| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicholas Chun, Rosalind L Ang, Mark Chan, Robert L Fairchild, William M Baldwin Iii, Julian K Horwitz, Jesse D Gelles, Jerry Edward Chipuk, Michelle A Kelliher, Vasile I Pavlov, Yansui Li, Dirk Homann, Peter S Heeger, Adrian T Tin. T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death. JCI insight. 2021-11-09. PMID:34752416. |
tumor necrosis factor (tnf) ligation of tnf receptor 1 (tnfr1) promotes either inflammation and cell survival by inhibiting ripk1's death-signaling function and activating nf-kb, or causes ripk1 to associate with the death-inducing signaling complex to initiate apoptosis or necroptosis. |
2021-11-09 |
2023-08-13 |
Not clear |
| Anusha Jayaraman, Thein Than Htike, Rachel James, Carmen Picon, Richard Reynold. TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34625123. |
exposure of human ipsc-derived glutamatergic neurons to tnf increased necroptotic cell death when apoptosis was inhibited, which was significantly reversed by small molecule inhibitors of ripk1, ripk3, and mlkl. |
2021-11-05 |
2023-08-13 |
human |
| Mohammed M H Al-Gayyar, Abdullah Alattar, Reem Alshaman, Ahmed M Hamda. QNZ alleviated hepatocellular carcinoma by targeting inflammatory pathways in a rat model. Cytokine. vol 148. 2021-11-02. PMID:34564023. |
the expression levels of nuclear factor (nf)κb, tumor necrosis factor (tnf)-α, apoptosis signal regulating kinase (ask)-1, β-catenin, glycogen synthase kinase (gsk)-3 and tnf receptor-associated factor (traf) were examined in hepatic samples. |
2021-11-02 |
2023-08-13 |
rat |
| Minggang Zhang, Zeguo Zhao, Yuri Pritykin, Margaret Hannum, Andrew C Scott, Fengshen Kuo, Viraj Sanghvi, Timothy A Chan, Venkatraman Seshan, Hans-Guido Wendel, Andrea Schietinger, Michel Sadelain, Morgan Hus. Ectopic activation of the miR-200c-EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy. Science translational medicine. vol 13. issue 611. 2021-11-01. PMID:34524864. |
ctls transduced with mir-200c exhibited reduced apoptosis during engraftment and enhanced in vivo persistence, accompanied by up-regulation of the transcriptional regulator t cell factor 1 (tcf1) and the inflammatory cytokine tumor necrosis factor (tnf). |
2021-11-01 |
2023-08-13 |
mouse |
| Yuan Xu, Hui-Ting Wei, Hao-Yue Jing, Xiao-Yang Tan, Xiao-Tao Zhou, Yue-Rong M. Emerging role of TWEAK-Fn14 axis in lupus, a disease related to autoimmunity and fibrosis. International journal of rheumatic diseases. 2021-10-30. PMID:34716660. |
as an important marker in the tumor necrosis factor (tnf) superfamily, tnf-like weak inducer of apoptosis (tweak) has been given much attention with respect to its role in regulating pro-inflammatory immune response. |
2021-10-30 |
2023-08-13 |
Not clear |
| Tahany Saad Abdelwahab, Rania Ellisy Abdelhamed, Eman Noaman Ali, Nahla Ahmed Mansour, Mohga Shafik Abdall. Evaluation of Silver Nanoparticles Caffeic Acid Complex Compound as New Potential Therapeutic Agent against Cancer Incidence in Mice. Asian Pacific journal of cancer prevention : APJCP. vol 22. issue 10. 2021-10-29. PMID:34710995. |
the present work was designed to study the effect of new conjugated caffeic and folic acid with silver nanoparticles with definite molecular size applied with and without gamma radiation exposure, as an antitumor agent against experimentally induced ehrlich tumor and attempted to identify their potential molecular mechanisms of action throughout determination of anti-tumor activities using mtt cytotoxic assay against two human carcinoma cell lines in vitro, such as apoptosis analysis by flow cytometry through caspase-8, caspase-3 and tnf determination in vivo. |
