| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rendong Jiang, Xiaogang Zhang, Yicheng Li, Haikang Zhou, Huhu Wang, Fei Wang, Hairong Ma, Li Ca. Identification of the molecular mechanisms of Salvia miltiorrhiza relevant to the treatment of osteoarthritis based on network pharmacology. Discovery medicine. vol 30. issue 160. 2021-09-27. PMID:33382964. |
the go function and kegg pathway enrichment cluster of the common targets revealed that sm acts on oa mainly through the pi3k-akt, il-17, hif-1, and tnf signaling pathways and that its function is mainly to regulate metabolism, apoptosis, inflammation, and cell proliferation. |
2021-09-27 |
2023-08-13 |
Not clear |
| Deepika Singh, Mallika Tewari, Sunita Singh, Gopeshwar Naraya. Revisiting the role of TRAIL/TRAIL-R in cancer biology and therapy. Future oncology (London, England). vol 17. issue 5. 2021-09-27. PMID:33401962. |
tnf-related apoptosis-inducing ligand (trail), a member of the tnf superfamily, can induce apoptosis in cancer cells, sparing normal cells when bound to its associated death receptors (dr4/dr5). |
2021-09-27 |
2023-08-13 |
human |
| A L Heck, S Mishra, T Prenzel, L Feulner, E Achhammer, V Särchen, B S J Blagg, W Schneider-Brachert, S Schütze, J Fritsc. Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation. Immunobiology. vol 226. issue 2. 2021-09-27. PMID:33639524. |
co-incubation of cells with either tnf or trail in combination with the hsp90β inhibitor kunb105 but not hsp90α selective inhibition promotes apoptosis induction. |
2021-09-27 |
2023-08-13 |
Not clear |
| Kai Meng, Chengbo Fan. Knockdown of Tripartite motif-containing 22 (TRIM22)relieved the apoptosis of lens epithelial cells by suppressing the expression of TNF receptor-associated factor 6 (TRAF6). Bioengineered. vol 12. issue 1. 2021-09-27. PMID:34558381. |
knockdown of tripartite motif-containing 22 (trim22)relieved the apoptosis of lens epithelial cells by suppressing the expression of tnf receptor-associated factor 6 (traf6). |
2021-09-27 |
2023-08-13 |
Not clear |
| Xuwen Gao, Chao Niu, Zhuo Wang, Shuo Jia, Meijing Han, Yingying Ma, Xueting Guan, Li Wang, Xinyuan Qiao, Yigang X. Comprehensive analysis of lncRNA expression profiles in cytopathic biotype BVDV-infected MDBK cells provides an insight into biological contexts of host-BVDV interactions. Virulence. vol 12. issue 1. 2021-09-24. PMID:33258421. |
co-expression network analysis elucidated that de lncrnas were significant enrichment in nod-like receptor, tnf, nf-ĸb, erbb, ras, apoptosis, and fatty acid biosynthesis pathways, indicating that de lncrnas play important roles in host-bvdv interactions. |
2021-09-24 |
2023-08-13 |
cattle |
| Longfei Deng, Xuan Zhai, Ping Liang, Hongjuan Cu. Overcoming TRAIL Resistance for Glioblastoma Treatment. Biomolecules. vol 11. issue 4. 2021-09-20. PMID:33919846. |
the tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) shows a promising therapeutic potential in cancer treatment as it exclusively causes apoptosis in a broad spectrum of cancer cells through triggering the extrinsic apoptosis pathway via binding to cognate death receptors, with negligible toxicity in normal cells. |
2021-09-20 |
2023-08-13 |
Not clear |
| Wiktoria Ratajczak, Sarah D Atkinson, Catriona Kell. The TWEAK/Fn14/CD163 axis-implications for metabolic disease. Reviews in endocrine & metabolic disorders. 2021-09-20. PMID:34542797. |
