| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hidenari Nagai, Takenori Kanekawa, Kojiro Kobayashi, Takanori Mukozu, Daigo Matsui, Teppei Matsui, Masahiro Kanayama, Noritaka Wakui, Kouichi Momiyama, Mie Shinohara, Koji Ishii, Yoshinori Igarashi, Yasukiyo Sumin. Changes of cytokines in patients with liver cirrhosis and advanced hepatocellular carcinoma treated by sorafenib. Cancer chemotherapy and pharmacology. vol 73. issue 2. 2014-06-23. PMID:24220937. |
tumor necrosis factor (tnf) induces apoptosis of tumor cells by binding to tnf-related apoptosis-inducing ligand, while binding of the fas ligand on cytotoxic t lymphocytes to the fas receptor on hepatocytes also causes apoptosis. |
2014-06-23 |
2023-08-12 |
Not clear |
| Hanis H Harith, Margaret J Morris, Mary M Kavurm. On the TRAIL of obesity and diabetes. Trends in endocrinology and metabolism: TEM. vol 24. issue 11. 2014-06-12. PMID:23948591. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) has been extensively studied for its preferential ability to induce apoptosis of cancer cells. |
2014-06-12 |
2023-08-12 |
Not clear |
| Rachele Ciccocioppo, Alessandro Vanoli, Catherine Klersy, Venerina Imbesi, Vincenzo Boccaccio, Rachele Manca, Elena Betti, Giuseppina Cristina Cangemi, Elena Strada, Roberta Besio, Antonio Rossi, Colomba Falcone, Sandro Ardizzone, Paolo Fociani, Piergiorgio Danelli, Gino Roberto Corazz. Role of the advanced glycation end products receptor in Crohn's disease inflammation. World journal of gastroenterology. vol 19. issue 45. 2014-06-12. PMID:24363518. |
to investigate the level of mucosal expression and the involvement of the receptor for the advanced glycation end products (rage) in delayed apoptosis and tumor necrosis factor (tnf)-α production in crohn's disease (cd). |
2014-06-12 |
2023-08-12 |
Not clear |
| W Wei-Lynn Wong, James E Vince, Najoua Lalaoui, Kate E Lawlor, Diep Chau, Aleksandra Bankovacki, Holly Anderton, Donald Metcalf, Lorraine O'Reilly, Philipp J Jost, James M Murphy, Warren S Alexander, Andreas Strasser, David L Vaux, John Silk. cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood. vol 123. issue 16. 2014-06-05. PMID:24497535. |
loss of inhibitor of apoptosis proteins (iaps), particularly ciap1, can promote production of tumor necrosis factor (tnf) and sensitize cancer cell lines to tnf-induced necroptosis by promoting formation of a death-inducing signaling complex containing receptor-interacting serine/threonine-protein kinase (ripk) 1 and 3. |
2014-06-05 |
2023-08-12 |
mouse |
| Angelos Oikonomopoulos, Welmoed K van Deen, Daniel W Homme. Anti-TNF antibodies in inflammatory bowel disease: do we finally know how it works? Current drug targets. vol 14. issue 12. 2014-05-27. PMID:23627866. |
various mechanisms of action have been proposed such as activation of transmembrane tnf mediated reverse signaling, induction of apoptosis, pro-inflammatory cytokine down-regulation, complement dependent cytotoxicity, antibodydependent cell-mediated cytotoxicity, and finally activation of regulatory immune cells via interactions with the fc receptors. |
2014-05-27 |
2023-08-12 |
Not clear |
| Daniel W Stuckey, Khalid Sha. TRAIL on trial: preclinical advances in cancer therapy. Trends in molecular medicine. vol 19. issue 11. 2014-05-19. PMID:24076237. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand, or trail, is a promising anticancer agent as it can induce apoptosis in a wide range of cancers whilst generally sparing non-malignant cells. |
2014-05-19 |
2023-08-12 |
Not clear |
