| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Y Yu, P Q Zhao, X H Yan, B Liu, Q Q Zhang, R Wang, C H Ma, X H Liang, F L Zhu, L F Ga. Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population. Genetics and molecular research : GMR. vol 12. issue 3. 2014-04-08. PMID:24065684. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is expressed in different tissues and cells, including the pancreas and lymphocytes, and it can selectively induce apoptosis in tumor cells but not in most normal cells. |
2014-04-08 |
2023-08-12 |
Not clear |
| Weimin Wang, Jiansuo Zhou, Juan Shi, Yaxi Zhang, Shilian Liu, Yanxin Liu, Dexian Zhen. Human T-cell leukemia virus type 1 Tax-deregulated autophagy pathway and c-FLIP expression contribute to resistance against death receptor-mediated apoptosis. Journal of virology. vol 88. issue 5. 2014-04-08. PMID:24352466. |
htlv-1 tax-expressing cells show resistance to apoptosis induced by fas ligand (fasl) and tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail). |
2014-04-08 |
2023-08-12 |
human |
| Sho Morioka, Peter Broglie, Emily Omori, Yuka Ikeda, Giichi Takaesu, Kunihiro Matsumoto, Jun Ninomiya-Tsuj. TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation. The Journal of cell biology. vol 204. issue 4. 2014-04-08. PMID:24535827. |
tak1 kinase switches cell fate from apoptosis to necrosis following tnf stimulation. |
2014-04-08 |
2023-08-12 |
Not clear |
| Sho Morioka, Peter Broglie, Emily Omori, Yuka Ikeda, Giichi Takaesu, Kunihiro Matsumoto, Jun Ninomiya-Tsuj. TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation. The Journal of cell biology. vol 204. issue 4. 2014-04-08. PMID:24535827. |
tnf activates three distinct intracellular signaling cascades leading to cell survival, caspase-8-mediated apoptosis, or receptor interacting protein kinase 3 (ripk3)-dependent necrosis, also called necroptosis. |
2014-04-08 |
2023-08-12 |
Not clear |
| O V Dolgikh, A V Krivtsov, O A Bubnova, R A Predeina, D G Dianova, O O Sinitsyna, N N Maliutina, L A Taranenk. [Immunogenetic features of apoptosis in workers engaged in methanol production]. Meditsina truda i promyshlennaia ekologiia. issue 11. 2014-04-04. PMID:24640084. |
genetic changes in the main group are associated with reliable decrease in occurrence of transcription protein p53 and tnf receptor, and with altered ratio of intracellular apoptosis factors (bax and bcl-2) towards slower programmed cellular death in chemical production. |
2014-04-04 |
2023-08-12 |
Not clear |
| Li-Qiang Pan, Hai-Bin Wang, Jun Lai, Ying-Chun Xu, Chen Zhang, Shu-Qing Che. Site-specific PEGylation of a mutated-cysteine residue and its effect on tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). Biomaterials. vol 34. issue 36. 2014-03-25. PMID:23981355. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a promising antitumor agent that specifically induces apoptosis in broad-spectrum tumor cell lines, meanwhile leaving normal cells unaffected. |
2014-03-25 |
2023-08-12 |
Not clear |
| Mohamed H M Ezzat, Tarek M A El-Gammasy, Kareem Y A Shaheen, Ramzi A M El-Mezdawi, Mervat S M Yousse. Up regulation of serum tumor necrosis factor-related apoptosis inducing ligand in juvenile-onset systemic lupus erythematosus: relations with disease activity, antibodies to double -stranded DNA, nephritis and neutropenia. International journal of rheumatic diseases. vol 16. issue 3. 2014-03-17. PMID:23981753. |
apoptosis is induced by binding of death receptor ligands, members of the tumor necrosis factor (tnf) superfamily, to their cognate receptors. |