tweak (tumor necrosis factor-like weak inducer of apoptosis) is a member of the tnf superfamily that controls a multitude of cellular events including proliferation, migration, differentiation, apoptosis, angiogenesis, and inflammation. |
2021-09-20 |
2023-08-13 |
Not clear |
| Limeng Yang, Vanessa A N Kraft, Susanne Pfeiffer, Juliane Merl-Pham, Xuanwen Bao, Yu An, Stefanie M Hauck, Joel A Schic. Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1. Molecular oncology. vol 14. issue 10. 2021-09-10. PMID:32602581. |
suppressor with morphogenetic effect on genitalia 7 (smg7) is an nmd complex protein and a regulator of tumor necrosis factor (tnf)-induced extrinsic apoptosis; however, this unique function has not been explored in detail. |
2021-09-10 |
2023-08-13 |
Not clear |
| Jingbo Pang, Mark Maienschein-Cline, Timothy J Ko. Reduced apoptosis of monocytes and macrophages is associated with their persistence in wounds of diabetic mice. Cytokine. vol 142. 2021-09-10. PMID:33810946. |
scrnaseq analysis implicated tnf, mapk, jak-stat, and foxo signaling pathways in promoting wound mo/mΦ apoptosis in non-diabetic mice while cell proliferation related pathways appeared to be activated in diabetic mice. |
2021-09-10 |
2023-08-13 |
mouse |
| Xiaoping Liang, Yujie Liu, Ling Chen, Suyu Che. The natural compound puerarin alleviates inflammation and apoptosis in experimental cell and rat preeclampsia models. International immunopharmacology. vol 99. 2021-09-08. PMID:34311188. |
abnormal placental inflammatory cytokines (tnf, il-6, ifn-γ, and il-4) and apoptosis markers (bcl-2, bax, caspase-3, caspase-8, and caspase-9) expressions in the lps-treated group were reversed after pue treatment. |
2021-09-08 |
2023-08-13 |
rat |
| Zhuyun Qin, Shixuan Shen, Kaiyong Qu, Yu Nie, Haitao Zhan. Mild hypothermia in rat with acute myocardial ischaemia-reperfusion injury complicating severe sepsis. Journal of cellular and molecular medicine. 2021-09-04. PMID:34057282. |
tumor necrosis factor (tnf)-α and caspase-3 was performed by immunohistochemistry to exam myocardial inflammation and apoptosis. |
2021-09-04 |
2023-08-13 |
rat |
| Yi-Ting Gong, Yan-Ping Li, Ya-Ru Cheng, Xiu-Jia Shi, Li Yang, Dong-Ping Yang, Wen-Juan Xu, Ling Don. [Molecular mechanism of Qishen Yiqi Dripping Pills in treating myocardial ischemia:a study based on HIF-1 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 15. 2021-09-03. PMID:34472272. |
the results of network pharmacology indicated that qsyq, containing 18 active ingredients and 82 key targets, could protect cardiomyocytes by regulating biological functions, such as nitric oxide biosynthesis, apoptosis, inflammation, and angiogenesis, through tnf signaling pathway, hif-1 signaling pathway, pi3 k-akt signaling pathway, etc. |
2021-09-03 |
2023-08-13 |
Not clear |
| Jiongbo Wang, Hongju Sun, Yunshun Li. The proliferative and anti-apoptosis functions of KGF/KGFR contributes to bronchial epithelial repair in asthma. Pulmonary pharmacology & therapeutics. vol 63. 2021-09-01. PMID:32818548. |
in vitro, treatment of kgf may limit ifn-γ and tnf-α induced apoptosis by inhibiting apoptosis-associated markers in the tnf signaling pathway. |
2021-09-01 |
2023-08-13 |
human |
| Hao-Yang Ma, Shuang Chen, Wei-Dong Cao, Cui-Ting Mi. Diagnostic value of TWEAK for predicting active lupus nephritis in patients with systemic lupus erythematosus: a systematic review and meta-analysis. Renal failure. vol 43. issue 1. 2021-08-30. PMID:33307926. |