| Zitong Zhao, Cheng Yang, Lingyan Wang, Long Li, Tian Zhao, Linkun Hu, Ruiming Rong, Ming Xu, Tongyu Zh. The regulatory T cell effector soluble fibrinogen-like protein 2 induces tubular epithelial cell apoptosis in renal transplantation. Experimental biology and medicine (Maywood, N.J.). vol 239. issue 2. 2014-05-14. PMID:24414480. |
the human tec was stimulated with sfgl2, tumor necrosis factor (tnf)-α, or phosphate buffered saline and investigated for apoptosis in vitro. |
2014-05-14 |
2023-08-12 |
human |
| Shuo Yang, Bingwei Wang, Lisa S Tang, Jakub Siednienko, John J Callanan, Paul N Moynag. Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α. Nature communications. vol 4. 2014-05-01. PMID:24113711. |
tumour necrosis factor-α (tnf) can activate nf-κb to induce pro-inflammatory genes but can also stimulate the caspase cascade to promote apoptosis. |
2014-05-01 |
2023-08-12 |
mouse |
| Shuo Yang, Bingwei Wang, Lisa S Tang, Jakub Siednienko, John J Callanan, Paul N Moynag. Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α. Nature communications. vol 4. 2014-05-01. PMID:24113711. |
pellino3-deficient mice also show increased sensitivity to tnf-induced apoptosis and greatly increased lethality in response to tnf administration. |
2014-05-01 |
2023-08-12 |
mouse |
| Cagri Sakalar, Merve Yuruk, Tugba Kaya, Metin Aytekin, Salih Kuk, Halit Canata. Pronounced transcriptional regulation of apoptotic and TNF-NF-kappa-B signaling genes during the course of thymoquinone mediated apoptosis in HeLa cells. Molecular and cellular biochemistry. vol 383. issue 1-2. 2014-04-29. PMID:23943306. |
at high dose (100 μm), tq mediated the expression of 21 genes implicated directly in apoptosis (6 genes), tnf signaling (10 genes), and nf-kappa-b signaling (3 genes) such as bik, bid, tnfrsf10a, tnfrsf10b, tnf, traf3, rela, and relb. |
2014-04-29 |
2023-08-12 |
human |
| Cagri Sakalar, Merve Yuruk, Tugba Kaya, Metin Aytekin, Salih Kuk, Halit Canata. Pronounced transcriptional regulation of apoptotic and TNF-NF-kappa-B signaling genes during the course of thymoquinone mediated apoptosis in HeLa cells. Molecular and cellular biochemistry. vol 383. issue 1-2. 2014-04-29. PMID:23943306. |
at the same time, our results strongly suggest that tq intervenes with tnf and nf-kappa-b signaling during tq-mediated induction of apoptosis in cancer cells. |
2014-04-29 |
2023-08-12 |
human |
| Guohua Song, Min Li, Hui Sang, Liying Zhang, Xiuhong Li, Shutong Yao, Yang Yu, Chuanlong Zong, Yazhuo Xue, Shucun Qi. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of lipid research. vol 54. issue 7. 2014-04-25. PMID:23610159. |
in addition, we found h2 significantly improved hdl functionality assessed in four independent ways, namely, i) protection against ldl oxidation, ii) inhibition of tumor necrosis factor (tnf)-α-induced monocyte adhesion to endothelial cells, iii) stimulation of cholesterol efflux from macrophage foam cells, and iv) protection of endothelial cells from tnf-α-induced apoptosis. |
2014-04-25 |
2023-08-12 |
Not clear |
| Fei Wu, Lili Guo, Aniela Jakubowski, Lihe Su, Wan-Chun Li, Susan Bonner-Weir, Linda C Burkl. TNF-like weak inducer of apoptosis (TWEAK) promotes beta cell neogenesis from pancreatic ductal epithelium in adult mice. PloS one. vol 8. issue 8. 2014-04-21. PMID:23991053. |
here we test whether the tnf family member tweak (tnf-like weak inducer of apoptosis) promotes β-cell neogenesis from proliferating pancreatic ductal epithelium in adult mice. |
2014-04-21 |
2023-08-12 |
mouse |
| Avijeet S Chopra, Anton Kuratnik, Eric W Scocchera, Dennis L Wright, Charles Giardin. Identification of novel compounds that enhance colon cancer cell sensitivity to inflammatory apoptotic ligands. Cancer biology & therapy. vol 14. issue 5. 2014-04-15. PMID:23377828. |
