| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shyama Pal, Bhavani S Shankar, Krishna B Saini. Cytokines from the tumor microenvironment modulate sirtinol cytotoxicity in A549 lung carcinoma cells. Cytokine. vol 64. issue 1. 2014-04-15. PMID:23972545. |
we have chosen tumor necrosis factor α (tnf-α), tnf related apoptosis inducing ligand (trail), insulin-like growth factor 1 (igf-1) and transforming growth factor β (tgf-β) as representative pro-inflammatory, pro-apoptotic, anti-apoptotic and anti-inflammatory tumor derived cytokines. |
2014-04-15 |
2023-08-12 |
Not clear |
| Jong Hwan Yoon, Hyun Ho Par. Preliminary X-ray crystallographic studies of the TRAF domain of human TRAF4. Acta crystallographica. Section F, Structural biology and crystallization communications. vol 69. issue Pt 9. 2014-04-15. PMID:23989155. |
tnf receptor-associated factor (traf) proteins were initially identified as tumour necrosis factor receptor (tnfr)-interacting proteins that perform critical functions in the regulation of inflammation, antiviral responses and apoptosis. |
2014-04-15 |
2023-08-12 |
human |
| Hossein Ameri, Hua Liu, Rong Liu, Yonju Ha, Adriana A Paulucci-Holthauzen, Shuqun Hu, Massoud Motamedi, Bernard F Godley, Ronald G Tilton, Wenbo Zhan. TWEAK/Fn14 pathway is a novel mediator of retinal neovascularization. Investigative ophthalmology & visual science. vol 55. issue 2. 2014-04-14. PMID:24408972. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) and its receptor, fibroblast growth factor inducible-14 (fn14), have been implicated in angiogenesis, but their role in retinal diseases is unknown. |
2014-04-14 |
2023-08-12 |
Not clear |
| R Rajandram, N C Bennett, C Morais, D W Johnson, G C Gob. Renal cell carcinoma: resistance to therapy, role of apoptosis, and the prognostic and therapeutic target potential of TRAF proteins. Medical hypotheses. vol 78. issue 2. 2014-04-09. PMID:22153576. |
here we present the hypothesis that select members of the tumor necrosis factor (tnf) superfamily, the tnf receptor-associated factors (trafs), have a role in rcc apoptosis and may have prognostic significance for rcc. |
2014-04-09 |
2023-08-12 |
Not clear |
| Tomohiko Machida, Masahiro Tanemura, Yoshiaki Ohmura, Tsukasa Tanida, Hiroshi Wada, Shogo Kobayashi, Shigeru Marubashi, Hidetoshi Eguchi, Toshinori Ito, Hiroaki Nagano, Masaki Mori, Yuichiro Doki, Yoshiki Saw. Significant improvement in islet yield and survival with modified ET-Kyoto solution: ET-Kyoto/Neutrophil elastase inhibitor. Cell transplantation. vol 22. issue 1. 2014-04-08. PMID:22472201. |
ne and proinflammatory cytokines such as tumor necrosis factor (tnf)-α and interleukin (il)-6 increased markedly at the end of warm digestion during islet isolation and exhibited direct cytotoxic activity against the islets causing their apoptosis. |
2014-04-08 |
2023-08-12 |
mouse |
| M Y Yu, P Q Zhao, X H Yan, B Liu, Q Q Zhang, R Wang, C H Ma, X H Liang, F L Zhu, L F Ga. Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population. Genetics and molecular research : GMR. vol 12. issue 3. 2014-04-08. PMID:24065684. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is expressed in different tissues and cells, including the pancreas and lymphocytes, and it can selectively induce apoptosis in tumor cells but not in most normal cells. |
2014-04-08 |
2023-08-12 |
Not clear |
| Weimin Wang, Jiansuo Zhou, Juan Shi, Yaxi Zhang, Shilian Liu, Yanxin Liu, Dexian Zhen. Human T-cell leukemia virus type 1 Tax-deregulated autophagy pathway and c-FLIP expression contribute to resistance against death receptor-mediated apoptosis. Journal of virology. vol 88. issue 5. 2014-04-08. PMID:24352466. |
