| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laurel A Grisant. TRAIL and its receptors in cardiac diseases. Frontiers in physiology. vol 14. 2023-08-25. PMID:37621762. |
extrinsic apoptosis occurs through a subset of tumor necrosis receptor (tnf) family receptors termed "death receptors." |
2023-08-25 |
2023-09-07 |
Not clear |
| Laurel A Grisant. TRAIL and its receptors in cardiac diseases. Frontiers in physiology. vol 14. 2023-08-25. PMID:37621762. |
one poorly characterized cardiac tnf related ligand is tnf-related apoptosis inducing ligand (trail). |
2023-08-25 |
2023-09-07 |
Not clear |
| Nicholas S Jones, Smita Kshirsagar, Vishnu Mohanan, Vidya Ramakrishnan, Flavia Di Nucci, Ling Ma, Jialin Mao, Hao Ding, Sha Klabunde, Domagoj Vucic, Lin Pan, Annemarie N Lekkerkerker, Yuan Chen, Michael E Rothenber. A phase I, randomized, ascending-dose study to assess safety, pharmacokinetics, and activity of GDC-8264, a RIP1 inhibitor, in healthy volunteers. Clinical and translational science. 2023-08-24. PMID:37596814. |
rip1 kinase activity mediates apoptosis and necroptosis induced by tumor necrosis factor (tnf)-α, toll-like receptors, and ischemic tissue damage. |
2023-08-24 |
2023-09-07 |
human |
| Xupu Wang, Lizheng Wang, Wenmo Liu, Xinyao Liu, Xinyuan Jia, Xinyao Feng, Fangshen Li, Rui Zhu, Jiahao Yu, Haihong Zhang, Hui Wu, Jiaxin Wu, Chu Wang, Bin Yu, Xianghui Y. Dose-related immunomodulatory effects of recombinant TRAIL in the tumor immune microenvironment. Journal of experimental & clinical cancer research : CR. vol 42. issue 1. 2023-08-22. PMID:37605148. |
in addition to specifically inducing tumor cell apoptosis, recombinant tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) has also been reported to influence the cancer immune microenvironment; however, its underlying effects and mechanisms remain unclear. |
2023-08-22 |
2023-09-07 |
Not clear |
| Lien Verboom, Christopher J Anderson, Maude Jans, Ioanna Petta, Gillian Blancke, Arne Martens, Mozes Sze, Tino Hochepied, Kodi S Ravichandran, Lars Vereecke, Geert van Lo. OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection. Cell death & disease. vol 14. issue 8. 2023-08-19. PMID:37598207. |
we show that mice with intestinal epithelial cell (iec)-specific otulin deficiency exhibit increased susceptibility to experimental colitis and are highly sensitive to tnf toxicity, due to excessive apoptosis of otulin deficient iecs. |
2023-08-19 |
2023-09-07 |
mouse |
| Kaibo Zhang, Bin Zhang, Yeqiang Son. Molecular Mechanism of Bai-Bo Formula for Treatment of Vitiligo Based on Network Pharmacology and Molecular Docking. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 5. 2023-08-12. PMID:37571906. |
bai-bo formula regulates immune inflammation, apoptosis, and autophagy via various pathways, including age-rage, pi3k-akt, and tnf signaling. |
2023-08-12 |
2023-08-16 |
Not clear |
| Yanhong Li, Guiying Shi, Wei Liang, Haiquan Shang, Huiwu Li, Yunlin Han, Wenjie Zhao, Lin Bai, Chuan Qi. Allogeneic Adipose-Derived Mesenchymal Stem Cell Transplantation Alleviates Atherosclerotic Plaque by Inhibiting Ox-LDL Uptake, Inflammatory Reaction and Endothelial Damage in Rabbits. Cells. vol 12. issue 15. 2023-08-11. PMID:37566014. |
compared with the model group, blood lipid levels declined, the plaque area, oxidized low-density lipoprotein (ox-ldl) uptake, scavenger receptor a1 and cluster of differentiation (cd) 36 levels were all significantly reduced, and the accumulation of inflammatory m1 macrophages, apoptosis, interleukin (il)-6 and tumor necrosis factor (tnf)-α expression were decreased. |
