| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Min Ni, Mitchell R McGill, Xiaojuan Chao, Benjamin L Woolbright, Hartmut Jaeschke, Wen-Xing Din. Caspase Inhibition Prevents Tumor Necrosis Factor-α-Induced Apoptosis and Promotes Necrotic Cell Death in Mouse Hepatocytes in Vivo and in Vitro. The American journal of pathology. vol 186. issue 10. 2017-10-11. PMID:27616656. |
we determined the interrelation of apoptosis, necrosis, and autophagy in tumor necrosis factor (tnf)-α/actinomycin d (actd) and lipopolysaccharide/d-galactosamine (galn)-induced hepatotoxicity in vitro and in vivo. |
2017-10-11 |
2023-08-13 |
mouse |
| Patricia Martínez-Miguel, Diana Medrano-Andrés, Mercedes Griera-Merino, Alberto Ortiz, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol, Susana López-Ongi. Tweak up-regulates endothelin-1 system in mouse and human endothelial cells. Cardiovascular research. vol 113. issue 2. 2017-10-10. PMID:28025386. |
tnf-like weak inducer of apoptosis (tweak) is a member of tnf superfamily; it has different biological functions such as inflammation, angiogenesis, proliferation, and apoptosis. |
2017-10-10 |
2023-08-13 |
mouse |
| L Catrysse, M Farhang Ghahremani, L Vereecke, S A Youssef, C Mc Guire, M Sze, A Weber, M Heikenwalder, A de Bruin, R Beyaert, G van Lo. A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death. Cell death & disease. vol 7. issue 6. 2017-10-09. PMID:27253414. |
hepatocyte-specific a20 knockout mice show sustained nf-κb-dependent gene expression in the liver upon tumor necrosis factor (tnf) or lipopolysaccharide injection, as well as hepatocyte apoptosis and lethality upon challenge with sublethal doses of tnf, demonstrating an essential role for a20 in the protection of mice against acute liver failure. |
2017-10-09 |
2023-08-13 |
mouse |
| Benjamin Nelson, Xiuqin Zhou, Mitchell White, Kevan Hartshorn, Kazue Takahashi, T Bernard Kinane, Asha Anandaiah, Henry Kozie. Recombinant human mannose-binding lectin dampens human alveolar macrophage inflammatory responses to influenza A virus in vitro. Journal of leukocyte biology. vol 95. issue 5. 2017-10-06. PMID:24399838. |
in the current study, focusing on human macrophages (u937 cell line and clinically relevant human am), data demonstrated that unopsonized iav is readily internalized, induced release of tnf and ros, and promoted macrophage apoptosis. |
2017-10-06 |
2023-08-12 |
human |
| Benjamin Nelson, Xiuqin Zhou, Mitchell White, Kevan Hartshorn, Kazue Takahashi, T Bernard Kinane, Asha Anandaiah, Henry Kozie. Recombinant human mannose-binding lectin dampens human alveolar macrophage inflammatory responses to influenza A virus in vitro. Journal of leukocyte biology. vol 95. issue 5. 2017-10-06. PMID:24399838. |
in contrast, iav, opsonized with rhmbl, reduced iav uptake and macrophage apoptosis and dramatically reduced tnf release and ros. |
2017-10-06 |
2023-08-12 |
human |
| Yousef R Badran, Fatma Dedeoglu, Juan Manuel Leyva Castillo, Wayne Bainter, Toshiro K Ohsumi, Athos Bousvaros, Jeffrey D Goldsmith, Raif S Geha, Janet Cho. Human The Journal of experimental medicine. vol 214. issue 7. 2017-10-06. PMID:28600438. |
tnf activates opposing pathways leading to caspase-8-mediated apoptosis as well as nuclear factor κb (nf-κb)-dependent cell survival. |
2017-10-06 |
2023-08-13 |
human |
| Jun Cai, Dong Wang, Zhi-Gang Bai, Jie Yin, Jun Zhang, Zhong-Tao Zhan. The long noncoding RNA XIAP-AS1 promotes XIAP transcription by XIAP-AS1 interacting with Sp1 in gastric cancer cells. PloS one. vol 12. issue 8. 2017-10-06. PMID:28792527. |
