| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valentina Masola, Nicola Greco, Pamela Tozzo, Luciana Caenazzo, Maurizio Onist. The role of SPATA2 in TNF signaling, cancer, and spermatogenesis. Cell death & disease. vol 13. issue 11. 2022-11-19. PMID:36402749. |
the activation of tnf receptors can lead to cell death with a mechanism of cell necrosis regulated genetically and distinct from apoptosis which is defined as necroptosis. |
2022-11-19 |
2023-08-14 |
mouse |
| Karol Alí Apaza Alccayhuaman, Patrick Heimel, Jung Seok Lee, Stefan Tangl, Ulrike Kuchler, Julie Marchesan, Layla Panahipour, Stefan Lettner, Eva Matalová, Reinhard Grube. FasL is a catabolic factor in alveolar bone homeostasis. Journal of clinical periodontology. 2022-11-17. PMID:36384160. |
fas ligand (fasl) belongs to the tumor necrosis factor (tnf) superfamily regulating bone turnover, inflammation, and apoptosis. |
2022-11-17 |
2023-08-14 |
Not clear |
| Olena Zaitseva, Annett Hoffmann, Christoph Otto, Harald Wajan. Targeting fibroblast growth factor (FGF)-inducible 14 (Fn14) for tumor therapy. Frontiers in pharmacology. vol 13. 2022-11-07. PMID:36339601. |
fibroblast growth factor-inducible 14 (fn14) is a member of the tumor necrosis factor (tnf) receptor superfamily (tnfrsf) and is activated by its ligand tnf-like weak inducer of apoptosis (tweak). |
2022-11-07 |
2023-08-14 |
Not clear |
| Zhaoqun Liu, Mingxun An, Xinxing Geng, Zhongjie Wu, Wenqi Cai, Jia Tang, Kaidian Zhang, Zhi Zho. The scleractinian coral Pocillopora damicornis relies on neuroendocrine regulation to cope with polycyclic aromatic hydrocarbons under heat stress. Environmental pollution (Barking, Essex : 1987). 2022-11-04. PMID:36332711. |
results from the transcriptome data further indicated that corals might perform stress responses upon pahs and heat challenges through the tnf and apoptosis pathways, which perhaps was modulated by the neuroendocrine system of corals. |
2022-11-04 |
2023-08-14 |
Not clear |
| Khalidah Ibraheem, Albashir M A Yhmed, Mohamed M Nasef, Nikolaos T Georgopoulo. TRAF3/p38-JNK Signalling Crosstalk with Intracellular-TRAIL/Caspase-10-Induced Apoptosis Accelerates ROS-Driven Cancer Cell-Specific Death by CD40. Cells. vol 11. issue 20. 2022-10-27. PMID:36291141. |
the capacity to induce tumour-cell specific apoptosis represents the most unique feature of the tnf receptor (tnfr) family member cd40. |
2022-10-27 |
2023-08-14 |
Not clear |
| Delphine Stephan, Anais Roger, Jehanne Aghzadi, Sylvie Carmona, Christophe Picard, Jean-Philippe Dales, Sophie Desplat-Jég. TWEAK and TNFα, Both TNF Ligand Family Members and Multiple Sclerosis-Related Cytokines, Induce Distinct Gene Response in Human Brain Microvascular Endothelial Cells. Genes. vol 13. issue 10. 2022-10-27. PMID:36292599. |
tumor necrosis factor-like weak inducer of apoptosis (tweak) is a member of the tnf ligand family involved in various diseases including brain inflammatory pathologies such as multiple sclerosis. |
2022-10-27 |
2023-08-14 |
human |
| Yi-Fan Liao, Feng-Lin Luo, Shan-Shan Tang, Jing-Wei Huang, Ying Yang, Shuang Wang, Tang-Yu Jiang, Qiong Man, Sha Liu, Yi-Ying W. Network analysis and experimental pharmacology study explore the protective effects of Isoliquiritigenin on 5-fluorouracil-Induced intestinal mucositis. Frontiers in pharmacology. vol 13. 2022-10-24. PMID:36278232. |
in addition, kegg and go enrichment analysis revealed that the hif-1, tnf, mapk, il-17, pi3k-akt, ras, nf-kappa b signaling pathway, and biological processes of the inflammatory response, apoptosis regulation, no production and nf-kappa b transcription factor activity might be involved in the mechanism of isl against intestinal mucositis. |
2022-10-24 |
2023-08-14 |
mouse |
| Zeze Wang, Xue Luo, Zhen Luo, Yulong Tan, Genlin He, Ping Li, Xuesen Yan. Transcriptome sequencing reveals neurotoxicity in embryonic neural stem/progenitor cells under heat stress. Toxicology in vitro : an international journal published in association with BIBRA. 2022-10-22. PMID:36272530. |
pcr arrays confirmed that the tnf receptor family plays an important role in the apoptosis of nspcs during heat stress. |
