| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tugba Bagci-Onder, Wanlu Du, Jose-Luiz Figueiredo, Jordi Martinez-Quintanilla, Khalid Sha. Targeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cells. Brain : a journal of neurology. vol 138. issue Pt 6. 2015-08-07. PMID:25910782. |
based on the recent findings that metastatic tumour cells adopt unique mechanisms of evading apoptosis to successfully colonize in the brain, we reasoned that tnf receptor superfamily member 10a/10b apoptosis-inducing ligand (trail) based pro-apoptotic therapies that induce death receptor signalling within the metastatic tumour cells might be a favourable therapeutic approach. |
2015-08-07 |
2023-08-13 |
mouse |
| Subhadeep Mukherjee, Tapas Biswa. Activation of TOLLIP by porin prevents TLR2-associated IFN-γ and TNF-α-induced apoptosis of intestinal epithelial cells. Cellular signalling. vol 26. issue 12. 2015-08-06. PMID:25152369. |
interferon (ifn)-γ and tumor necrosis factor (tnf)-α cause chronic inflammation of the intestine leading to progression of inflammatory bowel disease (ibd), which is manifested through rapid apoptosis of the intestinal epithelial cells (iecs). |
2015-08-06 |
2023-08-13 |
Not clear |
| Gregor Ebert, Simon Preston, Cody Allison, James Cooney, Jesse G Toe, Michael D Stutz, Samar Ojaimi, Hamish W Scott, Nikola Baschuk, Ueli Nachbur, Joseph Torresi, Ruth Chin, Danielle Colledge, Xin Li, Nadia Warner, Peter Revill, Scott Bowden, John Silke, C Glenn Begley, Marc Pellegrin. Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 18. 2015-08-05. PMID:25902529. |
here, we show that cellular inhibitor of apoptosis proteins (ciaps) attenuate tnf signaling during hepatitis b infection, and they restrict the death of infected hepatocytes, thus allowing viral persistence. |
2015-08-05 |
2023-08-13 |
mouse |
| Pradeep M Nair, Heather Flores, Alvin Gogineni, Scot Marsters, David A Lawrence, Robert F Kelley, Hai Ngu, Meredith Sagolla, Laszlo Komuves, Richard Bourgon, Jeffrey Settleman, Avi Ashkenaz. Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 18. 2015-08-04. PMID:25902490. |
tnf superfamily death ligands are expressed on the surface of immune cells and can trigger apoptosis in susceptible cancer cells by engaging cognate death receptors. |
2015-08-04 |
2023-08-13 |
Not clear |
| An Hue Vy Tran, Soo-Hyun Hahm, Se Hee Han, Ji Hyung Chung, Geon Tae Park, Ye Sun Ha. Functional interaction between hMYH and hTRADD in the TNF-α-mediated survival and death pathways of HeLa cells. Mutation research. vol 777. 2015-08-03. PMID:25912078. |
the tumor necrosis factor (tnf) signaling pathway is a classical immune system pathway that plays a key role in regulating cell survival and apoptosis. |
2015-08-03 |
2023-08-13 |
human |
| An Hue Vy Tran, Soo-Hyun Hahm, Se Hee Han, Ji Hyung Chung, Geon Tae Park, Ye Sun Ha. Functional interaction between hMYH and hTRADD in the TNF-α-mediated survival and death pathways of HeLa cells. Mutation research. vol 777. 2015-08-03. PMID:25912078. |
the tnf receptor-associated death domain (tradd) protein is recruited to the death domain of tnf receptor 1 (tnfr1), where it interacts with tnf receptor-associated factor 2 (traf2) and receptor-interacting protein (rip) for the induction of apoptosis, necrosis, nuclear factor kappa-light-chain-enhancer of activated b cells (nfκb), and mitogen-activated protein (map) kinase activation. |
2015-08-03 |
2023-08-13 |
human |
| Jannie Pedersen, Eric C LaCasse, Jakob B Seidelin, Mehmet Coskun, Ole H Nielse. Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation. Trends in molecular medicine. vol 20. issue 11. 2015-07-23. PMID:25282548. |
the inhibitor of apoptosis (iap) family members, notably ciap1, ciap2, and xiap, are critical and universal regulators of tumor necrosis factor (tnf) mediated survival, inflammatory, and death signaling pathways. |
2015-07-23 |
