| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Hui Zhou, Li-Na Yang, Christian Roder, Holger Kalthoff, Anna Trauzol. TRAIL-induced expression of uPA and IL-8 strongly enhanced by overexpression of TRAF2 and Bcl-xL in pancreatic ductal adenocarcinoma cells. Hepatobiliary & pancreatic diseases international : HBPD INT. vol 12. issue 1. 2013-07-30. PMID:23392805. |
the death ligand, tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail), induces apoptosis and non-apoptotic signaling in some tumor cells. |
2013-07-30 |
2023-08-12 |
Not clear |
| Jinbo Han, Priya Sridevi, Michael Ramirez, Kirsten J Ludwig, Jean Y J Wan. β-Catenin-dependent lysosomal targeting of internalized tumor necrosis factor-α suppresses caspase-8 activation in apoptosis-resistant colon cancer cells. Molecular biology of the cell. vol 24. issue 4. 2013-07-25. PMID:23264463. |
we show here that activated β-catenin is required to suppress caspase-8 activation, but only in colon cancer cells that are resistant to tumor necrosis factor-α (tnf)-induced apoptosis. |
2013-07-25 |
2023-08-12 |
mouse |
| Jinbo Han, Priya Sridevi, Michael Ramirez, Kirsten J Ludwig, Jean Y J Wan. β-Catenin-dependent lysosomal targeting of internalized tumor necrosis factor-α suppresses caspase-8 activation in apoptosis-resistant colon cancer cells. Molecular biology of the cell. vol 24. issue 4. 2013-07-25. PMID:23264463. |
in a mouse model of inflammation-associated colon tumors, we found nuclear expression of β-catenin, resistance to tnf-induced apoptosis, and reactivation of apoptosis in vivo after cotreatment of tnf with a v-atpase inhibitor. |
2013-07-25 |
2023-08-12 |
mouse |
| Shuichi Sato, Yuji Ogura, Vivek Mishra, Jonghyun Shin, Shephali Bhatnagar, Bradford G Hill, Ashok Kuma. TWEAK promotes exercise intolerance by decreasing skeletal muscle oxidative phosphorylation capacity. Skeletal muscle. vol 3. issue 1. 2013-07-16. PMID:23835416. |
proinflammatory cytokine tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) and its receptor fn14 are the major regulators of skeletal muscle mass in many catabolic conditions. |
2013-07-16 |
2023-08-12 |
Not clear |
| Tiziana Bachetti, Sabrina Chiesa, Patrizio Castagnola, Daniele Bani, Eleonora Di Zanni, Alessia Omenetti, Andrea D'Osualdo, Alessandro Fraldi, Andrea Ballabio, Roberto Ravazzolo, Alberto Martini, Marco Gattorno, Isabella Ceccherin. Autophagy contributes to inflammation in patients with TNFR-associated periodic syndrome (TRAPS). Annals of the rheumatic diseases. vol 72. issue 6. 2013-07-12. PMID:23117241. |
tumour necrosis factor (tnf) receptor-associated periodic syndrome (traps) is caused by tnfrsf1a mutations, known to induce intracellular retention of the tnfα receptor 1 (tnfr1) protein, defective tnfα-induced apoptosis, and production of reactive oxygen species. |
2013-07-12 |
2023-08-12 |
Not clear |
| Georgia Levidou, Irene Thymara, Angelica A Saetta, Polyanthi Papanastasiou, Petros Pavlopoulos, Stratigoula Sakellariou, Paraskevi Fragkou, Efstratios Patsouris, Penelope Korkolopoulo. TRAIL and osteoprotegerin (OPG) expression in bladder urothelial carcinoma: correlation with clinicopathological parameters and prognosis. Pathology. vol 45. issue 2. 2013-07-11. PMID:23277172. |
to investigate the expression of tumour necrosis factor (tnf)-related apoptosis-inducing ligand (trail) and osteoprotegerin (opg) in bladder urothelial carcinomas (ucs) and assess possible interrelations with other regulators of trail induced apoptosis (p65/nf-κb, p-erk1/2, p-akt) and fgfr3, as well as to elucidate their potential involvement in bladder tumourigenesis and determine their potential prognostic utility. |