2021-10-29 |
2023-08-13 |
mouse |
| Leszek Gromadziński, Łukasz Paukszto, Agnieszka Skowrońska, Piotr Holak, Michał Smoliński, Elżbieta Łopieńska-Biernat, Ewa Lepiarczyk, Aleksandra Lipka, Jan Paweł Jastrzębski, Marta Majewsk. Transcriptomic Profiling of Femoral Veins in Deep Vein Thrombosis in a Porcine Model. Cells. vol 10. issue 7. 2021-10-28. PMID:34206566. |
kegg analysis disclosed tnf, nf-κb and apoptosis pathways' overexpression in dvt samples. |
2021-10-28 |
2023-08-13 |
human |
| Karol Alí Apaza Alccayhuaman, Patrick Heimel, Jung-Seok Lee, Stefan Tangl, Franz J Strauss, Alexandra Stähli, Eva Matalová, Reinhard Grube. FasL Is Required for Osseous Healing in Extraction Sockets in Mice. Frontiers in immunology. vol 12. 2021-10-26. PMID:34135904. |
fas ligand (fasl) is a member of the tumor necrosis factor (tnf) superfamily involved in the activation of apoptosis. |
2021-10-26 |
2023-08-13 |
mouse |
| Lili Zhao, Mengfan Xu, Xin Pan, Bolin Zhang, Qingnan Do. Binding and detoxification ability of lactobacillus acidophilus towards di-n-butyl phthalate: Change of MAPK pathway in Caco-2 cell model. Journal of proteomics. vol 247. 2021-10-22. PMID:34298185. |
the molecular mechanism of dbp toxicity alleviated by strain ncfm was involved the mapk pathway, via dbp bind to strain ncfm and avoid the activation of tnf receptor by dbp, so down-regulated the nf-κb, creb, p21, gadd45, and casp3, relieving the apoptosis of caco-2 cells. |
2021-10-22 |
2023-08-13 |
human |
| Aaiz Hussain, Targol Tarahomi, Lavi Singh, Murali Bollampally, Milad Heydari-Kamjani, Marc M Kesselma. Cardiovascular Risk Associated With TNF Alpha Inhibitor Use in Patients With Rheumatoid Arthritis. Cureus. vol 13. issue 9. 2021-10-22. PMID:34660128. |
treatment commonly targets inflammatory cytokines, including tumor necrosis factor (tnf) alpha, which is a potent inflammatory cytokine required for cell signaling, regulation, and apoptosis, as well as for other cellular functions including immune response. |
2021-10-22 |
2023-08-13 |
Not clear |
| Ryo Yoriki, Satoru Akashi, Masayuki Sho, Takeo Nomi, Ichiro Yamato, Kiyohiko Hotta, Tomoyoshi Takayama, Sohei Matsumoto, Kohei Wakatsuki, Kazuhiro Migita, Hideo Yagita, Yoshiyuki Nakajim. Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer. Experimental and therapeutic medicine. vol 2. issue 1. 2021-10-21. PMID:22977477. |
tumor necrosis factor-like weak inducer of apoptosis (tweak) is a member of the tnf superfamily. |
2021-10-21 |
2023-08-12 |
human |
| Stephan Munich, Andrea Sobo-Vujanovic, William J Buchser, Donna Beer-Stolz, Nikola L Vujanovi. Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands. Oncoimmunology. vol 1. issue 7. 2021-10-21. PMID:23170255. |
in the present study, we demonstrate that, similar to dcs, dc-derived exosomes (dcex) express on their surface tnf, fasl and trail, by which they can trigger caspase activation and apoptosis in tumor cells. |
2021-10-21 |
2023-08-12 |
Not clear |
| Alaa Refaat, Sherif Abdelhamed, Hideo Yagita, Hiroki Inoue, Satoru Yokoyama, Yoshihiro Hayakawa, Ikuo Saik. Berberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer. Oncology letters. vol 6. issue 3. 2021-10-21. PMID:24137422. |
although evidence supports the theory that tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a promising candidate for treating cancer, its usage may be limited due to the resistance to the trail-induced apoptosis of cancer cells. |
2021-10-21 |
2023-08-12 |
Not clear |
