| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Irina T Nizamutdinova, Rakeshwar S Guleria, Amar B Singh, Jonathan A Kendall, Kenneth M Baker, Jing Pa. Retinoic acid protects cardiomyocytes from high glucose-induced apoptosis through inhibition of NF-κB signaling pathway. Journal of cellular physiology. vol 228. issue 2. 2013-01-24. PMID:22718360. |
activated nf-κb signaling has an important role in hg-induced cardiomyocyte apoptosis and gene expression of interleukin-6 (il-6), tumor necrosis factor (tnf)-α, and monocyte chemoattractant protein-1 (mcp-1). |
2013-01-24 |
2023-08-12 |
rat |
| Dimitrios Makrygiannakis, Anca Irinel Catrin. Apoptosis as a mechanism of action of tumor necrosis factor antagonists in rheumatoid arthritis. The Journal of rheumatology. vol 39. issue 4. 2013-01-22. PMID:22422498. |
one unresolved issue is to what extent apoptosis is affected by tnf blockade in ra. |
2013-01-22 |
2023-08-12 |
Not clear |
| Kathrin Steinwede, Stefanie Henken, Jennifer Bohling, Regina Maus, Bianca Ueberberg, Christina Brumshagen, Erik L Brincks, Thomas S Griffith, Tobias Welte, Ulrich A Mau. TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice. The Journal of experimental medicine. vol 209. issue 11. 2013-01-18. PMID:23071253. |
here, we examined the role of the tnf superfamily member tnf-related apoptosis-inducing ligand (trail) in s. pneumoniae-induced macrophage apoptosis, and investigated the potential benefit of trail-based therapy during pneumococcal pneumonia in mice. |
2013-01-18 |
2023-08-12 |
mouse |
| Brian W C Tse, Kieran F Scott, Pamela J Russel. Paradoxical roles of tumour necrosis factor-alpha in prostate cancer biology. Prostate cancer. vol 2012. 2013-01-18. PMID:23326670. |
on the other hand, tnf has also been reported to inhibit neovascularisation, induce apoptosis of pca cells, and stimulate antitumour immunity. |
2013-01-18 |
2023-08-12 |
Not clear |
| Christian Winkel, Simon Neumann, Christina Surulescu, Peter Scheuric. A minimal mathematical model for the initial molecular interactions of death receptor signalling. Mathematical biosciences and engineering : MBE. vol 9. issue 3. 2013-01-10. PMID:22881031. |
a subgroup of the tnf ligand family, including tnf, signals via so-called death receptors, capable to induce a major form of programmed cell death, called apoptosis. |
2013-01-10 |
2023-08-12 |
Not clear |
| Mingxing Lei, Xiufeng Bai, Tian Yang, Xiangdong Lai, Weiming Qiu, Li Yang, Xiaohua Lia. Gsdma3 is a new factor needed for TNF-α-mediated apoptosis signal pathway in mouse skin keratinocytes. Histochemistry and cell biology. vol 138. issue 3. 2013-01-07. PMID:22585037. |
apoptosis of skin keratinocytes is strictly regulated by a series of signal pathways, among of which, tumor necrosis factor (tnf)-α-induced signal pathway has been extensively studied. |
2013-01-07 |
2023-08-12 |
mouse |
| R Savanh Chanthaphavong, Patricia A Loughran, Tiffany Y S Lee, Melanie J Scott, Timothy R Billia. A role for cGMP in inducible nitric-oxide synthase (iNOS)-induced tumor necrosis factor (TNF) α-converting enzyme (TACE/ADAM17) activation, translocation, and TNF receptor 1 (TNFR1) shedding in hepatocytes. The Journal of biological chemistry. vol 287. issue 43. 2012-12-28. PMID:22898814. |
in vitro, hepatocytes are protected from tumor necrosis factor (tnf) α-induced apoptosis via cgmp-dependent and cgmp-independent mechanisms. |
2012-12-28 |
2023-08-12 |
