| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Othman Al-Sawaf, Athanassios Fragoulis, Christian Rosen, Yuet Wai Kan, Tolga Taha Sönmez, Thomas Pufe, Christoph Jan Wruc. Nrf2 protects against TWEAK-mediated skeletal muscle wasting. Scientific reports. vol 4. 2014-08-26. PMID:24406502. |
particularly, the inflammatory cytokine tumour necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is a potent inducer of skeletal muscle wasting and fibrosis. |
2014-08-26 |
2023-08-12 |
mouse |
| Sushil Kumar Pathak, Raquel Tavares, Nele de Klerk, Anna-Lena Spetz, Ann-Beth Jonsso. Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223737. |
helicobacter pylori protein jhp0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (tnf)-dependent and independent pathways. |
2014-08-20 |
2023-08-12 |
human |
| Sushil Kumar Pathak, Raquel Tavares, Nele de Klerk, Anna-Lena Spetz, Ann-Beth Jonsso. Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223737. |
exposure to rjhp0290 induced apoptosis in macrophages concurrent with release of proinflammatory cytokine tumor necrosis factor (tnf). |
2014-08-20 |
2023-08-12 |
human |
| Sushil Kumar Pathak, Raquel Tavares, Nele de Klerk, Anna-Lena Spetz, Ann-Beth Jonsso. Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223737. |
a mutant strain of h. pylori disrupted in the jhp0290 gene was significantly impaired in its ability to induce apoptosis and tnf in macrophages confirming the role of endogenous protein in regulating macrophage responses. |
2014-08-20 |
2023-08-12 |
human |
| Sushil Kumar Pathak, Raquel Tavares, Nele de Klerk, Anna-Lena Spetz, Ann-Beth Jonsso. Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223737. |
intracellular signaling involving src family of tyrosine kinases (sfks) and erk mapk were required for rjhp0290-induced tnf release and apoptosis in macrophages. |
2014-08-20 |
2023-08-12 |
human |
| Sushil Kumar Pathak, Raquel Tavares, Nele de Klerk, Anna-Lena Spetz, Ann-Beth Jonsso. Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223737. |
neutralizing antibodies against tnf partially blocked rjhp0290-induced macrophage apoptosis indicating tnf-independent pathways were also involved. |
2014-08-20 |
2023-08-12 |
human |
| Sushil Kumar Pathak, Raquel Tavares, Nele de Klerk, Anna-Lena Spetz, Ann-Beth Jonsso. Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223737. |
by virtue of its ability to induce tnf, an acid suppressive proinflammatory cytokine and induction of macrophage apoptosis, jhp0290 possibly helps in persistent survival of the bacterium inside the stomach. |
2014-08-20 |
2023-08-12 |
human |
| Andrew Volk, Jing Li, Junping Xin, Dewen You, Jun Zhang, Xinli Liu, Yechen Xiao, Peter Breslin, Zejuan Li, Wei Wei, Rachel Schmidt, Xingyu Li, Zhou Zhang, Paul C Kuo, Sucha Nand, Jianke Zhang, Jianjun Chen, Jiwang Zhan. Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML. The Journal of experimental medicine. vol 211. issue 6. 2014-08-20. PMID:24842373. |
although stimulating hspc with tnf promotes necroptosis and apoptosis, similar treatment with aml cells (leukemic cells, lcs) results in an increase in survival and proliferation. |
2014-08-20 |
2023-08-13 |
human |
| Harald Wajan. The TWEAK-Fn14 system as a potential drug target. British journal of pharmacology. vol 170. issue 4. 2014-08-19. PMID:23957828. |
fn14 becomes activated by tnf-like weak inducer of apoptosis (tweak), a typical member of the tnf ligand family. |
2014-08-19 |
2023-08-12 |
mouse |
| Stephen W G Tait, Andrew Oberst, Giovanni Quarato, Sandra Milasta, Martina Haller, Ruoning Wang, Maria Karvela, Gabriel Ichim, Nader Yatim, Matthew L Albert, Grahame Kidd, Randall Wakefield, Sharon Frase, Stefan Krautwald, Andreas Linkermann, Douglas R Gree. Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell reports. vol 5. issue 4. 2014-08-19. PMID:24268776. |
mitochondria-deficient cells were resistant to the mitochondrial pathway of apoptosis, but efficiently died via tumor necrosis factor (tnf)-induced, ripk3-dependent programmed necrosis or as a result of direct oligomerization of ripk3. |
2014-08-19 |
2023-08-12 |
Not clear |
| Yan Tang, Meng-hong Wan. [MicroRNA-21 protects cardiomyocytes from tumor necrosis factor-α induced apoptosis in vitro via modulating PTEN/AKT/FOXO3a pathway]. Zhonghua xin xue guan bing za zhi. vol 41. issue 2. 2014-08-11. PMID:23710745. |
to explore the effect of microrna-21 on tumor necrosis factor (tnf)-α induced cardiomyocytes apoptosis and the association with pten/akt/foxo3a signaling pathway. |
2014-08-11 |
2023-08-12 |