2022-10-22 |
2023-08-14 |
mouse |
| Xiushen Li, Weizheng Liang, Chengwei Yu, Qingxue Meng, Weiwen Zhang, Xueliang Wu, Jun Xue, Shoulong Deng, Hao Wan. Potential therapeutic strategies for quercetin targeting critical pathological mechanisms associated with colon adenocarcinoma and COVID-19. Frontiers in pharmacology. vol 13. 2022-10-17. PMID:36249762. |
bioinformatic analysis of these 105 genes revealed that the mechanisms for quercetin the treatment of coad/covid-19 may be associated with oxidative stress, apoptosis, anti-inflammatory, immune, anti-viral and multiple pathways containing il-17, tnf, hif-1. |
2022-10-17 |
2023-08-14 |
Not clear |
| Dong-Xu Hua, Kai-Shu Ma, Jia-Yi Cheng, Ying Liu, Jing Sun, Qi-Yuan He, You-Peng Deng, Jin Yang, Lin Fu, Hui Zha. Serum TRAIL predicts severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study. Internal and emergency medicine. 2022-10-14. PMID:36241932. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) can trigger the apoptosis pathways through binding to relative death receptors. however, the relationship of trail with community-acquired pneumonia (cap) was unclear. |
2022-10-14 |
2023-08-14 |
Not clear |
| Antonella Montinaro, Henning Walcza. Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries. Cell death and differentiation. 2022-10-04. PMID:36195672. |
tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail) can induce apoptosis in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any essential normal cells. |
2022-10-04 |
2023-08-14 |
Not clear |
| Simeng Hou, Haotian Wu, Si Chen, Xubo Li, Zhenxing Zhang, Yiwen Cheng, Yuanyuan Chen, Meirong He, Qi An, Churiga Man, Li Du, Qiaoling Chen, Fengyang Wan. Bovine skin fibroblasts mediated immune responses to defend against bovine Acinetobacter baumannii infection. Microbial pathogenesis. 2022-09-30. PMID:36179976. |
kyoto encyclopedia of genes and genomes (kegg) enrichment showed that innate immune pathways were significantly enriched, such as tnf, il-17, nlr, mapk, nf-κb, endocytosis, apoptosis and hif-1 signaling pathways. |
2022-09-30 |
2023-08-14 |
cattle |
| Jun Li, Kaiping Yang, Yunhui Guo, Lukang Cao, Fangling Cheng, Nannan Zhan. Material basis and action mechanism of Euryale Ferox Salisb in preventing and treating diabetic kidney disease. Journal of food biochemistry. 2022-09-27. PMID:36165567. |
they are involved primarily in signal transduction, inflammatory responses, tnf regulation, apoptosis, mapk, and other signaling pathways. |
2022-09-27 |
2023-08-14 |
Not clear |
| Jun Li, Kaiping Yang, Yunhui Guo, Lukang Cao, Fangling Cheng, Nannan Zhan. Material basis and action mechanism of Euryale Ferox Salisb in preventing and treating diabetic kidney disease. Journal of food biochemistry. 2022-09-27. PMID:36165567. |
in general, this approach provides an effective strategy in which es acts primarily against dkd through oleic acid and vitamin e, targeting the protein encoded by ppara, lpl, fabp1, mapk1 to regulate tnf, apoptosis, mapk, and other signaling pathways. |
2022-09-27 |
2023-08-14 |
Not clear |
| Song-Hee Kim, Seung-Il Baek, Jihye Jung, Eung-Seok Lee, Younghwa Na, Bang Yeon Hwang, Yoon-Seok Roh, Jin Tae Hong, Sang-Bae Han, Youngsoo Ki. Chemical inhibition of TRAF6-TAK1 axis as therapeutic strategy of endotoxin-induced liver disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-09-23. PMID:36150308. |
following exposure to endotoxin lps, tlr4-mediated phosphorylation of tak1 and transcription of cell-death cytokine tnf-α were triggered in kupffer cells but not in hepatocytes as well as tnf receptor-mediated and caspase-3-executed apoptosis was occurred in d-galactosamine (galn)-sensitized hepatocytes under co-culture with kupffer cells. |
2022-09-23 |
2023-08-14 |
mouse |
| Xin Liu, Jimmy J Yao, Zhongxuan Chen, Wei Lei, Rong Duan, Zhenqiang Ya. Lipopolysaccharide sensitizes the therapeutic response of breast cancer to IAP antagonist. Frontiers in immunology. vol 13. 2022-09-19. PMID:36119107. |
consistent with this, mda-mb-231 cell apoptosis induced by lps plus sm-164 is also blocked by the tnf inhibitor. |
