| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gelin Wang, Xiaoming Wang, Hong Yu, Shuguang Wei, Noelle Williams, Daniel L Holmes, Randal Halfmann, Jacinth Naidoo, Lai Wang, Lin Li, She Chen, Patrick Harran, Xiaoguang Lei, Xiaodong Wan. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nature chemical biology. vol 9. issue 2. 2013-03-19. PMID:23292651. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) activates apoptosis through the death receptors dr4 and dr5. |
2013-03-19 |
2023-08-12 |
human |
| Jianxin Lu, Cheuk-Chun Szeto, Lai-Shan Tam, Fernand Mac-Moune Lai, Edmund Kwok-Ming Li, Kai-Ming Chow, Philip Kam-Tao Li, Bonnie Ching-Ha Kwa. Relationship of intrarenal gene expression and the histological class of lupus nephritis -- a study on repeat renal biopsy. The Journal of rheumatology. vol 39. issue 10. 2013-03-14. PMID:22896023. |
to study the role of tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak)/fn14 and the interferon-inducible protein (ip-10)/cxcr3 axis in lupus nephritis (ln). |
2013-03-14 |
2023-08-12 |
Not clear |
| Jun-Jie Chen, H-C Jennifer Shen, Leslie A Rivera Rosado, Yaqin Zhang, Xu Di, Baolin Zhan. Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells. Oncotarget. vol 3. issue 8. 2013-03-12. PMID:22909995. |
multiple clinical trials are ongoing to evaluate the potential antitumor activity of human tnf variants, fas ligand (fasl), tnf-related apoptosis inducing ligand (trail) and its agonistic antibodies. |
2013-03-12 |
2023-08-12 |
human |
| V V Kolobov, Z I Storozheva, M A Gruden, V V Sherstne. Regional features of the expression of genes involved in neurogenesis and apoptosis in the brain of adult rats. Bulletin of experimental biology and medicine. vol 153. issue 5. 2013-03-12. PMID:23113275. |
the expression of mrna of genes involved in neurogenesis and apoptosis (apaf1, ascl1, bax, bcl2, casp3, casp8, casp9, dffb, myh10, naip2, napa, notch2, numb, pura, s100a6, tnf) in the prefrontal cortex, hippocampus, and cerebellum was studied in adult rats. |
2013-03-12 |
2023-08-12 |
rat |
| Christopher S McAllister, Omar Lakhdari, Guillaume Pineton de Chambrun, Mélanie G Gareau, Alexis Broquet, Gin Hyug Lee, Steven Shenouda, Lars Eckmann, Martin F Kagnof. TLR3, TRIF, and caspase 8 determine double-stranded RNA-induced epithelial cell death and survival in vivo. Journal of immunology (Baltimore, Md. : 1950). vol 190. issue 1. 2013-03-12. PMID:23209324. |
dsrna-induced apoptosis was independent of tnf signaling. |
2013-03-12 |
2023-08-12 |
mouse |
| Christopher S McAllister, Omar Lakhdari, Guillaume Pineton de Chambrun, Mélanie G Gareau, Alexis Broquet, Gin Hyug Lee, Steven Shenouda, Lars Eckmann, Martin F Kagnof. TLR3, TRIF, and caspase 8 determine double-stranded RNA-induced epithelial cell death and survival in vivo. Journal of immunology (Baltimore, Md. : 1950). vol 190. issue 1. 2013-03-12. PMID:23209324. |
consistent with direct activation of the tlr3-trif-caspase 8 signaling pathway by dsrna in iecs, dsrna-induced signaling of apoptosis was independent of non-tlr3 dsrna signaling pathways, il-15, tnf, il-1, il-6, ifn regulatory factor 3, type i ifn receptor, adaptive immunity, as well as dendritic cells, nk cells, and other hematopoietic cells. |
2013-03-12 |
2023-08-12 |
mouse |