Not clear |
| Fangmei An, Bangdong Gong, Hui Wang, Dongshan Yu, Gangde Zhao, Lanyi Lin, Weiliang Tang, Hong Yu, Shisan Bao, Qing Xi. miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure. Apoptosis : an international journal on programmed cell death. vol 17. issue 7. 2012-12-21. PMID:22374434. |
mir-15b and mir-16 regulate tnf mediated hepatocyte apoptosis via bcl2 in acute liver failure. |
2012-12-21 |
2023-08-12 |
Not clear |
| Fangmei An, Bangdong Gong, Hui Wang, Dongshan Yu, Gangde Zhao, Lanyi Lin, Weiliang Tang, Hong Yu, Shisan Bao, Qing Xi. miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure. Apoptosis : an international journal on programmed cell death. vol 17. issue 7. 2012-12-21. PMID:22374434. |
inhibition of mir-15b and/or mir-16 reduced hepatic apoptosis and tnf production. |
2012-12-21 |
2023-08-12 |
Not clear |
| Fangmei An, Bangdong Gong, Hui Wang, Dongshan Yu, Gangde Zhao, Lanyi Lin, Weiliang Tang, Hong Yu, Shisan Bao, Qing Xi. miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure. Apoptosis : an international journal on programmed cell death. vol 17. issue 7. 2012-12-21. PMID:22374434. |
these data suggest that mir-15b and mir-16 regulate tnf mediated hepatic apoptosis via bcl2 during alf, and may shed light on the development of a therapeutic strategy for treatment of alf. |
2012-12-21 |
2023-08-12 |
Not clear |
| J Jurgensmeier, P Hofler, G Baue. Tgf-Beta-induced apoptosis of transformed fibroblasts by normal fibroblasts - independence of cell-to-cell contact and dependence on reactive oxygen species. International journal of oncology. vol 5. issue 3. 2012-12-20. PMID:21559608. |
kinetic experiments revealed two steps: first, the elimination process is induced in the normal cells by tgf-beta and later, the apoptosis of transformed cells is mediated by a short-lived effector different from tgf-beta and tnf. |
2012-12-20 |
2023-08-12 |
Not clear |
| Laura E White, Yan Cui, Carolyn M Feltes Shelak, Mihaela L Lie, Heitham T Hassou. Lung endothelial cell apoptosis during ischemic acute kidney injury. Shock (Augusta, Ga.). vol 38. issue 3. 2012-12-14. PMID:22777112. |
rat lung microvascular ecs treated +/- etanercept, a tnf-α/tnfr1 signaling inhibitor, underwent custom real-time polymerase chain reaction analysis for proapoptotic and tnf superfamily transcriptional events, and apoptosis was identified with caspase 3 and poly(adp-ribose) polymerase activity assays. |
2012-12-14 |
2023-08-12 |
mouse |
| Rachita K Sumbria, Ruben J Boado, William M Pardridg. Brain protection from stroke with intravenous TNFα decoy receptor-Trojan horse fusion protein. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 32. issue 10. 2012-12-11. PMID:22714051. |
tumor necrosis factor (tnf)-α is produced in brain in response to acute cerebral ischemia, and promotes neuronal apoptosis. |
2012-12-11 |
2023-08-12 |
mouse |
| Regina Golan-Gerstl, Shulamit B Wallach-Dayan, Philip Zisman, Wellington V Cardoso, Ronald H Goldstein, Raphael Breue. Cellular FLICE-like inhibitory protein deviates myofibroblast fas-induced apoptosis toward proliferation during lung fibrosis. American journal of respiratory cell and molecular biology. vol 47. issue 3. 2012-11-30. PMID:22582174. |
using the animal model, we show that fibrotic lung myofibroblasts divert fas signaling from apoptosis to proliferation and that this requires signaling by tnf receptor-associated factor (traf) and nf-κb. |