2013-07-11 |
2023-08-12 |
Not clear |
| John Silke, Andreas Strasse. The FLIP Side of Life. Science signaling. vol 6. issue 258. 2013-06-28. PMID:23322903. |
when activated by their respective ligands, tnf, fas ligand (fasl), and tnf-related apoptosis-inducing ligand (trail), these receptors cause caspase-8-mediated apoptosis. |
2013-06-28 |
2023-08-12 |
mouse |
| Casandra M Cartagena, Kara E Schmid, Katie L Phillips, Frank C Tortella, Jitendra R Dav. Changes in apoptotic mechanisms following penetrating ballistic-like brain injury. Journal of molecular neuroscience : MN. vol 49. issue 2. 2013-06-27. PMID:22684621. |
in the death receptor-mediated apoptosis pathway, the relative quantities (rqs) of mrna for tnfr1, fas, and tnf were upregulated while trail mrna was downregulated. |
2013-06-27 |
2023-08-12 |
Not clear |
| Mark S Chapman, Lan Wu, Aldo Amatucci, Steffan N Ho, Jennifer S Michaelso. TWEAK signals through JAK-STAT to induce tumor cell apoptosis. Cytokine. vol 61. issue 1. 2013-06-19. PMID:23107828. |
the tweak receptor fn14 (tnfrsf12), a member of the tnf receptor superfamily, can mediate many processes, including apoptosis. |
2013-06-19 |
2023-08-12 |
mouse |
| Tatiana Goncharov, Kyle Niessen, Maria Cristina de Almagro, Anita Izrael-Tomasevic, Anna V Fedorova, Eugene Varfolomeev, David Arnott, Kurt Deshayes, Donald S Kirkpatrick, Domagoj Vuci. OTUB1 modulates c-IAP1 stability to regulate signalling pathways. The EMBO journal. vol 32. issue 8. 2013-06-19. PMID:23524849. |
the cellular inhibitor of apoptosis (c-iap) proteins are e3 ubiquitin ligases that are critical regulators of tumour necrosis factor (tnf) receptor (tnfr)-mediated signalling. |
2013-06-19 |
2023-08-12 |
zebrafish |
| San-Yuan Tang, Mei-Zuo Zhong, Guang-Jin Yuan, Su-Ping Hou, Lei-Lan Yin, Hao Jiang, Zheng-Υang Y. Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells. Oncology reports. vol 29. issue 2. 2013-06-13. PMID:23135489. |
we investigated the effect of casticin on apoptosis induced by tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail). |
2013-06-13 |
2023-08-12 |
human |
| R Tohidi, I B Idris, J Malar Panandam, M Hair Bej. The effects of polymorphisms in 7 candidate genes on resistance to Salmonella Enteritidis in native chickens. Poultry science. vol 92. issue 4. 2013-06-13. PMID:23472012. |
seven candidate genes were selected on the basis of their physiological role in immune response, as determined by prior studies in other genetic lines: natural resistance-associated protein 1 (nramp1), transforming growth factor β3 (tgfβ3), transforming growth factor β4 (tgfβ4), inhibitor of apoptosis protein 1 (iap1), caspase 1 (casp1), lipopolysaccharide-induced tumor necrosis factor (tnf) α factor (litaf), and tnf-related apoptosis-inducing ligand (trail). |
2013-06-13 |
2023-08-12 |
Not clear |
| Pedro Henrique Gazzinelli-Guimarães, Elaine Maria Souza-Fagundes, Guilherme Grossi Lopes Cancado, Virgillio Gandra Martins, Lucas Carvalho Dhom-Lemos, Natasha Delaqua Ricci, Jacqueline Araujo Fiuza, Lilian Lacerda Bueno, Rodrigo Rodrigues Cambraia Miranda, Silvia Guatimosim, Andrea Gazzinelli, Rodrigo Correa-Oliveira, Daniella Castanheira Bartholomeu, Ricardo Toshio Fujiwar. Cell apoptosis induced by hookworm antigens: a strategy of immunomodulation. Frontiers in bioscience (Elite edition). vol 5. 2013-06-05. PMID:23277021. |
the downmodulation of tnf receptors, as well as the up-regulation of the pro-apoptotic genes belonging to the bcl-2 and p53 families, suggest that hookworm antigens induced apoptosis by an intrinsic mitochondrial pathway, acting as a sophisticated strategy to safeguard parasite long-term survival in their hosts. |
