chan. Inhibition of c-FLIP by RNAi enhances sensitivity of the human osteogenic sarcoma cell line U2OS to TRAIL-induced apoptosis. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 6. 2016-01-08. PMID:25824746. |
to study effects of cellular flice (fadd-like il-1β-converting enzyme)-inhibitory protein (c-flip) inhibition by rna interference (rnai) on sensitivity of u2os cells to tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-induced apoptosis, plasmid psuper-c-flip-sirna was constructed and then transfected into u2os cells. |
2016-01-08 |
2023-08-13 |
human |
| Keith Rennier, Julie Y J. Shear stress attenuates apoptosis due to TNFα, oxidative stress, and serum depletion via death-associated protein kinase (DAPK) expression. BMC research notes. vol 8. 2016-01-08. PMID:25890206. |
current studies have shown that the pro-apoptotic dapk expression and function to be regulated in part by shear stress, and that shearing cells already treated with cytokine tumor necrosis factor (tnf) α significantly reduced apoptosis. |
2016-01-08 |
2023-08-13 |
Not clear |
| Yves Dondelinger, Sandrine Jouan-Lanhouet, Tatyana Divert, Emilie Theatre, John Bertin, Peter J Gough, Piero Giansanti, Albert J R Heck, Emmanuel Dejardin, Peter Vandenabeele, Mathieu J M Bertran. NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling. Molecular cell. vol 60. issue 1. 2016-01-05. PMID:26344099. |
activation of tnfr1 by tnf can result in both ripk1-independent apoptosis and ripk1 kinase-dependent apoptosis or necroptosis. |
2016-01-05 |
2023-08-13 |
Not clear |
| Yan-Ying Du, Yan-Xia Zhao, Yu-Ping Liu, Wei Liu, Ming-Ming Wang, Chong-Ming Yua. Regulatory Tweak/Fn14 signaling pathway as a potent target for controlling bone loss. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 70. 2016-01-04. PMID:25776497. |
the increasing evidence showed that tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak)/fibroblast growth factor-inducible 14 (fn14) signalling controls a variety of cellular activities in biological processes, such as proliferation, differentiation, and apoptosis and has diverse biological functions in pathological mechanisms like inflammation that are associated with the process of bone metabolism. |
2016-01-04 |
2023-08-13 |
Not clear |
| Yu Wang, Lei Li, Naimin Shao, Zhiqi Hu, Hui Chen, Leqin Xu, Changping Wang, Yiyun Cheng, Jianru Xia. Triazine-modified dendrimer for efficient TRAIL gene therapy in osteosarcoma. Acta biomaterialia. vol 17. 2015-12-31. PMID:25595474. |
tumor necrosis factor (tnf) related apoptosis inducing ligand (trail) gene therapy is a new strategy in the treatment of cancers, however, the lack of efficient and low toxic vectors remains the major obstacle in trail gene therapy. |
2015-12-31 |
2023-08-13 |
mouse |
| Zhiqiang Zhang, Yongchao Fang, Qiang Wang, Yu Sun, Chuanzhi Xiong, Li Cao, Beiyue Wang, Nirong Bao, Jianning Zha. Tumor necrosis factor-like weak inducer of apoptosis regulates particle-induced inflammatory osteolysis via the p38 mitogen-activated protein kinase signaling pathway. Molecular medicine reports. vol 12. issue 1. 2015-12-30. PMID:25815691. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is a member of the tnf family and is a multifunctional cytokine, which regulates cellular proliferation, angiogenesis, inflammation and apoptosis via the p38 mapk signaling pathway. |
2015-12-30 |
2023-08-13 |
Not clear |
| Ferhat Hanikoglu, Aysegul Cort, Hakan Ozben, Aysegul Hanikoglu, Tomris Ozbe. Epoxomicin Sensitizes Resistant Osteosarcoma Cells to TRAIL Induced Apoptosis. Anti-cancer agents in medicinal chemistry. vol 15. issue 4. 2015-12-21. PMID:25666501. |
tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail) and proteasome inhibitors (epoxomicin, mg132, bortezomib) represent new promising approaches in cancer treatment. |
2015-12-21 |
2023-08-13 |
Not clear |
| Channy Park, Sung Wook Hong, Sung Ho Jin, Nam Song Kim, Kyung Ho Cho, Jin Ho Cheon, Jae Yeon Ahn, Jung Ku Yang, Raekil Par. TRAIL-Mediated Apoptosis in Human Liver Chang Cells. Cancer research and treatment. vol 35. issue 4. 2015-12-19. PMID:26680957. |
tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail)/apo-2l is a member of the tnf family that can kill a wide variety of tumor cells, but not normal cells. |
2015-12-19 |
2023-08-13 |
human |
| Hong Cheng, Na Zhan, Dong Ding, Xiaoming Liu, Xiaoyan Zou, Ke Li, Yumin Xi. HPV Type 16 Infection Switches Keratinocytes from Apoptotic to Proliferative Fate under TWEAK/Fn14 Interaction. The Journal of investigative dermatology. vol 135. issue 10. 2015-12-14. PMID:26016896. |
previously, tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) had been known to be an inducer of apoptosis of keratinocytes by engaging the fn14 receptor. |
2015-12-14 |
2023-08-13 |
human |
| Jiqin Zhang, Huanjiao Jenny Zhou, Weidong Ji, Wang Mi. AIP1-mediated stress signaling in atherosclerosis and arteriosclerosis. Current atherosclerosis reports. vol 17. issue 5. 2015-12-03. PMID:25732743. |