xiap-as1 knockdown promoted tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-induced apoptosis in gastric tumor cells, as cleaved caspase-3 and caspase-9 was detected. |
2017-10-06 |
2023-08-13 |
mouse |
| Wenjun Wu, Yang Yang, Gang Deng, Liang Ma, Guoqing Wei, Gaofeng Zheng, Xiaoyan Han, Donghua He, Yi Zhao, Jinsong He, Zhen Cai, Rui Y. Vernodalol enhances TRAIL-induced apoptosis in diffuse large B-cell lymphoma cells. Molecular carcinogenesis. vol 56. issue 10. 2017-10-04. PMID:28467689. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a potent anti-tumor agent that triggers apoptosis in cells from multiple types of carcinoma but not in normal cells. |
2017-10-04 |
2023-08-13 |
Not clear |
| Ian E Gentle, Kevin T McHenry, Arnim Weber, Arlena Metz, Oliver Kretz, Dale Porter, Georg Häcke. TIR-domain-containing adapter-inducing interferon-β (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy. The FEBS journal. vol 284. issue 13. 2017-10-02. PMID:28453927. |
a main signalling pathway triggered by tlr3 caused apoptosis, which was controlled by inhibitor of apoptosis proteins and was dependent on ripk1 and independent of tnf. |
2017-10-02 |
2023-08-13 |
Not clear |
| Sébastien Pasquereau, Amit Kumar, Georges Herbei. Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs. Viruses. vol 9. issue 4. 2017-09-27. PMID:28358311. |
several cellular functions such as apoptosis, cellular proliferation, inflammation, and immune regulation involve the tumor necrosis factor-α (tnf)/tnf receptor (tnfr) pathway. |
2017-09-27 |
2023-08-13 |
human |
| Christopher E Pedigo, Gloria Michelle Ducasa, Farah Leclercq, Alexis Sloan, Alla Mitrofanova, Tahreem Hashmi, Judith Molina-David, Mengyuan Ge, Mariann I Lassenius, Carol Forsblom, Markku Lehto, Per-Henrik Groop, Matthias Kretzler, Sean Eddy, Sebastian Martini, Heather Reich, Patricia Wahl, GianMarco Ghiggeri, Christian Faul, George W Burke, Oliver Kretz, Tobias B Huber, Armando J Mendez, Sandra Merscher, Alessia Fornon. Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury. The Journal of clinical investigation. vol 126. issue 9. 2017-09-26. PMID:27482889. |
exogenous tnf administration or local tnf expression was equally sufficient to cause free cholesterol-dependent apoptosis in podocytes by acting through a dual mechanism that required a reduction in atp-binding cassette transporter a1-mediated (abca1-mediated) cholesterol efflux and reduced cholesterol esterification by sterol-o-acyltransferase 1 (soat1). |
2017-09-26 |
2023-08-13 |
mouse |
| Xiaoling Zhang, Ning Yin, Annan Guo, Qi Zhang, Yalei Zhang, Youjun Xu, Hongbo Liu, Bo Tang, Luhua La. NF-κB signaling and cell-fate decision induced by a fast-dissociating tumor necrosis factor mutant. Biochemical and biophysical research communications. vol 489. issue 3. 2017-09-25. PMID:28554843. |
we used tnf mutants with different receptor binding kinetics to study their effects on nf-κb signaling dynamics and cell apoptosis. |
2017-09-25 |
2023-08-13 |
Not clear |
| Steven D Quistad, Juris A Grasis, Jeremy J Barr, Forest L Rohwe. Viruses and the origin of microbiome selection and immunity. The ISME journal. vol 11. issue 4. 2017-09-20. PMID:27983723. |
if a resident virus became pathogenic or if a non-beneficial infection occurred, we propose that tumor necrosis factor (tnf)-mediated programmed cell death, as well as other apoptosis mechanisms, were utilized to remove virally infected cells. |
2017-09-20 |
2023-08-13 |
Not clear |
| Brandon M L Linz, Crystal J Neely, Laurel B Kartchner, April E Mendoza, Amal L Khoury, Agnieszka Truax, Gregory Sempowski, Timothy Eitas, June Brickey, Jenny P Y Ting, Bruce A Cairns, Robert Mail. Innate Immune Cell Recovery Is Positively Regulated by NLRP12 during Emergency Hematopoiesis. Journal of immunology (Baltimore, Md. : 1950). vol 198. issue 6. 2017-09-15. PMID:28159904. |