2013-06-05 |
2023-08-12 |
human |
| Reto A Rapold, Stephan Wueest, Adrian Knoepfel, Eugen J Schoenle, Daniel Konra. Fas activates lipolysis in a Ca2+-CaMKII-dependent manner in 3T3-L1 adipocytes. Journal of lipid research. vol 54. issue 1. 2013-05-28. PMID:23089915. |
fas (cd95) is a member of the tumor necrosis factor (tnf) receptor superfamily and plays a crucial role in the induction of apoptosis. |
2013-05-28 |
2023-08-12 |
mouse |
| T Lu, N Shao, C J. Targeting microRNAs to modulate TRAIL-induced apoptosis of cancer cells. Cancer gene therapy. vol 20. issue 1. 2013-05-27. PMID:23138871. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail), as a member of the tnf family, is an attractive therapeutic target in cancer because it directly induces tumor cell apoptosis and has no cytotoxicity to normal cell types in vitro or in vivo. |
2013-05-27 |
2023-08-12 |
Not clear |
| Asha Anandaiah, Sanjeev Sinha, Medhavi Bole, Surendra K Sharma, Narendra Kumar, Kalpana Luthra, Xin Li, Xiuqin Zhou, Benjamin Nelson, Xinbing Han, Souvenir D Tachado, Naimish R Patel, Henry Kozie. Vitamin D rescues impaired Mycobacterium tuberculosis-mediated tumor necrosis factor release in macrophages of HIV-seropositive individuals through an enhanced Toll-like receptor signaling pathway in vitro. Infection and immunity. vol 81. issue 1. 2013-05-20. PMID:23071135. |
alveolar macrophages from hiv(+) persons demonstrate specific and targeted impairment of critical host cell responses, including impaired m. tuberculosis-mediated tumor necrosis factor (tnf) release and macrophage apoptosis. |
2013-05-20 |
2023-08-12 |
human |
| Carlos Rotman, Larry Fischel, Gabriela Cortez, Hisham Greiss, Nasiruddin Rana, John Rinehart, Carolyn B Coula. A search to identify genetic risk factors for endometriosis. American journal of reproductive immunology (New York, N.Y. : 1989). vol 69. issue 1. 2013-05-17. PMID:23167810. |
to search for molecular markers of endometriosis the following polymorphisms: p53 codon 72 pro (apoptosis), tnf alpha-308 (inflammation), vegf-1164aa (angiogenesis), and sod2 (oxidative stress) were investigated. |
2013-05-17 |
2023-08-12 |
Not clear |
| Yu Wang, Xingang Wang, Hui Zhao, Bo Liang, Qihang D. Clusterin confers resistance to TNF-alpha-induced apoptosis in breast cancer cells through NF-kappaB activation and Bcl-2 overexpression. Journal of chemotherapy (Florence, Italy). vol 24. issue 6. 2013-04-29. PMID:23174100. |
secretory clusterin (sclu) is an anti-apoptotic protein that plays a role in protecting cells from tumour-necrosis factor (tnf)-alpha-induced apoptosis. |
2013-04-29 |
2023-08-12 |
Not clear |
| Conor J Kearney, Clare Sheridan, Sean P Cullen, Graham A Tynan, Susan E Logue, Inna S Afonina, Domagoj Vucic, Ed C Lavelle, Seamus J Marti. Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production. The Journal of biological chemistry. vol 288. issue 7. 2013-04-29. PMID:23275336. |
inhibitor of apoptosis proteins (iaps) and their antagonists regulate spontaneous and tumor necrosis factor (tnf)-induced proinflammatory cytokine and chemokine production. |
2013-04-29 |
2023-08-12 |
Not clear |
| Conor J Kearney, Clare Sheridan, Sean P Cullen, Graham A Tynan, Susan E Logue, Inna S Afonina, Domagoj Vucic, Ed C Lavelle, Seamus J Marti. Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production. The Journal of biological chemistry. vol 288. issue 7. 2013-04-29. PMID:23275336. |
inhibitor of apoptosis proteins (iaps) play a major role in determining whether cells undergo apoptosis in response to tnf as well as other stimuli. |
2013-04-29 |
2023-08-12 |
Not clear |