| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaamar Azijli, Saravanan Yuvaraj, Maikel P Peppelenbosch, Thomas Würdinger, Henk Dekker, Jos Joore, Evert van Dijk, Wim J Quax, Godefridus J Peters, Steven de Jong, Frank A E Kruy. Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells. Journal of cell science. vol 125. issue Pt 19. 2013-04-26. PMID:22797920. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) triggers apoptosis selectively in tumor cells through interaction with trail-r1/dr4 or trail-r2/dr5 and this process is considered a promising avenue for cancer treatment. |
2013-04-26 |
2023-08-12 |
human |
| Ana Belen Sanz, Maria D Sanchez-Niño, Alberto Orti. TWEAK, a multifunctional cytokine in kidney injury. Kidney international. vol 80. issue 7. 2013-04-17. PMID:21697814. |
tumor necrosis factor-like weak inducer of apoptosis (tweak) is a cytokine of the tnf superfamily that activates the fn14 receptor. |
2013-04-17 |
2023-08-12 |
human |
| S Jouan-Lanhouet, M I Arshad, C Piquet-Pellorce, C Martin-Chouly, G Le Moigne-Muller, F Van Herreweghe, N Takahashi, O Sergent, D Lagadic-Gossmann, P Vandenabeele, M Samson, M-T Dimanche-Boitre. TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. Cell death and differentiation. vol 19. issue 12. 2013-04-17. PMID:22814620. |
although trail (tumor necrosis factor (tnf)-related apoptosis inducing ligand) is a well-known apoptosis inducer, we have previously demonstrated that acidic extracellular ph (phe) switches trail-induced apoptosis to regulated necrosis (or necroptosis) in human ht29 colon and hepg2 liver cancer cells. |
2013-04-17 |
2023-08-12 |
mouse |
| Jiang-Hu Piao, Hideo Yagita, Ko Okumura, Hiroyasu Nakan. Aberrant accumulation of interleukin-10-secreting neutrophils in TRAF2-deficient mice. Immunology and cell biology. vol 90. issue 9. 2013-04-11. PMID:22546736. |
we have previously reported that tumor necrosis factor (tnf) receptor-associated factor (traf)2(-/-) mice spontaneously develop severe colitis and that the development of colitis largely depends on tnfα-dependent apoptosis of colonic epithelial cells. |
2013-04-11 |
2023-08-12 |
mouse |
| Piyushi Gupta, Deobrat Dixit, Ellora Se. Oncrasin targets the JNK-NF-κB axis to sensitize glioma cells to TNFα-induced apoptosis. Carcinogenesis. vol 34. issue 2. 2013-04-03. PMID:23125226. |
resistance of glioblastoma multiforme (gbm) to tumor necrosis factor (tnf) α-induced apoptosis have been attributed to increased nuclear factor-kappab (nf-κb) activation. |
2013-04-03 |
2023-08-12 |
Not clear |
| Gelin Wang, Xiaoming Wang, Hong Yu, Shuguang Wei, Noelle Williams, Daniel L Holmes, Randal Halfmann, Jacinth Naidoo, Lai Wang, Lin Li, She Chen, Patrick Harran, Xiaoguang Lei, Xiaodong Wan. Small-molecule activation of the TRAIL receptor DR5 in human cancer cells. Nature chemical biology. vol 9. issue 2. 2013-03-19. PMID:23292651. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) activates apoptosis through the death receptors dr4 and dr5. |
2013-03-19 |
2023-08-12 |
human |
| Jianxin Lu, Cheuk-Chun Szeto, Lai-Shan Tam, Fernand Mac-Moune Lai, Edmund Kwok-Ming Li, Kai-Ming Chow, Philip Kam-Tao Li, Bonnie Ching-Ha Kwa. Relationship of intrarenal gene expression and the histological class of lupus nephritis -- a study on repeat renal biopsy. The Journal of rheumatology. vol 39. issue 10. 2013-03-14. PMID:22896023. |