htlv-1 tax-expressing cells show resistance to apoptosis induced by fas ligand (fasl) and tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail). |
2014-04-08 |
2023-08-12 |
human |
| Sho Morioka, Peter Broglie, Emily Omori, Yuka Ikeda, Giichi Takaesu, Kunihiro Matsumoto, Jun Ninomiya-Tsuj. TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation. The Journal of cell biology. vol 204. issue 4. 2014-04-08. PMID:24535827. |
tak1 kinase switches cell fate from apoptosis to necrosis following tnf stimulation. |
2014-04-08 |
2023-08-12 |
Not clear |
| Sho Morioka, Peter Broglie, Emily Omori, Yuka Ikeda, Giichi Takaesu, Kunihiro Matsumoto, Jun Ninomiya-Tsuj. TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation. The Journal of cell biology. vol 204. issue 4. 2014-04-08. PMID:24535827. |
tnf activates three distinct intracellular signaling cascades leading to cell survival, caspase-8-mediated apoptosis, or receptor interacting protein kinase 3 (ripk3)-dependent necrosis, also called necroptosis. |
2014-04-08 |
2023-08-12 |
Not clear |
| O V Dolgikh, A V Krivtsov, O A Bubnova, R A Predeina, D G Dianova, O O Sinitsyna, N N Maliutina, L A Taranenk. [Immunogenetic features of apoptosis in workers engaged in methanol production]. Meditsina truda i promyshlennaia ekologiia. issue 11. 2014-04-04. PMID:24640084. |
genetic changes in the main group are associated with reliable decrease in occurrence of transcription protein p53 and tnf receptor, and with altered ratio of intracellular apoptosis factors (bax and bcl-2) towards slower programmed cellular death in chemical production. |
2014-04-04 |
2023-08-12 |
Not clear |
| Li-Qiang Pan, Hai-Bin Wang, Jun Lai, Ying-Chun Xu, Chen Zhang, Shu-Qing Che. Site-specific PEGylation of a mutated-cysteine residue and its effect on tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Biomaterials. vol 34. issue 36. 2014-03-25. PMID:23981355. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a promising antitumor agent that specifically induces apoptosis in broad-spectrum tumor cell lines, meanwhile leaving normal cells unaffected. |
2014-03-25 |
2023-08-12 |
Not clear |
| Mohamed H M Ezzat, Tarek M A El-Gammasy, Kareem Y A Shaheen, Ramzi A M El-Mezdawi, Mervat S M Yousse. Up regulation of serum tumor necrosis factor-related apoptosis inducing ligand in juvenile-onset systemic lupus erythematosus: relations with disease activity, antibodies to double -stranded DNA, nephritis and neutropenia. International journal of rheumatic diseases. vol 16. issue 3. 2014-03-17. PMID:23981753. |
apoptosis is induced by binding of death receptor ligands, members of the tumor necrosis factor (tnf) superfamily, to their cognate receptors. |
2014-03-17 |
2023-08-12 |
Not clear |
| Julia Freimuth, Jörg-Martin Bangen, Daniela Lambertz, Wei Hu, Yulia Alexandrowna Nevzorova, Roland Sonntag, Nikolaus Gassler, Dieter Riethmacher, Christian Trautwein, Christian Liedtk. Loss of caspase-8 in hepatocytes accelerates the onset of liver regeneration in mice through premature nuclear factor kappa B activation. Hepatology (Baltimore, Md.). vol 58. issue 5. 2014-03-12. PMID:23728913. |
tnf stimulates at least three different pathways leading to nuclear factor kappa b (nf-κb) activation, apoptosis signaling by way of caspase-8 (casp8), and activation of cjun n-terminal kinases (jnk). |
2014-03-12 |
2023-08-12 |
mouse |
| José Antonio Carmona Arana, Axel Seher, Manfred Neumann, Isabell Lang, Daniela Siegmund, Harald Wajan. TNF Receptor-Associated Factor 1 is a Major Target of Soluble TWEAK. Frontiers in immunology. vol 5. 2014-03-06. PMID:24600451. |
