| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S L Petersen, T T Chen, D A Lawrence, S A Marsters, F Gonzalvez, A Ashkenaz. TRAF2 is a biologically important necroptosis suppressor. Cell death and differentiation. vol 22. issue 11. 2016-05-09. PMID:25882049. |
here, we show that tnf receptor-associated factor 2 (traf2)-previously implicated in apoptosis suppression-also inhibits necroptotic signaling by tnfα. |
2016-05-09 |
2023-08-13 |
mouse |
| Barun Mahata, Soumika Biswas, Patricia Rayman, Ali Chahlavi, Jennifer Ko, Ashish Bhattacharjee, Yu-Teh Li, Yuntao Li, Tanya Das, Gaurisankar Sa, Baisakhi Raychaudhuri, Michael A Vogelbaum, Charles Tannenbaum, James H Finke, Kaushik Biswa. GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway. PloS one. vol 10. issue 7. 2016-05-04. PMID:26226135. |
here we show that gbm-derived gangliosides induce apoptosis through involvement of the tnf receptor and activation of the caspase cascade. |
2016-05-04 |
2023-08-13 |
human |
| Barun Mahata, Soumika Biswas, Patricia Rayman, Ali Chahlavi, Jennifer Ko, Ashish Bhattacharjee, Yu-Teh Li, Yuntao Li, Tanya Das, Gaurisankar Sa, Baisakhi Raychaudhuri, Michael A Vogelbaum, Charles Tannenbaum, James H Finke, Kaushik Biswa. GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway. PloS one. vol 10. issue 7. 2016-05-04. PMID:26226135. |
thus, gbm-ganglioside can mediate t cell apoptosis by interacting with the tnf receptor followed by activation of both the extrinsic and the intrinsic pathway of caspases. |
2016-05-04 |
2023-08-13 |
human |
| Sean M Ronnekleiv-Kelly, Manabu Nukaya, Carol J Díaz-Díaz, Bryant W Megna, Patrick R Carney, Peter G Geiger, Gregory D Kenned. Aryl hydrocarbon receptor-dependent apoptotic cell death induced by the flavonoid chrysin in human colorectal cancer cells. Cancer letters. vol 370. issue 1. 2016-04-27. PMID:26515162. |
we identified that the involvement of up-regulation of pro-apoptotic cytokines tumor necrosis factor (tnf) α and β genes and consequent activation of the tnf-mediated transcriptional pathway in chrysin-induced apoptosis. |
2016-04-27 |
2023-08-13 |
human |
| Rafia S Al-Lamki, Tanya N Mayada. TNF receptors: signaling pathways and contribution to renal dysfunction. Kidney international. vol 87. issue 2. 2016-04-25. PMID:25140911. |
tumor necrosis factor (tnf), initially reported to induce tumor cell apoptosis and cachexia, is now considered a central mediator of a broad range of biological activities from cell proliferation, cell death and differentiation to induction of inflammation and immune modulation. |
2016-04-25 |
2023-08-13 |
Not clear |
| Cemil Bilir, Huseyin Engin, Murat Can, Yasemin Bakkal Temi, Derya Demirta. The prognostic role of inflammation and hormones in patients with metastatic cancer with cachexia. Medical oncology (Northwood, London, England). vol 32. issue 3. 2016-04-25. PMID:25638467. |
serum total testosterone, free testosterone, interleukin 1 (il) alpha and beta, il6, tumor necrosis factor (tnf) alpha, orexin, galanin, neuropeptide y, tumor necrosis factor-like weak inducer of apoptosis and tumor necrosis factor receptor-associated factor 6, and c-reactive protein (crp) levels were investigated. |
2016-04-25 |
2023-08-13 |
Not clear |
| Bin Yu, Bin Zhang, Wen-Bo Zhou, Qiu-Wei Wang, Pei Yuan, Yu-Qi Yang, Jing Kon. Assessing apoptosis gene expression profiling with a PCR array in the hippocampus of Ts65Dn mice. BioMed research international. vol 2015. 2016-04-22. PMID:26075220. |