2023-08-11 |
2023-08-16 |
rabbit |
| Edward S Mocarsk. Programmed Necrosis in Host Defense. Current topics in microbiology and immunology. 2023-08-10. PMID:37563336. |
pro-apoptotic caspase-8 activity (along with caspase-10 in humans) executes extrinsic apoptosis, a nonlytic form of cell death triggered by tnf family death receptors (drs). |
2023-08-10 |
2023-08-16 |
Not clear |
| Olena Zaitseva, Annett Hoffmann, Margaretha Löst, Mohamed A Anany, Tengyu Zhang, Kirstin Kucka, Armin Wiegering, Christoph Otto, Harald Wajan. Antibody-based soluble and membrane-bound TWEAK mimicking agonists with FcγR-independent activity. Frontiers in immunology. vol 14. 2023-08-07. PMID:37545514. |
in contrast to conventional 18d1, the majority of 18d1 antibody variants with four or more fn14 binding sites displayed a strong ability to trigger the alternative nfκb pathway and to enhance tnf-induced cell death and therefore resemble in their activity soluble (tnf)-like weak inducer of apoptosis (tweak), one form of the natural occurring ligand of fn14. |
2023-08-07 |
2023-08-14 |
Not clear |
| Junqi Xiao, Yang Xie, Qing Duan, Tao Liu, Rong Ye, Xunhong Duan, Zhibiao Le, Nan Deng, Fengen Li. LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models. International heart journal. vol 64. issue 4. 2023-07-30. PMID:37518356. |
afterward, gain- and loss-of-function assays were performed in huvecs, followed by detection of cell viability, invasion, migration, and apoptosis and the expression of inflammatory factors [tumor necrosis factor (tnf) -α, interleukin (il) -1β, and il-6], endmt-related proteins [cd31, vascular epithelium (ve) -cadherin, vimentin, α-smooth muscle actin (sma), snai1, snai2, and twist1], and the apoptotic protein cleaved caspase-3. |
2023-07-30 |
2023-08-14 |
human |
| So-Young Lee, Geun-Hye Hong, Ji Hyung Chung, Kun-Young Par. Anticancer Effects of Washed-Dehydrated Solar Salt Doenjang on Colon Cancer-Induced C57BL/6 Mice. Journal of medicinal food. 2023-07-27. PMID:37498372. |
besides, wdsd regulated the protein expression of apoptosis (bcl-2-associated x protein [bax], b cell lymphoma-2 [bcl-2], b cell lymphoma-extra large [bcl-xl], and caspase 9, caspase 3), and p53, p21, and proinflammatory cytokines (interleukin [il]-6, tumor necrosis factor [tnf]- |
2023-07-27 |
2023-08-14 |
mouse |
| Vishal S Patil, Darasaguppe R Harish, Ganesh H Sampat, Subarna Roy, Sunil S Jalalpure, Pukar Khanal, Swarup S Gujarathi, Harsha V Hegd. System Biology Investigation Revealed Lipopolysaccharide and Alcohol-Induced Hepatocellular Carcinoma Resembled Hepatitis B Virus Immunobiology and Pathogenesis. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446321. |
in accordance with the enrichment analysis, hbv activates the signaling pathways for apoptosis, cell cycle, pi3k-akt, tnf, jak-stat, mapk, chemokines, nf-kappa b, and tgf-beta. |
2023-07-14 |
2023-08-14 |
Not clear |
| Poulami Tapadar, Ambika Pal, Nirajan Ghosal, Bhupender Kumar, Tamalika Paul, Nabendu Biswas, Ranjana Pa. CDH1 overexpression sensitizes TRAIL resistant breast cancer cells towards rhTRAIL induced apoptosis. Molecular biology reports. 2023-07-08. PMID:37422537. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is well known for its unique ability to induce apoptosis in cancer cells but not normal cells. |
2023-07-08 |
2023-08-14 |
Not clear |
| Ming Huang, Zhongbing Wu, Lei Jia, Yu Wang, Shuang Gao, Ying Liu, Yushuang Zhang, Jing L. Bioinformatics and network pharmacology identify promotional effects and potential mechanisms of ethanol on esophageal squamous cell carcinoma and experimental validation. Toxicology and applied pharmacology. 2023-07-05. PMID:37406968. |