2022-09-19 |
2023-08-14 |
mouse |
| Yuhong Pan, Ke Liu, Juan Huang, Anchun Cheng, Mingshu Wang, Shun Chen, Qiao Yang, Ying Wu, Di Sun, Sai Mao, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Qun Gao, Xumin Ou, Bin Tian, Zhongqiong Yin, Renyong Ji. Molecular cloning, functional characterization of duck TRADD and its effect on infection with duck Tembusu virus. Veterinary microbiology. vol 274. 2022-09-18. PMID:36116188. |
tumor necrosis factor receptor 1 (tnfr1) associated death domain protein (tradd) is a pivotal adaptor in tnf signaling pathway and plays an important role in apoptosis and immune regulation. |
2022-09-18 |
2023-08-14 |
Not clear |
| Ismael Obaidi, Alfonso Blanco Fernández, Tara McMorro. Curcumin Sensitises Cancerous Kidney Cells to TRAIL Induced Apoptosis via Let-7C Mediated Deregulation of Cell Cycle Proteins and Cellular Metabolism. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36076967. |
the use of tumour necrosis factor (tnf)-related apoptosis inducing ligand (trail) as an anticancer therapy has attracted the attention of the scientific community and created great excitement due to its selectivity in targeting cancerous cells with no toxic impacts on normal tissues. |
2022-09-09 |
2023-08-14 |
Not clear |
| Jin Ding, Pan Zheng, Ying-Ying Sun, Xiao-Ran Wang, Yan-Chen Fen. [Analysis of Wumei Pills in treating chronic digestive system diseases with concept of "treating different diseases with same method" based on network pharmacology and molecular docking]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 15. 2022-09-01. PMID:36046907. |
the present study explored the material basis and underlying mechanism of wumei pills in the treatment of ulcerative colitis(uc), diabetic enteropathy(de), and irritable bowel syndrome(ibs) based on network pharmacology and molecular docking.the active components and targets of wumei pills were obtained and screened out from tcmsp, and the target names were standardized by uniprot.the related targets of uc, de, and ibs were searched from genecards, disgenet, drugbank, and omim.the venn dia-gram was constructed using the venny 2.1 online analysis tool to obtain the common targets of the drug and diseases.the "drug-active ingredient-target" network was constructed by cytoscape 3.7.2.gene ontology(go) function enrichment and kyoto encyclopedia of genes and genomes(kegg) pathway enrichment analyses of common targets were carried out by david.the main active components and targets were docked by autodock.the therapeutic mechanism of wumei pills was presumedly related to the regulation of the cancer pathway, tnf signaling pathway, hif-1 signaling pathway, pi3 k-akt signaling pathway, nf-κb signaling pathway, toll-like receptor signaling pathway, jak-stat signaling pathway, etc.the results of molecular docking showed that the main active components could bind to the core targets, possessing stable conformation.the therapeutic effects of wumei pills against three diseases involved a variety of compounds such as flavonoids, sterols, and alkaloids in the prescriptions, which acted on key targets through multiple organs and participated in multiple signaling pathways such as apoptosis and immune inflammation, thereby exerting the therapeutic action on different diseases with the same method.this study explained the underlying mechanism of wumei pills in "treating different diseases with same method", and is expected to provide a theoretical basis for further understanding the mechanism of wumei pills and exploring the new clinical application. |
2022-09-01 |
2023-08-14 |
Not clear |
| Natalia Ortí-Casañ, Inge S Zuhorn, Petrus J W Naudé, Peter P De Deyn, Pauline E M van Schaik, Harald Wajant, Ulrich L M Eise. A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer's disease mouse model. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 37. 2022-08-29. PMID:36037389. |
previous research has associated this with the antithetic functions of the two tnf receptors, tnf receptor 1, associated with inflammation and apoptosis, and tnf receptor 2 (tnfr2), associated with neuroprotection. |
2022-08-29 |
2023-08-14 |
mouse |