| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mengge Yang, Huizhen Ge, Suqiong Ji, Yue Li, Li Xu, Zhuajin Bi, Bitao B. TWEAK and Fn14 is overexpressed in immune-mediated necrotizing myopathy: implications for muscle damage and repair. Rheumatology (Oxford, England). 2023-03-14. PMID:36916753. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) and its sole receptor fibroblast growth factor-inducible 14 (fn14), are involved in various inflammatory conditions. |
2023-03-14 |
2023-08-14 |
Not clear |
| Hina Agraval, Taylor Crue, Niccolette Schaunaman, Mari Numata, Brian J Day, Hong Wei Ch. Electronic Cigarette Exposure Increases the Severity of Influenza a Virus Infection via TRAIL Dysregulation in Human Precision-Cut Lung Slices. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901724. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail), a protein of the tnf family involved in cell apoptosis, is upregulated in copd patients and during influenza a virus (iav) infections, but its role in viral infection during ec exposures remains unclear. |
2023-03-11 |
2023-08-14 |
human |
| Katherine S Ventre, Kevin Roehle, Elisa Bello, Aladdin M Bhuiyan, Tamara Biary, Stephanie J Crowley, Patrick T Bruck, Max Heckler, Patrick J Lenehan, Lestat R Ali, Courtney T Stump, Victoria Lippert, Eleanor Clancy-Thompson, Winiffer D Conce Alberto, Megan T Hoffman, Li Qiang, Marc Pelletier, James J Akin, Michael Dougan, Stephanie K Douga. cIAP1/2 Antagonism Induces Antigen-Specific T Cell-Dependent Immunity. Journal of immunology (Baltimore, Md. : 1950). 2023-03-07. PMID:36881882. |
in tumor cells, ciap1/2 antagonists can increase tnf production and tnf-mediated apoptosis; however, pancreatic cancer cells are resistant to cytokine-mediated apoptosis, even in the presence of ciap1/2 antagonism. |
2023-03-07 |
2023-08-14 |
mouse |
| Mai Sakai, Zhiqian Yu, Masayuki Taniguchi, Rosanne Picotin, Nanami Oyama, David Stellwagen, Chiaki Ono, Yoshie Kikuchi, Ko Matsui, Miharu Nakanishi, Hatsumi Yoshii, Tomoyuki Furuyashiki, Takaaki Abe, Hiroaki Tomit. N-Acetylcysteine Suppresses Microglial Inflammation and Induces Mortality Dose-Dependently via Tumor Necrosis Factor-α Signaling. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36835209. |
n-acetylcysteine (nac) is an antioxidant that prevents tumor necrosis factor (tnf)-α-induced cell death, but it also acts as a pro-oxidant, promoting reactive oxygen species independent apoptosis. |
2023-02-25 |
2023-08-14 |
mouse |
| Zimo Liu, Xuefei Zhou, Qi Li, Youqing Shen, Tianhua Zhou, Xiangrui Li. Macrophage-evading and tumor-specific apoptosis inducing nanoparticles for targeted cancer therapy. Acta pharmaceutica Sinica. B. vol 13. issue 1. 2023-02-23. PMID:36815044. |
the fabricated nanoparticles (tm-cq/nps) were coated with fibroblast cell membrane expressing tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail). |
2023-02-23 |
2023-08-14 |
Not clear |
| Yoshinaga Ito, Deng Pan, Wubing Zhang, Xixi Zhang, Tiffany Y Juan, Jason W Pyrdol, Oleksandr Kyrysyuk, John G Doench, X Shirley Liu, Kai W Wucherpfenni. Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-secreted Cytokines. Cancer discovery. 2023-02-22. PMID:36811466. |
autophagy and tnf signaling emerged as top pathways, and inactivation of rnf31 (tnf signaling) and atg5 (autophagy) sensitized mhc-i deficient tumor cells to apoptosis by t cell-derived cytokines. |
2023-02-22 |
2023-08-14 |
Not clear |
| Dinesh Parshuram Satpute, Urjita Shirwadkar, Anil Kumar Tharalla, Sangita Dattatray Shinde, Gargi Nikhil Vaidya, Swarali Joshi, Priyanka Patel Vatsa, Alok Jain, Abhishek A Singh, Rachana Garg, Amit Mandoli, Dinesh Kuma. Discovery of fluorinated 2‑Styryl 4(3H)-quinazolinone as potential therapeutic hit for oral cancer. Bioorganic & medicinal chemistry. vol 81. 2023-02-16. PMID:36796126. |