to study the role of tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak)/fn14 and the interferon-inducible protein (ip-10)/cxcr3 axis in lupus nephritis (ln). |
2013-03-14 |
2023-08-12 |
Not clear |
| Jun-Jie Chen, H-C Jennifer Shen, Leslie A Rivera Rosado, Yaqin Zhang, Xu Di, Baolin Zhan. Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells. Oncotarget. vol 3. issue 8. 2013-03-12. PMID:22909995. |
multiple clinical trials are ongoing to evaluate the potential antitumor activity of human tnf variants, fas ligand (fasl), tnf-related apoptosis inducing ligand (trail) and its agonistic antibodies. |
2013-03-12 |
2023-08-12 |
human |
| V V Kolobov, Z I Storozheva, M A Gruden, V V Sherstne. Regional features of the expression of genes involved in neurogenesis and apoptosis in the brain of adult rats. Bulletin of experimental biology and medicine. vol 153. issue 5. 2013-03-12. PMID:23113275. |
the expression of mrna of genes involved in neurogenesis and apoptosis (apaf1, ascl1, bax, bcl2, casp3, casp8, casp9, dffb, myh10, naip2, napa, notch2, numb, pura, s100a6, tnf) in the prefrontal cortex, hippocampus, and cerebellum was studied in adult rats. |
2013-03-12 |
2023-08-12 |
rat |
| Christopher S McAllister, Omar Lakhdari, Guillaume Pineton de Chambrun, Mélanie G Gareau, Alexis Broquet, Gin Hyug Lee, Steven Shenouda, Lars Eckmann, Martin F Kagnof. TLR3, TRIF, and caspase 8 determine double-stranded RNA-induced epithelial cell death and survival in vivo. Journal of immunology (Baltimore, Md. : 1950). vol 190. issue 1. 2013-03-12. PMID:23209324. |
dsrna-induced apoptosis was independent of tnf signaling. |
2013-03-12 |
2023-08-12 |
mouse |
| Christopher S McAllister, Omar Lakhdari, Guillaume Pineton de Chambrun, Mélanie G Gareau, Alexis Broquet, Gin Hyug Lee, Steven Shenouda, Lars Eckmann, Martin F Kagnof. TLR3, TRIF, and caspase 8 determine double-stranded RNA-induced epithelial cell death and survival in vivo. Journal of immunology (Baltimore, Md. : 1950). vol 190. issue 1. 2013-03-12. PMID:23209324. |
consistent with direct activation of the tlr3-trif-caspase 8 signaling pathway by dsrna in iecs, dsrna-induced signaling of apoptosis was independent of non-tlr3 dsrna signaling pathways, il-15, tnf, il-1, il-6, ifn regulatory factor 3, type i ifn receptor, adaptive immunity, as well as dendritic cells, nk cells, and other hematopoietic cells. |
2013-03-12 |
2023-08-12 |
mouse |
| Shuangxin Liu, Wei Shi, Houqin Xiao, Xinling Liang, Chunyu Deng, Zhiming Ye, Ping Mei, Suxia Wang, Xiaoying Liu, Zhixin Shan, Yongzheng Liang, Bin Zhang, Wenjian Wang, Yanhui Liu, Lixia Xu, Yunfeng Xia, Jianchao Ma, Zhilian L. Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury. PloS one. vol 7. issue 7. 2013-03-11. PMID:22848465. |
tnf and tnf receptor superfamilies are important in the pathogenesis of podocyte injury and apoptosis. |
2013-03-11 |
2023-08-12 |
Not clear |
| Jessica K Bernard, Sean P McCann, Vrinda Bhardwaj, Mary K Washington, Mark R Fre. Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo. The Journal of biological chemistry. vol 287. issue 47. 2013-02-19. PMID:23033483. |
nrg4 treatment, either in cultured cells or in mice, blocked colonic epithelial apoptosis induced by tnf and ifn-γ. |
2013-02-19 |
2023-08-12 |
mouse |
| Natalya Benderska, Saritha Chakilam, Manuela Hugle, Jelena Ivanovska, Muktheshwar Gandesiri, Jan Schulze-Luhrmann, Khuloud Bajbouj, Ronald Croner, Regine Schneider-Stoc. Apoptosis signalling activated by TNF in the lower gastrointestinal tract--review. Current pharmaceutical biotechnology. vol 13. issue 11. 2013-02-12. PMID:21605069. |