while it was initially discovered as an apoptosis signal-regulating kinase 1 (ask1)-interacting protein, aip1 broadly suppresses inflammatory responses triggered by cytokines and stresses such as tnf, lps, vegf, and endoplasmic reticulum (er) stress in ec (therefore, aip1 is an anti-inflammatory protein). |
2015-12-03 |
2023-08-13 |
mouse |
| Fleur Bossi, Stella Bernardi, Giorgio Zauli, Paola Secchiero, Bruno Fabri. TRAIL modulates the immune system and protects against the development of diabetes. Journal of immunology research. vol 2015. 2015-12-01. PMID:25759846. |
trail or tumor necrosis factor (tnf) related apoptosis-inducing ligand is a member of the tnf superfamily of proteins, whose best characterized function is the induction of apoptosis in tumor, infected, or transformed cells through activation of specific receptors. |
2015-12-01 |
2023-08-13 |
Not clear |
| Hui Gu, Jingwen Yu, Daoying Dong, Qun Zhou, Jian-Ying Wang, Peixin Yan. The miR-322-TRAF3 circuit mediates the pro-apoptotic effect of high glucose on neural stem cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 144. issue 1. 2015-11-30. PMID:25516495. |
this study investigates the role of mir-322 and its putative target gene, tnf receptor-associated factor 3 (traf3), in high glucose-induced apoptosis. |
2015-11-30 |
2023-08-13 |
Not clear |
| M Elbaz, N Yanay, S Laban, M Rabie, S Mitrani-Rosenbaum, Y Nev. Life or death by NFκB, Losartan promotes survival in dy2J/dy2J mouse of MDC1A. Cell death & disease. vol 6. 2015-11-30. PMID:25766329. |
moreover, nfκb anti-apoptotic target genes tnf receptor-associated factor 1 (traf1), tnf receptor-associated factor 2 (traf2), cellular inhibitor of apoptosis (ciap2), and ferritin heavy chain (fth1) were increased following losartan treatment. |
2015-11-30 |
2023-08-13 |
mouse |
| Natalya Benderska, Jelena Ivanovska, Tilman T Rau, Jan Schulze-Luehrmann, Suma Mohan, Saritha Chakilam, Muktheshwar Gandesiri, Elisabeth Ziesché, Thomas Fischer, Stephan Söder, Abbas Agaimy, Luitpold Distel, Heinrich Sticht, Vijayalakshmi Mahadevan, Regine Schneider-Stoc. DAPK-HSF1 interaction as a positive-feedback mechanism stimulating TNF-induced apoptosis in colorectal cancer cells. Journal of cell science. vol 127. issue Pt 24. 2015-11-16. PMID:25380824. |
previously, we demonstrated that tumor necrosis factor (tnf) induced dapk-mediated apoptosis in colorectal cancer. |
2015-11-16 |
2023-08-13 |
human |
| Jessica L Doerner, Jing Wen, Yumin Xia, Karin Blecher Paz, David Schairer, Lan Wu, Samantha A Chalmers, Peter Izmirly, Jennifer S Michaelson, Linda C Burkly, Adam J Friedman, Chaim Putterma. TWEAK/Fn14 Signaling Involvement in the Pathogenesis of Cutaneous Disease in the MRL/lpr Model of Spontaneous Lupus. The Journal of investigative dermatology. vol 135. issue 8. 2015-11-16. PMID:25826425. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak, tnfsf12) and its sole receptor fn14, belonging to the tnf ligand and receptor superfamilies respectively, are involved in cell survival and cytokine production. |
2015-11-16 |
2023-08-13 |
mouse |
| Sung Kyun Lee, Sang Doo Kim, Minsoo Kook, Ha Young Lee, Jaewang Ghim, Youngwoo Choi, Brian A Zabel, Sung Ho Ryu, Yoe-Sik Ba. Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2. The Journal of experimental medicine. vol 212. issue 9. 2015-11-06. PMID:26282875. |
production of several inflammatory cytokines (tnf, il-1β, il-17, and il-23) and the chemokine cxcl1, as well as cellular apoptosis in immune tissues, kidney, and liver, are markedly decreased in pld2(-/-) mice. |
2015-11-06 |
2023-08-13 |
mouse |
| Henry Aceros, Georges Farah, Nicolas Noiseux, Suhayla Mukaddam-Dahe. Moxonidine modulates cytokine signalling and effects on cardiac cell viability. European journal of pharmacology. vol 740. 2015-11-03. PMID:25036265. |
studies were performed on neonatal rat cardiomyocytes and fibroblasts incubated with interleukin (il)-1β (5 ng/ml), tumor necrosis factor (tnf)-α (10 ng/ml), and moxonidine (10(-7) and 10(-5) m), separately and in combination, for 15 min, and 24 and 48 h for the measurement of mapks (erk1/2, jnk, and p38) and akt activation and inducible nos (inos) expression, by western blotting, and cardiac cell viability/proliferation and apoptosis by flow cytometry, mtt assay, and live/dead assay. |
2015-11-03 |
2023-08-13 |
rat |
| David J MacEwa. TWEAKing for a fight with GVHD. Blood. vol 126. issue 4. 2015-10-14. PMID:26206942. |
in this issue of blood, chopra et al provide convincing evidence that tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) ligand acting through its receptor, fibroblast growth factor-inducible 14 (fn14), is crucial to the intestinal apoptosis seen in graft-versus-host disease (gvhd) and associated mortality. |
2015-10-14 |
2023-08-13 |
Not clear |