| Shuangxin Liu, Wei Shi, Houqin Xiao, Xinling Liang, Chunyu Deng, Zhiming Ye, Ping Mei, Suxia Wang, Xiaoying Liu, Zhixin Shan, Yongzheng Liang, Bin Zhang, Wenjian Wang, Yanhui Liu, Lixia Xu, Yunfeng Xia, Jianchao Ma, Zhilian L. Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury. PloS one. vol 7. issue 7. 2013-03-11. PMID:22848465. |
tnf and tnf receptor superfamilies are important in the pathogenesis of podocyte injury and apoptosis. |
2013-03-11 |
2023-08-12 |
Not clear |
| Jessica K Bernard, Sean P McCann, Vrinda Bhardwaj, Mary K Washington, Mark R Fre. Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo. The Journal of biological chemistry. vol 287. issue 47. 2013-02-19. PMID:23033483. |
nrg4 treatment, either in cultured cells or in mice, blocked colonic epithelial apoptosis induced by tnf and ifn-γ. |
2013-02-19 |
2023-08-12 |
mouse |
| Natalya Benderska, Saritha Chakilam, Manuela Hugle, Jelena Ivanovska, Muktheshwar Gandesiri, Jan Schulze-Luhrmann, Khuloud Bajbouj, Ronald Croner, Regine Schneider-Stoc. Apoptosis signalling activated by TNF in the lower gastrointestinal tract--review. Current pharmaceutical biotechnology. vol 13. issue 11. 2013-02-12. PMID:21605069. |
apoptosis signalling activated by tnf in the lower gastrointestinal tract--review. |
2013-02-12 |
2023-08-12 |
Not clear |
| Arie J Hoogendijk, Joris J T H Roelofs, Janwillem Duitman, Miriam H P van Lieshout, Dana C Blok, Tom van der Poll, Catharina W Wielan. R-roscovitine reduces lung inflammation induced by lipoteichoic acid and Streptococcus pneumoniae. Molecular medicine (Cambridge, Mass.). vol 18. 2013-02-06. PMID:22692577. |
in vitro r-roscovitine enhanced apoptosis in pmns and reduced tumor necrosis factor (tnf)-α and keratinocyte chemoattractant (kc) production in mh-s (alveolar macrophage) and mle-12/mle-15 (respiratory epithelial) cell lines. |
2013-02-06 |
2023-08-12 |
Not clear |
| Chunxia Qiao, Meiyun Hu, Leiming Guo, Ming Lv, Zhou Lin, Jing Geng, Xiaoling Lang, Xinying Li, Yan Li, Yuanfang Ma, Jiannan Feng, Beifen She. Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation. BMC immunology. vol 13. 2013-02-06. PMID:22788777. |
as a member of the tnf superfamily, trail could induce human tumor cell apoptosis through its cognate death receptors dr4 or dr5, which can induce formation of the death inducing signaling complex (disc) and activation of the membrane proximal caspases (caspase-8 or caspase-10) and mitochondrial pathway. |
2013-02-06 |
2023-08-12 |
human |
| Tatiana Goretsky, Ramanarao Dirisina, Preetika Sinh, Navdha Mittal, Elizabeth Managlia, David B Williams, Daniela Posca, Hyunji Ryu, Rebecca B Katzman, Terrence A Barret. p53 mediates TNF-induced epithelial cell apoptosis in IBD. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22863952. |
chronic ulcerative colitis (cuc) is characterized by increased intestinal epithelial cell (iec) apoptosis associated with elevated tumor necrosis factor (tnf), inducible nitric oxide synthase (inos), and p53. |
2013-02-06 |
2023-08-12 |
mouse |
| Tatiana Goretsky, Ramanarao Dirisina, Preetika Sinh, Navdha Mittal, Elizabeth Managlia, David B Williams, Daniela Posca, Hyunji Ryu, Rebecca B Katzman, Terrence A Barret. p53 mediates TNF-induced epithelial cell apoptosis in IBD. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22863952. |
herein, we examined the roles of tnf and inos in regulating p53-induced iec apoptosis in cuc. |
2013-02-06 |
2023-08-12 |
mouse |
