| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sharron A N Brown, Emily Cheng, Mark S Williams, Jeffrey A Winkle. TWEAK-independent Fn14 self-association and NF-κB activation is mediated by the C-terminal region of the Fn14 cytoplasmic domain. PloS one. vol 8. issue 6. 2014-09-29. PMID:23750247. |
the tumor necrosis factor (tnf) superfamily member tnf-like weak inducer of apoptosis (tweak) is a pro-inflammatory and pro-angiogenic cytokine implicated in physiological tissue regeneration and wound repair. |
2014-09-29 |
2023-08-12 |
Not clear |
| Thorsten Braun, Pierre Fenau. Myelodysplastic Syndromes (MDS) and autoimmune disorders (AD): cause or consequence? Best practice & research. Clinical haematology. vol 26. issue 4. 2014-09-29. PMID:24507810. |
increased release of inflammatory cytokines like tumor necrosis factor-(tnf)-α and interferon (if)-γ triggers apoptosis of myeloid precursor cells leading to cytopenias. |
2014-09-29 |
2023-08-12 |
Not clear |
| Keren Mizrahi, Nadir Askenas. Physiological functions of TNF family receptor/ligand interactions in hematopoiesis and transplantation. Blood. vol 124. issue 2. 2014-09-25. PMID:24859365. |
secretion of ligands of the tumor necrosis factor (tnf) superfamily is a conserved response of parenchymal tissues to injury and inflammation that commonly perpetuates elimination of dysfunctional cellular components by apoptosis. |
2014-09-25 |
2023-08-13 |
Not clear |
| Chang-Chun Zhang, Guo-Peng Cui, Jian-Guo Hu, Yu-Zhou Xiao, Xin-She Zhou, Chen Shao, Qinghua Lin, Jian-Sheng Zho. Effects of adenoviral vector expressing hIGF-1 on apoptosis in nucleus pulposus cells in vitro. International journal of molecular medicine. vol 33. issue 2. 2014-09-18. PMID:24337543. |
it has been shown that the pro-inflammatory cytokine tumour necrosis factor (tnf)-α can induce disc cell apoptosis. |
2014-09-18 |
2023-08-12 |
human |
| William J Kaiser, Lisa P Daley-Bauer, Roshan J Thapa, Pratyusha Mandal, Scott B Berger, Chunzi Huang, Aarthi Sundararajan, Hongyan Guo, Linda Roback, Samuel H Speck, John Bertin, Peter J Gough, Siddharth Balachandran, Edward S Mocarsk. RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 21. 2014-09-02. PMID:24821786. |
in the face of complete rip1 deficiency, cells develop sensitivity to rip3-mixed lineage kinase domain-like-mediated necroptosis as well as to casp8-mediated apoptosis activated by diverse innate immune stimuli (e.g., tnf, ifn, double-stranded rna). |
2014-09-02 |
2023-08-13 |
mouse |
| Othman Al-Sawaf, Athanassios Fragoulis, Christian Rosen, Yuet Wai Kan, Tolga Taha Sönmez, Thomas Pufe, Christoph Jan Wruc. Nrf2 protects against TWEAK-mediated skeletal muscle wasting. Scientific reports. vol 4. 2014-08-26. PMID:24406502. |
particularly, the inflammatory cytokine tumour necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is a potent inducer of skeletal muscle wasting and fibrosis. |
2014-08-26 |
2023-08-12 |
mouse |
| Sushil Kumar Pathak, Raquel Tavares, Nele de Klerk, Anna-Lena Spetz, Ann-Beth Jonsso. Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223737. |
helicobacter pylori protein jhp0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (tnf)-dependent and independent pathways. |
2014-08-20 |
2023-08-12 |
human |
| Sushil Kumar Pathak, Raquel Tavares, Nele de Klerk, Anna-Lena Spetz, Ann-Beth Jonsso. Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223737. |
exposure to rjhp0290 induced apoptosis in macrophages concurrent with release of proinflammatory cytokine tumor necrosis factor (tnf). |
2014-08-20 |
2023-08-12 |
human |
| Sushil Kumar Pathak, Raquel Tavares, Nele de Klerk, Anna-Lena Spetz, Ann-Beth Jonsso. Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223737. |
a mutant strain of h. pylori disrupted in the jhp0290 gene was significantly impaired in its ability to induce apoptosis and tnf in macrophages confirming the role of endogenous protein in regulating macrophage responses. |
2014-08-20 |
2023-08-12 |
human |
| Sushil Kumar Pathak, Raquel Tavares, Nele de Klerk, Anna-Lena Spetz, Ann-Beth Jonsso. Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223737. |
intracellular signaling involving src family of tyrosine kinases (sfks) and erk mapk were required for rjhp0290-induced tnf release and apoptosis in macrophages. |
2014-08-20 |
2023-08-12 |
human |
| Sushil Kumar Pathak, Raquel Tavares, Nele de Klerk, Anna-Lena Spetz, Ann-Beth Jonsso. Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223737. |