we identified a number of novel compounds with this activity, the most active of these, ak3 and ak10, sensitized colon cancer cells to tnf at 0.5 μm and 2 μm, respectively, without inducing apoptosis on their own. |
2014-04-15 |
2023-08-12 |
Not clear |
| M Park, B Lee, J Le. Expression of tumor necrosis factor-like weak inducer of apoptosis in human middle ear cholesteatoma. ORL; journal for oto-rhino-laryngology and its related specialties. vol 75. issue 4. 2014-04-15. PMID:23900149. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) was recently identified as a member of the tnf superfamily of structurally related cytokines. |
2014-04-15 |
2023-08-12 |
human |
| Shyama Pal, Bhavani S Shankar, Krishna B Saini. Cytokines from the tumor microenvironment modulate sirtinol cytotoxicity in A549 lung carcinoma cells. Cytokine. vol 64. issue 1. 2014-04-15. PMID:23972545. |
we have chosen tumor necrosis factor α (tnf-α), tnf related apoptosis inducing ligand (trail), insulin-like growth factor 1 (igf-1) and transforming growth factor β (tgf-β) as representative pro-inflammatory, pro-apoptotic, anti-apoptotic and anti-inflammatory tumor derived cytokines. |
2014-04-15 |
2023-08-12 |
Not clear |
| Jong Hwan Yoon, Hyun Ho Par. Preliminary X-ray crystallographic studies of the TRAF domain of human TRAF4. Acta crystallographica. Section F, Structural biology and crystallization communications. vol 69. issue Pt 9. 2014-04-15. PMID:23989155. |
tnf receptor-associated factor (traf) proteins were initially identified as tumour necrosis factor receptor (tnfr)-interacting proteins that perform critical functions in the regulation of inflammation, antiviral responses and apoptosis. |
2014-04-15 |
2023-08-12 |
human |
| Hossein Ameri, Hua Liu, Rong Liu, Yonju Ha, Adriana A Paulucci-Holthauzen, Shuqun Hu, Massoud Motamedi, Bernard F Godley, Ronald G Tilton, Wenbo Zhan. TWEAK/Fn14 pathway is a novel mediator of retinal neovascularization. Investigative ophthalmology & visual science. vol 55. issue 2. 2014-04-14. PMID:24408972. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) and its receptor, fibroblast growth factor inducible-14 (fn14), have been implicated in angiogenesis, but their role in retinal diseases is unknown. |
2014-04-14 |
2023-08-12 |
Not clear |
| R Rajandram, N C Bennett, C Morais, D W Johnson, G C Gob. Renal cell carcinoma: resistance to therapy, role of apoptosis, and the prognostic and therapeutic target potential of TRAF proteins. Medical hypotheses. vol 78. issue 2. 2014-04-09. PMID:22153576. |
here we present the hypothesis that select members of the tumor necrosis factor (tnf) superfamily, the tnf receptor-associated factors (trafs), have a role in rcc apoptosis and may have prognostic significance for rcc. |
2014-04-09 |
2023-08-12 |
Not clear |
| Tomohiko Machida, Masahiro Tanemura, Yoshiaki Ohmura, Tsukasa Tanida, Hiroshi Wada, Shogo Kobayashi, Shigeru Marubashi, Hidetoshi Eguchi, Toshinori Ito, Hiroaki Nagano, Masaki Mori, Yuichiro Doki, Yoshiki Saw. Significant improvement in islet yield and survival with modified ET-Kyoto solution: ET-Kyoto/Neutrophil elastase inhibitor. Cell transplantation. vol 22. issue 1. 2014-04-08. PMID:22472201. |
ne and proinflammatory cytokines such as tumor necrosis factor (tnf)-α and interleukin (il)-6 increased markedly at the end of warm digestion during islet isolation and exhibited direct cytotoxic activity against the islets causing their apoptosis. |
2014-04-08 |
2023-08-12 |
mouse |