| Tatiana Goretsky, Ramanarao Dirisina, Preetika Sinh, Navdha Mittal, Elizabeth Managlia, David B Williams, Daniela Posca, Hyunji Ryu, Rebecca B Katzman, Terrence A Barret. p53 mediates TNF-induced epithelial cell apoptosis in IBD. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22863952. |
iec p53 levels and apoptosis were reduced in il-10(-/-) colitic mice treated with neutralizing tnf mab and the inos inhibitor, aminoguanidine, further suggesting that tnf and inos are upstream of p53 during colitis-induced iec apoptosis. |
2013-02-06 |
2023-08-12 |
mouse |
| Jin-Sil Park, Mi-Kyung Park, Seon-Yeong Lee, Hye-Jwa Oh, Mi-Ae Lim, Woo-Tae Cho, Eun-Kyung Kim, Ji-Hyeon Ju, Young-Woo Park, Sung-Hwan Park, Mi-La Cho, Ho-Youn Ki. TWEAK promotes the production of Interleukin-17 in rheumatoid arthritis. Cytokine. vol 60. issue 1. 2013-02-01. PMID:22819243. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is an inflammatory cytokine that modulates several biological responses by inducing chemokines and proinflammatory cytokines. |
2013-02-01 |
2023-08-12 |
mouse |
| Xin-Qiu Li, Xian-Zhu Ke, Yu-Ming Wan. Treatment of malignant melanoma by downregulation of XIAP and overexpression of TRAIL with a conditionally replicating oncolytic adenovirus. Asian Pacific journal of cancer prevention : APJCP. vol 13. issue 4. 2013-01-30. PMID:22799350. |
the tumor necrosis factor (tnf)- related apoptosis-inducing ligand has a significant impact on therapy for patients with x-linked inhibitor of apoptosis protein-downregulation malignant melanoma. |
2013-01-30 |
2023-08-12 |
Not clear |
| G L Robinson, D Dinsdale, M Macfarlane, K Cai. Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL. Oncogene. vol 31. issue 48. 2013-01-29. PMID:22310286. |
trail (tnf (tumour necrosis factor)-related apoptosis-inducing ligand) a putative anti-cancer cytokine induces apoptosis through disc (death-inducing signalling complex)-mediated activation of caspase-8 and/or cleavage of bid. |
2013-01-29 |
2023-08-12 |
Not clear |
| O M Andriankaja, J Galicia, G Dong, W Xiao, F Alawi, D T Grave. Gene expression dynamics during diabetic periodontitis. Journal of dental research. vol 91. issue 12. 2013-01-29. PMID:23103632. |
others were down-regulated by tnf inhibition and included genes associated with host defense, apoptosis, cell signaling and activity, and coagulation/hemostasis/complement. |
2013-01-29 |
2023-08-12 |
rat |
| Ashish Nagarsekar, Mohan E Tulapurkar, Ishwar S Singh, Sergei P Atamas, Nirav G Shah, Jeffrey D Hasda. Hyperthermia promotes and prevents respiratory epithelial apoptosis through distinct mechanisms. American journal of respiratory cell and molecular biology. vol 47. issue 6. 2013-01-25. PMID:22962066. |
exposing mle15 cells to heat shock (hs; 42°c, 2 h) or febrile-range hyperthermia (39.5°c) concurrent with activation of the death receptors, tnf receptor 1 or fas, greatly accelerated apoptosis, which was detectable within 30 minutes and was associated with accelerated activation of caspase-2, -8, and -10, and the proapoptotic protein, bcl2-interacting domain (bid). |
2013-01-25 |
2023-08-12 |
mouse |
| Nataly Shulga, John G Pastorin. GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis. Journal of cell science. vol 125. issue Pt 12. 2013-01-24. PMID:22393233. |
tumor necrosis factor (tnf) can induce necroptosis, wherein inhibition of caspase activity prevents apoptosis but initiates an alternative programmed necrosis. |
2013-01-24 |
2023-08-12 |
Not clear |