| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthias G J Baud, Matthias R Bauer, Lorena Verduci, Felix A Dingler, Ketan J Patel, Deeptee Horil Roy, Andreas C Joerger, Alan R Fersh. Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. European journal of medicinal chemistry. vol 152. 2018-06-19. PMID:29702446. |
reduction of viability correlated with increased and selective transcription of p53 target genes such as btg2, p21, puma, fas, tnf, and tnfrsf10b, which promote apoptosis and cell cycle arrest, suggesting compound-mediated transcriptional activation of the y220c mutant. |
2018-06-19 |
2023-08-13 |
Not clear |
| Conor J Kearney, Najoua Lalaoui, Andrew J Freeman, Kelly M Ramsbottom, John Silke, Jane Oliar. PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF. Cell death and differentiation. vol 24. issue 10. 2018-06-18. PMID:28665401. |
smac-mimetics can induce tnf production from a subset of tumor cells and simultaneously sensitize them to tnf-induced apoptosis. |
2018-06-18 |
2023-08-13 |
Not clear |
| Yingmei Zhao, Binqiang Tian, Yong Wang, Haiying Din. Kaempferol Sensitizes Human Ovarian Cancer Cells-OVCAR-3 and SKOV-3 to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis via JNK/ERK-CHOP Pathway and Up-Regulation of Death Receptors 4 and 5. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-06-18. PMID:29070784. |
tumor necrosis factor-related apoptosis-inducing ligand (trail) is a member of the tumor necrosis factor (tnf) superfamily which preferentially induces apoptosis of cancer cells. |
2018-06-18 |
2023-08-13 |
human |
| Fatma Guesmi, Sahdeo Prasad, Amit K Tyagi, Ahmed Landouls. Antinflammatory and anticancer effects of terpenes from oily fractions of Teucruim alopecurus, blocker of IκBα kinase, through downregulation of NF-κB activation, potentiation of apoptosis and suppression of NF-κB-regulated gene expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 95. 2018-06-07. PMID:28968948. |
ta-1 functions as an anticancer agent by triggering apoptosis potentiated by chemotherapeutic agents and tnf in human myeloid leukemia cells (kbm5) through a mechanism involving poly(adp-ribose) polymerase (parp) cleavage and initiator and effector caspases activation. |
2018-06-07 |
2023-08-13 |
human |
| Li Jiang, Xueqin Li, Yingying Zhang, Mengying Zhang, Zongsheng Tang, Kun L. Microarray and bioinformatics analyses of gene expression profiles in BALB/c murine macrophage polarization. Molecular medicine reports. vol 16. issue 5. 2018-06-06. PMID:28944843. |
signaling pathway analysis revealed that these degs were mainly involved in apoptosis, hypoxia‑inducible factor (hif) 1a pathway, innate immune system, tumor necrosis factor (tnf) signaling pathway, cytokine‑cytokine receptor interaction, and other signal transduction pathways. |
2018-06-06 |
2023-08-13 |
Not clear |
| Miyuki Iwai-Shimada, Tsutomu Takahashi, Min-Seok Kim, Masatake Fujimura, Hitoyasu Ito, Takashi Toyama, Akira Naganuma, Gi-Wook Hwan. Methylmercury induces the expression of TNF-α selectively in the brain of mice. Scientific reports. vol 6. 2018-05-29. PMID:27910896. |
the tumor necrosis factor (tnf) superfamily includes representative cytokines that participate in the inflammatory response as well as cell survival, and apoptosis. |
2018-05-29 |
2023-08-13 |
mouse |
| Takayuki Takahashi, Yukitoshi Mine, Tadashi Okamot. Intracellular reduction of coenzyme Q homologues with a short isoprenoid side chain induces apoptosis of HeLa cells. Journal of biochemistry. vol 163. issue 4. 2018-05-25. PMID:29319808. |
however, because dicumarol did not affect well-known apoptosis inducers, such as anti-fas igg, tumor necrosis factor (tnf)-α, tnf-related apoptosis-inducing ligand, uv-b and h2o2 of hela cells at all, we concluded that nqo1-related intracellular reduction of coq, or its reduced product, ubiquinol, may participate in the apoptosis induction of hela cells. |
2018-05-25 |
2023-08-13 |
Not clear |
| Mieczysław Dutka, Rafał Bobińsk. [Osteoprotegerin – is it only a cardiovascular risk marker?]. Przeglad lekarski. vol 73. issue 9. 2018-05-16. PMID:29688678. |