soluble tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak), in contrast to membrane tweak and tnf, is only a weak activator of the classical nfκb pathway. |
2014-03-06 |
2023-08-12 |
Not clear |
| Boris Guennewig, Martina Roos, Afzal M Dogar, Luca F R Gebert, Julian A Zagalak, Valentina Vongrad, Karin J Metzner, Jonathan Hal. Synthetic pre-microRNAs reveal dual-strand activity of miR-34a on TNF-α. RNA (New York, N.Y.). vol 20. issue 1. 2014-02-28. PMID:24249224. |
we use syn-pre-mirnas to show that mir-34a uses its 5p and 3p mirnas in two pathways: apoptosis during tgf-β signaling, where sirt1 and sp4 are suppressed by mir-34a-5p and mir-34a-3p, respectively; and the lipopolysaccharide (lps)-activation of primary human monocyte-derived macrophages, where tnf (tnfα) is suppressed by mir-34a-5p indirectly and mir-34a-3p directly. |
2014-02-28 |
2023-08-12 |
human |
| Wei Ruan, Suobei Li, Junmei Xu, Feng Xiao, Rong Ta. [Silencing of MST1 expression by siRNA diminishes TNF-α- mediated human umbilical vein endothelial cell apoptosis]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 37. issue 7. 2014-02-27. PMID:22886217. |
to elucidate the effects of mammalian sterile 20-like kinase 1 (mst1) gene on tumor necrosis factor (tnf)-α-mediated human umbilical vein endothelial cell (huvec) apoptosis. |
2014-02-27 |
2023-08-12 |
human |
| T Kohl, N Gehrke, A Schad, M Nagel, M A Wörns, M F Sprinzl, T Zimmermann, Y-W He, P R Galle, M Schuchmann, J M Schattenber. Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells. Cell death & disease. vol 4. 2014-02-25. PMID:23828575. |
cflip regulates cellular injury from apoptosis signaling pathways, and loss of cflip was previously shown to promote injury from activated tnf and cd95/apo-1 receptors. |
2014-02-25 |
2023-08-12 |
mouse |
| Noritaka Yamaguchi, Masaaki Oyama, Hiroko Kozuka-Hata, Jun-ichiro Inou. Involvement of A20 in the molecular switch that activates the non-canonical NF-кB pathway. Scientific reports. vol 3. 2014-02-14. PMID:24008839. |
a critical event in activation of the non-canonical pathway is the attenuation of nf-κb-inducing kinase (nik) degradation, which is promoted by continuous polyubiquitination of nik catalyzed by the nik ubiquitin-ligase complex composed of cellular inhibitor of apoptosis protein 1 and 2 (ciap1/2), tnf receptor-associated factor 2 (traf2), and traf3. |
2014-02-14 |
2023-08-12 |
Not clear |
| Yuji Ogura, Vivek Mishra, Sajedah M Hindi, Shihuan Kuang, Ashok Kuma. Proinflammatory cytokine tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) suppresses satellite cell self-renewal through inversely modulating Notch and NF-κB signaling pathways. The Journal of biological chemistry. vol 288. issue 49. 2014-02-13. PMID:24151074. |
proinflammatory cytokine tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) suppresses satellite cell self-renewal through inversely modulating notch and nf-κb signaling pathways. |
2014-02-13 |
2023-08-12 |
mouse |
| Valerio Giacomo Minero, Amina Khadjavi, Paola Costelli, Francesco Maria Baccino, Gabriella Bonell. JNK activation is required for TNFα-induced apoptosis in human hepatocarcinoma cells. International immunopharmacology. vol 17. issue 1. 2014-02-03. PMID:23751896. |
a frequent distinctive feature of tumors, hepatocellular carcinomas included, is resistance to apoptosis induced by a variety of agents, among which the pleiotropic cytokine tumor necrosis factor-α (tnf). |
2014-02-03 |
2023-08-12 |
human |