| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin Chopra, Andreas Brandl, Daniela Siegmund, Anja Mottok, Viktoria Schäfer, Marlene Biehl, Sabrina Kraus, Carina A Bäuerlein, Miriam Ritz, Katharina Mattenheimer, Stefanie Schwinn, Axel Seher, Thomas Grabinger, Hermann Einsele, Andreas Rosenwald, Thomas Brunner, Andreas Beilhack, Harald Wajan. Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD. Blood. vol 126. issue 4. 2015-10-13. PMID:26012567. |
inhibition of the tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak)/fibroblast growth factor-inducible 14 (fn14) system reduces intestinal cell death and disease development in several models of colitis. |
2015-10-13 |
2023-08-13 |
mouse |
| C Lutz, M Mozaffari, V Tosevski, M Caj, P Cippà, B L McRae, C L Graff, G Rogler, M Fried, M Hausman. Increased lymphocyte apoptosis in mouse models of colitis upon ABT-737 treatment is dependent upon BIM expression. Clinical and experimental immunology. vol 181. issue 2. 2015-09-30. PMID:25845418. |
increased apoptosis upon abt-737 was determined in blood lymphocytes, splenocytes and peyer's patches and was accompanied by a decrease in tnf and il-1b. |
2015-09-30 |
2023-08-13 |
mouse |
| Dario R Lemos, Farshad Babaeijandaghi, Marcela Low, Chih-Kai Chang, Sunny T Lee, Daniela Fiore, Regan-Heng Zhang, Anuradha Natarajan, Sergei A Nedospasov, Fabio M V Ross. Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. Nature medicine. vol 21. issue 7. 2015-09-28. PMID:26053624. |
we found that infiltrating inflammatory macrophages, through their expression of tumor necrosis factor (tnf), directly induce apoptosis of fibro/adipogenic progenitors (faps). |
2015-09-28 |
2023-08-13 |
mouse |
| Carmen Palacios, Rosario Yerbes, Tania Sanchez-Perez, Rosa Martin-Perez, Ana Cano-Gonzalez, Abelardo Lopez-Riva. The long and winding road to cancer treatment: the TRAIL system. Current pharmaceutical design. vol 20. issue 17. 2015-09-23. PMID:23944369. |
activation of cell surface death receptors of the tumor necrosis factor (tnf) receptor superfamily by the appropriate ligands represents an attractive therapeutic strategy to induce cell death by apoptosis in cancer cells. |
2015-09-23 |
2023-08-12 |
mouse |
| Carmen Palacios, Rosario Yerbes, Tania Sanchez-Perez, Rosa Martin-Perez, Ana Cano-Gonzalez, Abelardo Lopez-Riva. The long and winding road to cancer treatment: the TRAIL system. Current pharmaceutical design. vol 20. issue 17. 2015-09-23. PMID:23944369. |
tnf-related apoptosis-inducing ligand (trail/apo-2l), another member of the tnf family, has been shown to induce apoptosis selectively in many tumor cell lines. |
2015-09-23 |
2023-08-12 |
mouse |
| Joerg Uwe Schmohl, Tina Nuebling, Julia Wild, Johannes Jung, Tanja Kroell, Lothar Kanz, Helmut R Salih, Helga Schmetze. Death Receptor Expression on Blasts in AML Is Associated with Unfavorable Prognosis. Anticancer research. vol 35. issue 7. 2015-09-22. PMID:26124353. |
tumor necrosis factor (tnf) receptor family members play a key role in the regulation of biological functions such as differentiation, proliferation and apoptosis of various cell types. |
2015-09-22 |
2023-08-13 |
Not clear |
| Ulrik N Lassen, Didier Meulendijks, Lilian L Siu, Vaios Karanikas, Morten Mau-Sorensen, Jan H M Schellens, Derek J Jonker, Aaron R Hansen, Mary E Simcox, Kathleen J Schostack, Dean Bottino, Hua Zhong, Markus Roessler, Suzana M Vega-Harring, Tiantom Jarutat, David Geho, Ka Wang, Mark DeMario, Glenwood D Gos. A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 21. issue 2. 2015-09-17. PMID:25388164. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) and fibroblast growth factor-inducible molecule 14 (fn14) are a ligand-receptor pair frequently overexpressed in solid tumors. |