subsequent rna-seq analysis revealed that the compound induces the activation of molecular pathways involved in apoptosis (such as tnf signalling through nf-κb, p53 pathways) and cell differentiation and suppresses the pathways of cellular growth and development (such as kras signaling) in cal-27 cancer cells. |
2023-02-16 |
2023-08-14 |
Not clear |
| Min Fei, Zheng Li, Yuanwu Cao, Chang Jiang, Haodong Lin, Zixian Che. MicroRNA-182 improves spinal cord injury in mice by modulating apoptosis and the inflammatory response via IKKβ/NF-κB. Laboratory investigation; a journal of technical methods and pathology. vol 101. issue 9. 2023-02-12. PMID:36775547. |
it was also observed that mir-182 overexpression reduced apoptosis and attenuated the inflammatory response in spinal cord tissue, as evidenced by the reduction of tumor necrosis factor (tnf)-α, interleukin (il)-6, and il-1β, and the induction of il-10. |
2023-02-12 |
2023-08-14 |
mouse |
| Hongting Yan, Yingjie Li, Bing Yang, Fengxi Long, Zhu Yang, Dongxin Tan. Exploring the mechanism of action of Yiyi Fuzi Baijiang powder in colorectal cancer based on network pharmacology and molecular docking studies. Biotechnology & genetic engineering reviews. 2023-02-03. PMID:36735641. |
yiyi fuzi baijiang powder may influence the pi3k-akt signaling pathway, tnf signaling route, and il-17 signaling pathway, which are involved in transcription, gene expression, apoptosis and proliferation regulation, among other biological processes, according to go and kegg enrichment analyses. |
2023-02-03 |
2023-08-14 |
Not clear |
| Piaoyi Guo, Liang Jin, Huifen Zhou, Yida Bao, Jiehong Yang, Jing Chen, Yu He, Daojun Yu, Haitong Wa. Glycyrrhetinic acid protects against Multidrug-resistant Acinetobacter baumannii-induced lung epithelial cells injury by regulating inflammation and oxidative stress. BMC pharmacology & toxicology. vol 24. issue 1. 2023-01-31. PMID:36717837. |
notwithstanding, ga could reverse mdr-ab-induced cell apoptosis, hampered adhesion and invasion of mdr-ab to cells, and inhibit pro-inflammatory cytokines expression of il-1β, il-6, and tnf. |
2023-01-31 |
2023-08-14 |
human |
| Jingmiao Yang, Shuai Yang, Yongshan Liao, Yuewen Deng, Yu Jia. Histone deacetylase inhibitor butyrate inhibits the cellular immunity and increases the serum immunity of pearl oyster Pinctada fucata martensii. Fish & shellfish immunology. 2023-01-12. PMID:36632915. |
meanwhile, butyrate inhibited the up-regulation of 31.54%-54.96% of the genes induced by lps, and these genes were mainly enriched in "notch signaling pathway", "cell proliferation", "nf-kappa b signaling pathway", "tnf signaling pathway", "apoptosis", "nod-like receptor signaling pathway", "rig-i-like receptor signaling pathway" and "cytosolic dna-sensing pathway". |
2023-01-12 |
2023-08-14 |
Not clear |
| Xuesong Wang, Yan Chai, Zhe Guo, Ziyi Wang, Haiyan Liao, Ziwen Wang, Zhong Wan. A new perspective on the potential application of RIPK1 in the treatment of sepsis. Immunotherapy. 2023-01-04. PMID:36597707. |
generally, ripk1 can induce cell apoptosis and necroptosis through tnf, fas and lipopolysaccharide stimulation, while its scaffold function can sense the fluctuation of cellular energy and promote cell survival. |
2023-01-04 |
2023-08-14 |
human |
| John J Krolewski, Shalini Singh, Kai Sha, Neha Jaiswal, Steven G Turowski, Chunliu Pan, Laurie J Rich, Mukund Seshadri, Kent L Nastiu. TNF Signaling Is Required for Castration-Induced Vascular Damage Preceding Prostate Cancer Regression. Cancers. vol 14. issue 24. 2022-12-23. PMID:36551505. |
these results demonstrate that tnf signaling is required for vascular regression, most likely by inducing endothelial cell apoptosis and increasing vessel permeability. |
2022-12-23 |
2023-08-14 |
mouse |
| Jon Huyghe, Dario Priem, Lisette Van Hove, Barbara Gilbert, Jürgen Fritsch, Yasuo Uchiyama, Esther Hoste, Geert van Loo, Mathieu J M Bertran. ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway. Science (New York, N.Y.). vol 378. issue 6625. 2022-12-15. PMID:36520901. |