bioinformatics results showed that the target genes tnf, il6, il1β and jun were highly expressed in esophageal tumor samples and positively correlated with tumor proliferation and apoptosis genes, and the genetic information of these genes was mutated to different degrees. |
2023-07-05 |
2023-08-14 |
mouse |
| Natalia Ortí-Casañ, Ate S Boerema, Karina Köpke, Amber Ebskamp, Jan Keijser, Yuequ Zhang, Tingting Chen, Amalia M Dolga, Kerensa Broersen, Roman Fischer, Klaus Pfizenmaier, Roland E Kontermann, Ulrich L M Eise. The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration. Scientific reports. vol 13. issue 1. 2023-06-30. PMID:37391534. |
tnf-α exerts distinct functions depending on interaction with its two tnf receptors, whereby tnf receptor 1 (tnfr1) is associated with neuroinflammation and apoptosis and tnf receptor 2 (tnfr2) with neuroprotection and immune regulation. |
2023-06-30 |
2023-08-14 |
mouse |
| Wei-Chao Ding, Juan Chen, Hao-Yu Liao, Jing Feng, Jing Wang, Yu-Hao Zhang, Xiao-Hang Ji, Qian Chen, Xin-Yao Wu, Zhao-Rui Sun, Shi-Nan Ni. [Mechanism of Xuebijing Injection in treatment of sepsis-associated ARDS based on network pharmacology and in vitro experiment]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 12. 2023-06-29. PMID:37382018. |
the in vitro experiment confirmed that xuebijing injection suppressed the hif-1, tnf, nf-κb, toll-like receptor, and nod-like receptor signaling pathways, inhibited cell apoptosis and reactive oxygen species generation, and down-regulated the expression of tnf-α, il-1β, and il-6 in cells. |
2023-06-29 |
2023-08-14 |
Not clear |
| Wei-Chao Ding, Juan Chen, Hao-Yu Liao, Jing Feng, Jing Wang, Yu-Hao Zhang, Xiao-Hang Ji, Qian Chen, Xin-Yao Wu, Zhao-Rui Sun, Shi-Nan Ni. [Mechanism of Xuebijing Injection in treatment of sepsis-associated ARDS based on network pharmacology and in vitro experiment]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 12. 2023-06-29. PMID:37382018. |
in conclusion, xuebijing injection can regulate apoptosis and response to inflammation and oxidative stress by acting on hif-1, tnf, nf-κb, toll-like receptor, and nod-like receptor signaling pathways to treat sepsis-associated ards. |
2023-06-29 |
2023-08-14 |
Not clear |
| Julio M Pimentel, Jun-Ying Zhou, Gen Sheng W. The Role of TRAIL in Apoptosis and Immunosurveillance in Cancer. Cancers. vol 15. issue 10. 2023-06-22. PMID:37345089. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a member of the tnf superfamily that selectively induces apoptosis in tumor cells without harming normal cells, making it an attractive agent for cancer therapy. |
2023-06-22 |
2023-08-14 |
Not clear |
| Francesca Sibilia, Nasim Sheikh-Bahaei, Wendy J Mack, Jeiran Choupa. Perivascular spaces in Alzheimer's disease are associated with inflammatory, stress-related, and hypertension biomarkers. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333097. |
in the pvs basal ganglia, a significant positive association was found with trail (a tnf receptor inducing apoptosis). |
2023-06-19 |
2023-08-14 |
Not clear |
| O Avci, A S Taskiran, O Gundogd. Dexmedetomidine, an α Revista espanola de anestesiologia y reanimacion. 2023-06-07. PMID:37286034. |
dexmedetomidine, an α the aim of the present study is to examine the possible effect de dexmedetomidine on the development of morphine tolerance in rats including nociception, morphine analgesia, apoptosis, oxidative stress, and tumour necrosis factor (tnf)/ interleukin-1 (il-1) pathways. |
2023-06-07 |
2023-08-14 |
rat |