we show that nlrp12 has a profound impact on hematopoietic recovery during rci by serving as a checkpoint of tnf signaling and preventing hematopoietic apoptosis. |
2017-09-15 |
2023-08-13 |
mouse |
| Trieu-My Van, Apostolos Polykratis, Beate Katharina Straub, Vangelis Kondylis, Nikoletta Papadopoulou, Manolis Pasparaki. Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis. The Journal of clinical investigation. vol 127. issue 7. 2017-09-14. PMID:28628031. |
while ablating either ripk1 or rela in liver parenchymal cells (lpcs) did not cause spontaneous liver pathology, mice with combined deficiency of ripk1 and rela in lpcs showed increased hepatocyte apoptosis and developed spontaneous chronic liver disease and cancer that were independent of tnf receptor 1 (tnfr1) signaling. |
2017-09-14 |
2023-08-13 |
mouse |
| Conor J Kearney, Seamus J Marti. An Inflammatory Perspective on Necroptosis. Molecular cell. vol 65. issue 6. 2017-09-08. PMID:28306512. |
necroptosis (programmed necrosis) occurs in response to tnf, fas, or trail, as well as certain tlr ligands, when caspase activity required for apoptosis is blocked. |
2017-09-08 |
2023-08-13 |
Not clear |
| Peter T Soboslay, Thorsten Orlikowsky, Xiangsheng Huang, Christian Gille, Bärbel Spring, Lars Kocherscheidt, Abram Agossou, Meba Banla, Michael Bonin, Carsten Köhle. Cellular gene expression induced by parasite antigens and allergens in neonates from parasite-infected mothers. Molecular immunology. vol 73. 2017-09-07. PMID:27062712. |
when ucbc from para-pos and para-neg newborns were exposed to helminth antigens or allergens consistent differences occurred in the expression of genes encoding for mhc class i and ii alleles, signal transducers of activation and transcription (stats), cytokines, chemokines, immunoglobulin heavy and light chains, and molecules associated with immune regulation (socs, tlr, tgf), inflammation (tnf, ccr) and apoptosis (casp). |
2017-09-07 |
2023-08-13 |
Not clear |
| Deepak Kumar, Robert M Moore, Brian M Mercer, Joseph M Mansour, Raymond W Redline, John J Moor. The physiology of fetal membrane weakening and rupture: Insights gained from the determination of physical properties revisited. Placenta. vol 42. 2017-09-01. PMID:27238715. |
within this model tnf (modeling inflammation) and thrombin (modeling bleeding) both weaken human fm with concomitant up regulation of mmp9 and cellular apoptosis, mimicking the characteristics of the spontaneous fm rupture site. |
2017-09-01 |
2023-08-13 |
human |
| Lance W Peterson, Naomi H Philip, Christopher P Dillon, John Bertin, Peter J Gough, Douglas R Green, Igor E Brodsk. Cell-Extrinsic TNF Collaborates with TRIF Signaling To Promote Yersinia-Induced Apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 197. issue 10. 2017-08-11. PMID:27733552. |
cell-extrinsic tnf collaborates with trif signaling to promote yersinia-induced apoptosis. |
2017-08-11 |
2023-08-13 |
mouse |
| Lance W Peterson, Naomi H Philip, Christopher P Dillon, John Bertin, Peter J Gough, Douglas R Green, Igor E Brodsk. Cell-Extrinsic TNF Collaborates with TRIF Signaling To Promote Yersinia-Induced Apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 197. issue 10. 2017-08-11. PMID:27733552. |
moreover, tnf production by this subpopulation was necessary for maximal apoptosis in the population of highly injected cells, and tnfr-deficient mice displayed enhanced susceptibility to yersinia infection. |
2017-08-11 |
2023-08-13 |
mouse |