| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aurélie Rossin, Giorgia Miloro, Anne-Odile Huebe. TRAIL and FasL Functions in Cancer and Autoimmune Diseases: Towards an Increasing Complexity. Cancers. vol 11. issue 5. 2020-09-30. PMID:31072029. |
tumor necrosis factor-related apoptosis inducing ligand (trail/tnfsf10) and fas ligand (fasl/tnfsf6), two major cytokines of the tnf (tumor necrosis factor) superfamily, exert their main functions from the immune system compartment. |
2020-09-30 |
2023-08-13 |
mouse |
| Nani Wang, Hailiang Xin, Pingcui Xu, Zhongming Yu, Dan Sho. Erxian Decoction Attenuates TNF-α Induced Osteoblast Apoptosis by Modulating the Akt/Nrf2/HO-1 Signaling Pathway. Frontiers in pharmacology. vol 10. 2020-09-30. PMID:31551787. |
evaluations of bone mineral density, serum estradiol level, trabecular area fraction, serum calcium levels, and tumor necrosis factor (tnf)-α levels in ovariectomized rats, as well as cell proliferation assays, apoptosis assays, and western blotting in mc3t3-e1 osteoblasts were performed for further experimental validation. |
2020-09-30 |
2023-08-13 |
rat |
| Reena Kumari, Senthilnathan Palaniyandi, Ethan Strattan, Timothy Huang, Katharina Kohler, Nashwan Jabbour, Joanna Dalland, Jing Du, Melissa V Kesler, Youhai H Chen, Gerhard C Hildebrand. TNFAIP8 Deficiency Exacerbates Acute Graft Versus Host Disease in a Murine Model of Allogeneic Hematopoietic Cell Transplantation. Transplantation. vol 104. issue 3. 2020-09-30. PMID:31634333. |
tumor necrosis factor (tnf)-alpha-induced protein 8 (tnfaip8 or tipe) acts as a negative mediator of apoptosis via inhibition of caspase-3 activation, promotes cell proliferation and tipe deficiency is associated with increased inflammation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bin Yang, Ping Yan, Hui Gong, Lin Zuo, Ying Shi, Jian Guo, Rui Guo, Jun Xie, Bao L. TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner. American journal of translational research. vol 8. issue 9. 2020-09-30. PMID:27725864. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak), a member of tnf superfamily, is a pro-inflammatory and pro-angiogenic cytokine implicated in physiological tissue regeneration and wound repair and is closely related to cardiac remodeling, dysfunction and fibrosis. |
2020-09-30 |
2023-08-13 |
rat |
| Dinesh Babu, Georges Leclercq, Roberto Motterlini, Romain A Lefebvr. Differential Effects of CORM-2 and CORM-401 in Murine Intestinal Epithelial MODE-K Cells under Oxidative Stress. Frontiers in pharmacology. vol 8. 2020-09-30. PMID:28228725. |
the water-soluble corm-a1 reduced apoptosis and nadph oxidase (nox)-derived reactive oxygen species (ros) induced by tumor necrosis factor (tnf)-α/cycloheximide (chx) in mouse mode-k intestinal epithelial cells (iecs), without influencing tnf-α/chx-induced mitochondrial superoxide anion ([formula: see text]). |
2020-09-30 |
2023-08-13 |
mouse |
| Jun-Juan Lu, Qing Wang, Li Hua Xie, Qiang Zhang, Sheng Hua Su. Tumor necrosis factor-like weak inducer of apoptosis regulates quadriceps muscle atrophy and fiber-type alteration in a rat model of chronic obstructive pulmonary disease. Tobacco induced diseases. vol 15. 2020-09-29. PMID:29151827. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak), as a member of the tnf superfamily, has recently been identified as a key regulator of skeletal muscle wasting and metabolic dysfunction. |
2020-09-29 |
2023-08-13 |
rat |
| Yosuke Osawa, Ekumi Kojika, Yukiko Hayashi, Masamichi Kimura, Koji Nishikawa, Sachiyo Yoshio, Hiroyoshi Doi, Tatsuya Kanto, Kiminori Kimur. Tumor necrosis factor-α-mediated hepatocyte apoptosis stimulates fibrosis in the steatotic liver in mice. Hepatology communications. vol 2. issue 4. 2020-09-29. PMID:29619419. |
however, it is unclear whether the induction of tumor necrosis factor (tnf)-α-mediated hepatocyte apoptosis in the simple fatty liver triggers liver fibrosis. |
2020-09-29 |
2023-08-13 |
mouse |
| Marine Lambert, Geneviève Pépin, Oscar Peralta-Zaragoza, Raphaël Matusiak, Sophia Ly, Patricia Landry, Patrick Provos. TWEAK Negatively Regulates Human Dicer. Non-coding RNA. vol 2. issue 4. 2020-09-29. PMID:29657270. |
this approach identified tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) as a dicer-interacting protein candidate. |
2020-09-29 |
2023-08-13 |
human |
| Chong Li, Panpan Zhang, Yanming Hao, Dawei He, Yixin Shen, Rongzhu L. Expression and significance of quantum dots in RAW 264.7 macrophages. Oncology letters. vol 16. issue 5. 2020-09-29. PMID:30333871. |
the mrna expression levels of genes encoding inflammatory cytokines [tumor necrosis factor (tnf)-α and interleukin (il)-1β] were determined, and cellular assays were performed to investigate the activation, proliferation and apoptosis of raw 264.7 cells. |
2020-09-29 |
2023-08-13 |
Not clear |
| Rosalind L Ang, Mark Chan, Adrian T Tin. Ripoptocide - A Spark for Inflammation. Frontiers in cell and developmental biology. vol 7. 2020-09-29. PMID:31457011. |