2015-09-17 |
2023-08-13 |
Not clear |
| Cui Wang, Quan Zhang, Yi Qian, Meirong Zha. p,p'-DDE induces apoptosis through the modulation of tumor necrosis factor α in PC12 cells. Chemical research in toxicology. vol 27. issue 4. 2015-09-15. PMID:24576310. |
microarray results indicate that the tnf family plays a key role in p,p'-dde-induced apoptosis among 84-apoptotic genes. |
2015-09-15 |
2023-08-12 |
zebrafish |
| Ahmed M Abu El-Asrar, Gert De Hertogh, Mohd Imtiaz Nawaz, Mohammad Mairaj Siddiquei, Kathleen Van den Eynde, Ghulam Mohammad, Ghislain Opdenakker, Karel Geboe. The tumor necrosis factor superfamily members TWEAK, TNFSF15 and fibroblast growth factor-inducible protein 14 are upregulated in proliferative diabetic retinopathy. Ophthalmic research. vol 53. issue 3. 2015-09-14. PMID:25676319. |
tumor necrosis factor-like weak inducer of apoptosis (tweak) and tumor necrosis factor superfamily member 15 (tnfsf15), members of the tnf superfamily, play important roles in the modulation of inflammation and neovascularization. |
2015-09-14 |
2023-08-13 |
rat |
| Taeko Dohi, Rei Kawashima, Yuki I Kawamura, Takeshi Otsubo, Teruki Hagiwara, Aldo Amatucci, Jennifer Michaelson, Linda C Burkl. Pathological activation of canonical nuclear-factor κB by synergy of tumor necrosis factor α and TNF-like weak inducer of apoptosis in mouse acute colitis. Cytokine. vol 69. issue 1. 2015-09-10. PMID:25022957. |
tnf-like weak inducer of apoptosis (tweak) is a member of the tnf superfamily that promotes inflammatory tissue damage through its receptor, fgf-inducible molecule 14 (fn14). |
2015-09-10 |
2023-08-13 |
mouse |
| Armita Valizadeh, Ahmad Ahmadzadeh, Ali Teimoori, Ali Khodadadi, Ghasem Sak. Effects of TNF secreting HEK cells on B lymphocytes' apoptosis in human chronic lymphocytic leukemias. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 22. 2015-08-27. PMID:25520123. |
effects of tnf secreting hek cells on b lymphocytes' apoptosis in human chronic lymphocytic leukemias. |
2015-08-27 |
2023-08-13 |
human |
| Danilo Swann Matassa, Ilenia Agliarulo, Maria Rosaria Amoroso, Francesca Maddalena, Leandra Sepe, Maria Carla Ferrari, Vinay Sagar, Silvia D'Amico, Fabrizio Loreni, Giovanni Paolella, Matteo Landriscina, Franca Esposit. TRAP1-dependent regulation of p70S6K is involved in the attenuation of protein synthesis and cell migration: relevance in human colorectal tumors. Molecular oncology. vol 8. issue 8. 2015-08-19. PMID:24962791. |
tnf receptor-associated protein 1 (trap1) is an hsp90 chaperone involved in stress protection and apoptosis in mitochondrial and extramitochondrial compartments. |
2015-08-19 |
2023-08-13 |
human |
| Y Zeng, E Katsani. The complex pathophysiology of acquired aplastic anaemia. Clinical and experimental immunology. vol 180. issue 3. 2015-08-11. PMID:25683099. |
dysregulated cd8(+) cytotoxic t cells, cd4(+) t cells including t helper type 1 (th1), th2, regulatory t cells and th17 cells, natural killer (nk) cells and nk t cells, along with the abnormal production of cytokines including interferon (ifn)-γ, tumour necrosis factor (tnf)-α and transforming growth factor (tgf)-β, induce apoptosis of hspcs, constituting a consistent and defining feature of severe aaa. |
2015-08-11 |
2023-08-13 |
human |
| Rajesh Palanisamy, Venkatesh Kumaresan, Ramasamy Harikrishnan, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Jesu Arockiara. Functional roles and gene regulation of tumor necrosis factor receptor 1 in freshwater striped murrel. Molecular immunology. vol 66. issue 2. 2015-08-11. PMID:25841174. |