more and more studiesconfirm, that osteoprotegerin is associatedwith cardiovascular diseases.in many studies it has been confirmedthat high plasma concentration of osteoprotegerinand low concentrationof tnf – related apoptosis inducingligand (trail) and high opg/trailratio are predictors of a poor prognosisin patients with myocardial infarction.high plasma concentration and highopg/trail ratio in the acute phaseof myocardial infarction are mainlyprognostic indicators of adverse leftventricular remodelling and the developmentof postinfarction heart failure.in a group of patients with high plasmaconcentration of osteoprotegerin in theacute phase of myocardial infarction,it has also been established that thereare a lower number of mesenchymalstem cells (msc) recruited from bonemarrow and circulating in peripheralblood. |
2018-05-16 |
2023-08-13 |
Not clear |
| Merve Cingi Yirün, Onur Yirün, Kübranur Ünal, Rabia Nazik Yüksel, Neslihan Altunsoy, Elif Tatlidil Yaylaci, Makbule Çiğdem Aydemir, Erol Gök. Serum TNF-related weak inducer of apoptosis (TWEAK) and TNF-related apoptosis-inducing ligand (TRAIL) levels of patients with bipolar disorder in manic episode, in remission and healthy controls. Psychiatry research. vol 257. 2018-05-14. PMID:28800513. |
tnf-related weak inducer of apoptosis (tweak) and tnf-related apoptosis-inducing ligand (trail) are members of tnf superfamily, which has various roles in immunologic and inflammatory reactions in the organism. |
2018-05-14 |
2023-08-13 |
Not clear |
| Hemn Mohammadpour, Ali Akbar Pourfathollah, Mahin Nikougoftar Zarif, Amir Ali Shahbazfa. Irradiation enhances susceptibility of tumor cells to the antitumor effects of TNF-α activated adipose derived mesenchymal stem cells in breast cancer model. Scientific reports. vol 6. 2018-05-09. PMID:27329316. |
here, we showed that the expression of tnf related apoptosis-inducing ligand (trail) and dickouf-3 (dkk-3), the promising anticancer proteins, increased in murine adipose-derived mesenchymal stromal cells (ad-mscs) following activation with tnf-α, resulting in the induction of apoptosis in cancer cells. |
2018-05-09 |
2023-08-13 |
mouse |
| Mohd Farhan, Haitao Wang, Uma Gaur, Peter J Little, Jiangping Xu, Wenhua Zhen. FOXO Signaling Pathways as Therapeutic Targets in Cancer. International journal of biological sciences. vol 13. issue 7. 2018-05-04. PMID:28808415. |
during apoptosis, foxos are involved in mitochondria-dependent and -independent processes triggering the expression of death receptor ligands like fas ligand, tnf apoptosis ligand and bcl‑x |
2018-05-04 |
2023-08-13 |
Not clear |
| Hisaaki Shinohara, Kentaro Inoue, Noriko Yumoto, Takeshi Nagashima, Mariko Okada-Hatakeyam. Stimulus-Dependent Inhibitor of Apoptosis Protein Expression Prolongs the Duration of B Cell Signalling. Scientific reports. vol 6. 2018-04-26. PMID:27277891. |
we conducted a time-course transcriptome analysis after bcr or cd40 stimulation and identified the following four candidate genes as feedback regulators for ikk and erk: inhibitor of apoptosis protein (iap), tnf alpha-induced protein 3, dual-specificity phosphatase 5, and sprouty homolog 2. |
2018-04-26 |
2023-08-13 |
Not clear |
| Xiwen Dong, Zhaohui Zheng, Xing Luo, Jin Ding, Ying Li, Zhiqin Li, Sijia Li, Mengyao Rong, Yalu Fu, Zhenbiao Wu, Ping Zh. Combined utilization of untimed single urine of MCP-1 and TWEAK as a potential indicator for proteinuria in lupus nephritis: A case-control study. Medicine. vol 97. issue 16. 2018-04-25. PMID:29668584. |
the aim of this study was to determine whether combined utilization of untimed single urine monocyte chemoattractant protein 1 (umcp-1) and tumor necrosis factor (tnf)-like weak inducer of apoptosis (utweak) could serve as a screening test for proteinuria in patients with lupus nephritis (ln).a case-control study that contained 39 biopsy-proven ln patients, 20 non-ln systemic lupus erythematosus (sle) patients, and 10 healthy controls (hcs) were carried out. |
2018-04-25 |
2023-08-13 |
Not clear |
| Zhaoqun Liu, Lingling Wang, Zhi Zhou, Ying Sun, Mengqiang Wang, Hao Wang, Zhanhui Hou, Dahai Gao, Qiang Gao, Linsheng Son. The simple neuroendocrine-immune regulatory network in oyster Crassostrea gigas mediates complex functions. Scientific reports. vol 6. 2018-04-19. PMID:27193598. |