2012-11-30 |
2023-08-12 |
mouse |
| Aleksandra Mielczarek-Palacz, Zdzisława Kondera-Anasz, Justyna Sikor. Higher serum levels of tumour necrosis factor and its soluble receptors are associated with ovarian tumours. Archives of medical science : AMS. vol 8. issue 5. 2012-11-28. PMID:23185194. |
tumour necrosis factor (tnf) and its soluble receptors type 1 (stnf-r1) and type 2 (stnf-r2) have been suggested as key mediators between apoptosis and cancer cell progression. |
2012-11-28 |
2023-08-12 |
Not clear |
| Christian Liedtke, Christian Trautwei. The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer. European journal of cell biology. vol 91. issue 6-7. 2012-11-07. PMID:22153863. |
tumor necrosis factor (tnf) alpha is a pleiotropic cytokine triggering either pro-inflammatory effects via nf-κb related pathways or apoptosis through activation of caspase-8. |
2012-11-07 |
2023-08-12 |
mouse |
| M A Rezvanfar, M A Rezvanfar, A Ahmadi, H A Shojaei-Saadi, M Baeeri, M Abdollah. Molecular mechanisms of a novel selenium-based complementary medicine which confers protection against hyperandrogenism-induced polycystic ovary. Theriogenology. vol 78. issue 3. 2012-11-05. PMID:22541319. |
to determine the role of oxidative stress (os) in hyperandrogenism-induced pco, concentrations of cellular lipid peroxidation (lpo), superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), peroxynitrite (onoo), and tumor necrosis factor (tnf)-α as a marker of inflammation and apoptosis were measured in serum and ovaries. |
2012-11-05 |
2023-08-12 |
rat |
| Vincenzo C Russo, Sandra Higgins, George A Werther, Fergus J Camero. Effects of fluctuating glucose levels on neuronal cells in vitro. Neurochemical research. vol 37. issue 8. 2012-11-05. PMID:22565596. |
on the other hand the glucose mediated osmotic stress-modulated genes were mostly within the extrinsic apoptotic pathway, including tnf receptor and their ligands and adaptors/activators/initiators of apoptosis. |
2012-11-05 |
2023-08-12 |
human |
| Weidong Ji, Yonghao Li, Ting Wan, Jing Wang, Haifeng Zhang, Hong Chen, Wang Mi. Both internalization and AIP1 association are required for tumor necrosis factor receptor 2-mediated JNK signaling. Arteriosclerosis, thrombosis, and vascular biology. vol 32. issue 9. 2012-10-29. PMID:22743059. |
the proinflammtory cytokine tumor necrosis factor (tnf), primarily via tnf receptor 1 (tnfr1), induces nuclear factor-κb (nf-κb)-dependent cell survival, and c-jun n-terminal kinase (jnk) and caspase-dependent cell death, regulating vascular endothelial cell (ec) activation and apoptosis. |
2012-10-29 |
2023-08-12 |
Not clear |
| Alessandro Antonelli, Silvia Martina Ferrari, Poupak Fallahi, Simona Piaggi, Andrea Di Domenicantonio, David Galleri, Libero Santarpia, Fulvio Basolo, Ele Ferrannini, Paolo Miccol. Variable modulation by cytokines and thiazolidinediones of the prototype Th1 chemokine CXCL10 in anaplastic thyroid cancer. Cytokine. vol 59. issue 2. 2012-10-16. PMID:22633083. |
this study aimed to test in "primary human atc cells" (ana) vs "normal thyroid follicular cells" (tfc): (a) cxcl10 secretion basally and after interferon (ifn)-γ and/or tumor necrosis factor (tnf)-α stimulation; (b) peroxisome proliferator-activated receptor (ppar)-γ activation by thiazolidinediones, rosiglitazone or pioglitazone, on cxcl10 secretion, on proliferation and apoptosis in ana. |
2012-10-16 |
2023-08-12 |
human |