apoptosis signalling activated by tnf in the lower gastrointestinal tract--review. |
2013-02-12 |
2023-08-12 |
Not clear |
| Arie J Hoogendijk, Joris J T H Roelofs, Janwillem Duitman, Miriam H P van Lieshout, Dana C Blok, Tom van der Poll, Catharina W Wielan. R-roscovitine reduces lung inflammation induced by lipoteichoic acid and Streptococcus pneumoniae. Molecular medicine (Cambridge, Mass.). vol 18. 2013-02-06. PMID:22692577. |
in vitro r-roscovitine enhanced apoptosis in pmns and reduced tumor necrosis factor (tnf)-α and keratinocyte chemoattractant (kc) production in mh-s (alveolar macrophage) and mle-12/mle-15 (respiratory epithelial) cell lines. |
2013-02-06 |
2023-08-12 |
Not clear |
| Chunxia Qiao, Meiyun Hu, Leiming Guo, Ming Lv, Zhou Lin, Jing Geng, Xiaoling Lang, Xinying Li, Yan Li, Yuanfang Ma, Jiannan Feng, Beifen She. Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation. BMC immunology. vol 13. 2013-02-06. PMID:22788777. |
as a member of the tnf superfamily, trail could induce human tumor cell apoptosis through its cognate death receptors dr4 or dr5, which can induce formation of the death inducing signaling complex (disc) and activation of the membrane proximal caspases (caspase-8 or caspase-10) and mitochondrial pathway. |
2013-02-06 |
2023-08-12 |
human |
| Tatiana Goretsky, Ramanarao Dirisina, Preetika Sinh, Navdha Mittal, Elizabeth Managlia, David B Williams, Daniela Posca, Hyunji Ryu, Rebecca B Katzman, Terrence A Barret. p53 mediates TNF-induced epithelial cell apoptosis in IBD. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22863952. |
chronic ulcerative colitis (cuc) is characterized by increased intestinal epithelial cell (iec) apoptosis associated with elevated tumor necrosis factor (tnf), inducible nitric oxide synthase (inos), and p53. |
2013-02-06 |
2023-08-12 |
mouse |
| Tatiana Goretsky, Ramanarao Dirisina, Preetika Sinh, Navdha Mittal, Elizabeth Managlia, David B Williams, Daniela Posca, Hyunji Ryu, Rebecca B Katzman, Terrence A Barret. p53 mediates TNF-induced epithelial cell apoptosis in IBD. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22863952. |
herein, we examined the roles of tnf and inos in regulating p53-induced iec apoptosis in cuc. |
2013-02-06 |
2023-08-12 |
mouse |
| Tatiana Goretsky, Ramanarao Dirisina, Preetika Sinh, Navdha Mittal, Elizabeth Managlia, David B Williams, Daniela Posca, Hyunji Ryu, Rebecca B Katzman, Terrence A Barret. p53 mediates TNF-induced epithelial cell apoptosis in IBD. The American journal of pathology. vol 181. issue 4. 2013-02-06. PMID:22863952. |
iec p53 levels and apoptosis were reduced in il-10(-/-) colitic mice treated with neutralizing tnf mab and the inos inhibitor, aminoguanidine, further suggesting that tnf and inos are upstream of p53 during colitis-induced iec apoptosis. |
2013-02-06 |
2023-08-12 |
mouse |
| Jin-Sil Park, Mi-Kyung Park, Seon-Yeong Lee, Hye-Jwa Oh, Mi-Ae Lim, Woo-Tae Cho, Eun-Kyung Kim, Ji-Hyeon Ju, Young-Woo Park, Sung-Hwan Park, Mi-La Cho, Ho-Youn Ki. TWEAK promotes the production of Interleukin-17 in rheumatoid arthritis. Cytokine. vol 60. issue 1. 2013-02-01. PMID:22819243. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is an inflammatory cytokine that modulates several biological responses by inducing chemokines and proinflammatory cytokines. |
2013-02-01 |
2023-08-12 |
mouse |