accumulative studies showed that tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) was up-regulated in the blood and urine from patients diagnosed with lupus nephritis (ln) and that it might be used as a novel biomarker for active ln. |
2021-08-30 |
2023-08-13 |
Not clear |
| Min Fei, Zheng Li, Yuanwu Cao, Chang Jiang, Haodong Lin, Zixian Che. MicroRNA-182 improves spinal cord injury in mice by modulating apoptosis and the inflammatory response via IKKβ/NF-κB. Laboratory investigation; a journal of technical methods and pathology. vol 101. issue 9. 2021-08-27. PMID:34059758. |
it was also observed that mir-182 overexpression reduced apoptosis and attenuated the inflammatory response in spinal cord tissue, as evidenced by the reduction of tumor necrosis factor (tnf)-α, interleukin (il)-6, and il-1β, and the induction of il-10. |
2021-08-27 |
2023-08-13 |
mouse |
| Kai Wang, Lu Lei, Jinyi Cao, Yi Qiao, Ruimin Liang, Jialin Duan, Zhijun Feng, Yi Ding, Yang Ma, Zhifu Yang, Enhu Zhan. Network pharmacology-based prediction of the active compounds and mechanism of Buyang Huanwu Decoction for ischemic stroke. Experimental and therapeutic medicine. vol 22. issue 4. 2021-08-27. PMID:34434264. |
furthermore, the tnf, il17, apoptosis, pi3k-akt, toll-like receptor, mapk, nf-κb and hif-1 signaling pathways were identified to be associated with ischemic stroke. |
2021-08-27 |
2023-08-13 |
Not clear |
| Shirin Lotfipanah, Parichehreh Yaghmaei, Majid Zeinali, Seyed Ali Haeri Rohani, Sosan Kabodanian Ardestan. Evaluation of Iranian journal of biotechnology. vol 19. issue 2. 2021-08-27. PMID:34435060. |
apoptosis is an important issue in toxicological studies, and tumor necrosis factor (tnf) family members execute crucial roles in apoptosis and inflammation. |
2021-08-27 |
2023-08-13 |
rat |
| Isabelle Allaeys, Flavia Ribeiro de Vargas, Sylvain G Bourgoin, Patrice E Poubell. Human Inflammatory Neutrophils Express Genes Encoding Peptidase Inhibitors: Production of Elafin Mediated by NF-κB and CCAAT/Enhancer-Binding Protein β. Journal of immunology (Baltimore, Md. : 1950). vol 206. issue 8. 2021-08-23. PMID:33762327. |
by using microarrays, quantitative rt-pcr, and elisas, we showed that long-lived (ll) neutrophils obtained after 48 h of culture in the presence of gm-csf, tnf, and il-4 differentially expressed genes related to apoptosis, mhc class ii, immune response, and inflammation. |
2021-08-23 |
2023-08-13 |
human |
| ZhiYong Xu, MingXue Zheng, Yan Liu, Li Zhang, XueSong Zhang, Rui Ba. Roles of TNF receptor-associated and Fas-associated death domain proteins in the apoptosis of Eimeria tenella host cells. Veterinary parasitology. vol 290. 2021-08-20. PMID:33476903. |
roles of tnf receptor-associated and fas-associated death domain proteins in the apoptosis of eimeria tenella host cells. |
2021-08-20 |
2023-08-13 |
chicken |
| ZhiYong Xu, MingXue Zheng, Yan Liu, Li Zhang, XueSong Zhang, Rui Ba. Roles of TNF receptor-associated and Fas-associated death domain proteins in the apoptosis of Eimeria tenella host cells. Veterinary parasitology. vol 290. 2021-08-20. PMID:33476903. |
the present study aimed to investigate the effects of death receptor adapter proteins, namely, tnf receptor-associated death domain (tradd) and fas-associated death domain (fadd) proteins, on eimeria tenella-induced host cell apoptosis. |
2021-08-20 |
2023-08-13 |
chicken |