tnf is also a well-known trigger of caspase-dependent apoptosis or caspase-independent necroptosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Hua-Wei Zhao, Hao Liu, Li-Ying Liu, Zhi Liu, Xue-Song Don. Analysis of microRNA expression profiling during paraquat-induced injury of murine lung alveolar epithelial cells. The Journal of toxicological sciences. vol 45. issue 8. 2020-09-29. PMID:32741895. |
the bioinformatic analyses suggested that the target genes of these mirnas were involved in mitochondrial apoptosis pathway and dna methylation, and participated in the regulation of pi3k-akt, mtor, ras, tnf, mapk and other signal pathways which related to oxidative stress and apoptosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Valentina Pileczki, Laura Pop, Cornelia Braicu, Livia Budisan, Gabriela Bolba Morar, Paloma Del C Monroig-Bosque, Robert V Sandulescu, Ioana Berindan-Neago. Double gene siRNA knockdown of mutant p53 and TNF induces apoptosis in triple-negative breast cancer cells. OncoTargets and therapy. vol 9. 2020-09-29. PMID:27956838. |
double gene sirna knockdown of mutant p53 and tnf induces apoptosis in triple-negative breast cancer cells. |
2020-09-29 |
2023-08-13 |
human |
| Valentina Pileczki, Laura Pop, Cornelia Braicu, Livia Budisan, Gabriela Bolba Morar, Paloma Del C Monroig-Bosque, Robert V Sandulescu, Ioana Berindan-Neago. Double gene siRNA knockdown of mutant p53 and TNF induces apoptosis in triple-negative breast cancer cells. OncoTargets and therapy. vol 9. 2020-09-29. PMID:27956838. |
simultaneous inhibition of p53 and tnf in hs578t tnbc human cell line revealed a panel of up- and downregulated genes involved in apoptosis. |
2020-09-29 |
2023-08-13 |
human |
| George E Naoum, Donald J Buchsbaum, Fady Tawadros, Ammad Farooqi, Waleed O Arafa. Journey of TRAIL from Bench to Bedside and its Potential Role in Immuno-Oncology. Oncology reviews. vol 11. issue 1. 2020-09-29. PMID:28584572. |
since its identification as a tnf family member, trail (tnf-related apoptosis-inducing ligand) paved a new path in apoptosis inducing cancer therapies. |
2020-09-29 |
2023-08-13 |
Not clear |
| Sorah Yoon, Xiwei Wu, Brian Armstrong, Nagy Habib, John J Ross. An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma. Molecular therapy. Nucleic acids. vol 14. 2020-09-28. PMID:30594071. |
pdr3 also upregulated serine phosphorylation of p53, which subsequently mediated apoptosis through the death receptors: tumor necrosis factor (tnf)-related apoptosis-inducing ligand receptors 1/2 (trail-r1/r2), fas-associated via death domain (fadd), and fas. |
2020-09-28 |
2023-08-13 |
human |
| Zhaoqian Su, Yinghao W. A computational model for understanding the oligomerization mechanisms of TNF receptor superfamily. Computational and structural biotechnology journal. vol 18. 2020-09-28. PMID:32021664. |
by recognizing members in the tumor necrosis factor (tnf) receptor superfamily, tnf ligand proteins function as extracellular cytokines to activate various signaling pathways involved in inflammation, proliferation, and apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Dirk Geerts, Christina Chopra, Linda Connell. Osteoprotegerin: Relationship to Breast Cancer Risk and Prognosis. Frontiers in oncology. vol 10. 2020-09-28. PMID:32318347. |
in the primary tumor, opg may interact with another tnf superfamily member, tnf-related apoptosis inducing ligand (trail; tnfsf10) to prevent apoptosis induction. |
2020-09-28 |
2023-08-13 |
Not clear |
| Lili Liang, Chuantao Cheng, Guanglei Hu, Xuening Wang, Jing Liu, Zhu Yan, Weihui Zeng, Yumin Xi. TWEAK Promotes the Proliferation of Squamous Cell Carcinoma Cells Through Activating cIAP1 Signals. Frontiers in oncology. vol 10. 2020-09-28. PMID:32351884. |
recent studies showed that tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) induces the proliferation of squamous cell carcinoma (scc) cells. |
2020-09-28 |
2023-08-13 |
human |
| Changhong Ke, Huan Hou, Jiayu Li, Kui Su, Chaohong Huang, Yue Lin, Zhiqiang Lu, Zhiyun Du, Wen Tan, Zhengqiang Yua. Extracellular Vesicle Delivery of TRAIL Eradicates Resistant Tumor Growth in Combination with CDK Inhibition by Dinaciclib. Cancers. vol 12. issue 5. 2020-09-28. PMID:32375399. |
tumour necrosis factor (tnf)-related apoptosis inducing ligand (trail) is a promising anti-cancer agent that rapidly induces apoptosis in cancer cells. |
2020-09-28 |
2023-08-13 |
human |
| Marilena Kampa, George Notas, Efstathios N Stathopoulos, Andreas Tsapis, Elias Castana. The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer. Frontiers in oncology. vol 10. 2020-09-28. PMID:32612943. |
tumor necrosis factor (tnf) superfamily consists of 19 ligands and 29 receptors and is related to multiple cellular events from proliferation and differentiation to apoptosis and tumor reduction. |
2020-09-28 |
2023-08-13 |
Not clear |