here, we describe a checkpoint that prevents apoptosis through the detoxification of the cytotoxic complex iia that forms upon tnf sensing. |
2022-12-15 |
2023-08-14 |
mouse |
| Hua Huang, Haochuan Yu, Xuanguang Li, Yongwen Li, Guangsheng Zhu, Lianchun Su, Mingbiao Li, Chen Chen, Min Gao, Di Wu, Ruihao Zhang, Peijun Cao, Hongyu Liu, Jun Che. Genomic analysis of TNF-related genes with prognosis and characterization of the tumor immune microenvironment in lung adenocarcinoma. Frontiers in immunology. vol 13. 2022-12-12. PMID:36505472. |
the tumor necrosis factor (tnf) family plays a role in modulating cellular functions that regulate cellular differentiation, survival, apoptosis, and especially cellular immune functions. |
2022-12-12 |
2023-08-14 |
Not clear |
| Kang-Wei Wang, Qin-Qin Liu, Jian Zhu, Xin Deng, Li Luo, Shi-Mei Lin, Chuan-Jie Qin, Yong-Jun Che. Transcriptome analysis provides insights into the molecular mechanism of liver inflammation and apoptosis in juvenile largemouth bass Micropterus salmoides fed low protein high starch diets. Comparative biochemistry and physiology. Part D, Genomics & proteomics. vol 45. 2022-12-12. PMID:36508948. |
besides mediating inflammation and immune response, tnf-α signal transduction participated in mediating apoptosis through the receptor of tnf (tnf-r1) pathway by up-regulating the expression of caspase 8 and cytochrome c. in conclusion, our results demonstrated that feeding low protein and high starch diets induced hepatocytes inflammation and apoptosis in lmb through the pi3k/akt/nf-κb signaling pathway. |
2022-12-12 |
2023-08-14 |
Not clear |
| Manjari Kundu, Yoshimi Endo Greer, Jennifer L Dine, Stanley Lipkowit. Targeting TRAIL Death Receptors in Triple-Negative Breast Cancers: Challenges and Strategies for Cancer Therapy. Cells. vol 11. issue 23. 2022-12-11. PMID:36496977. |
the tumor necrosis factor (tnf) superfamily member tnf-related apoptosis-inducing ligand (trail) induces apoptosis in cancer cells via death receptor (dr) activation with little toxicity to normal cells or tissues. |
2022-12-11 |
2023-08-14 |
Not clear |
| David E Lee, Lauren K McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A Taylor, Gurpreet S Baht, James P Whit. Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling. Nature communications. vol 13. issue 1. 2022-12-09. PMID:36494364. |
using ex vivo media exchange and in vivo tnf inhibition, we demonstrate a mechanism of metrnl action during regeneration, showing it counteracts a pro-fibrotic gene program by triggering tnfα-induced apoptosis of fibro/adipogenic progenitor cells. |
2022-12-09 |
2023-08-14 |
Not clear |
| Sherif A El-Kafrawy, Mai M El-Daly, Leena H Bajrai, Thamir A Alandijany, Arwa A Faizo, Mohammad Mobashir, Sunbul S Ahmed, Sarfraz Ahmed, Shoaib Alam, Raja Jeet, Mohammad Amjad Kamal, Syed Tauqeer Anwer, Bushra Khan, Manal Tashkandi, Moshahid A Rizvi, Esam Ibraheem Azha. Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma. Frontiers in genetics. vol 13. 2022-12-08. PMID:36479247. |
pi3k, camp, tgf, tnf, rap1, nf-kb, apoptosis, longevity regulating pathway, signaling pathways regulating pluripotency of stem cells, cytokine-cytokine receptor interaction, p53 signaling, wnt signaling, toll-like receptor signaling, and hippo signaling pathways are just a few of the most commonly enriched pathways. |
2022-12-08 |
2023-08-14 |
human |
| Naoki Yamamoto, Himeno Takeuchi, Manami Yamaoka, Tomoya Nakanishi, Shingo Tonai, Ryo Nishimura, Takehito Morita, Masashi Nagano, Shingo Kameda, Kaori Genda, Jun Kawase, Yasuhisa Yamashit. Lipopolysaccharide (LPS) suppresses follicle development marker expression and enhances cytokine expressions, which results in fail to granulosa cell proliferation in developing follicle in cows. Reproductive biology. vol 23. issue 1. 2022-12-05. PMID:36470010. |
ce contraction significantly increased cytokine expressions (tnf, il-1a, and il-1b) in granulosa cells and suppressed apoptosis of granulosa cells compared to normal cows. |
2022-12-05 |
2023-08-14 |
Not clear |