2014-03-17 |
2023-08-12 |
Not clear |
| Julia Freimuth, Jörg-Martin Bangen, Daniela Lambertz, Wei Hu, Yulia Alexandrowna Nevzorova, Roland Sonntag, Nikolaus Gassler, Dieter Riethmacher, Christian Trautwein, Christian Liedtk. Loss of caspase-8 in hepatocytes accelerates the onset of liver regeneration in mice through premature nuclear factor kappa B activation. Hepatology (Baltimore, Md.). vol 58. issue 5. 2014-03-12. PMID:23728913. |
tnf stimulates at least three different pathways leading to nuclear factor kappa b (nf-κb) activation, apoptosis signaling by way of caspase-8 (casp8), and activation of cjun n-terminal kinases (jnk). |
2014-03-12 |
2023-08-12 |
mouse |
| José Antonio Carmona Arana, Axel Seher, Manfred Neumann, Isabell Lang, Daniela Siegmund, Harald Wajan. TNF Receptor-Associated Factor 1 is a Major Target of Soluble TWEAK. Frontiers in immunology. vol 5. 2014-03-06. PMID:24600451. |
soluble tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak), in contrast to membrane tweak and tnf, is only a weak activator of the classical nfκb pathway. |
2014-03-06 |
2023-08-12 |
Not clear |
| Boris Guennewig, Martina Roos, Afzal M Dogar, Luca F R Gebert, Julian A Zagalak, Valentina Vongrad, Karin J Metzner, Jonathan Hal. Synthetic pre-microRNAs reveal dual-strand activity of miR-34a on TNF-α. RNA (New York, N.Y.). vol 20. issue 1. 2014-02-28. PMID:24249224. |
we use syn-pre-mirnas to show that mir-34a uses its 5p and 3p mirnas in two pathways: apoptosis during tgf-β signaling, where sirt1 and sp4 are suppressed by mir-34a-5p and mir-34a-3p, respectively; and the lipopolysaccharide (lps)-activation of primary human monocyte-derived macrophages, where tnf (tnfα) is suppressed by mir-34a-5p indirectly and mir-34a-3p directly. |
2014-02-28 |
2023-08-12 |
human |
| Wei Ruan, Suobei Li, Junmei Xu, Feng Xiao, Rong Ta. [Silencing of MST1 expression by siRNA diminishes TNF-α- mediated human umbilical vein endothelial cell apoptosis]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 37. issue 7. 2014-02-27. PMID:22886217. |
to elucidate the effects of mammalian sterile 20-like kinase 1 (mst1) gene on tumor necrosis factor (tnf)-α-mediated human umbilical vein endothelial cell (huvec) apoptosis. |
2014-02-27 |
2023-08-12 |
human |
| T Kohl, N Gehrke, A Schad, M Nagel, M A Wörns, M F Sprinzl, T Zimmermann, Y-W He, P R Galle, M Schuchmann, J M Schattenber. Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells. Cell death & disease. vol 4. 2014-02-25. PMID:23828575. |
cflip regulates cellular injury from apoptosis signaling pathways, and loss of cflip was previously shown to promote injury from activated tnf and cd95/apo-1 receptors. |
2014-02-25 |
2023-08-12 |
mouse |
| Noritaka Yamaguchi, Masaaki Oyama, Hiroko Kozuka-Hata, Jun-ichiro Inou. Involvement of A20 in the molecular switch that activates the non-canonical NF-кB pathway. Scientific reports. vol 3. 2014-02-14. PMID:24008839. |
a critical event in activation of the non-canonical pathway is the attenuation of nf-κb-inducing kinase (nik) degradation, which is promoted by continuous polyubiquitination of nik catalyzed by the nik ubiquitin-ligase complex composed of cellular inhibitor of apoptosis protein 1 and 2 (ciap1/2), tnf receptor-associated factor 2 (traf2), and traf3. |
2014-02-14 |
2023-08-12 |
Not clear |