however, some well-known genes related to cell apoptosis, such as the caspase family, bcl-2, bad, bid, fas, and tnf, did not show changes in expression levels. |
2016-04-22 |
2023-08-13 |
mouse |
| Min Zhang, Nanae Harashima, Tamami Moritani, Weidong Huang, Mamoru Harad. The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells. PloS one. vol 10. issue 5. 2016-04-21. PMID:26000607. |
death signaling provided by tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) can induce death in cancer cells with little cytotoxicity to normal cells; this cell death has been thought to involve caspase-dependent apoptosis. |
2016-04-21 |
2023-08-13 |
human |
| George D Kalliolias, Lionel B Ivashki. TNF biology, pathogenic mechanisms and emerging therapeutic strategies. Nature reviews. Rheumatology. vol 12. issue 1. 2016-04-19. PMID:26656660. |
the model of tnf receptor signalling has been extended to include linear ubiquitination and the formation of distinct signalling complexes that are linked with different functional outcomes, such as inflammation, apoptosis and necroptosis. |
2016-04-19 |
2023-08-13 |
Not clear |
| Xianqin Hu, Xiaozhe Fu, Ningqiu Li, Xingxing Dong, Lijuan Zhao, Jiangfeng Lan, Wei Ji, Weidong Zhou, Taoshan Ai, Shuqin Wu, Li Li. Transcriptomic analysis of Mandarin fish brain cells infected with infectious spleen and kidney necrosis virus with an emphasis on retinoic acid-inducible gene 1-like receptors and apoptosis pathways. Fish & shellfish immunology. vol 45. issue 2. 2016-04-07. PMID:25982401. |
in the apoptosis pathway, isknv infection could induce apoptosis mainly via tumor necrosis factor (tnf) mediated extrinsic pathway. |
2016-04-07 |
2023-08-13 |
Not clear |
| Peili Chen, Yan Chun Li, F Gary Tobac. AMP-18 Targets p21 to Maintain Epithelial Homeostasis. PloS one. vol 10. issue 4. 2016-04-05. PMID:25919700. |
tumor necrosis factor (tnf)-α, a pro-inflammatory cytokine known to mediate gastrointestinal (gi) mucosal injury in ibd, was used to induce intestinal epithelial cell injury, and study the effects of amp-18 on apoptosis and the cell cycle. |
2016-04-05 |
2023-08-13 |
mouse |
| A C West, B P Martin, D A Andrews, S J Hogg, A Banerjee, G Grigoriadis, R W Johnstone, J Short. The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock. Oncogenesis. vol 5. 2016-04-05. PMID:27043662. |
lcl-161 is a small molecule second mitochondrial activator of caspase (smac) mimetic, which both disengages iaps from caspases and induces proteasomal degradation of ciap-1 and -2, resulting in altered signaling through the nfκb pathway, enhanced tnf production and sensitization to apoptosis mediated by the extrinsic pathway. |
2016-04-05 |
2023-08-13 |
mouse |
| Mariam Anees, Peter Horak, Ana-Iris Schiefer, Petr Vaňhara, Ahmed El-Gazzar, Paul Perco, Barbara Kiesewetter, Leonhard Müllauer, Berthold Streubel, Markus Raderer, Michael Kraine. The potential evasion of immune surveillance in mucosa associated lymphoid tissue lymphoma by DcR2-mediated up-regulation of nuclear factor-κB. Leukemia & lymphoma. vol 56. issue 5. 2016-03-25. PMID:25248880. |
this study investigated expression profiles of tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail) pathway components and mechanisms underlying trail-induced apoptosis in mucosa associated lymphoid tissue (malt) lymphoma. |
2016-03-25 |
2023-08-13 |
Not clear |
| Snehal Dabir, Adam Kresak, Michael Yang, Pingfu Fu, Gary Wildey, Afshin Dowlat. CD30 is a potential therapeutic target in malignant mesothelioma. Molecular cancer therapeutics. vol 14. issue 3. 2016-03-16. PMID:25589494. |