Not clear |
| Wei Wang, Mei Zhang, Weimin Sun, Shanmin Yang, Ying Su, Hengshan Zhang, Chaomei Liu, Xinfeng Li, Ling Lin, Sunghee Kim, Paul Okunieff, Zhenhuan Zhang, Lurong Zhan. Reduction of decoy receptor 3 enhances TRAIL-mediated apoptosis in pancreatic cancer. PloS one. vol 8. issue 10. 2014-08-04. PMID:24204567. |
most human pancreatic cancer cells are resistant to tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-mediated apoptosis. |
2014-08-04 |
2023-08-12 |
human |
| Jia Cai, Youhua Huang, Shina Wei, Zhengliang Ouyang, Xiaohong Huang, Qiwei Qi. Characterization of LPS-induced TNFα factor (LITAF) from orange-spotted grouper, Epinephelus coioides. Fish & shellfish immunology. vol 35. issue 6. 2014-07-29. PMID:24091064. |
overexpression of ec-litaf in vitro up-regulated the expression of tumor necrosis factors (tnf1 and tnf2) and tnf receptors (tnfr1 and tnfr2), and the expression of itself initiated apoptosis in fish cells. |
2014-07-29 |
2023-08-12 |
Not clear |
| Hong Zhu, Min Huang, Daoling Ren, Jianping He, Fen Zhao, Cheng Yi, Ying Huan. The synergistic effects of low dose fluorouracil and TRAIL on TRAIL-resistant human gastric adenocarcinoma AGS cells. BioMed research international. vol 2013. 2014-07-29. PMID:24324958. |
the tnf-related apoptosis-inducing ligand (trail) is a tnf family member which has been under intense focus because of its remarkable ability to induce apoptosis in malignant human cells while leaving normal cells unscathed. |
2014-07-29 |
2023-08-12 |
human |
| A Son, T Oshio, Y I Kawamura, T Hagiwara, M Yamazaki, K Inagaki-Ohara, T Okada, P Wu, M Iseki, S Takaki, L C Burkly, T Doh. TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice. Mucosal immunology. vol 6. issue 6. 2014-07-18. PMID:23462911. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak), a tnf superfamily member, induces damage of the epithelial cells (ecs) and production of inflammatory mediaters through its receptor fn14 in a model of acute colitis. |
2014-07-18 |
2023-08-12 |
mouse |
| Stéphanie Solier, Yves Pommie. The nuclear γ-H2AX apoptotic ring: implications for cancers and autoimmune diseases. Cellular and molecular life sciences : CMLS. vol 71. issue 12. 2014-07-10. PMID:24448903. |
apoptosis involves intrinsic pathways typically initiated by dna damaging agents and engaging mitochondria, and extrinsic pathways typically initiated by "death receptors" and their ligands trail and tnf at the cell surface. |
2014-07-10 |
2023-08-12 |
Not clear |
| Jason Dubbert, Amy Bowers, Yutao Su, David McClenaha. Effect of TRIF on permeability and apoptosis in bovine microvascular endothelial cells exposed to lipopolysaccharide. Veterinary journal (London, England : 1997). vol 198. issue 2. 2014-07-09. PMID:24075204. |
effects were measured using trans-well endothelial electrical resistance to determine cell monolayer permeability, annexin staining to estimate apoptosis and real-time pcr to measure levels of expression of il-1β and tumor necrosis factor (tnf)-α mrna. |
2014-07-09 |
2023-08-12 |
cattle |
| Joan Vendrell, Matilde R Chacó. TWEAK: A New Player in Obesity and Diabetes. Frontiers in immunology. vol 4. 2014-06-24. PMID:24416031. |
tumor necrosis factor weak inducer of apoptosis (tweak), a cytokine of the tumor necrosis (tnf) superfamily, is gaining attention as an important player in chronic inflammatory diseases. |
2014-06-24 |
2023-08-12 |
Not clear |
| Luis M Blanco-Coli. TWEAK/Fn14 Axis: A Promising Target for the Treatment of Cardiovascular Diseases. Frontiers in immunology. vol 5. 2014-06-24. PMID:24478772. |
tnf-like weak inducer of apoptosis (tweak) and its functional receptor and fibroblast growth factor-inducible molecule 14 (fn14) are two proteins belonging to the tnf superfamily that activate nf-κb by both canonical and non-canonical pathways and regulate several cell functions such as proliferation, migration, differentiation, cell death, inflammation, and angiogenesis. |
2014-06-24 |
2023-08-12 |
Not clear |
| Benjamin J Dwyer, John K Olynyk, Grant A Ramm, Janina E E Tirnitz-Parke. TWEAK and LTβ Signaling during Chronic Liver Disease. Frontiers in immunology. vol 5. 2014-06-24. PMID:24592262. |
recent studies from our group and others have suggested the potential for cytokine and chemokine cross-talk between lpcs and hscs, which is mainly driven by the tumor necrosis factor (tnf) family members, tnf-like weak inducer of apoptosis (tweak) and lymphotoxin-β, potentially dictating the pathological outcomes of chronic liver injury. |
2014-06-24 |
2023-08-12 |
Not clear |