| Yuji Ogura, Vivek Mishra, Sajedah M Hindi, Shihuan Kuang, Ashok Kuma. Proinflammatory cytokine tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) suppresses satellite cell self-renewal through inversely modulating Notch and NF-κB signaling pathways. The Journal of biological chemistry. vol 288. issue 49. 2014-02-13. PMID:24151074. |
proinflammatory cytokine tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) suppresses satellite cell self-renewal through inversely modulating notch and nf-κb signaling pathways. |
2014-02-13 |
2023-08-12 |
mouse |
| Valerio Giacomo Minero, Amina Khadjavi, Paola Costelli, Francesco Maria Baccino, Gabriella Bonell. JNK activation is required for TNFα-induced apoptosis in human hepatocarcinoma cells. International immunopharmacology. vol 17. issue 1. 2014-02-03. PMID:23751896. |
a frequent distinctive feature of tumors, hepatocellular carcinomas included, is resistance to apoptosis induced by a variety of agents, among which the pleiotropic cytokine tumor necrosis factor-α (tnf). |
2014-02-03 |
2023-08-12 |
human |
| Valerio Giacomo Minero, Amina Khadjavi, Paola Costelli, Francesco Maria Baccino, Gabriella Bonell. JNK activation is required for TNFα-induced apoptosis in human hepatocarcinoma cells. International immunopharmacology. vol 17. issue 1. 2014-02-03. PMID:23751896. |
compared to other cell types, hepatocytes and hepatoma-derived cell lines are poorly susceptible to tnf-induced apoptosis, which is largely ascribed to activation of the prosurvival transcription factor nf-κb and can be overcome by associating tnf to low doses of protein synthesis inhibitors or other drugs. |
2014-02-03 |
2023-08-12 |
human |
| Xia Liu, Xue-mei Ji, Xi-ning Du, Xi-cui Zong, Ding-fang Liang, Li Ma, Hai-tao Wu, Shuang-quan Zhan. Molecular cloning, expression, bioinformatics analysis, and bioactivity of TNFSF13 (APRIL) in the South African clawed frog (Xenopus laevi): a new model to study immunological diseases. Omics : a journal of integrative biology. vol 17. issue 7. 2014-01-23. PMID:23829578. |
tnfsf13 is one of the tumor necrosis factor (tnf) superfamily members that plays important roles in immune homeostasis and proliferation or apoptosis of certain tumor cell lines. |
2014-01-23 |
2023-08-12 |
mouse |
| Jing Xu, Zhengfan Xu, Jun-Ying Zhou, Zhengping Zhuang, Enhua Wang, Julie Boerner, Gen Sheng W. Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. The Journal of biological chemistry. vol 288. issue 46. 2014-01-23. PMID:24100030. |
regulation of the src-pp2a interaction in tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-induced apoptosis. |
2014-01-23 |
2023-08-12 |
Not clear |
| Su-Geun Lim, Kyoungho Suk, Won-Ha Le. Reverse signaling from LIGHT promotes pro-inflammatory responses in the human monocytic leukemia cell line, THP-1. Cellular immunology. vol 285. issue 1-2. 2014-01-20. PMID:24044961. |
light is a type ii transmembrane protein belonging to the tnf superfamily which is involved in co-stimulation of t cells or apoptosis in tumors. |
2014-01-20 |
2023-08-12 |
human |
| Divya Mehta, Charles L Raison, Bobbi J Woolwine, Ebrahim Haroon, Elisabeth B Binder, Andrew H Miller, Jennifer C Felge. Transcriptional signatures related to glucose and lipid metabolism predict treatment response to the tumor necrosis factor antagonist infliximab in patients with treatment-resistant depression. Brain, behavior, and immunity. vol 31. 2014-01-16. PMID:23624296. |
responders also demonstrated inhibition of genes related to apoptosis through tnf signaling at 6 h and 24 h after infusion. |
2014-01-16 |
2023-08-12 |
Not clear |