neutralizing antibodies against tnf partially blocked rjhp0290-induced macrophage apoptosis indicating tnf-independent pathways were also involved. |
2014-08-20 |
2023-08-12 |
human |
| Sushil Kumar Pathak, Raquel Tavares, Nele de Klerk, Anna-Lena Spetz, Ann-Beth Jonsso. Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223737. |
by virtue of its ability to induce tnf, an acid suppressive proinflammatory cytokine and induction of macrophage apoptosis, jhp0290 possibly helps in persistent survival of the bacterium inside the stomach. |
2014-08-20 |
2023-08-12 |
human |
| Andrew Volk, Jing Li, Junping Xin, Dewen You, Jun Zhang, Xinli Liu, Yechen Xiao, Peter Breslin, Zejuan Li, Wei Wei, Rachel Schmidt, Xingyu Li, Zhou Zhang, Paul C Kuo, Sucha Nand, Jianke Zhang, Jianjun Chen, Jiwang Zhan. Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML. The Journal of experimental medicine. vol 211. issue 6. 2014-08-20. PMID:24842373. |
although stimulating hspc with tnf promotes necroptosis and apoptosis, similar treatment with aml cells (leukemic cells, lcs) results in an increase in survival and proliferation. |
2014-08-20 |
2023-08-13 |
human |
| Harald Wajan. The TWEAK-Fn14 system as a potential drug target. British journal of pharmacology. vol 170. issue 4. 2014-08-19. PMID:23957828. |
fn14 becomes activated by tnf-like weak inducer of apoptosis (tweak), a typical member of the tnf ligand family. |
2014-08-19 |
2023-08-12 |
mouse |
| Stephen W G Tait, Andrew Oberst, Giovanni Quarato, Sandra Milasta, Martina Haller, Ruoning Wang, Maria Karvela, Gabriel Ichim, Nader Yatim, Matthew L Albert, Grahame Kidd, Randall Wakefield, Sharon Frase, Stefan Krautwald, Andreas Linkermann, Douglas R Gree. Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell reports. vol 5. issue 4. 2014-08-19. PMID:24268776. |
mitochondria-deficient cells were resistant to the mitochondrial pathway of apoptosis, but efficiently died via tumor necrosis factor (tnf)-induced, ripk3-dependent programmed necrosis or as a result of direct oligomerization of ripk3. |
2014-08-19 |
2023-08-12 |
Not clear |
| Yan Tang, Meng-hong Wan. [MicroRNA-21 protects cardiomyocytes from tumor necrosis factor-α induced apoptosis in vitro via modulating PTEN/AKT/FOXO3a pathway]. Zhonghua xin xue guan bing za zhi. vol 41. issue 2. 2014-08-11. PMID:23710745. |
to explore the effect of microrna-21 on tumor necrosis factor (tnf)-α induced cardiomyocytes apoptosis and the association with pten/akt/foxo3a signaling pathway. |
2014-08-11 |
2023-08-12 |
Not clear |
| Wei Wang, Mei Zhang, Weimin Sun, Shanmin Yang, Ying Su, Hengshan Zhang, Chaomei Liu, Xinfeng Li, Ling Lin, Sunghee Kim, Paul Okunieff, Zhenhuan Zhang, Lurong Zhan. Reduction of decoy receptor 3 enhances TRAIL-mediated apoptosis in pancreatic cancer. PloS one. vol 8. issue 10. 2014-08-04. PMID:24204567. |
most human pancreatic cancer cells are resistant to tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-mediated apoptosis. |
2014-08-04 |
2023-08-12 |
human |
| Jia Cai, Youhua Huang, Shina Wei, Zhengliang Ouyang, Xiaohong Huang, Qiwei Qi. Characterization of LPS-induced TNFα factor (LITAF) from orange-spotted grouper, Epinephelus coioides. Fish & shellfish immunology. vol 35. issue 6. 2014-07-29. PMID:24091064. |
overexpression of ec-litaf in vitro up-regulated the expression of tumor necrosis factors (tnf1 and tnf2) and tnf receptors (tnfr1 and tnfr2), and the expression of itself initiated apoptosis in fish cells. |
2014-07-29 |
2023-08-12 |
Not clear |
| Hong Zhu, Min Huang, Daoling Ren, Jianping He, Fen Zhao, Cheng Yi, Ying Huan. The synergistic effects of low dose fluorouracil and TRAIL on TRAIL-resistant human gastric adenocarcinoma AGS cells. BioMed research international. vol 2013. 2014-07-29. PMID:24324958. |
the tnf-related apoptosis-inducing ligand (trail) is a tnf family member which has been under intense focus because of its remarkable ability to induce apoptosis in malignant human cells while leaving normal cells unscathed. |
2014-07-29 |
2023-08-12 |
human |
| A Son, T Oshio, Y I Kawamura, T Hagiwara, M Yamazaki, K Inagaki-Ohara, T Okada, P Wu, M Iseki, S Takaki, L C Burkly, T Doh. TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice. Mucosal immunology. vol 6. issue 6. 2014-07-18. PMID:23462911. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak), a tnf superfamily member, induces damage of the epithelial cells (ecs) and production of inflammatory mediaters through its receptor fn14 in a model of acute colitis. |
2014-07-18 |
2023-08-12 |
mouse |