in the present study, the bioinformatical analysis of the transcriptomic data from oyster crassostrea gigas and further biological validation revealed that oyster tnf (cgtnf-1 cgi_10018786) could activate the transcription factors nf-κb and hsf (heat shock transcription factor) through mapk signaling pathway, and then regulate apoptosis, redox reaction, neuro-regulation and protein folding in oyster haemocytes. |
2018-04-19 |
2023-08-13 |
Not clear |
| Sebastian Bittner, Gertrud Knoll, Martin Ehrenschwende. Hyperosmotic stress enhances cytotoxicity of SMAC mimetics. Cell death & disease. vol 8. issue 8. 2018-04-17. PMID:28771230. |
here, we show that hyperosmotic stress boosts sm cytotoxicity in human and murine cells through hypertonicity-induced upregulation of tnf with subsequent induction of apoptosis and/or necroptosis. |
2018-04-17 |
2023-08-13 |
human |
| Changlong Xu, Liang Shi, Weilai Chen, Peipei Fang, Jie Li, Lingxiang Jin, Zhenzhen Pan, Chenwei Pa. MiR-106b inhibitors sensitize TRAIL-induced apoptosis in hepatocellular carcinoma through increase of death receptor 4. Oncotarget. vol 8. issue 26. 2018-04-06. PMID:28410209. |
tnf-related apoptosis-inducing ligand (trail), which is a member of the tnf superfamily, can induce tumor cell apoptosis. |
2018-04-06 |
2023-08-13 |
Not clear |
| Willie M Lüdemann, Danijela Heide, Lars Kihm, Martin Zeier, Peter Scheurich, Vedat Schwenger, Julia Ranzinge. TNF Signaling in Peritoneal Mesothelial Cells: Pivotal Role of cFLIP Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. vol 37. issue 3. 2018-04-04. PMID:28096440. |
although tnf receptor 1 (tnfr1) is expressed in high numbers on the cells, tnf-induced apoptosis is inhibited. |
2018-04-04 |
2023-08-13 |
human |
| Parth Thakor, Ramalingam B Subramanian, Sampark S Thakkar, Arabinda Ray, Vasudev R Thakka. Phytol induces ROS mediated apoptosis by induction of caspase 9 and 3 through activation of TRAIL, FAS and TNF receptors and inhibits tumor progression factor Glucose 6 phosphate dehydrogenase in lung carcinoma cell line (A549). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-04-03. PMID:28575806. |
phytol induces ros mediated apoptosis by induction of caspase 9 and 3 through activation of trail, fas and tnf receptors and inhibits tumor progression factor glucose 6 phosphate dehydrogenase in lung carcinoma cell line (a549). |
2018-04-03 |
2023-08-13 |
human |
| Diego Rojas-Rivera, Tinneke Delvaeye, Ria Roelandt, Wim Nerinckx, Koen Augustyns, Peter Vandenabeele, Mathieu J M Bertran. When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157. Cell death and differentiation. vol 24. issue 6. 2018-03-29. PMID:28452996. |
tnf is a master pro-inflammatory cytokine that drives inflammation either directly by promoting gene activation, or indirectly by inducing ripk1 kinase-dependent cell death, in the form of apoptosis or necroptosis. |
2018-03-29 |
2023-08-13 |
mouse |
| Xian-Tao Zeng, Xiao-Ping Liu, Tong-Zu Liu, Xing-Huan Wan. The clinical significance of COL5A2 in patients with bladder cancer: A retrospective analysis of bladder cancer gene expression data. Medicine. vol 97. issue 10. 2018-03-19. PMID:29517678. |
gene set enrichment analysis was conducted to study the relevant mechanisms.bladder cancer patients in col5a2 low expression group were associated with better invasiveness (p < .0001), tumor grade (p = .001), t staging (p < .0001), n staging (p = .002), cancer specific survival (p < .0001), overall survival (p < .0001), and a trend of better m staging (p = .053) than those in col5a2 high expression group.col5a2 might affect the progression of bladder cancer through "coagulation," "hypoxia," "apical junction," "ultraviolet response," "epithelial mesenchymal transition," "angiogenesis," "kras (kras proto-oncogene, gtpase) signaling,""complement,""il2-stat5-signaling," "inflammatory response," "il6-jak-stat3-signaling," "myogenesis," "tnf α signaling," "apoptosis," and "hedgehog-signaling. |
2018-03-19 |
2023-08-13 |
Not clear |