cd30 is a cytokine receptor belonging to the tnf superfamily (tnfrsf8) that acts as a regulator of apoptosis. |
2016-03-16 |
2023-08-13 |
Not clear |
| Ya Ju Chang, Shih Lan Hsu, Yi Ting Liu, Yu Hsuan Lin, Ming Hui Lin, Shu Jung Huang, Ja-an Annie Ho, Li-Chen W. Gallic acid induces necroptosis via TNF-α signaling pathway in activated hepatic stellate cells. PloS one. vol 10. issue 3. 2016-03-15. PMID:25816210. |
the inhibition of rip1 by nec-1 diverted the cell death from necroptosis to apoptosis, as the activation of caspase 3 and the increase of cytochrome c. collectively, this is the first report indicating that ga induces tnf signaling-triggered necroptosis in ahscs, which may offer an alternative strategy for the amelioration of liver fibrosis. |
2016-03-15 |
2023-08-13 |
Not clear |
| Lakshmi Galam, Prasanna Tamarapu Parthasarathy, Young Cho, Seong Ho Cho, Yong Chul Lee, Richard F Lockey, Narasaiah Kolliput. Adenovirus-mediated transfer of the SOCS-1 gene to mouse lung confers protection against hyperoxic acute lung injury. Free radical biology & medicine. vol 84. 2016-03-04. PMID:25850028. |
socs-1 has been shown to protect cells from cellular damage and apoptosis induced by tumor necrosis factor (tnf), lipopolysaccharide (lps), and interferon gamma (il-γ). |
2016-03-04 |
2023-08-13 |
mouse |
| Wan-Li Li, Wei Xiang, Ye Pin. Activation of novel estrogen receptor GPER results in inhibition of cardiocyte apoptosis and cardioprotection. Molecular medicine reports. vol 12. issue 2. 2016-03-02. PMID:25936661. |
b-cell lymphoma 2 (bcl-2) and bcl-2 associated x (bax) levels were measured, hoechst 33258 staining was performed to assess apoptosis, and superoxide dismutase (sod), tumor necrosis factor (tnf)-α and adenosine triphosphatase (atpase) levels were determined. |
2016-03-02 |
2023-08-13 |
Not clear |
| M C de Almagro, T Goncharov, K Newton, D Vuci. Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination. Cell death & disease. vol 6. 2016-02-18. PMID:26111062. |
tumor necrosis factor-α (tnfα)-stimulated assembly of the tnfr1 (tnf receptor 1)-associated signaling complex leads to the recruitment of rip1, whose ubiquitination is mediated by the cellular inhibitors of apoptosis (c-iaps). |
2016-02-18 |
2023-08-13 |
Not clear |
| E S Robinson, V P Wert. The role of cytokines in the pathogenesis of cutaneous lupus erythematosus. Cytokine. vol 73. issue 2. 2016-02-08. PMID:25767072. |
ultraviolet (uv) light plays a central role in the pathogenesis of cle, triggering keratinocyte apoptosis, transport of nucleoprotein autoantigens to the keratinocyte cell surface and the release of inflammatory cytokines (including interferons (ifns), tumor necrosis factor (tnf)-α, interleukin (il)-1, il-6, il-8, il-10 and il-17). |
2016-02-08 |
2023-08-13 |
Not clear |
| Anne Hamacher-Brady, Nathan Ryan Brad. Bax/Bak-dependent, Drp1-independent Targeting of X-linked Inhibitor of Apoptosis Protein (XIAP) into Inner Mitochondrial Compartments Counteracts Smac/DIABLO-dependent Effector Caspase Activation. The Journal of biological chemistry. vol 290. issue 36. 2016-02-01. PMID:26134559. |
importantly, mitochondrial xiap actions are activated cell-intrinsically by typical apoptosis inducers tnf and staurosporine, and xiap overexpression reduces the lag time between the administration of an apoptotic stimuli and the onset of mitochondrial permeabilization. |
2016-02-01 |
2023-08-13 |
Not clear |