2023-08-13 |
Not clear |
| Yumin Xia, Leal C Herlitz, Simona Gindea, Jing Wen, Rahul D Pawar, Alexander Misharin, Harris Perlman, Lan Wu, Ping Wu, Jennifer S Michaelson, Linda C Burkly, Chaim Putterma. Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis. Journal of the American Society of Nephrology : JASN. vol 26. issue 5. 2015-07-20. PMID:25270074. |
tnf ligand superfamily member 12, also known as tnf-related weak inducer of apoptosis (tweak), acts through its receptor, fibroblast growth factor-inducible 14 (fn14), to mediate several key pathologic processes involved in tissue injury relating to lupus nephritis. |
2015-07-20 |
2023-08-13 |
mouse |
| Eui-Soon Park, Seunga Choi, Bongjin Shin, Jungeun Yu, Jiyeon Yu, Jung-Me Hwang, Hyeongseok Yun, Young-Ho Chung, Jong-Soon Choi, Yongwon Choi, Jaerang Rh. Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction. The Journal of biological chemistry. vol 290. issue 15. 2015-06-26. PMID:25716317. |
the signaling pathway downstream of tnf receptor (tnfr) is involved in the induction of a wide range of cellular processes, including cell proliferation, activation, differentiation, and apoptosis. |
2015-06-26 |
2023-08-13 |
Not clear |
| H Ehlken, S Krishna-Subramanian, L Ochoa-Callejero, V Kondylis, N E Nadi, B K Straub, P Schirmacher, H Walczak, G Kollias, M Pasparaki. Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout. Cell death and differentiation. vol 21. issue 11. 2015-06-25. PMID:24971483. |
tnf deficiency in all cells or conditional lpc-specific ablation of tnfr1, fas or trail-r did not prevent hepatocyte apoptosis, hepatitis and hcc development in nemo(lpc-ko) mice. |
2015-06-25 |
2023-08-13 |
mouse |
| Tiina Öhman, Sandra Söderholm, Petteri Hintsanen, Elina Välimäki, Niina Lietzén, Carol MacKintosh, Tero Aittokallio, Sampsa Matikainen, Tuula A Nyma. Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA recognition pathway. Molecular & cellular proteomics : MCP. vol 13. issue 10. 2015-06-18. PMID:24997996. |
functional studies showed that rela-associated inhibitor regulated dsrna-induced apoptosis and tnf production. |
2015-06-18 |
2023-08-13 |
human |
| Antonio Hernandes Chaves Neto, Karin Juliane Pelizzaro-Rocha, Maruska Neufert Fernandes, Carmen Veríssima Ferreira-Halde. Antitumor activity of irradiated riboflavin on human renal carcinoma cell line 786-O. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 2. 2015-06-12. PMID:25273173. |
ir treatment was characterized by downregulation of fas ligand (tnf superfamily, member 6)/fas (tnf receptor superfamily member 6) (fasl/fas) and tumor necrosis factor receptor superfamily, member 1a (tnfr1)/tnfrsf1a-associated via death domain (tradd)/tnf receptor-associated factor 2 (traf) signaling pathways (the extrinsic apoptosis pathway), while the intrinsic apoptotic pathway was upregulated, as observed by an elevated bcl-2 associated x protein/b-cell cll/lymphoma 2 (bax/bcl-2) ratio, reduced cellular inhibitor of apoptosis 1 (c-iap1) expression, and increased expression of apoptosis-inducing factor (aif). |
2015-06-12 |
2023-08-13 |
mouse |
| G Cantarella, G Pignataro, G Di Benedetto, S Anzilotti, A Vinciguerra, O Cuomo, G F Di Renzo, C Parenti, L Annunziato, R Bernardin. Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype. Cell death & disease. vol 5. 2015-06-04. PMID:25032854. |
tnf-related apoptosis inducing ligand (trail), a member of the tnf superfamily released by microglia, appears to be involved in the induction of apoptosis following focal brain ischemia. |
2015-06-04 |
2023-08-13 |
rat |
| Lili Wei, Dave Hoole, Baojian Su. Identification of apoptosis-related genes and transcription variations in response to microcystin-LR in zebrafish liver. Toxicology and industrial health. vol 30. issue 9. 2015-05-27. PMID:23064767. |