| Hongman Wang, Lisheng Xu, Jiping Zhao, Donghui Wang, Ranran Guo, Junfei Wang, Wenbin Gong, Tian Liu, Yuanyuan Zhang, Liang Don. Regulatory mechanism of pyrrolidine dithiocarbamate is mediated by nuclear factor-κB and inhibits neutrophil accumulation in ARDS mice. Experimental and therapeutic medicine. vol 8. issue 2. 2021-10-21. PMID:25009629. |
in addition, flow cytometry was used to investigate the apoptosis rate of pmns in the bronchoalveolar fluid, and the expression levels of interleukin (il)-1β, il-8 and tumor necrosis factor (tnf)-α and myeloperoxidase (mpo) activity were also determined. |
2021-10-21 |
2023-08-13 |
mouse |
| Ling-Han Qu, Xia Hong, Yan Zhang, Xin Cong, Ruo-Lan Xiang, Mei Mei, Jia-Zeng Su, Li-Ling Wu, Guang-Yan Y. C1q/tumor necrosis factor-related protein-6 attenuates TNF-α-induced apoptosis in salivary acinar cells via AMPK/SIRT1-modulated miR-34a-5p expression. Journal of cellular physiology. vol 236. issue 8. 2021-10-20. PMID:33400820. |
ctrp6 inhibited the apoptosis rate and reversed the increased levels of cleaved caspase 3, caspase 8, caspase 9, and cytochrome c and the decreased bcl-2 expression induced by tumor necrosis factor (tnf)-α in both smg-c6 cells and cultured human smg tissues. |
2021-10-20 |
2023-08-13 |
mouse |
| Can G Pham, Salvatore Papa, Concetta Bubici, Francesca Zazzeroni, Guido Franzos. In the Crosshairs: NF-κB Targets the JNK Signaling Cascade. Current medicinal chemistry. Anti-inflammatory & anti-allergy agents. vol 4. issue 6. 2021-10-20. PMID:19829748. |
nf-κb also blocks programmed cell death (pcd) or apoptosis triggered by proinflammatory cytokine, tumor necrosis factor (tnf)α. |
2021-10-20 |
2023-08-12 |
human |
| Yang Ye, Fen Ye, Xue Li, Qi Yang, Jianwei Zhou, Wenrong Xu, Michael Aschner, Rongzhu Lu, Shuhan Mia. 3,3'-diindolylmethane exerts antiproliferation and apoptosis induction by TRAF2-p38 axis in gastric cancer. Anti-cancer drugs. vol 32. issue 2. 2021-10-19. PMID:33315588. |
tumor necrosis factor (tnf) receptor-associated factor 2 (traf2), one of the signal transduction proteins, plays critical role in proliferation and apoptosis of human gastric cancer cells, but there are still lack of practical pharmacological modulators for potential clinical application. |
2021-10-19 |
2023-08-13 |
human |
| Ludmila Cardoso Alves, Nadia Corazza, Olivier Micheau, Philippe Kreb. The multifaceted role of TRAIL signaling in cancer and immunity. The FEBS journal. vol 288. issue 19. 2021-10-14. PMID:33215853. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a member of the tnf superfamily that can lead to the induction of apoptosis in tumor or infected cells. |
2021-10-14 |
2023-08-13 |
Not clear |
| Pratyusha Mandal, Lynsey N Nagrani, Liliana Hernandez, Anita Louise McCormick, Christopher P Dillon, Heather S Koehler, Linda Roback, Emad S Alnemri, Douglas R Green, Edward S Mocarsk. Multiple Autonomous Cell Death Suppression Strategies Ensure Cytomegalovirus Fitness. Viruses. vol 13. issue 9. 2021-10-10. PMID:34578288. |
second, the virus deflected tnf-mediated extrinsic apoptosis, a pathway dependent on autocrine tnf production by macrophages that proceeds independently of mitochondrial death machinery or ripk3. |
2021-10-10 |
2023-08-13 |
Not clear |
| Prachi Pathare-Ingawale, Preeti Chavan-Gauta. The balance between cell survival and death in the placenta: Do neurotrophins have a role? Systems biology in reproductive medicine. 2021-10-07. PMID:34615417. |
these include the trk, tropomyosin-related kinase family of high-affinity tropomyosin-related kinase receptors, which induces cell survival, and the p75ntr, p75 neurotrophin receptor, a member of the tumor necrosis factor(tnf) receptor superfamily, which induces apoptosis in neuronal cells. |
2021-10-07 |
2023-08-13 |
Not clear |