the cstnfr1 encoded a type i membrane receptor protein that contains 399 amino acids including three cysteine-rich domains (crds) at crd1(41-46), crd2(79-118) and crd3(120-159) in the extracellular region and a putative tnf receptor-associated factor (traf) site at 245-253 and a death domain between 297 and 388 in the cytoplasmic region which is essential for induction of apoptosis. |
2015-08-11 |
2023-08-13 |
Not clear |
| Carmine Stolfi, Francesco Pallone, Giovanni Monteleon. Molecular targets of TRAIL-sensitizing agents in colorectal cancer. International journal of molecular sciences. vol 13. issue 7. 2015-08-07. PMID:22942679. |
tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail), a member of the tnf superfamily, interacts with its functional death receptors (drs) and induces apoptosis in a wide range of cancer cell types. |
2015-08-07 |
2023-08-12 |
Not clear |
| Tugba Bagci-Onder, Wanlu Du, Jose-Luiz Figueiredo, Jordi Martinez-Quintanilla, Khalid Sha. Targeting breast to brain metastatic tumours with death receptor ligand expressing therapeutic stem cells. Brain : a journal of neurology. vol 138. issue Pt 6. 2015-08-07. PMID:25910782. |
based on the recent findings that metastatic tumour cells adopt unique mechanisms of evading apoptosis to successfully colonize in the brain, we reasoned that tnf receptor superfamily member 10a/10b apoptosis-inducing ligand (trail) based pro-apoptotic therapies that induce death receptor signalling within the metastatic tumour cells might be a favourable therapeutic approach. |
2015-08-07 |
2023-08-13 |
mouse |
| Subhadeep Mukherjee, Tapas Biswa. Activation of TOLLIP by porin prevents TLR2-associated IFN-γ and TNF-α-induced apoptosis of intestinal epithelial cells. Cellular signalling. vol 26. issue 12. 2015-08-06. PMID:25152369. |
interferon (ifn)-γ and tumor necrosis factor (tnf)-α cause chronic inflammation of the intestine leading to progression of inflammatory bowel disease (ibd), which is manifested through rapid apoptosis of the intestinal epithelial cells (iecs). |
2015-08-06 |
2023-08-13 |
Not clear |
| Gregor Ebert, Simon Preston, Cody Allison, James Cooney, Jesse G Toe, Michael D Stutz, Samar Ojaimi, Hamish W Scott, Nikola Baschuk, Ueli Nachbur, Joseph Torresi, Ruth Chin, Danielle Colledge, Xin Li, Nadia Warner, Peter Revill, Scott Bowden, John Silke, C Glenn Begley, Marc Pellegrin. Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 18. 2015-08-05. PMID:25902529. |
here, we show that cellular inhibitor of apoptosis proteins (ciaps) attenuate tnf signaling during hepatitis b infection, and they restrict the death of infected hepatocytes, thus allowing viral persistence. |
2015-08-05 |
2023-08-13 |
mouse |
| Pradeep M Nair, Heather Flores, Alvin Gogineni, Scot Marsters, David A Lawrence, Robert F Kelley, Hai Ngu, Meredith Sagolla, Laszlo Komuves, Richard Bourgon, Jeffrey Settleman, Avi Ashkenaz. Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 18. 2015-08-04. PMID:25902490. |
tnf superfamily death ligands are expressed on the surface of immune cells and can trigger apoptosis in susceptible cancer cells by engaging cognate death receptors. |
2015-08-04 |
2023-08-13 |
Not clear |
| An Hue Vy Tran, Soo-Hyun Hahm, Se Hee Han, Ji Hyung Chung, Geon Tae Park, Ye Sun Ha. Functional interaction between hMYH and hTRADD in the TNF-α-mediated survival and death pathways of HeLa cells. Mutation research. vol 777. 2015-08-03. PMID:25912078. |
the tumor necrosis factor (tnf) signaling pathway is a classical immune system pathway that plays a key role in regulating cell survival and apoptosis. |
2015-08-03 |
2023-08-13 |
human |