the messenger rna abundance of some apoptosis-related genes was found to be increased, including five tumor necrosis factor (tnf)-related members (apoptosis regulatory protein siva, tumor necrosis factor-α (tnfa) tnf (ligand) superfamily member 10 (tnfsf10), tnf-inducible protein 6 (tnfaip6) and tnf receptor associated factor 2 binding protein (traf2bp)), three p53-related genes (tumor protein p53 inducible nuclear protein 1 (tp53inp1), p53-induced protein phosphatase 1 (ppm1d) and a novel apoptosis stimulating protein of p53 (aspp2)), bcl 2 family members (proapoptosis gene bax and antiapoptosis gene mcl 1), caspases (caspase y (caspy) and a pyd and card domain-containing protein (pycard)) and the transforming growth factor beta (tgf-β) induced apoptosis protein 2 (taip2). |
2015-05-27 |
2023-08-12 |
zebrafish |
| Guanghua Xu, Jing Wang, George Fu Gao, Cui Hua Li. Insights into battles between Mycobacterium tuberculosis and macrophages. Protein & cell. vol 5. issue 10. 2015-05-27. PMID:24938416. |
the signaling pathways that involve tnf, type i ifns and vitamin d are inter-connected, which play critical roles in the regulation of necroptosis, apoptosis, and autophagy of the infected macrophages. |
2015-05-27 |
2023-08-13 |
Not clear |
| Hiroshi Ohkawara, Toshiyuki Ishibashi, Koichi Sugimoto, Kazuhiko Ikeda, Kazuei Ogawa, Yasuchika Takeish. Membrane type 1-matrix metalloproteinase/Akt signaling axis modulates TNF-α-induced procoagulant activity and apoptosis in endothelial cells. PloS one. vol 9. issue 8. 2015-05-26. PMID:25162582. |
our hypothesis was that mt1-mmp cooperates with protein kinase b (akt) in tumor necrosis factor (tnf)-α-induced signaling pathways of vascular responses, including tissue factor (tf) procoagulant activity and endothelial apoptosis, in cultured human aortic endothelial cells (ecs). |
2015-05-26 |
2023-08-13 |
human |
| Pier-Luigi Meroni, Guido Valesin. Tumour necrosis factor α antagonists in the treatment of rheumatoid arthritis: an immunological perspective. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. vol 28 Suppl 1. 2015-05-21. PMID:24687234. |
other mechanisms of action proposed to be important for the efficacy of anti-tnf agents are as follows: induction of apoptosis of both monocytes and t cells; neutralization of membrane tnf; antibody-dependent cell-mediated and complement-dependent cytotoxicity; and reverse signaling via membrane tnf. |
2015-05-21 |
2023-08-12 |
Not clear |
| Achim Salamon, Stefanie Adam, Joachim Rychly, Kirsten Peter. Long-term tumor necrosis factor treatment induces NFκB activation and proliferation, but not osteoblastic differentiation of adipose tissue-derived mesenchymal stem cells in vitro. The international journal of biochemistry & cell biology. vol 54. 2015-05-21. PMID:25066315. |
in summary, we found continuous tnf exposure to induce the nuclear factor of kappa b pathway in asc as well as secretion of the pro-inflammatory chemokine interleukin 8, but not the mitogen-activated protein kinase and the apoptosis pathway in asc. |
2015-05-21 |
2023-08-13 |
Not clear |
| Jeny Shklover, Flonia Levy-Adam, Estee Kuran. The role of Drosophila TNF Eiger in developmental and damage-induced neuronal apoptosis. FEBS letters. vol 589. issue 8. 2015-05-20. PMID:25754009. |
the role of drosophila tnf eiger in developmental and damage-induced neuronal apoptosis. |
2015-05-20 |
2023-08-13 |
drosophila_melanogaster |
| Ya Wu, Minqian Zheng, Siqing Wang, Changzhi Song, Chuanbin Wang, Yueping Xiao, Lei Xu, Xiaozu X. Spatiotemporal pattern of TRAF3 expression after rat spinal cord injury. Journal of molecular histology. vol 45. issue 5. 2015-05-12. PMID:24803166. |
tnf receptor associated factor 3 (traf3), a member of the traf family of intracellular signaling proteins, can directly influence the phosphorylation status and activation of c-jun n-terminal kinase, participating in cd40-induced apoptosis in carcinoma. |
2015-05-12 |
2023-08-13 |
rat |